Duygu Tosun-Turgut, PhD
Professor
Radiology
School of Medicine

Dr. Tosun-Turgut obtained her BSc in Electrical and Electronic Engineering from Bilkent University, Turkey in 1999, and she received her MSE in Electrical and Computer Engineering from The Johns Hopkins University, Maryland in 2001. In 2003, she completed her MA in Mathematics from The Johns Hopkins University, and she earned her PhD in Electrical and Computer Engineering from The Johns Hopkins University in 2005, followed by a postdoctoral fellowship in Neurology from the University of California, Los Angeles in 2008. Her independent research career began as a Research Scientist at the Center for Imaging Neurodegenerative Diseases (CIND) at UCSF, followed by a faculty appointment at the Department of Radiology and Biomedical Imaging at UCSF in 2011. Since her initial faculty appointment at UCSF, she first appointed as Co-Director of CIND and then transitioned to the Founding Director of the Medical Imaging Informatics and Artificial Intelligence.

Dr. Tosun-Turgut’s research focuses on neuroimaging of neurodegenerative diseases and psychiatric disorders and aims to apply advanced imaging technology for discovery of multi-modal biomarkers to detect the progression of neurodegenerative pathologies before they cause irreversible damage to the brain. She aims to develop validated biomarkers of neurodegeneration that may be used for early diagnosis, initiation of prevention strategies in those at risk, monitoring of efficacy and regional specificity of therapies, and clinical trial enrichment. Her research has been funded by NIH, the California Department of Public Health, Department of Defense, Alzheimer’s Association, Michael J Fox Foundation, and industry partners.

Expertise: Computational neuroimaging

Specialty: Neurodegenerative brain diseases; Neuroimaging; Alzheimer’s disease; Front temporal dementia; Late-life depression; Biomarkers; Imaging statistics

Professional Interests: Medical image processing and analysis, computational medicine, magnetic resonance imaging (MRI), positron emission tomography (PET), multi-modality neuroimaging research, aging, Alzheimer's disease, neurodegenerative diseases, late-life depression, imaging biomarkers, biomarkers, prediction models, neuropathology

Education and Training:

• Bachelor of Science: Bilkent University, Turkey - Electrical and Electronic Engineering
• Masters of Science: Johns Hopkins University, Maryland - Electrical and Computer Engineering
• Masters in Art: Johns Hopkins University, Maryland - Mathematics
• Doctor of Philosophy: Johns Hopkins University, Maryland - Electrical and Computer Engineering
• Postdoctoral Fellowship: University of California, Los Angeles - Neurology

• Genomic loci influence patterns of structural covariance in the human brain.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Wen J, Nasrallah IM, Abdulkadir A, Satterthwaite TD, Yang Z, Erus G, Robert-Fitzgerald T, Singh A, Sotiras A, Boquet-Pujadas A, Mamourian E, Doshi J, Cui Y, Srinivasan D, Skampardoni I, Chen J, Hwang …
• Efficacy assessment of an active tau immunotherapy in Alzheimer's disease patients with amyloid and tau pathology: a post hoc analysis of the "ADAMANT" randomised, placebo-controlled, double-blind, multi-centre, phase 2 clinical trial.
  EBioMedicine 2023 Cullen NC, Novak P, Tosun D, Kovacech B, Hanes J, Kontsekova E, Fresser M, Ropele S, Feldman HH, Schmidt R, Winblad B, Zilka N
• Accuracy of TrUE-Net in comparison to established white matter hyperintensity segmentation methods: An independent validation study.
  NeuroImage 2023 Strain JF, Rahmani M, Dierker D, Owen C, Jafri H, Vlassenko AG, Womack K, Fripp J, Tosun D, Benzinger TLS, Weiner M, Masters C, Lee JM, Morris JC, Goyal MS, ADOPIC and ADNI Investigators
• Relationship of Hoarding and Depression Symptoms in Older Adults.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2023 Nutley S, Nguyen BK, Mackin RS, Insel PS, Tosun D, Butters M, Aisen P, Raman R, Saykin AJ, Toga AW, Jack C, Weiner MW, Nelson C, Kassel M, Kryza-Lacombe M, Eichenbaum J, Nosheny RL, Mathews CA
• The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Veitch DP, Weiner MW, Miller M, Aisen PS, Ashford MA, Beckett LA, Green RC, Harvey D, Jack CR, Jagust W, Landau SM, Morris JC, Nho KT, Nosheny R, Okonkwo O, Perrin RJ, Petersen RC, Rivera Mindt M, …
• Identifying individuals with non-Alzheimer's disease co-pathologies: A precision medicine approach to clinical trials in sporadic Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Tosun D, Yardibi O, Benzinger TLS, Kukull WA, Masters CL, Perrin RJ, Weiner MW, Simen A, Schwarz AJ, Alzheimer's Disease Neuroimaging Initiative
• Hoarding Symptoms in Late Life Depression are Associated With Greater Executive Dysfunction and Disability and Poorer Response to Depression Treatment.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2023 Kassel MT, Kryza-Lacombe M, Insel PS, Rhodes E, Satre DD, Nelson JC, Tosun D, Mathews CA, Mackin RS
• Magnetic Resonance Imaging of the Lumbar Spine: Recommendations for Acquisition and Image Evaluation from the BACPAC Spine Imaging Working Group.
  Pain medicine (Malden, Mass.) 2023 Sollmann N, Fields AJ, O'Neill C, Nardo L, Majumdar S, Chin CT, Tosun D, Han M, Vu AT, Ozhinsky E, Shah LM, Harris RE, Lobo R, Anderst W, Herzog R, Psioda MA, Standaert CJ, Price RT, Lotz JC, Link TM,…
• A universal neocortical mask for Centiloid quantification.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2023 Bourgeat P, Doré V, Rowe CC, Benzinger T, Tosun D, Goyal MS, LaMontagne P, Jin L, Weiner MW, Masters CL, Fripp J, Villemagne VL, Alzheimer's Disease Neuroimaging Initiative, OASIS3, and the AIBL …
• Personalising Alzheimer's Disease progression using brain atrophy markers.
  medRxiv : the preprint server for health sciences 2023 Verdi S, Rutherford S, Fraza C, Tosun D, Altmann A, Raket LL, Schott JM, Marquand AF, Cole JH, Alzheimer’s Disease Neuroimaging Initiative
• Profiling and predicting distinct tau progression patterns: An unsupervised data-driven approach to flortaucipir positron emission tomography.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Tosun D, Thropp P, Southekal S, Spottiswoode B, Fahmi R, Alzheimer's Disease Neuroimaging Initiative
• Revealing Individual Neuroanatomical Heterogeneity in Alzheimer Disease Using Neuroanatomical Normative Modeling.
  Neurology 2023 Verdi S, Kia SM, Yong KXX, Tosun D, Schott JM, Marquand AF, Cole JH
• AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale.
  BMC psychiatry 2023 Fu CHY, Erus G, Fan Y, Antoniades M, Arnone D, Arnott SR, Chen T, Choi KS, Fatt CC, Frey BN, Frokjaer VG, Ganz M, Garcia J, Godlewska BR, Hassel S, Ho K, McIntosh AM, Qin K, Rotzinger S, Sacchet MD, …
• Increasing participant diversity in AD research: Plans for digital screening, blood testing, and a community-engaged approach in the Alzheimer's Disease Neuroimaging Initiative 4.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2022 Weiner MW, Veitch DP, Miller MJ, Aisen PS, Albala B, Beckett LA, Green RC, Harvey D, Jack CR, Jagust W, Landau SM, Morris JC, Nosheny R, Okonkwo OC, Perrin RJ, Petersen RC, Rivera-Mindt M, Saykin AJ, …
• A 1-year randomized controlled trial of a nutritional blend to improve nutritional biomarkers and prevent cognitive decline among community-dwelling older adults: The Nolan Study.
  Alzheimer's & dementia (New York, N. Y.) 2022 Giudici KV, Guyonnet S, Cantet C, de Souto Barreto P, Weiner MW, Tosun D, Boschat C, Hudry J, Andrieu S, Vellas B, Schmitt JAJ, Nolan/DSA group
• Cognitive outcomes are differentially associated with depression severity trajectories during psychotherapy treatment for late life major depressive disorder.
  International journal of geriatric psychiatry 2022 Kassel MT, Rhodes E, Insel PS, Woodworth K, Garrison-Diehn C, Satre DD, Nelson JC, Tosun D, Mackin RS
• β-amyloid PET harmonisation across longitudinal studies: Application to AIBL, ADNI and OASIS3.
  NeuroImage 2022 Bourgeat P, Doré V, Burnham SC, Benzinger T, Tosun D, Li S, Goyal M, LaMontagne P, Jin L, Rowe CC, Weiner MW, Morris JC, Masters CL, Fripp J, Villemagne VL, Alzheimer's Disease Neuroimaging Initiative…
• Traumatic brain injury and post-traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2022 Weiner MW, Harvey D, Landau SM, Veitch DP, Neylan TC, Grafman JH, Aisen PS, Petersen RC, Jack CR, Tosun D, Shaw LM, Trojanowski JQ, Saykin AJ, Hayes J, De Carli C, Alzheimer's Disease Neuroimaging …
• Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life Depression.
  JAMA psychiatry 2022 Wen J, Fu CHY, Tosun D, Veturi Y, Yang Z, Abdulkadir A, Mamourian E, Srinivasan D, Skampardoni I, Singh A, Nawani H, Bao J, Erus G, Shou H, Habes M, Doshi J, Varol E, Mackin RS, Sotiras A, Fan Y, …
• Network-wise concordance of multimodal neuroimaging features across the Alzheimer's disease continuum.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2022 Stocks J, Popuri K, Heywood A, Tosun D, Alpert K, Beg MF, Rosen H, Wang L, Alzheimer's Disease Neuroimaging Initiative
• Multiple Cortical to Striatal Accumulation Trajectories of β-Amyloid: Do All Roads Lead to Rome?
  Neurology 2022 Vogel JW, Tosun D
• Regional uptakes from early-frame amyloid PET and 18F-FDG PET scans are comparable independent of disease state.
  European journal of hybrid imaging 2022 Myoraku A, Klein G, Landau S, Tosun D, Alzheimer’s Disease Neuroimaging Initiative
• Age-dependent brain morphometry in Major Depressive disorder.
  NeuroImage. Clinical 2021 Myoraku A, Lang A, Taylor CT, Scott Mackin R, Meyerhoff DJ, Mueller S, Strigo IA, Tosun D
• Thalamic Dorsomedial Nucleus Free Water Correlates with Cognitive Decline in Parkinson's Disease.
  Movement disorders : official journal of the Movement Disorder Society 2021 Guttuso T, Sirica D, Tosun D, Zivadinov R, Pasternak O, Weintraub D, Baglio F, Bergsland N
• Deep learning for Alzheimer's disease: Mapping large-scale histological tau protein for neuroimaging biomarker validation.
  NeuroImage 2021 Ushizima D, Chen Y, Alegro M, Ovando D, Eser R, Lee W, Poon K, Shankar A, Kantamneni N, Satrawada S, Junior EA, Heinsen H, Tosun D, Grinberg LT
• Using imputation to provide harmonized longitudinal measures of cognition across AIBL and ADNI.
  Scientific reports 2021 Shishegar R, Cox T, Rolls D, Bourgeat P, Doré V, Lamb F, Robertson J, Laws SM, Porter T, Fripp J, Tosun D, Maruff P, Savage G, Rowe CC, Masters CL, Weiner MW, Villemagne VL, Burnham SC
• White matter changes in drug-naïve Parkinson's disease patients with impulse control & probable REM sleep behavior disorders.
  Journal of the neurological sciences 2021 Dolatshahi M, Ashraf-Ganjouei A, Wu IW, Zhang Y, Aarabi MH, Tosun D, Parkinson's Progression Marker Initiative
• Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2021 Tosun D, Demir Z, Veitch DP, Weintraub D, Aisen P, Jack CR, Jagust WJ, Petersen RC, Saykin AJ, Shaw LM, Trojanowski JQ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2021 Veitch DP, Weiner MW, Aisen PS, Beckett LA, DeCarli C, Green RC, Harvey D, Jack CR, Jagust W, Landau SM, Morris JC, Okonkwo O, Perrin RJ, Petersen RC, Rivera-Mindt M, Saykin AJ, Shaw LM, Toga AW, …
• Network-constrained technique to characterize pathology progression rate in Alzheimer's disease.
  Brain communications 2021 Powell F, Tosun D, Raj A, Alzheimer’s Disease Neuroimaging Initiative
• ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer's disease.
  Nature aging 2021 Novak P, Kovacech B, Katina S, Schmidt R, Scheltens P, Kontsekova E, Ropele S, Fialova L, Kramberger M, Paulenka-Ivanovova N, Smisek M, Hanes J, Stevens E, Kovac A, Sutovsky S, Parrak V, Koson P, …
• The search for a convenient procedure to detect one of the earliest signs of Alzheimer's disease: A systematic review of the prediction of brain amyloid status.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2021 Ashford MT, Veitch DP, Neuhaus J, Nosheny RL, Tosun D, Weiner MW
• Lower cerebral perfusion is associated with tau-PET in the entorhinal cortex across the Alzheimer's continuum.
  Neurobiology of aging 2021 Rubinski A, Tosun D, Franzmeier N, Neitzel J, Frontzkowski L, Weiner M, Ewers M
• Detection of β-amyloid positivity in Alzheimer's Disease Neuroimaging Initiative participants with demographics, cognition, MRI and plasma biomarkers.
  Brain communications 2021 Tosun D, Veitch D, Aisen P, Jack CR, Jagust WJ, Petersen RC, Saykin AJ, Bollinger J, Ovod V, Mawuenyega KG, Bateman RJ, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Weiner MW
• The Impact of Amyloid Burden and APOE on Rates of Cognitive Impairment in Late Life Depression.
  Journal of Alzheimer's disease : JAD 2021 Rhodes E, Insel PS, Butters MA, Morin R, Bickford D, Tosun D, Gessert D, Rosen HJ, Aisen P, Raman R, Landau S, Saykin A, Toga A, Jack CR, Weiner MW, Nelson C, Mackin S, Alzheimer’s Disease …
• Improvements in Functional Disability After Psychotherapy for Depression Are Associated With Reduced Suicide Ideation Among Older Adults.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2020 Lutz J, Mackin RS, Otero MC, Morin R, Bickford D, Tosun D, Satre DD, Gould CE, Nelson JC, Beaudreau SA
• Late-Life Depression Is Associated With Reduced Cortical Amyloid Burden: Findings From the Alzheimer's Disease Neuroimaging Initiative Depression Project.
  Biological psychiatry 2020 Mackin RS, Insel PS, Landau S, Bickford D, Morin R, Rhodes E, Tosun D, Rosen HJ, Butters M, Aisen P, Raman R, Saykin A, Toga A, Jack C, Koeppe R, Weiner MW, Nelson C, Alzheimer’s Disease Neuroimaging …
• Impact of hybrid supervision approaches on the performance of artificial intelligence for the classification of chest radiographs.
  Computers in biology and medicine 2020 Ellis R, Ellestad E, Elicker B, Hope MD, Tosun D
• Clinical and Dopamine Transporter Imaging Characteristics of Leucine Rich Repeat Kinase 2 (LRRK2) and Glucosylceramidase Beta (GBA) Parkinson's Disease Participants in the Parkinson's Progression Markers Initiative: A Cross-Sectional Study.
  Movement disorders : official journal of the Movement Disorder Society 2020 Simuni T, Brumm MC, Uribe L, Caspell-Garcia C, Coffey CS, Siderowf A, Alcalay RN, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Nudelman K, Tosun-Turgut D, Poston K, …
• Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study.
  The Lancet. Neurology 2019 Simuni T, Uribe L, Cho HR, Caspell-Garcia C, Coffey CS, Siderowf A, Trojanowski JQ, Shaw LM, Seibyl J, Singleton A, Toga AW, Galasko D, Foroud T, Tosun D, Poston K, Weintraub D, Mollenhauer B, Tanner …
• Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.
  Brain : a journal of neurology 2019 Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF, Lambert C, Cardenas-Blanco A, Pine K, Passamonti L, Loane C, Keuken MC, Trujillo P, Lüsebrink F, Mattern H, Liu KY, …
• Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.
  Neurobiology of aging 2019 Nosheny RL, Insel PS, Mattsson N, Tosun D, Buckley S, Truran D, Schuff N, Aisen PS, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration.
  Brain : a journal of neurology 2019 Tan CH, Bonham LW, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GD, Kauppi K, Holland D, McEvoy LK, Kukull WA, Tosun D, Weiner MW, …
• The Parkinson's progression markers initiative (PPMI) - establishing a PD biomarker cohort.
  Annals of clinical and translational neurology 2018 Marek K, Chowdhury S, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Simuni T, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, Toga AW, Mollenhauer B, …
• Chronic depressive symptomatology and CSF amyloid beta and tau levels in mild cognitive impairment.
  International journal of geriatric psychiatry 2018 Gonzales MM, Insel PS, Nelson C, Tosun D, Schöll M, Mattsson N, Sacuiu S, Bickford D, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative
• Telomere attrition is associated with declines in medial temporal lobe volume and white matter microstructure in functionally independent older adults.
  Neurobiology of aging 2018 Staffaroni AM, Tosun D, Lin J, Elahi FM, Casaletto KB, Wynn MJ, Patel N, Neuhaus J, Walters SM, Epel ES, Blackburn EH, Kramer JH
• Longitudinal Change of Clinical and Biological Measures in Early Parkinson's Disease: Parkinson's Progression Markers Initiative Cohort.
  Movement disorders : official journal of the Movement Disorder Society 2018 Simuni T, Siderowf A, Lasch S, Coffey CS, Caspell-Garcia C, Jennings D, Tanner CM, Trojanowski JQ, Shaw LM, Seibyl J, Schuff N, Singleton A, Kieburtz K, Toga AW, Mollenhauer B, Galasko D, Chahine LM, …
• Preserved Structural Network Organization Mediates Pathology Spread in Alzheimer's Disease Spectrum Despite Loss of White Matter Tract Integrity.
  Journal of Alzheimer's disease : JAD 2018 Powell F, Tosun D, Sadeghi R, Weiner M, Raj A, Alzheimer’s Disease Neuroimaging Initiative
• Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.
  NeuroImage. Clinical 2017 Elahi FM, Marx G, Cobigo Y, Staffaroni AM, Kornak J, Tosun D, Boxer AL, Kramer JH, Miller BL, Rosen HJ
• Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer's disease in Vietnam Veterans using the Alzheimer's Disease Neuroimaging Initiative: Preliminary Report.
  Alzheimer's & dementia (New York, N. Y.) 2017 Weiner MW, Harvey D, Hayes J, Landau SM, Aisen PS, Petersen RC, Tosun D, Veitch DP, Jack CR, Decarli C, Saykin AJ, Grafman J, Neylan TC, Department of Defense Alzheimer's Disease Neuroimaging …
• Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease.
  PloS one 2017 Caspell-Garcia C, Simuni T, Tosun-Turgut D, Wu IW, Zhang Y, Nalls M, Singleton A, Shaw LA, Kang JH, Trojanowski JQ, Siderowf A, Coffey C, Lasch S, Aarsland D, Burn D, Chahine LM, Espay AJ, Foster ED, …
• Association between tau deposition and antecedent amyloid-β accumulation rates in normal and early symptomatic individuals.
  Brain : a journal of neurology 2017 Tosun D, Landau S, Aisen PS, Petersen RC, Mintun M, Jagust W, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative
• Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2017 Gonzales MM, Insel PS, Nelson C, Tosun D, Mattsson N, Mueller SG, Sacuiu S, Bickford D, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative
• Independent value added by diffusion MRI for prediction of cognitive function in older adults.
  NeuroImage. Clinical 2017 Scott JA, Tosun D, Braskie MN, Maillard P, Thompson PM, Weiner M, DeCarli C, Carmichael OT, ADNI
• Progression of Regional Microstructural Degeneration in Parkinson's Disease: A Multicenter Diffusion Tensor Imaging Study.
  PloS one 2016 Zhang Y, Wu IW, Tosun D, Foster E, Schuff N, Parkinson’s Progression Markers Initiative
• Diagnostic utility of ASL-MRI and FDG-PET in the behavioral variant of FTD and AD.
  Annals of clinical and translational neurology 2016 Tosun D, Schuff N, Rabinovici GD, Ayakta N, Miller BL, Jagust W, Kramer J, Weiner MM, Rosen HJ
• Cerebral amyloid is associated with greater white-matter hyperintensity accrual in cognitively normal older adults.
  Neurobiology of aging 2016 Scott JA, Braskie MN, Tosun D, Maillard P, Thompson PM, Weiner M, DeCarli C, Carmichael OT, ADNI
• Amyloid status imputed from a multimodal classifier including structural MRI distinguishes progressors from nonprogressors in a mild Alzheimer's disease clinical trial cohort.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2016 Tosun D, Chen YF, Yu P, Sundell KL, Suhy J, Siemers E, Schwarz AJ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Accelerating rates of cognitive decline and imaging markers associated with β-amyloid pathology.
  Neurology 2016 Insel PS, Mattsson N, Mackin RS, Schöll M, Nosheny RL, Tosun D, Donohue MC, Aisen PS, Jagust WJ, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder.
  Frontiers in behavioral neuroscience 2015 Chao LL, Tosun D, Woodward SH, Kaufer D, Neylan TC
• Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly.
  Frontiers in aging neuroscience 2015 Scott JA, Braskie MN, Tosun D, Thompson PM, Weiner M, DeCarli C, Carmichael OT, Alzheimer’s Disease Neuroimaging Initiative
• Discriminative Power of Arterial Spin Labeling Magnetic Resonance Imaging and 18F-Fluorodeoxyglucose Positron Emission Tomography Changes for Amyloid-β-Positive Subjects in the Alzheimer's Disease Continuum.
  Neuro-degenerative diseases 2015 Tosun D, Schuff N, Jagust W, Weiner MW, Alzheimer''s Disease Neuroimaging Initiative
• Cortical thickness and sulcal depth: insights on development and psychopathology in paediatric epilepsy.
  BJPsych open 2015 Tosun D, Siddarth P, Levitt J, Caplan R
• Chronic Depressive Symptomatology in Mild Cognitive Impairment Is Associated with Frontal Atrophy Rate which Hastens Conversion to Alzheimer Dementia.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2015 Sacuiu S, Insel PS, Mueller S, Tosun D, Mattsson N, Jack CR, DeCarli C, Petersen R, Aisen PS, Weiner MW, Mackin RS, Alzheimer's Disease Neuroimaging Initiative
• Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease.
  Annals of clinical and translational neurology 2015 Insel PS, Mattsson N, Mackin RS, Kornak J, Nosheny R, Tosun-Turgut D, Donohue MC, Aisen PS, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Brain amyloid-β burden is associated with disruption of intrinsic functional connectivity within the medial temporal lobe in cognitively normal elderly.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Song Z, Insel PS, Buckley S, Yohannes S, Mezher A, Simonson A, Wilkins S, Tosun D, Mueller S, Kramer JH, Miller BL, Weiner MW
• Network Diffusion Model of Progression Predicts Longitudinal Patterns of Atrophy and Metabolism in Alzheimer's Disease.
  Cell reports 2015 Raj A, LoCastro E, Kuceyeski A, Tosun D, Relkin N, Weiner M, Alzheimer’s Disease Neuroimaging Initiative (ADNI)
• Emerging β-amyloid pathology and accelerated cortical atrophy.
  JAMA neurology 2014 Mattsson N, Insel PS, Nosheny R, Tosun D, Trojanowski JQ, Shaw LM, Jack CR, Donohue MC, Weiner MW, Alzheimer’s Disease Neuroimaging Initiative
• Parallel ICA of FDG-PET and PiB-PET in three conditions with underlying Alzheimer's pathology.
  NeuroImage. Clinical 2014 Laforce R, Tosun D, Ghosh P, Lehmann M, Madison CM, Weiner MW, Miller BL, Jagust WJ, Rabinovici GD
• Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment.
  Brain : a journal of neurology 2014 Mattsson N, Tosun D, Insel PS, Simonson A, Jack CR, Beckett LA, Donohue M, Jagust W, Schuff N, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Multimodal MRI-based Imputation of the Aβ+ in Early Mild Cognitive Impairment.
  Annals of clinical and translational neurology 2014 Tosun D, Joshi S, Weiner MW, the Alzheimer’s Disease Neuroimaging Initiative
• Effects of baseline CSF α-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease.
  PloS one 2013 Mattsson N, Insel P, Tosun D, Zhang J, Jack CR, Galasko D, Weiner M, Alzheimer’s Disease Neuroimaging Initiative
• Effects of cerebrospinal fluid proteins on brain atrophy rates in cognitively healthy older adults.
  Neurobiology of aging 2013 Mattsson N, Insel P, Nosheny R, Trojanowski JQ, Shaw LM, Jack CR, Tosun D, Weiner M, Alzheimer's Disease Neuroimaging Initiative
• Neuroimaging predictors of brain amyloidosis in mild cognitive impairment.
  Annals of neurology 2013 Tosun D, Joshi S, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• CSF protein biomarkers predicting longitudinal reduction of CSF β-amyloid42 in cognitively healthy elders.
  Translational psychiatry 2013 Mattsson N, Insel P, Nosheny R, Zetterberg H, Trojanowski JQ, Shaw LM, Tosun D, Weiner M, Alzheimer's Disease Neuroimaging Initiative
• Locally linear embedding (LLE) for MRI based Alzheimer's disease classification.
  NeuroImage 2013 Liu X, Tosun D, Weiner MW, Schuff N, Alzheimer's Disease Neuroimaging Initiative
• Voxel-wise co-analysis of macro- and microstructural brain alteration in mild cognitive impairment and Alzheimer's disease using anatomical and diffusion MRI.
  Journal of neuroimaging : official journal of the American Society of Neuroimaging 2013 Cardenas VA, Tosun D, Chao LL, Fletcher PT, Joshi S, Weiner MW, Schuff N
• Voxelwise multivariate analysis of multimodality magnetic resonance imaging.
  Human brain mapping 2013 Naylor MG, Cardenas VA, Tosun D, Schuff N, Weiner M, Schwartzman A
• Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2013 Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW
• The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2013 Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Patterns of Reduced Cortical Thickness in Late-Life Depression and Relationship to Psychotherapeutic Response.
  The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2012 Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW
• Increased Cortical Thickness in Male-to-Female Transsexualism.
  Journal of behavioral and brain science 2012 Luders E, Sánchez FJ, Tosun D, Shattuck DW, Gaser C, Vilain E, Toga AW
• MRI patterns of atrophy and hypoperfusion associations across brain regions in frontotemporal dementia.
  NeuroImage 2011 Tosun D, Rosen H, Miller BL, Weiner MW, Schuff N
• Impact of apolipoprotein E4-cerebrospinal fluid β-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2011 Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Thompson PM, Reiman EM, Jack CR, Fox NC, Jagust WJ, Harvey DJ, Beckett LA, Gamst A, Aisen PS, Petersen RC, Weiner MW, …
• Impact of methodologic choice for automatic detection of different aspects of brain atrophy by using temporal lobe epilepsy as a model.
  AJNR. American journal of neuroradiology 2011 Scanlon C, Mueller SG, Tosun D, Cheong I, Garcia P, Barakos J, Weiner MW, Laxer KD
• Joint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementia.
  International journal of Alzheimer's disease 2011 Zhang Y, Schuff N, Ching C, Tosun D, Zhan W, Nezamzadeh M, Rosen HJ, Kramer JH, Gorno-Tempini ML, Miller BL, Weiner MW
• Intelligence and cortical thickness in children with complex partial seizures.
  NeuroImage 2011 Tosun D, Caplan R, Siddarth P, Seidenberg M, Gurbani S, Toga AW, Hermann B
• Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes.
  Radiology 2011 Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang S, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Effects of childhood absence epilepsy on associations between regional cortical morphometry and aging and cognitive abilities.
  Human brain mapping 2011 Tosun D, Siddarth P, Toga AW, Hermann B, Caplan R
• Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment.
  Brain : a journal of neurology 2011 Tosun D, Schuff N, Mathis CA, Jagust W, Weiner MW, Alzheimer's Disease NeuroImaging Initiative
• Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence.
  Alcoholism, clinical and experimental research 2011 Durazzo TC, Tosun D, Buckley S, Gazdzinski S, Mon A, Fryer SL, Meyerhoff DJ
• Deformation-based morphometry of prospective neurodevelopmental changes in new onset paediatric epilepsy.
  Brain : a journal of neurology 2011 Tosun D, Dabbs K, Caplan R, Siddarth P, Toga A, Seidenberg M, Hermann B
• Relationship between CSF biomarkers of Alzheimer's disease and rates of regional cortical thinning in ADNI data.
  Journal of Alzheimer's disease : JAD 2011 Tosun D, Schuff N, Shaw LM, Trojanowski JQ, Weiner MW, Alzheimer's Disease NeuroImaging Initiative
• Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects.
  Neurology 2010 Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Jack CR, Aisen PS, Petersen RC, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Nonlinear time course of brain volume loss in cognitively normal and impaired elders.
  Neurobiology of aging 2010 Schuff N, Tosun D, Insel PS, Chiang GC, Truran D, Aisen PS, Jack CR, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Relations between brain tissue loss, CSF biomarkers, and the ApoE genetic profile: a longitudinal MRI study.
  Neurobiology of aging 2010 Tosun D, Schuff N, Truran-Sacrey D, Shaw LM, Trojanowski JQ, Aisen P, Peterson R, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
• Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2010 Jack CR, Bernstein MA, Borowski BJ, Gunter JL, Fox NC, Thompson PM, Schuff N, Krueger G, Killiany RJ, Decarli CS, Dale AM, Carmichael OW, Tosun D, Weiner MW, Alzheimer's Disease Neuroimaging …
• Joint analysis of structural and perfusion MRI for cognitive assessment and classification of Alzheimer's disease and normal aging.
  NeuroImage 2010 Tosun D, Mojabi P, Weiner MW, Schuff N
• An integrated multimodality MR brain imaging study: gray matter tissue loss mediates the association between cerebral hypoperfusion and Alzheimer's disease.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2009 Tosun D, Schuff N, Weiner M
• A geometry-driven optical flow warping for spatial normalization of cortical surfaces.
  IEEE transactions on medical imaging 2008 Tosun D, Prince JL
• 3-D analysis of cortical morphometry in differential diagnosis of Parkinson's plus syndromes: mapping frontal lobe cortical atrophy in progressive supranuclear palsy patients.
  Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention 2007 Tosun D, Duchesne S, Rolland Y, Toga AW, Vérin M, Barillot C
• Cortical reconstruction using implicit surface evolution: accuracy and precision analysis.
  NeuroImage 2005 Tosun D, Rettmann ME, Naiman DQ, Resnick SM, Kraut MA, Prince JL
• Program for Assisted Labeling of Sulcal Regions (PALS): description and reliability.
  NeuroImage 2005 Rettmann ME, Tosun D, Tao X, Resnick SM, Prince JL
• Cortical surface alignment using geometry driven multispectral optical flow.
  Information processing in medical imaging : proceedings of the ... conference 2005 Tosun D, Prince JL
• CRUISE: cortical reconstruction using implicit surface evolution.
  NeuroImage 2004 Han X, Pham DL, Tosun D, Rettmann ME, Xu C, Prince JL
• Mapping techniques for aligning sulci across multiple brains.
  Medical image analysis 2004 Tosun D, Rettmann ME, Prince JL
• Cortical surface segmentation and mapping.
  NeuroImage 2004 Tosun D, Rettmann ME, Han X, Tao X, Xu C, Resnick SM, Pham DL, Prince JL