Dioneia Araldi, PhD
Associate Researcher
Oral & Maxillofacial Surgery
School of Dentistry

Awards

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• RDO RAP Diversity Supplement Program for under-represented minority group, UCSF, 2021-2022
• Resource Allocation Program (RAP) - Pilot Award for Prevention and Treatment of Opioid Use Disorders, UCSF, 2021-2022

Publications (50)

Top publication keywords:
Rats, Sprague-DawleyNociceptorsGTP-Binding Protein alpha SubunitsHyperalgesiaSumatriptanPain ThresholdAnalgesics, OpioidEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Hyaluronic AcidFentanylNeuralgiaReceptors, Opioid, muMorphineGanglia, SpinalToll-Like Receptor 4

• Role of pattern recognition receptors in chemotherapy-induced neuropathic pain.
  Brain : a journal of neurology 2024 Araldi D, Khomula EV, Bonet IJM, Bogen O, Green PG, Levine JD
• The Primary Cilium and its Hedgehog Signaling in Nociceptors Contribute to Inflammatory and Neuropathic Pain.
  Research square 2024 Fitzsimons LA, Staurengo-Ferrari L, Bogen O, Araldi D, Bonet IJM, Jordan EE, Levine JD, Tucker KL
• Isolectin B4 (IB4)-conjugated streptavidin for the selective knockdown of proteins in IB4-positive (+) nociceptors.
  Molecular pain 2024 Bogen O, Araldi D, Sucher A, Kober K, Ohara PT, Levine JD
• Sensitization of human and rat nociceptors by low dose morphine is toll-like receptor 4-dependent.
  Molecular pain 2024 Khomula EV, Araldi D, Green PG, Levine JD
• The Primary Cilium and its Hedgehog Signaling in Nociceptors Contribute to Inflammatory and Neuropathic Pain.
  bioRxiv : the preprint server for biology 2023 Fitzsimons LA, Staurengo-Ferrari L, Bogen O, Araldi D, Bonet IJM, Jordan EE, Levine JD, Tucker KL

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• Topical coapplication of hyaluronan with transdermal drug delivery enhancers attenuates inflammatory and neuropathic pain.
  Pain 2023 Bonet IJM, Araldi D, Green PG, Levine JD
• Neuroendocrine mechanisms in oxaliplatin-induced hyperalgesic priming.
  Pain 2022 Staurengo-Ferrari L, Araldi D, Green PG, Levine JD
• Unveiling Targets for Treating Postoperative Pain: The Role of the TNF-α/p38 MAPK/NF-κB/Nav1.8 and Nav1.9 Pathways in the Mouse Model of Incisional Pain.
  International journal of molecular sciences 2022 de Lima FO, Lauria PSS, do Espírito-Santo RF, Evangelista AF, Nogueira TMO, Araldi D, Soares MBP, Villarreal CF
• Contribution of G-Protein α-Subunits to Analgesia, Hyperalgesia, and Hyperalgesic Priming Induced by Subanalgesic and Analgesic Doses of Fentanyl and Morphine.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Araldi D, Bonet IJM, Green PG, Levine JD
• Neuroendocrine Stress Axis-Dependence of Duloxetine Analgesia (Anti-Hyperalgesia) in Chemotherapy-Induced Peripheral Neuropathy.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Staurengo-Ferrari L, Bonet IJM, Araldi D, Green PG, Levine JD
• Second messengers mediating high-molecular-weight hyaluronan-induced antihyperalgesia in rats with chemotherapy-induced peripheral neuropathy.
  Pain 2021 Bonet IJM, Staurengo-Ferrari L, Araldi D, Green PG, Levine JD
• Depolarization induces nociceptor sensitization by CaV1.2-mediated PKA-II activation.
  The Journal of cell biology 2021 Isensee J, van Cann M, Despang P, Araldi D, Moeller K, Petersen J, Schmidtko A, Matthes J, Levine JD, Hucho T
• PI3Kγ/AKT Signaling in High Molecular Weight Hyaluronan (HMWH)-Induced Anti-Hyperalgesia and Reversal of Nociceptor Sensitization.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Bonet IJM, Khomula EV, Araldi D, Green PG, Levine JD
• Sexually Dimorphic Role of Toll-like Receptor 4 (TLR4) in High Molecular Weight Hyaluronan (HMWH)-induced Anti-hyperalgesia.
  The journal of pain 2021 Bonet IJM, Araldi D, Green PG, Levine JD
• Sexual dimorphism in the contribution of neuroendocrine stress axes to oxaliplatin-induced painful peripheral neuropathy.
  Pain 2021 Staurengo-Ferrari L, Green PG, Araldi D, Ferrari LF, Miaskowski C, Levine JD
• Involvement of TACAN, a Mechanotransducing Ion Channel, in Inflammatory But Not Neuropathic Hyperalgesia in the Rat.
  The journal of pain 2020 Bonet IJM, Araldi D, Bogen O, Levine JD
• Opioid-Induced Hyperalgesic Priming in Single Nociceptors.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Khomula EV, Araldi D, Bonet IJM, Levine JD
• Mechanisms Mediating High-Molecular-Weight Hyaluronan-Induced Antihyperalgesia.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Bonet IJM, Araldi D, Khomula EV, Bogen O, Green PG, Levine JD
• Peripheral Inflammatory Hyperalgesia Depends on P2X7 Receptors in Satellite Glial Cells.
  Frontiers in physiology 2020 Neves AF, Farias FH, de Magalhães SF, Araldi D, Pagliusi M, Tambeli CH, Sartori CR, Lotufo CMDC, Parada CA
• Marked sexual dimorphism in neuroendocrine mechanisms for the exacerbation of paclitaxel-induced painful peripheral neuropathy by stress.
  Pain 2020 Ferrari LF, Araldi D, Green PG, Levine JD
• In Vitro Nociceptor Neuroplasticity Associated with In Vivo Opioid-Induced Hyperalgesia.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Khomula EV, Araldi D, Levine JD
• Role of Nociceptor Toll-like Receptor 4 (TLR4) in Opioid-Induced Hyperalgesia and Hyperalgesic Priming.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Araldi D, Bogen O, Green PG, Levine JD
• Systemic Morphine Produces Dose-dependent Nociceptor-mediated Biphasic Changes in Nociceptive Threshold and Neuroplasticity.
  Neuroscience 2018 Ferrari LF, Araldi D, Bogen O, Green PG, Levine JD
• Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat.
  Neuroscience 2018 Araldi D, Ferrari LF, Levine JD
• Role of GPCR (mu-opioid)-receptor tyrosine kinase (epidermal growth factor) crosstalk in opioid-induced hyperalgesic priming (type II).
  Pain 2018 Araldi D, Ferrari LF, Levine JD
• Fentanyl Induces Rapid Onset Hyperalgesic Priming: Type I at Peripheral and Type II at Central Nociceptor Terminals.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Araldi D, Khomula EV, Ferrari LF, Levine JD
• CD44 Signaling Mediates High Molecular Weight Hyaluronan-Induced Antihyperalgesia.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Ferrari LF, Khomula EV, Araldi D, Levine JD
• Age-Dependent Sexual Dimorphism in Susceptibility to Develop Chronic Pain in the Rat.
  Neuroscience 2017 Ferrari LF, Araldi D, Green P, Levine JD
• Hyperalgesic priming (type II) induced by repeated opioid exposure: maintenance mechanisms.
  Pain 2017 Araldi D, Ferrari LF, Levine JD
• Antihyperalgesic effect of CB1 receptor activation involves the modulation of P2X3 receptor in the primary afferent neuron.
  European journal of pharmacology 2017 Oliveira-Fusaro MCG, Zanoni CIS, Dos Santos GG, Manzo LP, Araldi D, Bonet IJM, Tambeli CH, Dias EV, Parada CA
• Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IP3 Receptors in the Induction of Hyperalgesic Priming.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Khomula EV, Ferrari LF, Araldi D, Levine JD
• Regulation of Expression of Hyperalgesic Priming by Estrogen Receptor α in the Rat.
  The journal of pain 2017 Ferrari LF, Araldi D, Levine JD
• Marked sexual dimorphism in 5-HT1 receptors mediating pronociceptive effects of sumatriptan.
  Neuroscience 2016 Araldi D, Ferrari LF, Green P, Levine JD
• Janus kinase 2 activation participates in prostaglandin E2-induced hyperalgesia.
  Life sciences 2016 Vieira AS, Araldi D, Dias EV, do Prado FC, Tambeli CH, Parada CA
• Marked Sexual Dimorphism in the Role of the Ryanodine Receptor in a Model of Pain Chronification in the Rat.
  Scientific reports 2016 Ferrari LF, Khomula EV, Araldi D, Levine JD
• Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming.
  Pain 2016 Araldi D, Ferrari LF, Levine JD
• Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation.
  Neuroscience 2016 Ferrari LF, Araldi D, Bogen O, Levine JD
• Adenosine-A1 receptor agonist induced hyperalgesic priming type II.
  Pain 2016 Araldi D, Ferrari LF, Levine JD
• Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Araldi D, Ferrari LF, Levine JD
• Distinct terminal and cell body mechanisms in the nociceptor mediate hyperalgesic priming.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Ferrari LF, Araldi D, Levine JD
• Inflammatory sensitization of nociceptors depends on activation of NMDA receptors in DRG satellite cells.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Ferrari LF, Lotufo CM, Araldi D, Rodrigues MA, Macedo LP, Ferreira SH, Parada CA
• P2X3 receptors induced inflammatory nociception modulated by TRPA1, 5-HT3 and 5-HT1A receptors.
  Pharmacology, biochemistry, and behavior 2013 Krimon S, Araldi D, do Prado FC, Tambeli CH, Oliveira-Fusaro MC, Parada CA
• Peripheral inflammatory hyperalgesia depends on the COX increase in the dorsal root ganglion.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Araldi D, Ferrari LF, Lotufo CM, Vieira AS, Athié MC, Figueiredo JG, Duarte DB, Tambeli CH, Ferreira SH, Parada CA
• Neuronal P2X3 receptor activation is essential to the hyperalgesia induced by prostaglandins and sympathomimetic amines released during inflammation.
  Neuropharmacology 2012 Prado FC, Araldi D, Vieira AS, Oliveira-Fusaro MC, Tambeli CH, Parada CA
• Nanoassisted laser desorption-ionization-MS imaging of tumors.
  Analytical chemistry 2012 Tata A, Fernandes AM, Santos VG, Alberici RM, Araldi D, Parada CA, Braguini W, Veronez L, Silva Bisson G, Reis FH, Alberici LC, Eberlin MN
• Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia.
  Pain 2012 Cobos EJ, Ghasemlou N, Araldi D, Segal D, Duong K, Woolf CJ
• P2X3 and P2X2/3 receptors mediate mechanical hyperalgesia induced by bradykinin, but not by pro-inflammatory cytokines, PGE₂ or dopamine.
  European journal of pharmacology 2010 de Oliveira Fusaro MC, Pelegrini-da-Silva A, Araldi D, Parada CA, Tambeli CH
• Acute diphenyl diselenide treatment reduces hyperglycemia but does not change delta-aminolevulinate dehydratase activity in alloxan-induced diabetes in rats.
  Biological & pharmaceutical bulletin 2008 Barbosa NB, Oliveira C, Araldi D, Folmer V, Rocha JB, Nogueira CW
• On the mechanisms involved in antinociception induced by diphenyl diselenide.
  Environmental toxicology and pharmacology 2005 Zasso FB, Goncales CE, Jung EA, Araldi D, Zeni G, Rocha JB, Nogueira CW
• Antinociceptive properties of acetylenic thiophene and furan derivatives: evidence for the mechanism of action.
  Life sciences 2005 Goncales CE, Araldi D, Panatieri RB, Rocha JB, Zeni G, Nogueira CW