Di Lang, PhD, MS
Assistant Professor
Medicine
School of Medicine

My research interests focus on understanding the membrane nanodomain mediated compartmentalized cellular and molecular functioning and regulation of proteins in the cardiac physiology and pathology and developing therapeutic strategies targeting the cell cytoarchitectures using animal models, primary cardiomyocytes and human induced pluripotent stem cells (hiPSCs).

Education & Training

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• Postdoc in Pharmacology University of California Davis
• Scientist in Medicine University of Wisconsin Madison
• Ph.D. Biomedical Engineering Washington University in St. Louis

Interests

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• Cardiac arrhythmias
• heart failure
• calcium signaling
• sinoatrial node
• stem cells

Publications (35)

Top publication keywords:
Arrhythmias, CardiacMycobacterium tuberculosisAtherosclerosisMicrobiotaSick Sinus SyndromeSinoatrial NodeMutagenesisHSP40 Heat-Shock ProteinsDNA RepairZebrafishMolecular ChaperonesAntitubercular AgentsBacterial ProteinsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsBiomarkers

• Cholecystokinin-A Signaling Regulates Automaticity of Pacemaker Cardiomyocytes.
  bioRxiv : the preprint server for biology 2023 Ruan H, Mandla R, Ravi N, Galang G, Soe AW, Olgin JE, Lang D, Vedantham V
• Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome.
  eLife 2023 Gessner S, Martin ZA, Reiche MA, Santos JA, Dinkele R, Ramudzuli A, Dhar N, de Wet TJ, Anoosheh S, Lang DM, Aaron J, Chew TL, Herrmann J, Müller R, McKinney JD, Woodgate R, Mizrahi V, Venclovas C, …
• A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene.
  eLife 2022 Ding Y, Lang D, Yan J, Bu H, Li H, Jiao K, Yang J, Ni H, Morotti S, Le T, Clark KJ, Port J, Ekker SC, Cao H, Zhang Y, Wang J, Grandi E, Li Z, Shi Y, Li Y, Glukhov AV, Xu X
• Beyond Diagnosis: a Novel Microbiota Dependent Biomarker and Target for Atherosclerosis.
  Circulation research 2022 Lang D
• Region-specific distribution of transversal-axial tubule system organization underlies heterogeneity of calcium dynamics in the right atrium
  American Journal of Physiology-Heart and Circulatory Physiology 2022 Lang D,* Medvedev RY, Ratajczyk L, Zheng J, Yuan X, Lim E, Han OY, Valdivia HH, Glukhov AV.* *: corresponding author

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• Caveolin-3 prevents swelling-induced membrane damage via regulation of ICI, swell activity
  Biophysical Journal 2022 Turner D, Tyan L, DeGuire F, Medvedev R, Stroebel S, Lang D, Glukhov AV.
• Micropattern platform promotes extracellular matrix remodeling by human PSC‐derived cardiac fibroblasts and enhances contractility of co‐cultured cardiomyocytes
  Physiological Reports 2021 Napiwocki BN, Stempien A, Lang D, Kruepke RA, Kim G, Zhang J, Eckhardt LL, Glukhov AV, Kamp TJ, Crone WC
• Cellular and molecular mechanisms of functional hierarchy of pacemaker clusters in the sinoatrial node: New insights into sick sinus syndrome
  Journal of Cardiovascular Development and Disease 2021 Lang D, Glukhov AV
• Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts
  Biotechnology and bioengineering 2021 Napiwocki BN, Lang D, Stempien A, Zhang J, Vaidyanathan R, Makielski JC, Eckhardt LL, Glukhov AV, Kamp TJ, Crone WC
• Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology
  American Journal of Physiology-Heart and Circulatory Physiology 2021 de Lange WJ, Farrell ET, Kreitzer CR, Jacobs DR, Lang D, Glukhov AV, Ralphe JC.
• Genetic Loss of I K1 Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia
  Circulation: Arrhythmia and Electrophysiology 2020 Reilly L, Alvarado FJ, Lang D, Abozeid S, Van Ert H, Spellman C, Warden J, Makielski JC, Glukhov AV, Eckhardt LL
• Cardiomyocyte Microdomains: An Emerging Concept of Local Regulation and Remodeling
  Frontiers in Physiology 2020 Lang D, Calaghan SC, Gorelik J, Glukhov AV.
• Induced cardiac progenitor cells repopulate decellularized mouse heart scaffolds and differentiate to generate cardiac tissue
  Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 2020 lexanian RA, Mahapatra K, Lang D, Vaidyanathan R, Markandeya YS, Gill RK, Zhai AJ, Dhillon A, Lea MR, Abozeid S, Schmuck EG
• Caveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis
  Journal of the American Heart Association 2019 Egorov YV,* Lang D,* Tyan L, Turner D, Lim E, Piro ZD, Hernandez JJ, Lodin R, Wang R, Schmuck EG, Raval AN, Glukhov AV. *: co-first author
• Epigenetic priming of human pluripotent stem cell-derived cardiac progenitor cells accelerates cardiomyocyte maturation
  Stem Cells 2019 Biermann M, Cai W,* Lang D,* Hermsen J, Profio L, Zhou Y, Czirok A, Isai DG, Napiwocki BN, Rodriguez AM, Brown ME, Glukhov AV, Kamp TJ. *: Authors contribute equally
• Long QT syndrome caveolin‐3 mutations differentially modulate Kv4 and Cav1. 2 channels to contribute to action potential prolongation
  The Journal of physiology 2019 Tyan L, Foell JD, Vincent KP, Woon MT, Mesquitta WT, Lang D, Best JM, Ackerman MJ, McCulloch AD, Glukhov AV, Balijepalli RC, Kamp TJ.
• Functional microdomains in heart’s pacemaker: A step beyond classical electrophysiology and remodeling
  Frontiers in physiology 2018 Lang D, Glukhov AV
• Calcium-dependent arrhythmogenic foci created by weakly coupled myocytes in the failing heart
  Circulation Research 2017 Lang D, Sato D, Jiang Y, Ginsburg KS, Ripplinger CM, Bers DM
• β-Adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia
  Frontiers in physiology 2017 Murphy SR, Wang L, Wang Z, Domondon P, Lang D, Habecker BA, Myles RC, Ripplinger CM.
• An East Asian common variant vinculin P. Asp841His was associated with sudden unexplained nocturnal death syndrome in the Chinese Han population
  Journal of the American Heart Association 2017 Cheng J, Kyle JW, Lang D, Wiedmeyer B, Guo J, Yin K, Huang L, Vaidyanathan R, Su T, Makielski JC.
• Vinculin variant M94I identified in sudden unexplained nocturnal death syndrome decreases cardiac sodium current
  Scientific Reports 2017 16. Cheng J, Kyle JW, Wiedmeyer B, Lang D, Vaidyanathan R, Makielski JC
• High-resolution optical mapping of the mouse sino-atrial node
  JoVE 2016 Lang D, Glukhov AV
• Does sudden unexplained nocturnal death syndrome remain the autopsy-negative disorder: a gross, microscopic, and molecular autopsy investigation in Southern China
  Mayo Clinic Proceedings 2016 18. Zhang L,* Tester DJ,* Lang D,* Chen Y, Zheng J, Gao R, Corliss RF, Tang S, Kyle JW, Liu C, Ackerman MJ, Makielski JC, Cheng JD. *: co-first author
• Arrhythmogenic remodeling of β2 versus β1 adrenergic signaling in the human failing heart
  Circulation: Arrhythmia and Electrophysiology. 2015 Lang D, Holzem K, Kang C, Xiao M, Hwang HJ, Ewald GA, Yamada KA, Efimov IR.
• Junctional cleft [Ca2+] i measurements using novel cleft-targeted Ca2+ sensors
  Circulation research 2014 Despa S, Shui B, Bossuyt J, Lang D, Kotlikoff MI, Bers DM
• Multistage electrotherapy delivered through chronically-implanted leads terminates atrial fibrillation with lower energy than a single biphasic shock
  Journal of the American College of Cardiology 2014 Janardhan AH, Gutbrod SR, Li W, Lang D, Schuessler RB, Efimov IR
• Manu of Research Techniques in Cardiovascular Medicine
  Chapter 7: Optical Mapping of the Heart 2013 Lang, D., Gutbrod, S., Laughner, J., Efimov, IR
• Diabetes increases mortality after myocardial infarction by oxidizing CaMKII
  The Journal of clinical investigation 2013 Luo M, Guan X, Luczak ED, Lang D, Kutschke W, Gao Z, Yang J, Glynn P, Sossalla S, Swaminathan PD, Weiss RM, Anderson M,
• Right ventricular arrhythmogenesis in failing human heart: the role of conduction and repolarization remodeling
  American Journal of Physiology-Heart and Circulatory Physiology 2012 Lou Q, Janks DL, Holzem KM, Lang D, Onal B, Ambrosi CM, Fedorov VV, Wang IW, Efimov IR
• Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts
  American Journal of Physiology-Heart and Circulatory Physiology 2012 Cheng YJ,* Lang D,* Caruthers SD, Efimov IR, Chen J, Wickline SA. *: co-first author
• Cardiac Mapping, Ed: M. Shenasa
  Chapter 9: Optical Mapping of the SA node and AV node 2012 Janardhan, AJ., Lang, D., Efimov, IR
• Spatiotemporal control of heart rate in a rabbit heart
  Journal of electrocardiology 2011 Lang D, Petrov V, Lou Q, Osipov G, Efimov IR
• Role of Pyk2 in cardiac arrhythmogenesis
  American Journal of Physiology-Heart and Circulatory Physiology 2011 Lang D, Glukhov AV, Efimova T, Efimov IR
• Optical mapping of action potentials and calcium transients in the mouse heart
  JoVE 2011 Lang D, Sulkin M, Lou Q, Efimov IR
• Bi-directional transport of GLUT4 vesicles near the plasma membrane of primary rat adipocytes
  Biochemical and biophysical research communications 2007 Xu YK, Xu KD, Li JY, Feng LQ, Lang D, Zheng XX