Donna Peehl, PhD
Professor
Radiology
School of Medicine

During postdoctoral fellowship research at the University of California in Irvine and San Francisco, she investigated tumor suppressor genes and oncogenes in cancer. Prior to joining UCSF, Dr. Peehl became Professor Emerita at Stanford University, California, after 35 years as a basic scientist in the Department of Urology. She is widely recognized for her work in developing realistic and representative preclinical cell and tissue models of prostate and kidney cancer.

Dr. Peehl’s current studies focus on developing novel therapeutics for prostate and kidney cancer. In collaboration with investigators at UCSF and Stanford, she is testing novel inhibitors of the tyrosine kinase AXL and of the scaffold protein, IQGAP, for their anti-cancer activity in her patient-derived models of kidney cancer. Another project uses tissue slice cultures to investigate cancer-associated glycosylation as a novel immunotherapy target. Under the auspices of a new NIH U01 grant, Dr. Peehl is collaborating with Dr. John Kurhanewicz and others at UCSF to compare metabolism of four types of kidney cancer preclinical models by hyperpolarized molecular imaging.

Dr. Peehl has been the recipient of numerous grants from the NIH and Department of Defense (DoD) Prostate Cancer Research Program, and has received awards from the Prostate Cancer Foundation (formerly CaP CURE) to support her research. She has served as chair or scientist reviewer for many NIH and grant review panels and has reviewed or served on the editorial board for a large number of scientific journals. Her peer-reviews include over 200 articles and publications.

Expertise: Urology

Specialty: Prostate cancer, kidney cancer, molecular and cellular biology

Professional Interests: Patient-derived xenografts, tissue slice cultures, primary cultures, spheroid cultures, preclinical drug testing, biomarkers, metabolism, cancer biology, translational science

• MAP3K7 Loss Drives Enhanced Androgen Signaling and Independently Confers Risk of Recurrence in Prostate Cancer with Joint Loss of CHD1.
  Molecular cancer research : MCR 2021 Jillson LK, Rider LC, Rodrigues LU, Romero L, Karimpour-Fard A, Nieto C, Gillette C, Torkko K, Danis E, Smith EE, Nolley R, Peehl DM, Lucia MS, Costello JC, Cramer SD
• Resistance to Androgen Deprivation Leads to Altered Metabolism in Human and Murine Prostate Cancer Cell and Tumor Models.
  Metabolites 2021 Sun J, Bok RA, DeLos Santos J, Upadhyay D, DeLos Santos R, Agarwal S, Van Criekinge M, Vigneron DB, Aggarwal R, Peehl DM, Kurhanewicz J, Sriram R
• The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Xiao Y, Thakkar KN, Zhao H, Broughton J, Li Y, Seoane JA, Diep AN, Metzner TJ, von Eyben R, Dill DL, Brooks JD, Curtis C, Leppert JT, Ye J, Peehl DM, Giaccia AJ, Sinha S, Rankin EB
• Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures.
  Cancers 2020 Sriram R, Van Criekinge M, DeLos Santos J, Ahamed F, Qin H, Nolley R, Santos RD, Tabatabai ZL, Bok RA, Keshari KR, Vigneron DB, Peehl DM, Kurhanewicz J
• Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Hsu EC, Rice MA, Bermudez A, Marques FJG, Aslan M, Liu S, Ghoochani A, Zhang CA, Chen YS, Zlitni A, Kumar S, Nolley R, Habte F, Shen M, Koul K, Peehl DM, Zoubeidi A, Gambhir SS, Kunder CA, Pitteri SJ,…
• S100A10 Is a Critical Mediator of GAS6/AXL-Induced Angiogenesis in Renal Cell Carcinoma.
  Cancer research 2019 Xiao Y, Zhao H, Tian L, Nolley R, Diep AN, Ernst A, Fuh KC, Miao YR, von Eyben R, Leppert JT, Brooks JD, Peehl DM, Giaccia AJ, Rankin EB
• miR-22 Regulates Invasion, Gene Expression and Predicts Overall Survival in Patients with Clear Cell Renal Cell Carcinoma.
  Kidney cancer (Clifton, Va.) 2019 Gong X, Zhao H, Saar M, Peehl DM, Brooks JD
• NMR quantification of lactate production and efflux and glutamate fractional enrichment in living human prostate biopsies cultured with [1,6-13 C2 ]glucose.
  Magnetic resonance in medicine 2019 Bancroft Brown J, Sriram R, VanCriekinge M, Delos Santos R, Sun J, Delos Santos J, Tabatabai ZL, Shinohara K, Nguyen H, Peehl DM, Kurhanewicz J
• Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics.
  Angewandte Chemie (International ed. in English) 2017 Spiciarich DR, Nolley R, Maund SL, Purcell SC, Herschel J, Iavarone AT, Peehl DM, Bertozzi CR
• The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry.
  Clinical epigenetics 2017 Zhao H, Ning S, Nolley R, Scicinski J, Oronsky B, Knox SJ, Peehl DM
• RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials.
  Expert opinion on investigational drugs 2017 Oronsky B, Paulmurugan R, Foygel K, Scicinski J, Knox SJ, Peehl D, Zhao H, Ning S, Cabrales P, Summers TA, Reid TR, Fitch WL, Kim MM, Trepel JB, Lee MJ, Kesari S, Abrouk ND, Day RM, Oronsky A, Ray CM,…
• Cabozantinib inhibits tumor growth and metastasis of a patient-derived xenograft model of papillary renal cell carcinoma with MET mutation.
  Cancer biology & therapy 2016 Zhao H, Nolley R, Chan AMW, Rankin EB, Peehl DM
• Endoscopic detection of cancer with lensless radioluminescence imaging and machine vision.
  Scientific reports 2016 Türkcan S, Naczynski DJ, Nolley R, Sasportas LS, Peehl DM, Pratx G
• Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized 13C pyruvate magnetic resonance.
  Tomography (Ann Arbor, Mich.) 2016 Sriram R, Van Criekinge M, DeLos Santos J, Keshari KR, Wilson DM, Peehl D, Kurhanewicz J, Wang ZJ
• Spheroid culture of LuCaP 136 patient-derived xenograft enables versatile preclinical models of prostate cancer.
  Clinical & experimental metastasis 2016 Valta MP, Zhao H, Saar M, Tuomela J, Nolley R, Linxweiler J, Sandholm J, Lehtimäki J, Härkönen P, Coleman I, Nelson PS, Corey E, Peehl DM
• A Protective Role for Androgen Receptor in Clear Cell Renal Cell Carcinoma Based on Mining TCGA Data.
  PloS one 2016 Zhao H, Leppert JT, Peehl DM
• Epigenetic effects of RRx-001: a possible unifying mechanism of anticancer activity.
  Oncotarget 2015 Zhao H, Ning S, Scicinski J, Oronsky B, Knox SJ, Peehl DM
• Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor.
  The Prostate 2015 Keshari KR, Wilson DM, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O'Brien T, Sampath D, Carano RA, Kurhanewicz J
• Elevated serum microRNA levels associate with absence of high-grade prostate cancer in a retrospective cohort.
  PloS one 2015 Mihelich BL, Maranville JC, Nolley R, Peehl DM, Nonn L
• Hepcidin regulation in prostate and its disruption in prostate cancer.
  Cancer research 2015 Tesfay L, Clausen KA, Kim JW, Hegde P, Wang X, Miller LD, Deng Z, Blanchette N, Arvedson T, Miranti CK, Babitt JL, Lin HY, Peehl DM, Torti FM, Torti SV
• Coordinate loss of MAP3K7 and CHD1 promotes aggressive prostate cancer.
  Cancer research 2015 Rodrigues LU, Rider L, Nieto C, Romero L, Karimpour-Fard A, Loda M, Lucia MS, Wu M, Shi L, Cimic A, Sirintrapun SJ, Nolley R, Pac C, Chen H, Peehl DM, Xu J, Liu W, Costello JC, Cramer SD
• A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Cerchiari AE, Garbe JC, Jee NY, Todhunter ME, Broaders KE, Peehl DM, Desai TA, LaBarge MA, Thomson M, Gartner ZJ
• Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma.
  Endocrine-related cancer 2014 Wang Y, Roma A, Nolley R, Abdul-Karim F, Peehl DM, Eng C
• Spheroid culture of LuCaP 147 as an authentic preclinical model of prostate cancer subtype with SPOP mutation and hypermutator phenotype.
  Cancer letters 2014 Saar M, Zhao H, Nolley R, Young SR, Coleman I, Nelson PS, Vessella RL, Peehl DM
• Development of a realistic in vivo bone metastasis model of human renal cell carcinoma.
  Clinical & experimental metastasis 2014 Valta MP, Zhao H, Ingels A, Thong AE, Nolley R, Saar M, Peehl DM
• Phosphorylcholine-coated semiconducting polymer nanoparticles as rapid and efficient labeling agents for in vivo cell tracking.
  Advanced healthcare materials 2014 Pu K, Shuhendler AJ, Valta MP, Cui L, Saar M, Peehl DM, Rao J
• Optimization and comprehensive characterization of a faithful tissue culture model of the benign and malignant human prostate.
  Laboratory investigation; a journal of technical methods and pathology 2013 Maund SL, Nolley R, Peehl DM
• Imaging the glycosylation state of cell surface glycoproteins by two-photon fluorescence lifetime imaging microscopy.
  Angewandte Chemie (International ed. in English) 2013 Belardi B, de la Zerda A, Spiciarich DR, Maund SL, Peehl DM, Bertozzi CR
• Preclinical trial of a new dual mTOR inhibitor, MLN0128, using renal cell carcinoma tumorgrafts.
  International journal of cancer 2013 Ingels A, Zhao H, Thong AE, Saar M, Valta MP, Nolley R, Santos J, Peehl DM
• A tissue graft model of DNA damage response in the normal and malignant human prostate.
  The Journal of urology 2013 Af Hällström TM, Zhao H, Tian J, Rantanen V, Reese SW, Nolley R, Laiho M, Peehl DM
• Patient-derived tissue slice grafts accurately depict response of high-risk primary prostate cancer to androgen deprivation therapy.
  Journal of translational medicine 2013 Zhao H, Thong A, Nolley R, Reese SW, Santos J, Ingels A, Peehl DM
• Tissue slice grafts of human renal cell carcinoma: an authentic preclinical model with high engraftment rate and metastatic potential.
  Urologic oncology 2013 Thong AE, Zhao H, Ingels A, Valta MP, Nolley R, Santos J, Young SR, Peehl DM
• Establishment and serial passage of cell cultures derived from LuCaP xenografts.
  The Prostate 2013 Young SR, Saar M, Santos J, Nguyen HM, Vessella RL, Peehl DM
• Induced pluripotency of human prostatic epithelial cells.
  PloS one 2013 Zhao H, Sun N, Young SR, Nolley R, Santos J, Wu JC, Peehl DM
• Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor.
  The Prostate 2013 Keshari KR, Sriram R, Van Criekinge M, Wilson DM, Wang ZJ, Vigneron DB, Peehl DM, Kurhanewicz J
• Anti-Oligomannose Antibodies as Potential Serum Biomarkers of Aggressive Prostate Cancer.
  Drug development research 2013 Wang D, Dafik L, Nolley R, Huang W, Wolfinger RD, Wang LX, Peehl DM
• Transcript levels of androgen receptor variant AR-V1 or AR-V7 do not predict recurrence in patients with prostate cancer at indeterminate risk for progression.
  The Journal of urology 2012 Zhao H, Coram MA, Nolley R, Reese SW, Young SR, Peehl DM
• Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Tian J, Zhao H, Nolley R, Reese SW, Young SR, Li X, Peehl DM, Knox SJ
• Microfluidic integration for automated targeted proteomic assays.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Hughes AJ, Lin RK, Peehl DM, Herr AE
• Cell surface glycoproteomic analysis of prostate cancer-derived PC-3 cells.
  Bioorganic & medicinal chemistry letters 2011 Hubbard SC, Boyce M, McVaugh CT, Peehl DM, Bertozzi CR
• DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer.
  Genome research 2011 Kobayashi Y, Absher DM, Gulzar ZG, Young SR, McKenney JK, Peehl DM, Brooks JD, Myers RM, Sherlock G
• Serum Mac-2BP does not distinguish men with high grade, large volume prostate cancer from men with benign prostatic hyperplasia.
  The Prostate 2011 Peehl DM, Chen Z, Nolley R
• Stiffness mapping prostate biopsy samples using a tactile sensor.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2011 Peng Q, Omata S, Peehl DM, Constantinou CE
• Anti-tumor and radiosensitization activities of the iron chelator HDp44mT are mediated by effects on intracellular redox status.
  Cancer letters 2010 Tian J, Peehl DM, Zheng W, Knox SJ
• Tissue slice grafts: an in vivo model of human prostate androgen signaling.
  The American journal of pathology 2010 Zhao H, Nolley R, Chen Z, Peehl DM
• Targeting monoamine oxidase A in advanced prostate cancer.
  Journal of cancer research and clinical oncology 2010 Flamand V, Zhao H, Peehl DM
• Methods for metabolic evaluation of prostate cancer cells using proton and (13)C HR-MAS spectroscopy and [3-(13)C] pyruvate as a metabolic substrate.
  Magnetic resonance in medicine 2009 Levin YS, Albers MJ, Butler TN, Spielman D, Peehl DM, Kurhanewicz J
• Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells.
  BMC medical genomics 2009 Zhao H, Flamand V, Peehl DM
• Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts.
  The Prostate 2009 Zhao H, Peehl DM
• Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients.
  International journal of cancer 2009 Swami S, Krishnan AV, Moreno J, Bhattacharyya RS, Gardner C, Brooks JD, Peehl DM, Feldman D
• The significance of monoamine oxidase-A expression in high grade prostate cancer.
  The Journal of urology 2008 Peehl DM, Coram M, Khine H, Reese S, Nolley R, Zhao H
• Association of prostate-specific antigen promoter genotype with clinical and histopathologic features of prostate cancer.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008 Cramer SD, Sun J, Zheng SL, Xu J, Peehl DM
• Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis.
  Cancer research 2008 Kim J, Choi YL, Vallentin A, Hunrichs BS, Hellerstein MK, Peehl DM, Mochly-Rosen D
• Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level.
  Cancer research 2008 Das S, Hahn Y, Walker DA, Nagata S, Willingham MC, Peehl DM, Bera TK, Lee B, Pastan I
• The current state of preclinical prostate cancer animal models.
  The Prostate 2008 Pienta KJ, Abate-Shen C, Agus DB, Attar RM, Chung LW, Greenberg NM, Hahn WC, Isaacs JT, Navone NM, Peehl DM, Simons JW, Solit DB, Soule HR, VanDyke TA, Weber MJ, Wu L, Vessella RL
• Inhibition of monoamine oxidase A promotes secretory differentiation in basal prostatic epithelial cells.
  Differentiation; research in biological diversity 2008 Zhao H, Nolley R, Chen Z, Reese SW, Peehl DM
• Potentiation of the growth-inhibitory effects of vitamin D in prostate cancer by genistein.
  Nutrition reviews 2007 Krishnan AV, Swami S, Moreno J, Bhattacharyya RB, Peehl DM, Feldman D
• Vitamin D inhibition of the prostaglandin pathway as therapy for prostate cancer.
  Nutrition reviews 2007 Feldman D, Krishnan A, Moreno J, Swami S, Peehl DM, Srinivas S
• Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer.
  The Journal of steroid biochemistry and molecular biology 2007 Krishnan AV, Moreno J, Nonn L, Malloy P, Swami S, Peng L, Peehl DM, Feldman D
• Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer.
  The Journal of nutrition 2007 Swami S, Krishnan AV, Moreno J, Bhattacharyya RB, Peehl DM, Feldman D
• Distinctive gene expression of prostatic stromal cells cultured from diseased versus normal tissues.
  Journal of cellular physiology 2007 Zhao H, Ramos CF, Brooks JD, Peehl DM
• High resolution regional elasticity mapping of the human prostate.
  Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2007 Murayama Y, Omata S, Yajima T, Peng Q, Shishido K, Peehl DM, Constantinou CE
• Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells.
  Carcinogenesis 2006 Nonn L, Duong D, Peehl DM
• Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer.
  Endocrinology 2006 Bauman DR, Steckelbroeck S, Peehl DM, Penning TM
• Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D.
  Cancer research 2006 Nonn L, Peng L, Feldman D, Peehl DM
• Expression of CCL5 (RANTES) and CCR5 in prostate cancer.
  The Prostate 2006 Vaday GG, Peehl DM, Kadam PA, Lawrence DM
• Tumor-selective killing by selenite in patient-matched pairs of normal and malignant prostate cells.
  The Prostate 2006 Husbeck B, Nonn L, Peehl DM, Knox SJ
• Tumor-suppression function of transcription factor USF2 in prostate carcinogenesis.
  Oncogene 2006 Chen N, Szentirmay MN, Pawar SA, Sirito M, Wang J, Wang Z, Zhai Q, Yang HX, Peehl DM, Ware JL, Sawadogo M
• Comparative gene and protein expression in primary cultures of epithelial cells from benign prostatic hyperplasia and prostate cancer.
  Cancer letters 2005 Rose A, Xu Y, Chen Z, Fan Z, Stamey TA, McNeal JE, Caldwell M, Peehl DM
• Genistein potentiates the growth inhibitory effects of 1,25-dihydroxyvitamin D3 in DU145 human prostate cancer cells: role of the direct inhibition of CYP24 enzyme activity.
  Molecular and cellular endocrinology 2005 Swami S, Krishnan AV, Peehl DM, Feldman D
• Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease.
  Molecular endocrinology (Baltimore, Md.) 2005 Bauman DR, Steckelbroeck S, Williams MV, Peehl DM, Penning TM
• Molecular targets of doxazosin in human prostatic stromal cells.
  The Prostate 2005 Zhao H, Lai F, Nonn L, Brooks JD, Peehl DM
• Primary cell cultures as models of prostate cancer development.
  Endocrine-related cancer 2005 Peehl DM
• Preferential production of latent transforming growth factor beta-2 by primary prostatic epithelial cells and its activation by prostate-specific antigen.
  Journal of cellular physiology 2005 Dallas SL, Zhao S, Cramer SD, Chen Z, Peehl DM, Bonewald LF
• Redox modulation of human prostate carcinoma cells by selenite increases radiation-induced cell killing.
  Free radical biology & medicine 2005 Husbeck B, Peehl DM, Knox SJ
• Interaction of nuclear receptor ligands with the Vitamin D signaling pathway in prostate cancer.
  The Journal of steroid biochemistry and molecular biology 2004 Peehl DM, Feldman D
• Expression of transforming growth factor-beta 1 and growth in soft agar differentiate prostate carcinoma-associated fibroblasts from normal prostate fibroblasts.
  International journal of cancer 2004 San Francisco IF, DeWolf WC, Peehl DM, Olumi AF
• Molecular and cellular pathogenesis of benign prostatic hyperplasia.
  The Journal of urology 2004 Lee KL, Peehl DM
• Molecular activity of 1,25-dihydroxyvitamin D3 in primary cultures of human prostatic epithelial cells revealed by cDNA microarray analysis.
  The Journal of steroid biochemistry and molecular biology 2004 Peehl DM, Shinghal R, Nonn L, Seto E, Krishnan AV, Brooks JD, Feldman D
• Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells.
  Oncogene 2004 Khanim FL, Gommersall LM, Wood VH, Smith KL, Montalvo L, O'Neill LP, Xu Y, Peehl DM, Stewart PM, Turner BM, Campbell MJ
• Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells.
  Molecular and cellular endocrinology 2004 Ma JF, Nonn L, Campbell MJ, Hewison M, Feldman D, Peehl DM
• Analysis of vitamin D-regulated gene expression in LNCaP human prostate cancer cells using cDNA microarrays.
  The Prostate 2004 Krishnan AV, Shinghal R, Raghavachari N, Brooks JD, Peehl DM, Feldman D
• Are primary cultures realistic models of prostate cancer?
  Journal of cellular biochemistry 2004 Peehl DM
• Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenase.
  The Journal of steroid biochemistry and molecular biology 2003 He XY, Yang YZ, Peehl DM, Lauderdale A, Schulz H, Yang SY
• Elevated expression of inhibitor of apoptosis proteins in prostate cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Krajewska M, Krajewski S, Banares S, Huang X, Turner B, Bubendorf L, Kallioniemi OP, Shabaik A, Vitiello A, Peehl D, Gao GJ, Reed JC
• Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.
  Endocrinology 2003 Rizner TL, Lin HK, Peehl DM, Steckelbroeck S, Bauman DR, Penning TM
• Pathways mediating the growth-inhibitory actions of vitamin D in prostate cancer.
  The Journal of nutrition 2003 Peehl DM, Krishnan AV, Feldman D
• Primary culture model of peroxisome proliferator-activated receptor gamma activity in prostate cancer cells.
  Journal of cellular physiology 2003 Xu Y, Iyengar S, Roberts RL, Shappell SB, Peehl DM
• The role of vitamin D and retinoids in controlling prostate cancer progression.
  Endocrine-related cancer 2003 Peehl DM, Feldman D
• Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells.
  International journal of cancer 2003 Moore MG, Wetterau LA, Francis MJ, Peehl DM, Cohen P
• Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell line.
  The Prostate 2003 Lecane PS, Kiviharju TM, Sellers RG, Peehl DM
• Growth of prostatic epithelial and stromal cells in vitro.
  Methods in molecular medicine 2003 Peehl DM
• The role of vitamin D in prostate cancer.
  Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 2003 Krishnan AV, Peehl DM, Feldman D
• Vitamin D receptor start codon polymorphism (FokI) and prostate cancer progression.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003 Xu Y, Shibata A, McNeal JE, Stamey TA, Feldman D, Peehl DM
• Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells.
  The Journal of urology 2002 Peehl DM, Seto E, Hsu JY, Feldman D
• Polymorphisms in the androgen receptor and type II 5 alpha-reductase genes and prostate cancer prognosis.
  The Prostate 2002 Shibata A, Garcia MI, Cheng I, Stamey TA, McNeal JE, Brooks JD, Henderson S, Yemoto CE, Peehl DM
• Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2002 Kiviharju TM, Lecane PS, Sellers RG, Peehl DM
• Silencing of pi-class glutathione S-transferase in MDA PCa 2a and MDA PCa 2b cells.
  The Prostate 2002 Vidanes GM, Paton V, Wallen E, Peehl DM, Navone N, Brooks JD
• A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer.
  Endocrinology 2002 Krishnan AV, Zhao XY, Swami S, Brive L, Peehl DM, Ely KR, Feldman D
• Expression of matrix metalloproteinase-2 and -9 and their inhibitors, tissue inhibitor of metalloproteinase-1 and -2, in primary cultures of human prostatic stromal and epithelial cells.
  Journal of cellular physiology 2002 Wilson MJ, Sellers RG, Wiehr C, Melamud O, Pei D, Peehl DM
• Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens.
  Cancer research 2002 Guo X, Knudsen BS, Peehl DM, Ruiz A, Bok D, Rando RR, Rhim JS, Nanus DM, Gudas LJ
• Cadmium-induced neoplastic transformation of human prostate epithelial cells.
  International journal of oncology 2002 Nakamura K, Yasunaga Y, Ko D, Xu LL, Moul JW, Peehl DM, Srivastava S, Rhim JS
• Prostatic expression of hensin, a protein implicated in epithelial terminal differentiation.
  The Prostate 2001 Ma JF, Takito J, Vijayakumar S, Peehl DM, Olsson CA, Al-Awqati Q
• Overview consensus statement.
  Urology 2001 Carroll PR, Fair WR, Grossfeld GD, Heston WD, Lieberman R, Malkowicz SB, Stricker HJ, Sylvester J, Peehl DM, Meyer F, Hart C
• Rationale for combination ketoconazole/ vitamin D treatment of prostate cancer.
  Urology 2001 Peehl DM, Seto E, Feldman D
• Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway.
  Nature cell biology 2001 Miao H, Wei BR, Peehl DM, Li Q, Alexandrou T, Schelling JR, Rhim JS, Sedor JR, Burnett E, Wang B
• Cultured stromal cells: an in vitro model of prostatic mesenchymal biology.
  The Prostate 2000 Peehl DM, Sellers RG
• Brefeldin A induces p53-independent apoptosis in primary cultures of human prostatic cancer cells.
  The Journal of urology 2000 Wallen E, Sellers RG, Peehl DM
• Stepwise genetic changes associated with progression of nontumorigenic HPV-18 immortalized human prostate cancer-derived cell line to a malignant phenotype.
  Cancer genetics and cytogenetics 2000 Hukku B, Mally M, Cher ML, Peehl DM, Kung H, Rhim JS
• 1alpha,25-dihydroxyvitamin D3 inhibits prostate cancer cell growth by androgen-dependent and androgen-independent mechanisms.
  Endocrinology 2000 Zhao XY, Peehl DM, Navone NM, Feldman D
• Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia.
  Urology 2000 Choi J, Shendrik I, Peacocke M, Peehl D, Buttyan R, Ikeguchi EF, Katz AE, Benson MC
• Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.
  Nature medicine 2000 Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D
• Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a.
  The Journal of urology 1999 Zhao XY, Boyle B, Krishnan AV, Navone NM, Peehl DM, Feldman D
• Altered growth regulation and loss of response to retinoic acid accompany tumorigenic transformation of prostatic cells.
  Anticancer research 1999 Peehl DM, Sellers RG, Arnstein P, Kung HF, Rhim JS
• Induction of androgen receptor by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in LNCaP human prostate cancer cells.
  Endocrinology 1999 Zhao XY, Ly LH, Peehl DM, Feldman D
• Vitamin D and prostate cancer risk.
  European urology 1999 Peehl DM
• Defined medium for normal adult human prostatic stromal cells.
  In vitro cellular & developmental biology. Animal 1998 Peehl DM, Sellers RG, Wong ST
• Workgroup 2: human xenograft models of prostate cancer.
  The Prostate 1998 Stearns ME, Ware JL, Agus DB, Chang CJ, Fidler IJ, Fife RS, Goode R, Holmes E, Kinch MS, Peehl DM, Pretlow TG, Thalmann GN
• Basic FGF, EGF, and PDGF modify TGFbeta-induction of smooth muscle cell phenotype in human prostatic stromal cells.
  The Prostate 1998 Peehl DM, Sellers RG
• Expression of prostatic factors measured by reverse transcription polymerase chain reaction in human papillomavirus type 18 deoxyribonucleic acid immortalized prostate cell lines.
  Urology 1998 Weijerman PC, Zhang Y, Shen J, Dubbink HJ, Romijn JC, Peehl DM, Schröder FH
• 1alpha,25-dihydroxyvitamin D3 actions in LNCaP human prostate cancer cells are androgen-dependent.
  Endocrinology 1997 Zhao XY, Ly LH, Peehl DM, Feldman D
• Loss of response to epidermal growth factor and retinoic acid accompanies the transformation of human prostatic epithelial cells to tumorigenicity with v-Ki-ras.
  Carcinogenesis 1997 Peehl DM, Wong ST, Sellers RG, Jin S, Rhim JS
• Human papillomavirus detection by polymerase chain reaction in benign and malignant prostate tissue is dependent on the primer set utilized.
  Urology 1997 Terris MK, Peehl DM
• Acid-activated insulin-like growth factor binding protein protease activity of cathepsin D in normal and malignant prostatic epithelial cells and seminal plasma.
  Journal of cellular physiology 1997 Nunn SE, Peehl DM, Cohen P
• Induction of smooth muscle cell phenotype in cultured human prostatic stromal cells.
  Experimental cell research 1997 Peehl DM, Sellers RG
• Parathyroid hormone-related protein is not an autocrine growth factor for normal prostatic epithelial cells.
  The Prostate 1997 Peehl DM, Edgar MG, Cramer SD, Deftos LJ
• Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts.
  The Journal of urology 1996 Cramer SD, Chen Z, Peehl DM
• Role of prostatic basal cells in the regulation and suppression of human prostate cancer cells.
  Cancer letters 1996 Miniati DN, Chang Y, Shu WP, Peehl DM, Liu BC
• Keratin 19 in the adult human prostate: tissue and cell culture studies.
  Cell and tissue research 1996 Peehl DM, Sellers RG, McNeal JE
• Parathyroid hormone--related protein (PTHrP) is an epidermal growth factor-regulated secretory product of human prostatic epithelial cells.
  The Prostate 1996 Cramer SD, Peehl DM, Edgar MG, Wong ST, Deftos LJ, Feldman D
• Recent advances in the development of animal and cell culture models for prostate cancer research A minireview.
  Urologic oncology 1996 Bosland MC, Chung LW, Greenberg NM, Ho SM, Isaacs JT, Lane K, Peehl DM, Thompson TC, van Steenbrugge GJ, van Weerden WM
• The role of the Sertoli cell in active immunosuppression in the human testis.
  British journal of urology 1996 Turek PJ, Malkowicz SB, Tomaszewski JE, Wein AJ, Peehl D
• KGF and EGF differentially regulate the phenotype of prostatic epithelial cells.
  Growth regulation 1996 Peehl DM, Wong ST, Rubin JS
• Cellular biology of prostatic growth factors.
  The Prostate. Supplement 1996 Peehl DM
• The role of insulin-like growth factors in prostate biology.
  Journal of andrology 1996 Peehl DM, Cohen P, Rosenfeld RG
• Suramin, hydrocortisone, and retinoic acid modify inhibitory effects of 1,25-dihydroxyvitamin D(3) on prostatic epithelial cells.
  Urologic oncology 1995 Peehl DM, Wong ST, Cramer SD, Gross C, Feldman D
• Actions of vitamin D3, analogs on human prostate cancer cell lines: comparison with 1,25-dihydroxyvitamin D3.
  Endocrinology 1995 Skowronski RJ, Peehl DM, Feldman D
• Keratinocyte growth factor: an androgen-regulated mediator of stromal-epithelial interactions in the prostate.
  World journal of urology 1995 Peehl DM, Rubin JS
• The insulin-like growth factor system in the prostate.
  World journal of urology 1995 Peehl DM, Cohen P, Rosenfeld RG
• Lipofection-mediated immortalization of human prostatic epithelial cells of normal and malignant origin using human papillomavirus type 18 DNA.
  Cancer research 1994 Weijerman PC, König JJ, Wong ST, Niesters HG, Peehl DM
• Keratin expression: a measure of phenotypic modulation of human prostatic epithelial cells by growth inhibitory factors.
  Cell and tissue research 1994 Peehl DM, Leung GK, Wong ST
• Antiproliferative effects of 1,25-dihydroxyvitamin D3 on primary cultures of human prostatic cells.
  Cancer research 1994 Peehl DM, Skowronski RJ, Leung GK, Wong ST, Stamey TA, Feldman D
• Human papilloma virus type 18 DNA immortalized cell lines from the human prostate epithelium.
  Progress in clinical and biological research 1994 Weijerman PC, Romijn HC, Peehl DM
• PR1--a monoclonal antibody that reacts with an antigen on the surface of normal and malignant prostate cells.
  Journal of the National Cancer Institute 1993 Pastan I, Lovelace E, Rutherford AV, Kunwar S, Willingham MC, Peehl DM
• Vitamin D and prostate cancer: 1,25 dihydroxyvitamin D3 receptors and actions in human prostate cancer cell lines.
  Endocrinology 1993 Skowronski RJ, Peehl DM, Feldman D
• Oncogenes in prostate cancer. An update.
  Cancer 1993 Peehl DM
• Vitamin A regulates proliferation and differentiation of human prostatic epithelial cells.
  The Prostate 1993 Peehl DM, Wong ST, Stamey TA
• In vitro proton spectroscopy of normal and abnormal prostate.
  Magnetic resonance in medicine 1991 Yacoe ME, Sommer G, Peehl D
• Cytostatic effects of suramin on prostate cancer cells cultured from primary tumors.
  The Journal of urology 1991 Peehl DM, Wong ST, Stamey TA
• Culture of prostatic epithelial cells from ultrasound-guided needle biopsies.
  The Prostate 1991 Peehl DM, Wong ST, Terris MK, Stamey TA
• Searching for suppressor genes in prostate cancer.
  Cancer surveys 1991 Peehl DM
• Down-regulation of a calmodulin-related gene during transformation of human mammary epithelial cells.
  Proceedings of the National Academy of Sciences of the United States of America 1990 Yaswen P, Smoll A, Peehl DM, Trask DK, Sager R, Stampfer MR
• Analysis of somatic cell hybrids derived from normal human prostatic epithelial cells fused with HeLa cells.
  The Prostate 1990 Peehl DM, Wong ST, McNeal JE, Stamey TA
• Clonal growth of human prostatic epithelial cells is stimulated by fibroblasts.
  The Prostate 1989 Kabalin JN, Peehl DM, Stamey TA
• In vitro studies of human prostatic epithelial cells: attempts to identify distinguishing features of malignant cells.
  Growth factors (Chur, Switzerland) 1989 Peehl DM, Wong ST, Bazinet M, Stamey TA
• Clonal growth characteristics of adult human prostatic epithelial cells.
  In vitro cellular & developmental biology : journal of the Tissue Culture Association 1988 Peehl DM, Wong ST, Stamey TA
• Activated Ki-ras oncogene in human prostatic adenocarcinoma.
  The Prostate 1987 Peehl DM, Wehner N, Stamey TA
• Serum-free growth of adult human prostatic epithelial cells.
  In vitro cellular & developmental biology : journal of the Tissue Culture Association 1986 Peehl DM, Stamey TA
• Growth responses of normal, benign hyperplastic, and malignant human prostatic epithelial cells in vitro to cholera toxin, pituitary extract, and hydrocortisone.
  The Prostate 1986 Peehl DM, Stamey TA
• Keratin immunoreactivity in the benign and neoplastic human prostate.
  Cancer research 1985 Brawer MK, Peehl DM, Stamey TA, Bostwick DG