Donald Ganem, MD
Professor Emeritus
Microbiology and Immunology
School of Medicine
Education & Training
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- Residency School of Medicine University of California, San Francisco
Publications (71)
Top publication keywords:
Herpesviridae InfectionsVirus ReplicationMicroRNAsViral ProteinsGene Expression Regulation, ViralRNA, MessengerRNA, UntranslatedRNA, AntisenseRNA, ViralPalatine TonsilVirus LatencyBornaviridaeVirus ActivationHerpesvirus 8, HumanSarcoma, Kaposi
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A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production.
Cell reports 2019 Hyrina A, Jones C, Chen D, Clarkson S, Cochran N, Feucht P, Hoffman G, Lindeman A, Russ C, Sigoillot F, Tsang T, Uehara K, Xie L, Ganem D, Holdorf M -
JC polyoma viruria associates with protection from chronic kidney disease independently from apolipoprotein L1 genotype in African Americans.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2018 Freedman BI, Kistler AL, Skewes-Cox P, Ganem D, Spainhour M, Turner J, Divers J, Langefeld CD, Murea M, Hicks PJ, Hemal AK, Snipes JA, Zhao L, Abend JR, Lyles DS, Ma L, Skorecki KL -
Physician-Scientist Careers in the Biotechnology and Pharmaceutical Industries.
The Journal of infectious diseases 2018 Ganem D -
Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation.
Proceedings of the National Academy of Sciences of the United States of America 2015 Tropberger P, Mercier A, Robinson M, Zhong W, Ganem DE, Holdorf M -
Inefficient Codon Usage Impairs mRNA Accumulation: the Case of the v-FLIP Gene of Kaposi's Sarcoma-Associated Herpesvirus.
Journal of virology 2015 Bellare P, Dufresne A, Ganem D
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Site-specific association with host and viral chromatin by Kaposi's sarcoma-associated herpesvirus LANA and its reversal during lytic reactivation.
Journal of virology 2014 Mercier A, Arias C, Madrid AS, Holdorf MM, Ganem D -
KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features.
PLoS pathogens 2014 Arias C, Weisburd B, Stern-Ginossar N, Mercier A, Madrid AS, Bellare P, Holdorf M, Weissman JS, Ganem D -
A unique herpesviral transcriptional program in KSHV-infected lymphatic endothelial cells leads to mTORC1 activation and rapamycin sensitivity.
Cell host & microbe 2013 Chang HH, Ganem D -
Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis.
Proceedings of the National Academy of Sciences of the United States of America 2013 Chandriani S, Skewes-Cox P, Zhong W, Ganem DE, Divers TJ, Van Blaricum AJ, Tennant BC, Kistler AL -
Complete genome sequence of an astrovirus identified in a domestic rabbit (Oryctolagus cuniculus) with gastroenteritis.
Virology journal 2012 Stenglein MD, Velazquez E, Greenacre C, Wilkes RP, Ruby JG, Lankton JS, Ganem D, Kennedy MA, DeRisi JL -
Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44.
Journal of virology 2012 Madrid AS, Ganem D -
Multiple defects, including premature apoptosis, prevent Kaposi's sarcoma-associated herpesvirus replication in murine cells.
Journal of virology 2011 Austgen K, Oakes SA, Ganem D -
Infection of lymphoblastoid cell lines by Kaposi's sarcoma-associated herpesvirus: critical role of cell-associated virus.
Journal of virology 2011 Myoung J, Ganem D -
Transcriptome sequencing demonstrates that human papillomavirus is not active in cutaneous squamous cell carcinoma.
The Journal of investigative dermatology 2011 Arron ST, Ruby JG, Dybbro E, Ganem D, Derisi JL -
Generation of a doxycycline-inducible KSHV producer cell line of endothelial origin: maintenance of tight latency with efficient reactivation upon induction.
Journal of virological methods 2011 Myoung J, Ganem D -
Viral microRNA target allows insight into the role of translation in governing microRNA target accessibility.
Proceedings of the National Academy of Sciences of the United States of America 2011 Lin HR, Ganem D -
Infection of primary human tonsillar lymphoid cells by KSHV reveals frequent but abortive infection of T cells.
Virology 2011 Myoung J, Ganem D -
Active lytic infection of human primary tonsillar B cells by KSHV and its noncytolytic control by activated CD4+ T cells.
The Journal of clinical investigation 2011 Myoung J, Ganem D -
Serological evidence of human klassevirus infection.
Clinical and vaccine immunology : CVI 2010 Greninger AL, Holtz L, Kang G, Ganem D, Wang D, DeRisi JL -
Viral latency and its regulation: lessons from the gamma-herpesviruses.
Cell host & microbe 2010 Speck SH, Ganem D -
Avian bornavirus is present in many tissues of psittacine birds with histopathologic evidence of proventricular dilatation disease.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 2010 Raghav R, Taylor M, Delay J, Ojkic D, Pearl DL, Kistler AL, Derisi JL, Ganem D, Smith DA -
Human enterovirus 109: a novel interspecies recombinant enterovirus isolated from a case of acute pediatric respiratory illness in Nicaragua.
Journal of virology 2010 Yozwiak NL, Skewes-Cox P, Gordon A, Saborio S, Kuan G, Balmaseda A, Ganem D, Harris E, DeRisi JL -
The lytic transcriptome of Kaposi's sarcoma-associated herpesvirus reveals extensive transcription of noncoding regions, including regions antisense to important genes.
Journal of virology 2010 Chandriani S, Xu Y, Ganem D -
Achalasia and viral infection: new insights from veterinary medicine.
Science translational medicine 2010 Ganem D, Kistler A, DeRisi J -
KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine.
The Journal of clinical investigation 2010 Ganem D -
Making sense of antisense: seemingly noncoding RNAs antisense to the master regulator of Kaposi's sarcoma-associated herpesvirus lytic replication do not regulate that transcript but serve as mRNAs encoding small peptides.
Journal of virology 2010 Xu Y, Ganem D -
Array-based transcript profiling and limiting-dilution reverse transcription-PCR analysis identify additional latent genes in Kaposi's sarcoma-associated herpesvirus.
Journal of virology 2010 Chandriani S, Ganem D -
Regulation of KSHV lytic switch protein expression by a virus-encoded microRNA: an evolutionary adaptation that fine-tunes lytic reactivation.
Cell host & microbe 2009 Bellare P, Ganem D -
Analysis of naturally occurring avian bornavirus infection and transmission during an outbreak of proventricular dilatation disease among captive psittacine birds.
Journal of virology 2009 Kistler AL, Smith JM, Greninger AL, Derisi JL, Ganem D -
Experimental induction of proventricular dilatation disease in cockatiels (Nymphicus hollandicus) inoculated with brain homogenates containing avian bornavirus 4.
Virology journal 2009 Gancz AY, Kistler AL, Greninger AL, Farnoushi Y, Mechani S, Perl S, Berkowitz A, Perez N, Clubb S, DeRisi JL, Ganem D, Lublin A -
The complete genome of klassevirus - a novel picornavirus in pediatric stool.
Virology journal 2009 Greninger AL, Runckel C, Chiu CY, Haggerty T, Parsonnet J, Ganem D, DeRisi JL -
A Kaposi's sarcoma-associated herpesvirus protein that forms inhibitory complexes with type I interferon receptor subunits, Jak and STAT proteins, and blocks interferon-mediated signal transduction.
Journal of virology 2009 Bisson SA, Page AL, Ganem D -
Murine Polyomavirus encodes a microRNA that cleaves early RNA transcripts but is not essential for experimental infection.
Virology 2009 Sullivan CS, Sung CK, Pack CD, Grundhoff A, Lukacher AE, Benjamin TL, Ganem D -
Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAs.
Nature genetics 2008 Ziegelbauer JM, Sullivan CS, Ganem D -
MicroRNAs of Kaposi's sarcoma-associated herpes virus.
Seminars in cancer biology 2008 Ganem D, Ziegelbauer J -
Identification of cardioviruses related to Theiler's murine encephalomyelitis virus in human infections.
Proceedings of the National Academy of Sciences of the United States of America 2008 Chiu CY, Greninger AL, Kanada K, Kwok T, Fischer KF, Runckel C, Louie JK, Glaser CA, Yagi S, Schnurr DP, Haggerty TD, Parsonnet J, Ganem D, DeRisi JL -
Recovery of divergent avian bornaviruses from cases of proventricular dilatation disease: identification of a candidate etiologic agent.
Virology journal 2008 Kistler AL, Gancz A, Clubb S, Skewes-Cox P, Fischer K, Sorber K, Chiu CY, Lublin A, Mechani S, Farnoushi Y, Greninger A, Wen CC, Karlene SB, Ganem D, DeRisi JL -
Utility of DNA microarrays for detection of viruses in acute respiratory tract infections in children.
The Journal of pediatrics 2008 Chiu CY, Urisman A, Greenhow TL, Rouskin S, Yagi S, Schnurr D, Wright C, Drew WL, Wang D, Weintrub PS, Derisi JL, Ganem D -
Effects of NFkappaB activation on KSHV latency and lytic reactivation are complex and context-dependent.
Virology 2008 Grossmann C, Ganem D -
Host transcript accumulation during lytic KSHV infection reveals several classes of host responses.
PloS one 2007 Chandriani S, Ganem D -
Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity.
The Journal of infectious diseases 2007 Kistler A, Avila PC, Rouskin S, Wang D, Ward T, Yagi S, Schnurr D, Ganem D, DeRisi JL, Boushey HA -
Diagnosis of a critical respiratory illness caused by human metapneumovirus by use of a pan-virus microarray.
Journal of clinical microbiology 2007 Chiu CY, Alizadeh AA, Rouskin S, Merker JD, Yeh E, Yagi S, Schnurr D, Patterson BK, Ganem D, DeRisi JL -
Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion.
Proceedings of the National Academy of Sciences of the United States of America 2007 Rowe M, Glaunsinger B, van Leeuwen D, Zuo J, Sweetman D, Ganem D, Middeldorp J, Wiertz EJ, Ressing ME -
Induction of chemokine production by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells.
The Journal of general virology 2007 Xu Y, Ganem D -
Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006 Chiu CY, Rouskin S, Koshy A, Urisman A, Fischer K, Yagi S, Schnurr D, Eckburg PB, Tompkins LS, Blackburn BG, Merker JD, Patterson BK, Ganem D, DeRisi JL -
Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype.
Journal of virology 2006 Grossmann C, Podgrabinska S, Skobe M, Ganem D -
Phosphorylation and function of the kaposin B direct repeats of Kaposi's sarcoma-associated herpesvirus.
Journal of virology 2006 McCormick C, Ganem D -
KSHV infection and the pathogenesis of Kaposi's sarcoma.
Annual review of pathology 2006 Ganem D -
Messenger RNA turnover and its regulation in herpesviral infection.
Advances in virus research 2006 Glaunsinger BA, Ganem DE -
MicroRNAs and viral infection.
Molecular cell 2005 Sullivan CS, Ganem D -
RNAs in the virion of Kaposi's sarcoma-associated herpesvirus.
Journal of virology 2005 Bechtel J, Grundhoff A, Ganem D -
SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells.
Nature 2005 Sullivan CS, Grundhoff AT, Tevethia S, Pipas JM, Ganem D -
A virus-encoded inhibitor that blocks RNA interference in mammalian cells.
Journal of virology 2005 Sullivan CS, Ganem D -
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
Journal of virology 2005 Glaunsinger B, Chavez L, Ganem D -
Regulation of CD1d expression and function by a herpesvirus infection.
The Journal of clinical investigation 2005 Sanchez DJ, Gumperz JE, Ganem D -
Host and viral proteins in the virion of Kaposi's sarcoma-associated herpesvirus.
Journal of virology 2005 Bechtel JT, Winant RC, Ganem D -
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
Science (New York, N.Y.) 2005 McCormick C, Ganem D -
Highly selective escape from KSHV-mediated host mRNA shutoff and its implications for viral pathogenesis.
The Journal of experimental medicine 2004 Glaunsinger B, Ganem D -
RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA.
Journal of virology 2004 Liang Y, Ganem D -
Lytic KSHV infection inhibits host gene expression by accelerating global mRNA turnover.
Molecular cell 2004 Glaunsinger B, Ganem D -
Hepatitis B virus infection--natural history and clinical consequences.
The New England journal of medicine 2004 Ganem D, Prince AM -
Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis.
The Journal of clinical investigation 2004 Grundhoff A, Ganem D -
Viral discovery and sequence recovery using DNA microarrays.
PLoS biology 2003 Wang D, Urisman A, Liu YT, Springer M, Ksiazek TG, Erdman DD, Mardis ER, Hickenbotham M, Magrini V, Eldred J, Latreille JP, Wilson RK, Ganem D, DeRisi JL -
Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling.
Proceedings of the National Academy of Sciences of the United States of America 2003 Liang Y, Ganem D -
Host range of Kaposi's sarcoma-associated herpesvirus in cultured cells.
Journal of virology 2003 Bechtel JT, Liang Y, Hvidding J, Ganem D -
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus permits replication of terminal repeat-containing plasmids.
Journal of virology 2003 Grundhoff A, Ganem D -
PHD domains and E3 ubiquitin ligases: viruses make the connection.
Trends in cell biology 2003 Coscoy L, Ganem D -
Modulation of host gene expression by the constitutively active G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus.
Cancer research 2002 Polson AG, Wang D, DeRisi J, Ganem D -
The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.
Genes & development 2002 Liang Y, Chang J, Lynch SJ, Lukac DM, Ganem D -
Functional organization of MIR2, a novel viral regulator of selective endocytosis.
The Journal of biological chemistry 2001 Sanchez DJ, Coscoy L, Ganem D -
On the control of late gene expression in Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8).
The Journal of general virology 2000 Chang J, Ganem D