Donald McDonald, MD, PhD
Professor
Anatomy
School of Medicine

Current interests include developing approaches for preventing, stopping, or reversing disease-related changes in blood vessels and lymphatics and learning the consequences of these actions. Related interests include the regulation of endothelial barrier function, downstream effects of altered plasma leakage and cellular trafficking, and control mechanisms of tissue fluid and cell clearance by lymphatics.

Projects in the laboratory use mouse models to dissect the role of key growth factors and receptors involved in growth and remodeling of blood vessels and lymphatics and related disease processes. VEGF-A, VEGF-C, angiopoietins, TNF-alpha, HGF and their receptors are of current interest. Signaling is manipulated in vivo by switchable transgenic overexpression, genetic deletion, viral vectors, or pharmacological agonists or inhibitors. Ongoing studies are using the models to examine factors that drive or modify remodeling of blood vessels and lymphatics in inflammatory conditions, with an emphasis on the airways, lungs, and adipose tissue. We are also studying favorable and potentially unfavorable effects of destroying blood vessels and/or lymphatics in tumors, reflected by tumor growth, invasion, and metastasis. The overall goal is to advance the understanding and development of strategies that can stop or reverse angiogenesis and lymphangiogenesis and to characterize the downstream benefits and consequences in cancer, inflammatory disease, and obesity.

• Meningeal lymphatics can influence stroke outcome.
  The Journal of experimental medicine 2024 Koh GY, McDonald DM
• Nasopharyngeal lymphatic plexus is a hub for cerebrospinal fluid drainage.
  Nature 2024 Yoon JH, Jin H, Kim HJ, Hong SP, Yang MJ, Ahn JH, Kim YC, Seo J, Lee Y, McDonald DM, Davis MJ, Koh GY
• Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava.
  Cell and tissue research 2023 Baluk P, Shirakura K, Vestweber D, McDonald DM
• Molecular anatomy of adult mouse leptomeninges.
  Neuron 2023 Pietilä R, Del Gaudio F, He L, Vázquez-Liébanas E, Vanlandewijck M, Muhl L, Mocci G, Bjørnholm KD, Lindblad C, Fletcher-Sandersjöö A, Svensson M, Thelin EP, Liu J, van Voorden AJ, Torres M, Antila S, …
• VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation.
  Nature communications 2023 Mapunda JA, Pareja J, Vladymyrov M, Bouillet E, Hélie P, Pleskac P, Barcos S, Andrae J, Vestweber D, McDonald DM, Betsholtz C, Deutsch U, Proulx ST, Engelhardt B
• Shear stress control of vascular leaks and atheromas through Tie2 activation by VE-PTP sequestration.
  EMBO molecular medicine 2023 Shirakura K, Baluk P, Nottebaum AF, Ipe U, Peters KG, McDonald DM, Vestweber D
• Buttons and Zippers: Endothelial Junctions in Lymphatic Vessels.
  Cold Spring Harbor perspectives in medicine 2022 Baluk P, McDonald DM
• Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion.
  Circulation research 2022 Choi D, Park E, Yu RP, Cooper MN, Cho IT, Choi J, Yu J, Zhao L, Yum JI, Yu JS, Nakashima B, Lee S, Seong YJ, Jiao W, Koh CJ, Baluk P, McDonald DM, Saraswathy S, Lee JY, Jeon NL, Zhang Z, Huang AS, …
• Imaging Blood Vessels and Lymphatics in Mouse Trachea Wholemounts.
  Methods in molecular biology (Clifton, N.J.) 2022 Baluk P, McDonald DM
• Oncolytic vaccinia virus injected intravenously sensitizes pancreatic neuroendocrine tumors and metastases to immune checkpoint blockade.
  Molecular therapy oncolytics 2021 Inoue M, Kim M, Inoue T, Tait M, Byrne T, Nitschké M, Murer P, Cha H, Subramanian A, De Silva N, Chiaverotti T, McDonald DM
• Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing.
  Molecular cancer therapeutics 2021 Inoue T, Byrne T, Inoue M, Tait ME, Wall P, Wang A, Dermyer MR, Laklai H, Binder JJ, Lees C, Hollingsworth R, Maruri-Avidal L, Kirn DH, McDonald DM
• Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies.
  Trends in molecular medicine 2020 Claesson-Welsh L, Dejana E, McDonald DM
• Lymphatic Proliferation Ameliorates Pulmonary Fibrosis after Lung Injury.
  The American journal of pathology 2020 Baluk P, Naikawadi RP, Kim S, Rodriguez F, Choi D, Hong YK, Wolters PJ, McDonald DM
• Tighter lymphatic junctions prevent obesity.
  Science (New York, N.Y.) 2018 McDonald DM
• Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread.
  Science advances 2018 Ma Q, Dieterich LC, Ikenberg K, Bachmann SB, Mangana J, Proulx ST, Amann VC, Levesque MP, Dummer R, Baluk P, McDonald DM, Detmar M
• Imaging Lymphatics in Mouse Lungs.
  Methods in molecular biology (Clifton, N.J.) 2018 Baluk P, McDonald DM
• Amplification of Oncolytic Vaccinia Virus Widespread Tumor Cell Killing by Sunitinib through Multiple Mechanisms.
  Cancer research 2017 Kim M, Nitschké M, Sennino B, Murer P, Schriver BJ, Bell A, Subramanian A, McDonald CE, Wang J, Cha H, Bourgeois-Daigneault MC, Kirn DH, Bell JC, De Silva N, Breitbach CJ, McDonald DM
• The protective role of sphingosine-1-phosphate against the action of the vascular disrupting agent combretastatin A-4 3-O-phosphate.
  Oncotarget 2017 Shepherd J, Fisher M, Welford A, McDonald DM, Kanthou C, Tozer GM
• Rapamycin reversal of VEGF-C-driven lymphatic anomalies in the respiratory tract.
  JCI insight 2017 Baluk P, Yao LC, Flores JC, Choi D, Hong YK, McDonald DM
• Dijet imbalance measurements in Au+Au and pp collisions at sqrt[s_{NN}]=200  GeV at STAR.
  Physical review letters 2017 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Anderson DM, Aoyama R, Aparin A, Arkhipkin D, Aschenauer EC, Ashraf MU, Attri A, Averichev GS, Bai X, Bairathi V, Bellwied R, …
• Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations.
  The American journal of pathology 2017 Nitschké M, Bell A, Karaman S, Amouzgar M, Rutkowski JM, Scherer PE, Alitalo K, McDonald DM
• Measurement of azimuthal correlations of D mesons with charged particles in pp collisions at [Formula: see text] TeV and p-Pb collisions at [Formula: see text] TeV.
  The European physical journal. C, Particles and fields 2017 Adam J, Adamová D, Aggarwal MM, Aglieri Rinella G, Agnello M, Agrawal N, Ahammed Z, Ahmad S, Ahn SU, Aiola S, Akindinov A, Alam SN, Albuquerque DSD, Aleksandrov D, Alessandro B, Alexandre D, Alfaro …
• Charge-Dependent Directed Flow in Cu+Au Collisions at sqrt[s_{NN}]=200  GeV.
  Physical review letters 2017 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Anderson DM, Aoyama R, Aparin A, Arkhipkin D, Aschenauer EC, Ashraf MU, Attri A, Averichev GS, Bai X, Bairathi V, Bellwied R, …
• Correlated Event-by-Event Fluctuations of Flow Harmonics in Pb-Pb Collisions at sqrt[s_{NN}]=2.76  TeV.
  Physical review letters 2016 Adam J, Adamová D, Aggarwal MM, Aglieri Rinella G, Agnello M, Agrawal N, Ahammed Z, Ahmad S, Ahn SU, Aiola S, Akindinov A, Alam SN, Albuquerque DS, Aleksandrov D, Alessandro B, Alexandre D, Alfaro …
• Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation.
  The Journal of clinical investigation 2016 Kim M, Allen B, Korhonen EA, Nitschké M, Yang HW, Baluk P, Saharinen P, Alitalo K, Daly C, Thurston G, McDonald DM
• Tie1 controls angiopoietin function in vascular remodeling and inflammation.
  The Journal of clinical investigation 2016 Korhonen EA, Lampinen A, Giri H, Anisimov A, Kim M, Allen B, Fang S, D'Amico G, Sipilä TJ, Lohela M, Strandin T, Vaheri A, Ylä-Herttuala S, Koh GY, McDonald DM, Alitalo K, Saharinen P
• Centrality Dependence of the Charged-Particle Multiplicity Density at Midrapidity in Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.
  Physical review letters 2016 Adam J, Adamová D, Aggarwal MM, Aglieri Rinella G, Agnello M, Agrawal N, Ahammed Z, Ahmad S, Ahn SU, Aiola S, Akindinov A, Alam SN, Aleksandrov D, Alessandro B, Alexandre D, Alfaro Molina R, Alici A, …
• Measurement of an Excess in the Yield of J/ψ at Very Low p_{T} in Pb-Pb Collisions at sqrt[s]_{NN}=2.76  TeV.
  Physical review letters 2016 Adam J, Adamová D, Aggarwal MM, Aglieri Rinella G, Agnello M, Agrawal N, Ahammed Z, Ahn SU, Aiola S, Akindinov A, Alam SN, Aleksandrov D, Alessandro B, Alexandre D, Alfaro Molina R, Alici A, Alkin A, …
• Centrality dependence of charged jet production in p-Pb collisions at [Formula: see text] = 5.02 TeV.
  The European physical journal. C, Particles and fields 2016 Alice Collaboration, Adam J, Adamová D, Aggarwal MM, Aglieri Rinella G, Agnello M, Agrawal N, Ahammed Z, Ahmad S, Ahn SU, Aiola S, Akindinov A, Alam SN, Albuquerque DSD, Aleksandrov D, Alessandro B, …
• Production of K[Formula: see text](892)[Formula: see text] and [Formula: see text](1020) in p-Pb collisions at [Formula: see text] = 5.02 TeV.
  The European physical journal. C, Particles and fields 2016 Adam J, Adamová D, Aggarwal MM, Aglieri Rinella G, Agnello M, Agrawal N, Ahammed Z, Ahmad S, Ahn SU, Aiola S, Akindinov A, Alam SN, Aleksandrov D, Alessandro B, Alexandre D, Alfaro Molina R, Alici A, …
• Inclusive quarkonium production at forward rapidity in pp collisions at [Formula: see text]TeV.
  The European physical journal. C, Particles and fields 2016 Adam J, Adamová D, Aggarwal MM, Aglieri Rinella G, Agnello M, Agrawal N, Ahammed Z, Ahn SU, Aiola S, Akindinov A, Alam SN, Aleksandrov D, Alessandro B, Alexandre D, Alfaro Molina R, Alici A, Alkin A, …
• Anisotropic Flow of Charged Particles in Pb-Pb Collisions at √[s{NN}]=5.02 TeV.
  Physical review letters 2016 Adam J, Adamová D, Aggarwal MM, Aglieri Rinella G, Agnello M, Agrawal N, Ahammed Z, Ahmad S, Ahn SU, Aiola S, Akindinov A, Alam SN, Albuquerque DS, Aleksandrov D, Alessandro B, Alexandre D, Alfaro …
• Measurement of the Transverse Single-Spin Asymmetry in p^{↑}+p→W^{±}/Z^{0} at RHIC.
  Physical review letters 2016 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Aparin A, Arkhipkin D, Aschenauer EC, Attri A, Averichev GS, Bai X, Bairathi V, Banerjee A, Bellwied R, Bhasin A, Bhati AK, …
• Beam Energy Dependence of the Third Harmonic of Azimuthal Correlations in Au+Au Collisions at RHIC.
  Physical review letters 2016 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Aparin A, Arkhipkin D, Aschenauer EC, Attri A, Averichev GS, Bai X, Bairathi V, Bellwied R, Bhasin A, Bhati AK, Bhattarai P, …
• Multiplicity and transverse momentum evolution of charge-dependent correlations in pp, p-Pb, and Pb-Pb collisions at the LHC.
  The European physical journal. C, Particles and fields 2016 ALICE Collaboration, Adam J, Adamová D, Aggarwal MM, Aglieri Rinella G, Agnello M, Agrawal N, Ahammed Z, Ahn SU, Aiola S, Akindinov A, Alam SN, Aleksandrov D, Alessandro B, Alexandre D, Alfaro Molina …
• Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors.
  Clinical & experimental metastasis 2015 Moen I, Gebre M, Alonso-Camino V, Chen D, Epstein D, McDonald DM
• Synergistic actions of blocking angiopoietin-2 and tumor necrosis factor-α in suppressing remodeling of blood vessels and lymphatics in airway inflammation.
  The American journal of pathology 2015 Le CT, Laidlaw G, Morehouse CA, Naiman B, Brohawn P, Mustelin T, Connor JR, McDonald DM
• Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases.
  Journal of the American Society of Nephrology : JASN 2015 Huang JL, Woolf AS, Kolatsi-Joannou M, Baluk P, Sandford RN, Peters DJ, McDonald DM, Price KL, Winyard PJ, Long DA
• Measurement of pion, kaon and proton production in proton-proton collisions at [Formula: see text] TeV.
  The European physical journal. C, Particles and fields 2015 Adam J, Adamová D, Aggarwal MM, Rinella GA, Agnello M, Agrawal N, Ahammed Z, Ahmed I, Ahn SU, Aimo I, Aiola S, Ajaz M, Akindinov A, Alam SN, Aleksandrov D, Alessandro B, Alexandre D, Molina RA, Alici …
• Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux.
  PloS one 2015 Raymond WW, Xu X, Nimishakavi S, Le C, McDonald DM, Caughey GH
• Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice.
  PloS one 2015 Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF
• Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways.
  The American journal of pathology 2014 Baluk P, Phillips K, Yao LC, Adams A, Nitschké M, McDonald DM
• Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation.
  The American journal of pathology 2014 Baluk P, Adams A, Phillips K, Feng J, Hong YK, Brown MB, McDonald DM
• Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period.
  Circulation research 2014 Yao LC, Testini C, Tvorogov D, Anisimov A, Vargas SO, Baluk P, Pytowski B, Claesson-Welsh L, Alitalo K, McDonald DM
• Plasticity of airway lymphatics in development and disease.
  Advances in anatomy, embryology, and cell biology 2014 Yao LC, McDonald DM
• Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis.
  American journal of respiratory cell and molecular biology 2013 Xu X, Greenland J, Baluk P, Adams A, Bose O, McDonald DM, Caughey GH
• Iron administration before stem cell harvest enables MR imaging tracking after transplantation.
  Radiology 2013 Khurana A, Chapelin F, Beck G, Lenkov OD, Donig J, Nejadnik H, Messing S, Derugin N, Chan RC, Gaur A, Sennino B, McDonald DM, Kempen PJ, Tikhomirov GA, Rao J, Daldrup-Link HE
• IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.
  International immunology 2013 Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM
• Observation of an energy-dependent difference in elliptic flow between particles and antiparticles in relativistic heavy ion collisions.
  Physical review letters 2013 Adamczyk L, Adkins JK, Agakishiev G, Aggarwal MM, Ahammed Z, Alekseev I, Alford J, Anson CD, Aparin A, Arkhipkin D, Aschenauer E, Averichev GS, Balewski J, Banerjee A, Barnovska Z, Beavis DR, Bellwied…
• Molecular determinants of lung development.
  Annals of the American Thoracic Society 2013 Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince…
• Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways.
  The American journal of pathology 2013 Baluk P, Hogmalm A, Bry M, Alitalo K, Bry K, McDonald DM
• Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia.
  Oncogene 2012 Xi Y, Wei Y, Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM, Jablons DM, Chapman HA
• MR imaging features of gadofluorine-labeled matrix-associated stem cell implants in cartilage defects.
  PloS one 2012 Nejadnik H, Henning TD, Do T, Sutton EJ, Baehner F, Horvai A, Sennino B, McDonald D, Meier R, Misselwitz B, Link TM, Daldrup-Link HE
• Magnetic resonance imaging of ferumoxide-labeled mesenchymal stem cells in cartilage defects: in vitro and in vivo investigations.
  Molecular imaging 2012 Henning TD, Gawande R, Khurana A, Tavri S, Mandrussow L, Golovko D, Horvai A, Sennino B, McDonald D, Meier R, Wendland M, Derugin N, Link TM, Daldrup-Link HE
• Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Banfi A, von Degenfeld G, Gianni-Barrera R, Reginato S, Merchant MJ, McDonald DM, Blau HM
• Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo.
  Nature communications 2012 Orsenigo F, Giampietro C, Ferrari A, Corada M, Galaup A, Sigismund S, Ristagno G, Maddaluno L, Koh GY, Franco D, Kurtcuoglu V, Poulikakos D, Baluk P, McDonald D, Grazia Lampugnani M, Dejana E
• MET and VEGF: synergistic targets in castration-resistant prostate cancer.
  Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2011 Aftab DT, McDonald DM
• Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF).
  European journal of radiology 2011 Cyran CC, Sennino B, Fu Y, Rogut V, Shames DM, Chaopathomkul B, Wendland MF, McDonald DM, Brasch RC, Raatschen HJ
• In situ force mapping of mammary gland transformation.
  Integrative biology : quantitative biosciences from nano to macro 2011 Lopez JI, Kang I, You WK, McDonald DM, Weaver VM
• Increased vascular delivery and efficacy of chemotherapy after inhibition of platelet-derived growth factor-B.
  The American journal of pathology 2011 Falcon BL, Pietras K, Chou J, Chen D, Sennino B, Hanahan D, McDonald DM
• VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer.
  Cancer research 2011 You WK, Sennino B, Williamson CW, Falcón B, Hashizume H, Yao LC, Aftab DT, McDonald DM
• Lymphangiogenesis and hemangiogenesis: potential targets for therapy.
  Journal of surgical oncology 2011 Witte MH, Dellinger MT, McDonald DM, Nathanson SD, Boccardo FM, Campisi CC, Sleeman JP, Gershenwald JE
• Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors.
  Cancer research 2011 Falcon BL, Barr S, Gokhale PC, Chou J, Fogarty J, Depeille P, Miglarese M, Epstein DM, McDonald DM
• New antibody to stop tumor angiogenesis and lymphatic spread by blocking receptor partnering.
  Cancer cell 2010 McDonald DM
• Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody.
  Molecular cancer therapeutics 2010 Coxon A, Bready J, Min H, Kaufman S, Leal J, Yu D, Lee TA, Sun JR, Estrada J, Bolon B, McCabe J, Wang L, Rex K, Caenepeel S, Hughes P, Cordover D, Kim H, Han SJ, Michaels ML, Hsu E, Shimamoto G, …
• MR signal characteristics of viable and apoptotic human mesenchymal stem cells in matrix-associated stem cell implants for treatment of osteoarthritis.
  Investigative radiology 2010 Nedopil A, Klenk C, Kim C, Liu S, Wendland M, Golovko D, Schuster T, Sennino B, McDonald DM, Daldrup-Link HE
• Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.
  American journal of respiratory and critical care medicine 2010 Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn GW, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, …
• Lymphotoxin-alpha contributes to lymphangiogenesis.
  Blood 2010 Mounzer RH, Svendsen OS, Baluk P, Bergman CM, Padera TP, Wiig H, Jain RK, McDonald DM, Ruddle NH
• Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth.
  Cancer research 2010 Hashizume H, Falcón BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM
• Ricinus communis agglutinin I leads to rapid down-regulation of VEGFR-2 and endothelial cell apoptosis in tumor blood vessels.
  The American journal of pathology 2010 You WK, Kasman I, Hu-Lowe DD, McDonald DM
• Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways.
  The American journal of pathology 2010 Yao LC, Baluk P, Feng J, McDonald DM
• Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.
  The Journal of experimental medicine 2009 Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, Coughlin SR, McDonald DM, Schwab SR, Cyster JG
• Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels.
  The American journal of pathology 2009 Falcón BL, Hashizume H, Koumoutsakos P, Chou J, Bready JV, Coxon A, Oliner JD, McDonald DM
• TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice.
  The Journal of clinical investigation 2009 Baluk P, Yao LC, Feng J, Romano T, Jung SS, Schreiter JL, Yan L, Shealy DJ, McDonald DM
• Correlative dynamic contrast MRI and microscopic assessments of tumor vascularity in RIP-Tag2 transgenic mice.
  Magnetic resonance in medicine 2009 Sennino B, Raatschen HJ, Wendland MF, Fu Y, You WK, Shames DM, McDonald DM, Brasch RC
• Relaxation effects of ferucarbotran-labeled mesenchymal stem cells at 1.5T and 3T: discrimination of viable from lysed cells.
  Magnetic resonance in medicine 2009 Henning TD, Wendland MF, Golovko D, Sutton EJ, Sennino B, Malek F, Bauer JS, McDonald DM, Daldrup-Link H
• The influence of ferucarbotran on the chondrogenesis of human mesenchymal stem cells.
  Contrast media & molecular imaging 2009 Henning TD, Sutton EJ, Kim A, Golovko D, Horvai A, Ackerman L, Sennino B, McDonald D, Lotz J, Daldrup-Link HE
• Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice.
  The American journal of pathology 2009 Okazaki T, Ni A, Baluk P, Ayeni OA, Kearley J, Coyle AJ, Humbles A, McDonald DM
• alpha5beta1 Integrin blockade inhibits lymphangiogenesis in airway inflammation.
  The American journal of pathology 2009 Okazaki T, Ni A, Ayeni OA, Baluk P, Yao LC, Vossmeyer D, Zischinsky G, Zahn G, Knolle J, Christner C, McDonald DM
• Cellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitors.
  Cancer research 2009 Sennino B, Kuhnert F, Tabruyn SP, Mancuso MR, Hu-Lowe DD, Kuo CJ, McDonald DM
• The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis.
  BMB reports 2008 You WK, McDonald DM
• Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity.
  Genes & development 2008 Johnson NC, Dillard ME, Baluk P, McDonald DM, Harvey NL, Frase SL, Oliver G
• Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees.
  Cell and tissue research 2008 Dejana E, Orsenigo F, Molendini C, Baluk P, McDonald DM
• Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels.
  Circulation research 2008 Korpisalo P, Karvinen H, Rissanen TT, Kilpijoki J, Marjomäki V, Baluk P, McDonald DM, Cao Y, Eriksson U, Alitalo K, Ylä-Herttuala S
• Magnetic resonance imaging for monitoring the effects of thalidomide on experimental human breast cancers.
  European radiology 2008 Cyran CC, Sennino B, Chaopathomkul B, Fu Y, Rogut VS, Shames DM, Wendland MF, McDonald DM, Brasch RC
• Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Kuhnert F, Tam BY, Sennino B, Gray JT, Yuan J, Jocson A, Nayak NR, Mulligan RC, McDonald DM, Kuo CJ
• Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature.
  Investigative radiology 2008 Cyran CC, Sennino B, Chaopathomkul B, Fu Y, Rogut V, Shames DM, Wendland MF, McDonald DM, Brasch RC
• Vascular permeability during antiangiogenesis treatment: MR imaging assay results as biomarker for subsequent tumor growth in rats.
  Radiology 2008 Raatschen HJ, Simon GH, Fu Y, Sennino B, Shames DM, Wendland MF, McDonald DM, Brasch RC
• Markers for microscopic imaging of lymphangiogenesis and angiogenesis.
  Annals of the New York Academy of Sciences 2008 Baluk P, McDonald DM
• Disease-specific gene expression profiling in multiple models of lung disease.
  American journal of respiratory and critical care medicine 2007 Lewis CC, Yang JY, Huang X, Banerjee SK, Blackburn MR, Baluk P, McDonald DM, Blackwell TS, Nagabhushanam V, Peters W, Voehringer D, Erle DJ
• Functionally specialized junctions between endothelial cells of lymphatic vessels.
  The Journal of experimental medicine 2007 Baluk P, Fuxe J, Hashizume H, Romano T, Lashnits E, Butz S, Vestweber D, Corada M, Molendini C, Dejana E, McDonald DM
• Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102.
  Cancer research 2007 Sennino B, Falcón BL, McCauley D, Le T, McCauley T, Kurz JC, Haskell A, Epstein DM, McDonald DM
• Mechanisms of adverse effects of anti-VEGF therapy for cancer.
  British journal of cancer 2007 Kamba T, McDonald DM
• The biologic basis of in vivo angiogenesis imaging.
  Frontiers in bioscience : a journal and virtual library 2007 Ocak I, Baluk P, Barrett T, McDonald DM, Choyke P
• Cell labeling with the positive MR contrast agent Gadofluorine M.
  European radiology 2007 Henning TD, Saborowski O, Golovko D, Boddington S, Bauer JS, Fu Y, Meier R, Pietsch H, Sennino B, McDonald DM, Daldrup-Link HE
• In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin.
  Arteriosclerosis, thrombosis, and vascular biology 2006 Kim KE, Cho CH, Kim HZ, Baluk P, McDonald DM, Koh GY
• Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Daly C, Pasnikowski E, Burova E, Wong V, Aldrich TH, Griffiths J, Ioffe E, Daly TJ, Fandl JP, Papadopoulos N, McDonald DM, Thurston G, Yancopoulos GD, Rudge JS
• Rapid vascular regrowth in tumors after reversal of VEGF inhibition.
  The Journal of clinical investigation 2006 Mancuso MR, Davis R, Norberg SM, O'Brien S, Sennino B, Nakahara T, Yao VJ, Inai T, Brooks P, Freimark B, Shalinsky DR, Hu-Lowe DD, McDonald DM
• Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald DM, Homer RJ, Sessa WC, Elias JA
• Wanted: cancer boss.
  Nature 2006 McDonald D, Vogelstein B, King MC, Hong WK, Augustin H, Hanahan D, Lippman M
• Antiangiogenic therapy decreases integrin expression in normalized tumor blood vessels.
  Cancer research 2006 Yao VJ, Ozawa MG, Varner AS, Kasman IM, Chanthery YH, Pasqualini R, Arap W, McDonald DM
• Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors.
  Cancer research 2006 Nakahara T, Norberg SM, Shalinsky DR, Hu-Lowe DD, McDonald DM
• Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent.
  Journal of experimental therapeutics & oncology 2006 Ramakrishnan V, Bhaskar V, Law DA, Wong MH, DuBridge RB, Breinberg D, O'Hara C, Powers DB, Liu G, Grove J, Hevezi P, Cass KM, Watson S, Evangelista F, Powers RA, Finck B, Wills M, Caras I, Fang Y, …
• Imaging of angiogenesis in inflamed airways and tumors: newly formed blood vessels are not alike and may be wildly abnormal: Parker B. Francis lecture.
  Chest 2005 McDonald DM, Baluk P
• Angiogenesis with pericyte abnormalities in a transgenic model of prostate carcinoma.
  Cancer 2005 Ozawa MG, Yao VJ, Chanthery YH, Troncoso P, Uemura A, Varner AS, Kasman IM, Pasqualini R, Arap W, McDonald DM
• Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Aurora AB, Baluk P, Zhang D, Sidhu SS, Dolganov GM, Basbaum C, McDonald DM, Killeen N
• Mast cells protect mice from Mycoplasma pneumonia.
  American journal of respiratory and critical care medicine 2005 Xu X, Zhang D, Lyubynska N, Wolters PJ, Killeen NP, Baluk P, McDonald DM, Hawgood S, Caughey GH
• Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling.
  American journal of physiology. Heart and circulatory physiology 2005 Baffert F, Le T, Sennino B, Thurston G, Kuo CJ, Hu-Lowe D, McDonald DM
• VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature.
  American journal of physiology. Heart and circulatory physiology 2005 Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR, Norberg SM, O'Brien SM, Davis RB, Gowen LC, Anderson KD, Thurston G, Joho S, Springer ML, Kuo CJ, McDonald DM
• Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules.
  American journal of physiology. Heart and circulatory physiology 2005 Baffert F, Le T, Thurston G, McDonald DM
• Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers.
  Cancer research 2005 di Tomaso E, Capen D, Haskell A, Hart J, Logie JJ, Jain RK, McDonald DM, Jones R, Munn LL
• Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors.
  The American journal of pathology 2005 Parsons-Wingerter P, Kasman IM, Norberg S, Magnussen A, Zanivan S, Rissone A, Baluk P, Favre CJ, Jeffry U, Murray R, McDonald DM
• Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow.
  Circulation research 2005 Cho CH, Kim KE, Byun J, Jang HS, Kim DK, Baluk P, Baffert F, Lee GM, Mochizuki N, Kim J, Jeon BH, McDonald DM, Koh GY
• Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period.
  Development (Cambridge, England) 2005 Thurston G, Wang Q, Baffert F, Rudge J, Papadopoulos N, Jean-Guillaume D, Wiegand S, Yancopoulos GD, McDonald DM
• Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vessels.
  Cancer research 2005 Magnussen A, Kasman IM, Norberg S, Baluk P, Murray R, McDonald DM
• Cellular abnormalities of blood vessels as targets in cancer.
  Current opinion in genetics & development 2005 Baluk P, Hashizume H, McDonald DM
• Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.
  The Journal of clinical investigation 2005 Baluk P, Tammela T, Ator E, Lyubynska N, Achen MG, Hicklin DJ, Jeltsch M, Petrova TV, Pytowski B, Stacker SA, Ylä-Herttuala S, Jackson DG, Alitalo K, McDonald DM
• Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection.
  The American journal of pathology 2005 Yao VJ, Ozawa MG, Trepel M, Arap W, McDonald DM, Pasqualini R
• Shear stress-induced upregulation of connexin 43 expression in endothelial cells on upstream surfaces of rat cardiac valves.
  Histochemistry and cell biology 2004 Inai T, Mancuso MR, McDonald DM, Kobayashi J, Nakamura K, Shibata Y
• Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways.
  The American journal of pathology 2004 Baluk P, Lee CG, Link H, Ator E, Haskell A, Elias JA, McDonald DM
• Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.
  Nature medicine 2004 Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, Elias JA
• Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts.
  The American journal of pathology 2004 Inai T, Mancuso M, Hashizume H, Baffert F, Haskell A, Baluk P, Hu-Lowe DD, Shalinsky DR, Thurston G, Yancopoulos GD, McDonald DM
• Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling.
  American journal of physiology. Lung cellular and molecular physiology 2004 Baluk P, Raymond WW, Ator E, Coussens LM, McDonald DM, Caughey GH
• Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels.
  Circulation research 2004 Baffert F, Thurston G, Rochon-Duck M, Le T, Brekken R, McDonald DM
• Report from the society for biological therapy and vascular biology faculty of the NCI workshop on angiogenesis monitoring.
  Journal of immunotherapy (Hagerstown, Md. : 1997) 2004 McDonald DM, Teicher BA, Stetler-Stevenson W, Ng SS, Figg WD, Folkman J, Hanahan D, Auerbach R, O'Reilly M, Herbst R, Cheresh D, Gordon M, Eggermont A, Libutti SK
• Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis.
  The Journal of clinical investigation 2004 Ozawa CR, Banfi A, Glazer NL, Thurston G, Springer ML, Kraft PE, McDonald DM, Blau HM
• Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors.
  The American journal of pathology 2003 Baluk P, Morikawa S, Haskell A, Mancuso M, McDonald DM
• Mechanisms of increased immunogenicity for DNA-based vaccines adsorbed onto cationic microparticles.
  Cellular immunology 2003 Denis-Mize KS, Dupuis M, Singh M, Woo C, Ugozzoli M, O'Hagan DT, Donnelly JJ, Ott G, McDonald DM
• Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung.
  American journal of physiology. Heart and circulatory physiology 2003 Favre CJ, Mancuso M, Maas K, McLean JW, Baluk P, McDonald DM
• Imaging of angiogenesis: from microscope to clinic.
  Nature medicine 2003 McDonald DM, Choyke PL
• Probing the structural and molecular diversity of tumor vasculature.
  Trends in molecular medicine 2002 Pasqualini R, Arap W, McDonald DM
• Rapid changes in shape and number of MHC class II expressing cells in rat airways after Mycoplasma pulmonis infection.
  Cellular immunology 2002 Umemoto EY, Brokaw JJ, Dupuis M, McDonald DM
• Significance of blood vessel leakiness in cancer.
  Cancer research 2002 McDonald DM, Baluk P
• Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors.
  The American journal of pathology 2002 Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, McDonald DM
• Angiogenesis and remodeling of airway vasculature in chronic inflammation.
  American journal of respiratory and critical care medicine 2001 McDonald DM
• Vascular targeting and antigen presentation.
  Nature immunology 2001 Pasqualini R, McDonald DM, Arap W
• Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice.
  The EMBO journal 2001 Veikkola T, Jussila L, Makinen T, Karpanen T, Jeltsch M, Petrova TV, Kubo H, Thurston G, McDonald DM, Achen MG, Stacker SA, Alitalo K
• Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells.
  Developmental biology 2001 Gale NW, Baluk P, Pan L, Kwan M, Holash J, DeChiara TM, McDonald DM, Yancopoulos GD
• Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P.
  American journal of physiology. Lung cellular and molecular physiology 2001 Kwan ML, Gómez AD, Baluk P, Hashizume H, McDonald DM
• Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Chang YS, di Tomaso E, McDonald DM, Jones R, Jain RK, Munn LL
• Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells.
  Gene therapy 2000 Denis-Mize KS, Dupuis M, MacKichan ML, Singh M, Doe B, O'Hagan D, Ulmer JB, Donnelly JJ, McDonald DM, Ott G
• Microvascular remodelling in chronic airway inflammation in mice.
  Clinical and experimental pharmacology & physiology 2000 Thurston G, Maas K, Labarbara A, Mclean JW, McDonald DM
• Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice.
  Journal of immunology (Baltimore, Md. : 1950) 2000 Dupuis M, Denis-Mize K, Woo C, Goldbeck C, Selby MJ, Chen M, Otten GR, Ulmer JB, Donnelly JJ, Ott G, McDonald DM
• Angiopoietin-1 protects the adult vasculature against plasma leakage.
  Nature medicine 2000 Thurston G, Rudge JS, Ioffe E, Zhou H, Ross L, Croll SD, Glazer N, Holash J, McDonald DM, Yancopoulos GD
• Openings between defective endothelial cells explain tumor vessel leakiness.
  The American journal of pathology 2000 Hashizume H, Baluk P, Morikawa S, McLean JW, Thurston G, Roberge S, Jain RK, McDonald DM
• Determinants of endothelial cell phenotype in venules.
  Microcirculation (New York, N.Y. : 1994) 2000 Thurston G, Baluk P, McDonald DM
• Vasculogenic mimicry: how convincing, how novel, and how significant?
  The American journal of pathology 2000 McDonald DM, Munn L, Jain RK
• Endothelial cells of tumor vessels: abnormal but not absent.
  Cancer metastasis reviews 2000 McDonald DM, Foss AJ
• Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1.
  Science (New York, N.Y.) 1999 Thurston G, Suri C, Smith K, McClain J, Sato TN, Yancopoulos GD, McDonald DM
• Distribution of adjuvant MF59 and antigen gD2 after intramuscular injection in mice.
  Vaccine 1999 Dupuis M, McDonald DM, Ott G
• Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Corada M, Mariotti M, Thurston G, Smith K, Kunkel R, Brockhaus M, Lampugnani MG, Martin-Padura I, Stoppacciaro A, Ruco L, McDonald DM, Ward PA, Dejana E
• Endothelial cell heterogeneity in venules of mouse airways induced by polarized inflammatory stimulus.
  The American journal of pathology 1999 Murphy TJ, Thurston G, Ezaki T, McDonald DM
• Endothelial gaps as sites for plasma leakage in inflammation.
  Microcirculation (New York, N.Y. : 1994) 1999 McDonald DM, Thurston G, Baluk P
• Tissue macrophages associated with angiogenesis in chronic airway inflammation in rats.
  American journal of respiratory cell and molecular biology 1999 Dahlqvist K, Umemoto EY, Brokaw JJ, Dupuis M, McDonald DM
• Neurogenic plasma leakage in mouse airways.
  British journal of pharmacology 1999 Baluk P, Thurston G, Murphy TJ, Bunnett NW, McDonald DM
• Increased vascularization in mice overexpressing angiopoietin-1.
  Science (New York, N.Y.) 1998 Suri C, McClain J, Thurston G, McDonald DM, Zhou H, Oldmixon EH, Sato TN, Yancopoulos GD
• Angiogenesis in mice with chronic airway inflammation: strain-dependent differences.
  The American journal of pathology 1998 Thurston G, Murphy TJ, Baluk P, Lindsey JR, McDonald DM
• Glucocorticoid-induced apoptosis of dendritic cells in the rat tracheal mucosa.
  American journal of respiratory cell and molecular biology 1998 Brokaw JJ, White GW, Baluk P, Anderson GP, Umemoto EY, McDonald DM
• Endothelial gaps and adherent leukocytes in allergen-induced early- and late-phase plasma leakage in rat airways.
  The American journal of pathology 1998 Baluk P, Bolton P, Hirata A, Thurston G, McDonald DM
• Dendritic cells internalize vaccine adjuvant after intramuscular injection.
  Cellular immunology 1998 Dupuis M, Murphy TJ, Higgins D, Ugozzoli M, van Nest G, Ott G, McDonald DM
• Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice.
  The Journal of clinical investigation 1998 Thurston G, McLean JW, Rizen M, Baluk P, Haskell A, Murphy TJ, Hanahan D, McDonald DM
• Anti-inflammatory mystixin peptides inhibit plasma leakage without blocking endothelial gap formation.
  The Journal of pharmacology and experimental therapeutics 1998 Baluk P, Fine NW, Thomas HA, Wei ET, Mcdonald DM
• Characterization of tolerance to the anti-leakage effect of formoterol in rat airways.
  European journal of pharmacology 1997 Bowden JJ, Anderson GP, Lefevre PM, Sulakvelidze I, McDonald DM
• Dendritic-cell regulation of lung immunity.
  American journal of respiratory cell and molecular biology 1997 Dupuis M, McDonald DM
• Upregulation of substance P receptors in angiogenesis associated with chronic airway inflammation in rats.
  The American journal of physiology 1997 Baluk P, Bowden JJ, Lefevre PM, McDonald DM
• Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice.
  The American journal of physiology 1997 McLean JW, Fox EA, Baluk P, Bolton PB, Haskell A, Pearlman R, Thurston G, Umemoto EY, McDonald DM
• Salmeterol reduces early- and late-phase plasma leakage and leukocyte adhesion in rat airways.
  American journal of respiratory and critical care medicine 1997 Bolton PB, Lefevre P, McDonald DM
• Endothelial gaps: time course of formation and closure in inflamed venules of rats.
  The American journal of physiology 1997 Baluk P, Hirata A, Thurston G, Fujiwara T, Neal CR, Michel CC, McDonald DM
• Endocytosis and recycling of neurokinin 1 receptors in enteric neurons.
  Neuroscience 1996 Grady EF, Gamp PD, Jones E, Baluk P, McDonald DM, Payan DG, Bunnett NW
• Permeability-related changes revealed at endothelial cell borders in inflamed venules by lectin binding.
  The American journal of physiology 1996 Thurston G, Baluk P, Hirata A, McDonald DM
• Characterization of antisera specific to NK1, NK2, and NK3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1996 Grady EF, Baluk P, Böhm S, Gamp PD, Wong H, Payan DG, Ansel J, Portbury AL, Furness JB, McDonald DM, Bunnett NW
• NK1 receptor antagonist CP-99,994 inhibits cigarette smoke-induced neutrophil and eosinophil adhesion in rat tracheal venules.
  Experimental lung research 1996 Baluk P, Bertrand C, Geppetti P, McDonald DM, Nadel JA
• Sensory denervation by neonatal capsaicin treatment exacerbates Mycoplasma pulmonis infection in rat airways.
  The American journal of physiology 1996 Bowden JJ, Baluk P, Lefevre PM, Schoeb TR, Lindsey JR, McDonald DM
• Substance P (NK1) receptor immunoreactivity on endothelial cells of the rat tracheal mucosa.
  The American journal of physiology 1996 Bowden JJ, Baluk P, Lefevre PM, Vigna SR, McDonald DM
• Neurogenic inflammation. A model for studying efferent actions of sensory nerves.
  Advances in experimental medicine and biology 1996 McDonald DM, Bowden JJ, Baluk P, Bunnett NW
• Location of focal silver staining at endothelial gaps in inflamed venules examined by scanning electron microscopy.
  The American journal of physiology 1995 Hirata A, Baluk P, Fujiwara T, McDonald DM
• Upregulation of tachykinin receptors in chronic airway inflammation.
  Pulmonary pharmacology 1995 McDonald DM
• NK1 receptors mediate leukocyte adhesion in neurogenic inflammation in the rat trachea.
  The American journal of physiology 1995 Baluk P, Bertrand C, Geppetti P, McDonald DM, Nadel JA
• Dexamethasone and oxytetracycline reverse the potentiation of neurogenic inflammation in airways of rats with Mycoplasma pulmonis infection.
  American journal of respiratory and critical care medicine 1994 Bowden JJ, Schoeb TR, Lindsey JR, McDonald DM
• Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Bowden JJ, Garland AM, Baluk P, Lefevre P, Grady EF, Vigna SR, Bunnett NW, McDonald DM
• Proposed nomenclature for quantifying subdivisions of the bronchial wall.
  Journal of applied physiology (Bethesda, Md. : 1985) 1994 Bai A, Eidelman DH, Hogg JC, James AL, Lambert RK, Ludwig MS, Martin J, McDonald DM, Mitzner WA, Okazawa M
• Inhibition of neutrophil and eosinophil adhesion to venules of rat trachea by beta 2-adrenergic agonist formoterol.
  Journal of applied physiology (Bethesda, Md. : 1985) 1994 Bowden JJ, Sulakvelidze I, McDonald DM
• The beta 2-adrenergic receptor agonist formoterol reduces microvascular leakage by inhibiting endothelial gap formation.
  The American journal of physiology 1994 Baluk P, McDonald DM
• Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1994 Vigna SR, Bowden JJ, McDonald DM, Fisher J, Okamoto A, McVey DC, Payan DG, Bunnett NW
• Plasma extravasation induced in rat trachea by 6-OHDA is mediated by sensory nerves, not by sympathetic nerves.
  Journal of applied physiology (Bethesda, Md. : 1985) 1994 Sulakvelidze I, Baluk P, McDonald DM
• Anti-edema action of formoterol in rat trachea does not depend on capsaicin-sensitive sensory nerves.
  American journal of respiratory and critical care medicine 1994 Sulakvelidze I, McDonald DM
• Endothelial gaps and permeability of venules in rat tracheas exposed to inflammatory stimuli.
  The American journal of physiology 1994 McDonald DM
• Parainfluenza (Sendai) virus infects ciliated cells and secretory cells but not basal cells of rat tracheal epithelium.
  American journal of respiratory cell and molecular biology 1993 Massion PP, Funari CC, Ueki I, Ikeda S, McDonald DM, Nadel JA
• Calcitonin gene-related peptide in secretory granules of serous cells in the rat tracheal epithelium.
  American journal of respiratory cell and molecular biology 1993 Baluk P, Nadel JA, McDonald DM
• Peptidase inhibitors reverse steroid-induced suppression of neutrophil adhesion in rat tracheal blood vessels.
  The American journal of physiology 1993 Katayama M, Nadel JA, Piedimonte G, McDonald DM
• Neurogenic plasma extravasation in the rat nasal mucosa is potentiated by peptidase inhibitors.
  The Journal of pharmacology and experimental therapeutics 1993 Petersson G, Bacci E, McDonald DM, Nadel JA
• Distribution of catecholamine-containing nerves on blood vessels of the rat trachea.
  The Journal of comparative neurology 1992 Baker DG, McDonald DM
• Infections intensify neurogenic plasma extravasation in the airway mucosa.
  The American review of respiratory disease 1992 McDonald DM
• Substance P-immunoreactive sensory axons in the rat respiratory tract: a quantitative study of their distribution and role in neurogenic inflammation.
  The Journal of comparative neurology 1992 Baluk P, Nadel JA, McDonald DM
• Neutral endopeptidase and kininase II mediate glucocorticoid inhibition of neurogenic inflammation in the rat trachea.
  The Journal of clinical investigation 1991 Piedimonte G, McDonald DM, Nadel JA
• Mycoplasma pulmonis infections cause long-lasting potentiation of neurogenic inflammation in the respiratory tract of the rat.
  The Journal of clinical investigation 1991 McDonald DM, Schoeb TR, Lindsey JR
• Neurogenic inflammation of the rat trachea: fate of neutrophils that adhere to venules.
  Journal of applied physiology (Bethesda, Md. : 1985) 1990 Umeno E, Nadel JA, McDonald DM
• The ultrastructure and permeability of tracheobronchial blood vessels in health and disease.
  The European respiratory journal. Supplement 1990 McDonald DM
• Glucocorticoids inhibit neurogenic plasma extravasation and prevent virus-potentiated extravasation in the rat trachea.
  The Journal of clinical investigation 1990 Piedimonte G, McDonald DM, Nadel JA
• Hypertonic saline increases vascular permeability in the rat trachea by producing neurogenic inflammation.
  The Journal of clinical investigation 1990 Umeno E, McDonald DM, Nadel JA
• Mechanism of tachyphylaxis associated with neurogenic plasma extravasation in the rat trachea.
  The American review of respiratory disease 1990 Brokaw JJ, Hillenbrand CM, White GW, McDonald DM
• Sendai virus infection potentiates neurogenic inflammation in the rat trachea.
  Journal of applied physiology (Bethesda, Md. : 1985) 1990 Piedimonte G, Nadel JA, Umeno E, McDonald DM
• Histochemical comparison of mast cells obtained from the airways of mongrel dogs and Basenji-Greyhound dogs by bronchoalveolar lavage.
  The American review of respiratory disease 1989 Osborne ML, Sommerhoff CP, Nadel JA, McDonald DM
• Inhibition of neutral endopeptidase potentiates neurogenic inflammation in the rat trachea.
  Journal of applied physiology (Bethesda, Md. : 1985) 1989 Umeno E, Nadel JA, Huang HT, McDonald DM
• Neutral endopeptidase and neurogenic inflammation in rats with respiratory infections.
  Journal of applied physiology (Bethesda, Md. : 1985) 1989 Borson DB, Brokaw JJ, Sekizawa K, McDonald DM, Nadel JA
• Changes in epithelial secretory cells and potentiation of neurogenic inflammation in the trachea of rats with respiratory tract infections.
  Anatomy and embryology 1989 Huang HT, Haskell A, McDonald DM
• Neurogenic inflammation in the rat trachea. I. Changes in venules, leucocytes and epithelial cells.
  Journal of neurocytology 1988 McDonald DM
• Neurogenic inflammation in the rat trachea. II. Identity and distribution of nerves mediating the increase in vascular permeability.
  Journal of neurocytology 1988 McDonald DM, Mitchell RA, Gabella G, Haskell A
• Chymase and tryptase in dog mastocytoma cells: asynchronous expression as revealed by enzyme cytochemical staining.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1988 Caughey GH, Viro NF, Calonico LD, McDonald DM, Lazarus SC, Gold WM
• Ozone-induced bronchial hyperresponsiveness in the rat is not accompanied by neutrophil influx or increased vascular permeability in the trachea.
  The American review of respiratory disease 1988 Evans TW, Brokaw JJ, Chung KF, Nadel JA, McDonald DM
• Respiratory tract infections increase susceptibility to neurogenic inflammation in the rat trachea.
  The American review of respiratory disease 1988 McDonald DM
• Cutaneous allergic response in atopic dogs: relationship of cellular and histamine responses.
  The Journal of allergy and clinical immunology 1988 Becker AB, Chung F, McDonald DM, Frick OL, Gold WM
• Globule leukocytes and mast cells in the rat trachea: their number, distribution, and response to compound 48/80 and dexamethasone.
  Anatomy and embryology 1988 Tam EK, Calonico LD, Nadel JA, McDonald DM
• Neurally mediated increase in vascular permeability in the rat trachea: onset, duration, and tachyphylaxis.
  Experimental lung research 1988 Brokaw JJ, McDonald DM
• Substance P-induced increase in vascular permeability in the rat trachea does not depend on neutrophils or other components of circulating blood.
  Experimental lung research 1988 Bethel RA, Brokaw JJ, Evans TW, Nadel JA, McDonald DM
• Neurogenic inflammation in the respiratory tract: actions of sensory nerve mediators on blood vessels and epithelium of the airway mucosa.
  The American review of respiratory disease 1987 McDonald DM
• Cutaneous mast cell heterogeneity: response to antigen in atopic dogs.
  The Journal of allergy and clinical immunology 1986 Becker AB, Chung KF, McDonald DM, Lazarus SC, Frick OL, Gold WM
• The architecture of nerves and ganglia of the ferret trachea as revealed by acetylcholinesterase histochemistry.
  The Journal of comparative neurology 1986 Baker DG, McDonald DM, Basbaum CB, Mitchell RA
• Pharmacological studies on nonimmunologic contact urticaria in guinea pigs.
  Archives of dermatological research 1986 Lahti A, McDonald DM, Tammi R, Maibach HI
• Mast cell heterogeneity in dog skin.
  The Anatomical record 1985 Becker AB, Chung KF, McDonald DM, Lazarus SC, Frick OL, Gold WM
• Airway hyperresponsiveness and inflammation induced by toluene diisocyanate in guinea pigs.
  The American review of respiratory disease 1985 Gordon T, Sheppard D, McDonald DM, Distefano S, Scypinski L
• An ultrastructural analysis of dog mastocytoma cells and normal mast cells.
  The Anatomical record 1985 Calonico LD, Phillips MJ, McDonald DM, Gold WM
• Morphology of the rat carotid sinus nerve. I. Course, connections, dimensions and ultrastructure.
  Journal of neurocytology 1983 McDonald DM
• Morphology of the rat carotid sinus nerve. II. Number and size of axons.
  Journal of neurocytology 1983 McDonald DM
• A morphometric analysis of blood vessels and perivascular nerves in the rat carotid body.
  Journal of neurocytology 1983 McDonald DM
• The ultrastructure and connections of blood vessels supplying the rat carotid body and carotid sinus.
  Journal of neurocytology 1983 McDonald DM, Larue DT
• The neural pathway involved in "efferent inhibition" of chemoreceptors in the cat carotid body.
  The Journal of comparative neurology 1981 McDonald DM, Mitchell RA
• Location and size of carotid body-like organs (paraganglia) revealed in rats by the permeability of blood vessels to Evans blue dye.
  Journal of neurocytology 1981 McDonald DM, Blewett RW
• Regulation of chemoreceptor sensitivity in the carotid body: the role of presynaptic sensory nerves.
  Federation proceedings 1980 McDonald DM
• An ultrastructural analysis of neurites in the basal lamina of capillaries in the chinchilla cochlear nucleus.
  The Journal of comparative neurology 1977 McDonald DM, Rasmussen GL
• Chemoreceptive properties of regenerated endings of the carotid sinus nerve.
  Brain research 1972 Mitchell RA, Sinha AK, Mcdonald DM
• Ultrastructural characteristics of synaptic endings in the cochlear nucleus having acetylcholinesterase activity.
  Brain research 1971 McDonald DM, Rasmussen GL