Dolores Shoback, MD
Professor
Medicine
School of Medicine

Shoback's research interests include metabolic bone disease, the calcium-sensing receptor and parathyroid hormone.

Shoback completed her undergraduate studies at the University of Pennsylvania. She earned her medical degree from the Johns Hopkins School of Medicine and completed a residency in internal medicine at the Johns Hopkins Hospital. She completed a fellowship in endocrinology at Brigham and Women's Hospital.

• Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Pasieka JL, Wentworth K, Yeo CT, Cremers S, Dempster D, Fukumoto S, Goswami R, Houillier P, Levine MA, Pasternak JD, Perrier ND, Sitges-Serra A, Shoback DM
• Evaluation and Management of Hypoparathyroidism Summary Statement and Guidelines from the Second International Workshop.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Khan AA, Bilezikian JP, Brandi ML, Clarke BL, Gittoes NJ, Pasieka JL, Rejnmark L, Shoback DM, Potts JT, Guyatt GH, Mannstadt M
• Efficacy and Safety of Parathyroid Hormone Replacement With TransCon PTH in Hypoparathyroidism: 26-Week Results From the Phase 3 PaTHway Trial.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Khan AA, Rubin MR, Schwarz P, Vokes T, Shoback DM, Gagnon C, Palermo A, Marcocci C, Clarke BL, Abbott LG, Hofbauer LC, Kohlmeier L, Pihl S, An X, Eng WF, Smith AR, Ukena J, Sibley CT, Shu AD, Rejnmark…
• Bone marrow adipose tissue composition and glycemic improvements after gastric bypass surgery.
  Bone reports 2022 Kim TY, Schwartz AV, Li X, Xu K, Kazakia GJ, Grunfeld C, Nissenson RA, Shoback DM, Schafer AL
• Low cumulative disease activity is associated with higher bone mineral density in a majority Latinx and Asian US rheumatoid arthritis cohort.
  Seminars in arthritis and rheumatism 2022 Wysham KD, Shofer J, Lui G, Trupin L, Andrews JS, Black DM, Graf J, Shoback DM, Katz PP
• Risk of Fracture Among Older Adults With Primary Hyperparathyroidism Receiving Parathyroidectomy vs Nonoperative Management.
  JAMA internal medicine 2022 Seib CD, Meng T, Suh I, Harris AHS, Covinsky KE, Shoback DM, Trickey AW, Kebebew E, Tamura MK
• Sporadic Primary Hyperparathyroidism.
  Endocrinology and metabolism clinics of North America 2021 Kim SJ, Shoback DM
• The PARADIGHM (physicians advancing disease knowledge in hypoparathyroidism) registry for patients with chronic hypoparathyroidism: study protocol and interim baseline patient characteristics.
  BMC endocrine disorders 2021 Gittoes N, Rejnmark L, Ing SW, Brandi ML, Björnsdottir S, Hahner S, Hofbauer LC, Houillier P, Khan AA, Levine MA, Mannstadt M, Shoback DM, Vokes TJ, Zhang P, Marelli C, Germak J, Clarke BL
• A Distinction Without a Difference-Does It Matter Whether Fractures Are Nontraumatic or Traumatic?
  JAMA internal medicine 2021 Schafer AL, Shoback DM
• Osteoporosis and fractures in rheumatoid arthritis.
  Current opinion in rheumatology 2021 Wysham KD, Baker JF, Shoback DM
• Bone age is not just for kids.
  eLife 2021 Cauley JA, Shoback DM
• Sex differences in frailty and its association with low bone mineral density in rheumatoid arthritis.
  Bone reports 2020 Wysham KD, Shoback DM, Andrews JS, Katz PP
• A bridge too far? Attempting to bridge the treatment gap in osteoporosis.
  Endocrine 2020 Clarke BL, Shoback DM
• PTH hypersecretion triggered by a GABAB1 and Ca2+-sensing receptor heterocomplex in hyperparathyroidism.
  Nature metabolism 2020 Chang W, Tu CL, Jean-Alphonse FG, Herberger A, Cheng Z, Hwong J, Ho H, Li A, Wang D, Liu H, White AD, Suh I, Shen W, Duh QY, Khanafshar E, Shoback DM, Xiao K, Vilardaga JP
• Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Guideline Update.
  The Journal of clinical endocrinology and metabolism 2020 Shoback D, Rosen CJ, Black DM, Cheung AM, Murad MH, Eastell R
• Increases in PYY and uncoupling of bone turnover are associated with loss of bone mass after gastric bypass surgery.
  Bone 2019 Kim TY, Shoback DM, Black DM, Rogers SJ, Stewart L, Carter JT, Posselt AM, King NJ, Schafer AL
• Safety and Efficacy of 5 Years of Treatment With Recombinant Human Parathyroid Hormone in Adults With Hypoparathyroidism.
  The Journal of clinical endocrinology and metabolism 2019 Mannstadt M, Clarke BL, Bilezikian JP, Bone H, Denham D, Levine MA, Peacock M, Rothman J, Shoback DM, Warren ML, Watts NB, Lee HM, Sherry N, Vokes TJ
• Calcium-Sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Cheng Z, Li A, Tu CL, Maria CS, Szeto N, Herberger A, Chen TH, Song F, Wang J, Liu X, Shoback DM, Chang W
• New Frontiers in Osteoporosis Therapy.
  Annual review of medicine 2019 Cheng C, Wentworth K, Shoback DM
• Applying the Guidelines for Primary Hyperparathyroidism: The Path Not Taken.
  JAMA internal medicine 2019 Wentworth K, Shoback D
• Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society* Clinical Practice Guideline.
  The Journal of clinical endocrinology and metabolism 2019 Eastell R, Rosen CJ, Black DM, Cheung AM, Murad MH, Shoback D
• Changes in Lean Mass, Absolute and Relative Muscle Strength, and Physical Performance After Gastric Bypass Surgery.
  The Journal of clinical endocrinology and metabolism 2019 Alba DL, Wu L, Cawthon PM, Mulligan K, Lang T, Patel S, King NJ, Carter JT, Rogers SJ, Posselt AM, Stewart L, Shoback DM, Schafer AL
• Mechanisms Underlying Normal Fracture Healing and Risk Factors for Delayed Healing.
  Current osteoporosis reports 2019 Cheng C, Shoback D
• Rapid onset of hypercalcemia from high-grade lymphoma in the setting of HIV-related immune reconstitution inflammatory syndrome.
  Bone reports 2018 Kim SJ, Peluso MJ, Wang Y, Bikle D, Shoback D, Kim S
• Conventional Treatment of Hypoparathyroidism.
  Endocrinology and metabolism clinics of North America 2018 Babey M, Brandi ML, Shoback D
• Familial hypocalciuric hypercalcemia and related disorders.
  Best practice & research. Clinical endocrinology & metabolism 2018 Lee JY, Shoback DM
• Association of High Anti-Cyclic Citrullinated Peptide Seropositivity and Lean Mass Index With Low Bone Mineral Density in Rheumatoid Arthritis.
  Arthritis care & research 2018 Wysham KD, Shoback DM, Imboden JB, Katz PP
• Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture Occur Early and Particularly Impact Postmenopausal Women.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2018 Schafer AL, Kazakia GJ, Vittinghoff E, Stewart L, Rogers SJ, Kim TY, Carter JT, Posselt AM, Pasco C, Shoback DM, Black DM
• Recombinant Human Parathyroid Hormone Effect on Health-Related Quality of Life in Adults With Chronic Hypoparathyroidism.
  The Journal of clinical endocrinology and metabolism 2018 Vokes TJ, Mannstadt M, Levine MA, Clarke BL, Lakatos P, Chen K, Piccolo R, Krasner A, Shoback DM, Bilezikian JP
• Hypoparathyroidism.
  Nature reviews. Disease primers 2017 Mannstadt M, Bilezikian JP, Thakker RV, Hannan FM, Clarke BL, Rejnmark L, Mitchell DM, Vokes TJ, Winer KK, Shoback DM
• Diagnosis and Management of Osteopetrosis: Consensus Guidelines From the Osteopetrosis Working Group.
  The Journal of clinical endocrinology and metabolism 2017 Wu CC, Econs MJ, DiMeglio LA, Insogna KL, Levine MA, Orchard PJ, Miller WP, Petryk A, Rush ET, Shoback DM, Ward LM, Polgreen LE
• Hypoparathyroidism.
  Nature reviews. Disease primers 2017 Mannstadt M, Bilezikian JP, Thakker RV, Hannan FM, Clarke BL, Rejnmark L, Mitchell DM, Vokes TJ, Winer KK, Shoback DM
• Bone Marrow Fat Changes After Gastric Bypass Surgery Are Associated With Loss of Bone Mass.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017 Kim TY, Schwartz AV, Li X, Xu K, Black DM, Petrenko DM, Stewart L, Rogers SJ, Posselt AM, Carter JT, Shoback DM, Schafer AL
• Current Assays to Determine Free 25-Hydroxyvitamin D in Serum.
  Journal of AOAC International 2017 Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD
• Does parathyroid hormone control bone quality?
  Endocrine 2017 Shoback D
• Effects of parathyroid hormone rhPTH(1-84) on phosphate homeostasis and vitamin D metabolism in hypoparathyroidism: REPLACE phase 3 study.
  Endocrine 2016 Clarke BL, Vokes TJ, Bilezikian JP, Shoback DM, Lagast H, Mannstadt M
• Osteoporosis Therapy in Postmenopausal Women With High Risk of Fracture.
  JAMA 2016 Cappola AR, Shoback DM
• Management of Hypoparathyroidism: Summary Statement and Guidelines.
  The Journal of clinical endocrinology and metabolism 2016 Brandi ML, Bilezikian JP, Shoback D, Bouillon R, Clarke BL, Thakker RV, Khan AA, Potts JT
• Presentation of Hypoparathyroidism: Etiologies and Clinical Features.
  The Journal of clinical endocrinology and metabolism 2016 Shoback DM, Bilezikian JP, Costa AG, Dempster D, Dralle H, Khan AA, Peacock M, Raffaelli M, Silva BC, Thakker RV, Vokes T, Bouillon R
• Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism.
  Seminars in cell & developmental biology 2015 Santa Maria C, Cheng Z, Li A, Wang J, Shoback D, Tu CL, Chang W
• A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting.
  Calcified tissue international 2015 Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC
• European Society of Endocrinology Clinical Guideline: Treatment of chronic hypoparathyroidism in adults.
  European journal of endocrinology 2015 Bollerslev J, Rejnmark L, Marcocci C, Shoback DM, Sitges-Serra A, van Biesen W, Dekkers OM, European Society of Endocrinology
• Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations.
  The Journal of clinical endocrinology and metabolism 2015 Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I
• Sclerostin inhibition: a novel therapeutic approach in the treatment of osteoporosis.
  International journal of women's health 2015 Shah AD, Shoback D, Lewiecki EM
• Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 Schafer AL, Weaver CM, Black DM, Wheeler AL, Chang H, Szefc GV, Stewart L, Rogers SJ, Carter JT, Posselt AM, Shoback DM, Sellmeyer DE
• Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study.
  Bone 2015 Schafer AL, Li X, Schwartz AV, Tufts LS, Wheeler AL, Grunfeld C, Stewart L, Rogers SJ, Carter JT, Posselt AM, Black DM, Shoback DM
• Bone Mineral Density, Bone Turnover, and Systemic Inflammation in Non-cirrhotics with Chronic Hepatitis C.
  Digestive diseases and sciences 2015 Lai JC, Shoback DM, Zipperstein J, Lizaola B, Tseng S, Terrault NA
• Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop.
  The Journal of clinical endocrinology and metabolism 2014 Eastell R, Brandi ML, Costa AG, D'Amour P, Shoback DM, Thakker RV
• Medical management of primary hyperparathyroidism: proceedings of the fourth International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism.
  The Journal of clinical endocrinology and metabolism 2014 Marcocci C, Bollerslev J, Khan AA, Shoback DM
• Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 Schafer AL, Mumm S, El-Sayed I, McAlister WH, Horvai AE, Tom AM, Hsiao EC, Schaefer FV, Collins MT, Anderson MS, Whyte MP, Shoback DM
• Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY.
  Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2014 Canales BK, Schafer AL, Shoback DM, Carpenter TO
• Rescue of a primary myelofibrosis model by retinoid-antagonist therapy.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Hong SH, Dvorak-Ewell M, Stevens HY, Barish GD, Castro GL, Nofsinger R, Frangos JA, Shoback D, Evans RM
• Efficacy and safety of recombinant human parathyroid hormone (1-84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study.
  The lancet. Diabetes & endocrinology 2013 Mannstadt M, Clarke BL, Vokes T, Brandi ML, Ranganath L, Fraser WD, Lakatos P, Bajnok L, Garceau R, Mosekilde L, Lagast H, Shoback D, Bilezikian JP
• Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W
• Postmenopausal women treated with combination parathyroid hormone (1-84) and ibandronate demonstrate different microstructural changes at the radius vs. tibia: the PTH and Ibandronate Combination Study (PICS).
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2013 Schafer AL, Burghardt AJ, Sellmeyer DE, Palermo L, Shoback DM, Majumdar S, Black DM
• Calcimimetic and calcilytic drugs for treating bone and mineral-related disorders.
  Best practice & research. Clinical endocrinology & metabolism 2013 Nemeth EF, Shoback D
• Severe hypercalcemic hyperparathyroidism developing in a patient with hyperaldosteronism and renal resistance to parathyroid hormone.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Park-Sigal J, Don BR, Porzig A, Recker R, Griswold V, Sebastian A, Duh QY, Portale AA, Shoback D, Schambelan M
• Six months of parathyroid Hormone (1-84) administered concurrently versus sequentially with monthly ibandronate over two years: the PTH and ibandronate combination study (PICS) randomized trial.
  The Journal of clinical endocrinology and metabolism 2012 Schafer AL, Sellmeyer DE, Palermo L, Hietpas J, Eastell R, Shoback DM, Black DM
• Benefits and risks of bisphosphonate therapy for osteoporosis.
  The Journal of clinical endocrinology and metabolism 2012 Khosla S, Bilezikian JP, Dempster DW, Lewiecki EM, Miller PD, Neer RM, Recker RR, Shane E, Shoback D, Potts JT
• Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011 Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM
• Progressive craniofacial bone loss after cosmetic surgery at the forehead.
  Skeletal radiology 2011 Prasad AP, George V, Porzig A, Horvai AE, Gross A, Shoback D, Link TM
• Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1-84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH study).
  The Journal of clinical endocrinology and metabolism 2011 Schafer AL, Sellmeyer DE, Schwartz AV, Rosen CJ, Vittinghoff E, Palermo L, Bilezikian JP, Shoback DM, Black DM
• Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011 Bilezikian JP, Khan A, Potts JT, Brandi ML, Clarke BL, Shoback D, Jüppner H, D'Amour P, Fox J, Rejnmark L, Mosekilde L, Rubin MR, Dempster D, Gafni R, Collins MT, Sliney J, Sanders J
• Cinacalcet HCl reduces hypercalcemia in primary hyperparathyroidism across a wide spectrum of disease severity.
  The Journal of clinical endocrinology and metabolism 2010 Peacock M, Bilezikian JP, Bolognese MA, Borofsky M, Scumpia S, Sterling LR, Cheng S, Shoback D
• Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor function.
  The Journal of clinical endocrinology and metabolism 2010 Dong Q, Cheng Z, Chang W, Blackman BE, Conte FA, Hu J, Shoback D, Miller WL
• Assessing constitutive activity of extracellular calcium-sensing receptors in vitro and in bone.
  Methods in enzymology 2010 Chang W, Dvorak M, Shoback D
• Cinacalcet treatment of primary hyperparathyroidism: biochemical and bone densitometric outcomes in a five-year study.
  The Journal of clinical endocrinology and metabolism 2009 Peacock M, Bolognese MA, Borofsky M, Scumpia S, Sterling LR, Cheng S, Shoback D
• Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature review.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009 Pao VY, Chang S, Shoback DM, Bikle DD
• Cinacalcet reduces serum calcium concentrations in patients with intractable primary hyperparathyroidism.
  The Journal of clinical endocrinology and metabolism 2009 Marcocci C, Chanson P, Shoback D, Bilezikian J, Fernandez-Cruz L, Orgiazzi J, Henzen C, Cheng S, Sterling LR, Lu J, Peacock M
• Medical management of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop.
  The Journal of clinical endocrinology and metabolism 2009 Khan A, Grey A, Shoback D
• The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development.
  Science signaling 2008 Chang W, Tu C, Chen TH, Bikle D, Shoback D
• Clinical practice. Hypoparathyroidism.
  The New England journal of medicine 2008 Shoback D
• Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma.
  The Journal of clinical endocrinology and metabolism 2007 Silverberg SJ, Rubin MR, Faiman C, Peacock M, Shoback DM, Smallridge RC, Schwanauer LE, Olson KA, Klassen P, Bilezikian JP
• Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes.
  Endocrinology 2007 Cheng Z, Tu C, Rodriguez L, Chen TH, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W
• Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons.
  The Journal of biological chemistry 2007 Chang W, Tu C, Cheng Z, Rodriguez L, Chen TH, Gassmann M, Bettler B, Margeta M, Jan LY, Shoback D
• Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone.
  Endocrinology 2007 Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM
• Update in osteoporosis and metabolic bone disorders.
  The Journal of clinical endocrinology and metabolism 2007 Shoback D
• WITHDRAWN: Type B gamma-aminobutyric Acid Receptors Modulate the Expression and Function of the Extracellular Ca2+-sensing Receptor in Murine Growth Plate Chondrocytes.
  Endocrinology 2006 Cheng Z, Tu C, Rodriguez L, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W
• Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes.
  Endocrinology 2005 Rodriguez L, Tu C, Cheng Z, Chen TH, Bikle D, Shoback D, Chang W
• Extracellular Ca2+-sensing in cartilage.
  Journal of musculoskeletal & neuronal interactions 2004 Chang W, Rodriguez L, Chen TH, Tu C, Shoback D
• Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism.
  The Journal of clinical endocrinology and metabolism 2004 Peacock M, Bilezikian JP, Klassen PS, Guo MD, Turner SA, Shoback D
• cDNA cloning and functional expression of a Ca2+-sensing receptor with truncated C-terminal tail from the Mozambique tilapia (Oreochromis mossambicus).
  The Journal of biological chemistry 2004 Loretz CA, Pollina C, Hyodo S, Takei Y, Chang W, Shoback D
• Fanconi's syndrome in HIV+ adults: report of three cases and literature review.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 Earle KE, Seneviratne T, Shaker J, Shoback D
• Extracellular Ca2+-sensing receptors--an overview.
  Cell calcium 2004 Chang W, Shoback D
• The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism.
  The Journal of clinical endocrinology and metabolism 2003 Shoback DM, Bilezikian JP, Turner SA, McCary LC, Guo MD, Peacock M
• Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma.
  The New England journal of medicine 2003 Shattuck TM, Välimäki S, Obara T, Gaz RD, Clark OH, Shoback D, Wierman ME, Tojo K, Robbins CM, Carpten JD, Farnebo LO, Larsson C, Arnold A
• Mutational analyses of RB and BRCA2 as candidate tumour suppressor genes in parathyroid carcinoma.
  Clinical endocrinology 2003 Shattuck TM, Kim TS, Costa J, Yandell DW, Imanishi Y, Palanisamy N, Gaz RD, Shoback D, Clark OH, Monchik JM, Wierman ME, Hollenberg A, Tojo K, Chaganti RS, Arnold A
• Calcimimetics in the treatment of primary hyperparathyroidism.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002 Antoniucci DM, Shoback D
• Extracellular Ca(2+)-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells.
  Endocrinology 2002 Chang W, Tu C, Pratt S, Chen TH, Shoback D
• Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation.
  The Journal of biological chemistry 2001 Chang W, Pratt S, Chen TH, Bourguignon L, Shoback D
• Starvation amidst plenty--rickets and hypercalcemia in calcium receptor knockout mice.
  Endocrinology 2001 Shoback D, Chang W
• Parathyroid cells express dihydropyridine-sensitive cation currents and L-type calcium channel subunits.
  American journal of physiology. Endocrinology and metabolism 2001 Chang W, Pratt SA, Chen TH, Tu CL, Mikala G, Schwartz A, Shoback D
• Analysis of inositol phospholipid turnover during lymphocyte activation.
  Current protocols in immunology 2001 Imboden JB, Shoback DM, Inokuchi S
• Amino acids in the second and third intracellular loops of the parathyroid Ca2+-sensing receptor mediate efficient coupling to phospholipase C.
  The Journal of biological chemistry 2000 Chang W, Chen TH, Pratt S, Shoback D
• Paget's disease of bone: diagnosis and treatment update.
  Current rheumatology reports 2000 Noor M, Shoback D
• Protein kinase C activation blocks calcium receptor signaling in Xenopus laevis oocytes.
  Molecular and cellular endocrinology 1999 Chang W, Pratt S, Chen TH, Shoback D
• Expression and signal transduction of calcium-sensing receptors in cartilage and bone.
  Endocrinology 1999 Chang W, Tu C, Chen TH, Komuves L, Oda Y, Pratt SA, Miller S, Shoback D
• Calcium sensing in cultured chondrogenic RCJ3.1C5.18 cells.
  Endocrinology 1999 Chang W, Tu C, Bajra R, Komuves L, Miller S, Strewler G, Shoback D
• Clinical effects of raloxifene hydrochloride in women.
  Annals of internal medicine 1999 Khovidhunkit W, Shoback DM
• Regulation of extracellular calcium-activated cation currents by cAMP in parathyroid cells.
  The American journal of physiology 1998 Chang W, Chen TH, Pratt S, Shoback D
• Clinical profile of primary hyperparathyroidism in adolescents and young adults.
  Clinical endocrinology 1998 Loh KC, Duh QY, Shoback D, Gee L, Siperstein A, Clark OH
• Coupling of calcium receptors to inositol phosphate and cyclic AMP generation in mammalian cells and Xenopus laevis oocytes and immunodetection of receptor protein by region-specific antipeptide antisera.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998 Chang W, Pratt S, Chen TH, Nemeth E, Huang Z, Shoback D
• Hypercalcemia in malignant paraganglioma due to parathyroid hormone-related protein.
  Hormone research 1998 Loh K, Matthay KK, Hoover M, Bracho FA, Cortez AB, Conte FA, Albanese CT, Miller TR, Price DC, Flores AJ, Kaviani A, Shoback D
• Parathyroid Ca(2+)-conducting currents are modulated by muscarinic receptor agonists and antagonists.
  The American journal of physiology 1997 Chang W, Chen TH, Pratt SA, Yen B, Fu M, Shoback D
• The N-terminal region of the third intracellular loop of the parathyroid hormone (PTH)/PTH-related peptide receptor is critical for coupling to cAMP and inositol phosphate/Ca2+ signal transduction pathways.
  The Journal of biological chemistry 1996 Huang Z, Chen Y, Pratt S, Chen TH, Bambino T, Nissenson RA, Shoback DM
• Regulation of Ca(2+)-conducting currents in parathyroid cells by extracellular Ca(2+) and channel blockers.
  The American journal of physiology 1995 Chang W, Chen TH, Gardner P, Shoback D
• Mutational analysis of the cytoplasmic tail of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein: effects on receptor expression and signaling.
  Molecular endocrinology (Baltimore, Md.) 1995 Huang Z, Chen Y, Pratt S, Chen TH, Bambino T, Shoback DM, Nissenson RA
• Transient osteoporosis of the hip in pregnancy: natural history of changes in bone mineral density.
  Clinical endocrinology 1995 Funk JL, Shoback DM, Genant HK
• Thapsigargin stimulates intracellular calcium mobilization and inhibits parathyroid hormone release.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995 Shoback D, Chen TH, Pratt S, Lattyak B
• Injection of bovine parathyroid poly(A)+ RNA into Xenopus oocytes confers sensitivity to high extracellular calcium.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994 Chen TH, Pratt SA, Shoback DM
• Effects of high extracellular calcium and strontium on inositol polyphosphates in bovine parathyroid cells.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993 Shoback DM, Chen TH, Lattyak B, King K, Johnson RM
• Structure and function of the receptor for parathyroid hormone and parathyroid hormone-related protein.
  Receptor 1993 Nissenson RA, Huang Z, Blind E, Shoback D
• Effects of protein kinase C activation on inositol phosphate generation and intracellular Ca2+ mobilization in bovine parathyroid cells.
  Endocrinology 1990 Shoback DM, Chen TH
• Effects of phosphatidic acid on parathyroid hormone release, intracellular free Ca2+, and inositol phosphates in dispersed bovine parathyroid cells.
  Endocrinology 1990 McGhee JG, Shoback DM
• The effects of protein kinase-C agonists on parathyroid hormone release and intracellular free Ca2+ in bovine parathyroid cells.
  Endocrinology 1989 Membreño L, Chen TH, Woodley S, Gagucas R, Shoback D
• High calcium and other divalent cations increase inositol trisphosphate in bovine parathyroid cells.
  Endocrinology 1988 Shoback DM, Membreno LA, McGhee JG
• Fluoride stimulates the accumulation of inositol phosphates, increases intracellular free calcium, and inhibits parathyroid hormone release in dispersed bovine parathyroid cells.
  Endocrinology 1988 Shoback DM, McGhee JM
• Reverse T3 and modulators of the calcium messenger system rapidly decrease T4-5'-deiodinase II activity in cultured mouse neuroblastoma cells.
  Thyroidology 1988 Gavin LA, Moeller M, Shoback D, Cavalieri RR
• Renin suppression by saline is blunted in nonmodulating essential hypertension.
  Hypertension (Dallas, Tex. : 1979) 1987 Rabinowe SL, Redgrave JE, Shoback DM, Podolsky S, Hollenberg NK, Williams GH
• Ouabain and low extracellular potassium inhibit PTH secretion from bovine parathyroid cells by a mechanism that does not involve increases in the cytosolic calcium concentration.
  Metabolism: clinical and experimental 1987 Brown EM, Watson EJ, Thatcher JG, Koletsky R, Dawson-Hughes BF, Posillico JT, Shoback DM
• Abnormal renal sodium handling in essential hypertension. Relation to failure of renal and adrenal modulation of responses to angiotensin II.
  The American journal of medicine 1986 Hollenberg NK, Moore T, Shoback D, Redgrave J, Rabinowe S, Williams GH
• Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium.
  Proceedings of the National Academy of Sciences of the United States of America 1986 Imboden JB, Shoback DM, Pattison G, Stobo JD
• Regulation of parathyroid hormone release and cytosolic calcium by extracellular calcium in dispersed and cultured bovine and pathological human parathyroid cells.
  The Journal of clinical investigation 1985 LeBoff MS, Shoback D, Brown EM, Thatcher J, Leombruno R, Beaudoin D, Henry M, Wilson R, Pallotta J, Marynick S
• Interaction of extracellular calcium and magnesium in the regulation of cytosolic calcium and PTH release in dispersed bovine parathyroid cells.
  Molecular and cellular endocrinology 1984 Shoback DM, Thatcher JG, Brown EM
• PTH release stimulated by high extracellular potassium is associated with a decrease in cytosolic calcium in bovine parathyroid cells.
  Biochemical and biophysical research communications 1984 Shoback DM, Brown EM
• Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.
  Proceedings of the National Academy of Sciences of the United States of America 1984 Weiss A, Imboden J, Shoback D, Stobo J
• Forskolin increases cellular cyclic adenosine monophosphate content and parathyroid hormone release in dispersed bovine parathyroid cells.
  Metabolism: clinical and experimental 1984 Shoback DM, Brown EM
• Relationship between parathyroid hormone secretion and cytosolic calcium concentration in dispersed bovine parathyroid cells.
  Proceedings of the National Academy of Sciences of the United States of America 1984 Shoback DM, Thatcher J, Leombruno R, Brown EM
• The relationship between PTH secretion and cytosolic calcium concentration in bovine parathyroid cells.
  Progress in clinical and biological research 1984 Brown EM, Shoback DM
• Defect in the sodium-modulated tissue responsiveness to angiotensin II in essential hypertension.
  The Journal of clinical investigation 1983 Shoback DM, Williams GH, Moore TJ, Dluhy RG, Podolsky S, Hollenberg NK
• Time course and effect of sodium intake on vascular and hormonal responses to enalapril (MK 421) in normal subjects.
  Journal of cardiovascular pharmacology 1983 Shoback DM, Williams GH, Swartz SL, Davies RO, Hollenberg NK
• Endogenous angiotensin II as a determinant of sodium-modulated changes in tissue responsiveness to angiotensin II in normal man.
  The Journal of clinical endocrinology and metabolism 1983 Shoback DM, Williams GH, Hollenberg NK, Davies RO, Moore TJ, Dluhy RG
• Phaeochromocytoma and hypertrophic cardiomyopathy: apparent suppression of symptoms and noradrenaline secretion by calcium-channel blockade.
  Lancet (London, England) 1983 Serfas D, Shoback DM, Lorell BH
• Effects of extracellular Ca++ and Mg++ on cytosolic Ca++ and PTH release in dispersed bovine parathyroid cells.
  Endocrinology 1983 Shoback D, Thatcher J, Leombruno R, Brown E
• Delayed acute myocardial infarction after blunt chest trauma in a young woman.
  American heart journal 1980 Vlay SC, Blumenthal DS, Shoback D, Fehir K, Bulkley BH
• Familial cryoglobulinemia.
  The Johns Hopkins medical journal 1977 Shoback D
• Clinical-pathological conference.
  The Johns Hopkins medical journal 1977 Shoback D, Kan JA
• Pheochromocytoma.
  The Johns Hopkins medical journal 1976 Shoback D