Deepak Srivastava, MD
Professor
Pediatrics
School of Medicine

We focus on transcriptional and post-transcriptional steps, including those involving microRNAs. We have leveraged this knowledge to reprogram fibroblasts directly into cardiomyocyte-like cells for regenerative purposes. We also seek to identify the causes of human cardiovascular disease by applying modern genetic technologies for the study of complex traits such as congenital heart disease. By using a spectrum of approaches including mouse and human genetics, molecular and developmental biology, and biochemistry we hope to develop a broad understanding of the biology underlying cardiogenesis and cardiovascular disorders.

• Human spinal interneurons repair the injured spinal cord through synaptic integration.
  bioRxiv : the preprint server for biology 2024 Zholudeva LV, Fortino T, Agrawal A, Vila OF, Williams M, McDevitt T, Lane MA, Srivastava D
• Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes.
  Nature cardiovascular research 2023 Nishino T, Ranade SS, Pelonero A, van Soldt BJ, Ye L, Alexanian M, Koback F, Huang Y, Sadagopan N, Lam A, Zholudeva LV, Li F, Padmanabhan A, Thomas R, van Bemmel JG, Gifford CA, Costa MW, Srivastava D
• Single-cell multimodal analyses reveal epigenomic and transcriptomic basis for birth defects in maternal diabetes.
  Nature Cardiovascular Research 2023 Tomohiro Nishino, Sanjeev S. Ranade, Angelo Pelonero, Benjamin J. van Soldt, Lin Ye, Michael Alexanian, Frances Koback, Yu Huang, Langley Grace Wallace, Nandhini Sadagopan, Adrienne Lam, Lyandysha V. …
• The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5.
  Stem cell reports 2023 Maven BEJ, Gifford CA, Weilert M, Gonzalez-Teran B, Hüttenhain R, Pelonero A, Ivey KN, Samse-Knapp K, Kwong W, Gordon D, McGregor M, Nishino T, Okorie E, Rossman S, Costa MW, Krogan NJ, Zeitlinger J, …
• Improved Cardiac Function in Postischemic Rats Using an Optimized Cardiac Reprogramming Cocktail Delivered in a Single Novel Adeno-Associated Virus.
  Circulation 2023 Zhou H, Yang J, Srinath C, Zeng A, Wu I, Leon EC, Qureshi TN, Reid CA, Nettesheim ER, Xu E, Duclos Z, Mohamed TMA, Farshidfar F, Fejes A, Liu J, Jones S, Feathers C, Chung TW, Jing F, Prince WS, Lin J…
• Contribution of Previously Unrecognized RNA Splice-Altering Variants to Congenital Heart Disease.
  Circulation. Genomic and precision medicine 2023 Jang MY, Patel PN, Pereira AC, Willcox JAL, Haghighi A, Tai AC, Ito K, Morton SU, Gorham JM, McKean DM, DePalma SR, Bernstein D, Brueckner M, Chung WK, Giardini A, Goldmuntz E, Kaltman JR, Kim R, …
• A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors.
  Development (Cambridge, England) 2023 Krup AL, Winchester SAB, Ranade SS, Agrawal A, Devine WP, Sinha T, Choudhary K, Dominguez MH, Thomas R, Black BL, Srivastava D, Bruneau BG
• Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes.
  Circulation. Genomic and precision medicine 2023 Yu M, Aguirre M, Jia M, Gjoni K, Cordova-Palomera A, Munger C, Amgalan D, Rosa Ma X, Pereira A, Tcheandjieu C, Seidman C, Seidman J, Tristani-Firouzi M, Chung W, Goldmuntz E, Srivastava D, Loos RJF, …
• Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies.
  International immunopharmacology 2023 Bock-Marquette I, Maar K, Maar S, Lippai B, Faskerti G, Gallyas F, Olson EN, Srivastava D
• Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis.
  bioRxiv : the preprint server for biology 2023 Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Lee CY, Sadagopan N, Huang Y, Pelonero A, Auclair K, Zhu A, Teran BG, Flanigan W, Kim CK, Lumbao-Conradson K, Costa M, Jain R, Charo I, Haldar …
• Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.
  Science translational medicine 2022 Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS
• Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors.
  Circulation 2022 Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van …
• Cellular cross-talk in heart repair.
  Science (New York, N.Y.) 2022 Srivastava D
• Cell line specific alterations in genes associated with dopamine metabolism and signaling in midbrain dopaminergic neurons derived from 22q11.2 deletion carriers with elevated dopamine synthesis capacity.
  Schizophrenia research 2022 Reid MJ, Rogdaki M, Dutan L, Hanger B, Sabad K, Nagy R, Adhya D, Baron-Cohen S, McAlonan G, Price J, Vernon AC, Howes OD, Srivastava DP
• Anniversary reflections: ISSCR presidents on 20 years of progress.
  Cell stem cell 2022 Little M, Morrison SJ, Rossant J, Srivastava D, Daley GQ
• Neither cardiac mitochondrial DNA variation nor copy number contribute to congenital heart disease risk.
  American journal of human genetics 2022 Willcox JAL, Geiger JT, Morton SU, McKean D, Quiat D, Gorham JM, Tai AC, DePalma S, Bernstein D, Brueckner M, Chung WK, Giardini A, Goldmuntz E, Kaltman JR, Kim R, Newburger JW, Shen Y, Srivastava D, …
• Transcription factor protein interactomes reveal genetic determinants in heart disease.
  Cell 2022 Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, …
• Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure.
  Circulation 2022 Abouleisa RRE, Salama ABM, Ou Q, Tang XL, Solanki M, Guo Y, Nong Y, McNally L, Lorkiewicz PK, Kassem KM, Ahern BM, Choudhary K, Thomas R, Huang Y, Juhardeen HR, Siddique A, Ifthikar Z, Hammad SK, …
• Publisher Correction: BRD4 orchestrates genome folding to promote neural crest differentiation.
  Nature genetics 2021 Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom …
• BRD4 orchestrates genome folding to promote neural crest differentiation.
  Nature genetics 2021 Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom …
• Modeling Human Cardiac Chambers with Organoids.
  The New England journal of medicine 2021 Srivastava D
• Ebstein's Anomaly: Review of Arrhythmia Types and Morphogenesis of the Anomaly.
  JACC. Clinical electrophysiology 2021 He BJ, Merriman AF, Cakulev I, Stambler BS, Srivastava D, Scheinman MM
• A transcriptional switch governs fibroblast activation in heart disease.
  Nature 2021 Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, …
• Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease.
  JAMA cardiology 2021 Morton SU, Shimamura A, Newburger PE, Opotowsky AR, Quiat D, Pereira AC, Jin SC, Gurvitz M, Brueckner M, Chung WK, Shen Y, Bernstein D, Gelb BD, Giardini A, Goldmuntz E, Kim RW, Lifton RP, Porter GA, …
• Mouse gastruloids take heart.
  Nature reviews. Cardiology 2021 Srivastava D, McDevitt TC
• Mentorship in Science: Response to AlShebli et al., Nature Communications 2020.
  Stem cell reports 2021 Mummery C, Little M, Lin H, Clark A, Zaret K, ISSCR Board 2020–2021, Srivastava D, Fuchs E, Watt F, Temple S
• Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.
  Science (New York, N.Y.) 2020 Theodoris CV, Zhou P, Liu L, Zhang Y, Nishino T, Huang Y, Kostina A, Ranade SS, Gifford CA, Uspenskiy V, Malashicheva A, Ding S, Srivastava D
• BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes.
  Circulation 2020 Padmanabhan A, Alexanian M, Linares-Saldana R, González-Terán B, Andreoletti G, Huang Y, Connolly AJ, Kim W, Hsu A, Duan Q, Winchester SAB, Felix F, Perez-Bermejo JA, Wang Q, Li L, Shah PP, Haldar SM,…
• GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm.
  eLife 2020 Sharma A, Wasson LK, Willcox JA, Morton SU, Gorham JM, DeLaughter DM, Neyazi M, Schmid M, Agarwal R, Jang MY, Toepfer CN, Ward T, Kim Y, Pereira AC, DePalma SR, Tai A, Kim S, Conner D, Bernstein D, …
• De Novo Damaging Variants, Clinical Phenotypes, and Post-Operative Outcomes in Congenital Heart Disease.
  Circulation. Genomic and precision medicine 2020 Boskovski MT, Homsy J, Nathan M, Sleeper LA, Morton S, Manheimer KB, Tai A, Gorham J, Lewis M, Swartz M, Alfieris GM, Bacha EA, Karimi M, Meyer D, Nguyen K, Bernstein D, Romano-Adesman A, Porter GA, …
• Genomic analyses implicate noncoding de novo variants in congenital heart disease.
  Nature genetics 2020 Richter F, Morton SU, Kim SW, Kitaygorodsky A, Wasson LK, Chen KM, Zhou J, Qi H, Patel N, DePalma SR, Parfenov M, Homsy J, Gorham JM, Manheimer KB, Velinder M, Farrell A, Marth G, Schadt EE, Kaltman …
• Creating Opportunities to Advance Stem Cell Science: 2019-2020 Year in Review.
  Stem cell reports 2020 Srivastava D
• EM-mosaic detects mosaic point mutations that contribute to congenital heart disease.
  Genome medicine 2020 Hsieh A, Morton SU, Willcox JAL, Gorham JM, Tai AC, Qi H, DePalma S, McKean D, Griffin E, Manheimer KB, Bernstein D, Kim RW, Newburger JW, Porter GA, Srivastava D, Tristani-Firouzi M, Brueckner M, …
• Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.
  Circulation research 2019 Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MPY, Haldar SM, Lin CY, McKinsey TA
• Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects.
  Nature 2019 de Soysa TY, Ranade SS, Okawa S, Ravichandran S, Huang Y, Salunga HT, Schricker A, Del Sol A, Gifford CA, Srivastava D
• Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming.
  Cell stem cell 2019 Stone NR, Gifford CA, Thomas R, Pratt KJB, Samse-Knapp K, Mohamed TMA, Radzinsky EM, Schricker A, Ye L, Yu P, van Bemmel JG, Ivey KN, Pollard KS, Srivastava D
• Oligogenic inheritance of a human heart disease involving a genetic modifier.
  Science (New York, N.Y.) 2019 Gifford CA, Ranade SS, Samarakoon R, Salunga HT, de Soysa TY, Huang Y, Zhou P, Elfenbein A, Wyman SK, Bui YK, Cordes Metzler KR, Ursell P, Ivey KN, Srivastava D
• Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System.
  Frontiers in physiology 2019 Samal E, Evangelista M, Galang G, Srivastava D, Zhao Y, Vedantham V
• The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
  Cell 2018 Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, …
• Robust identification of deletions in exome and genome sequence data based on clustering of Mendelian errors.
  Human mutation 2018 Manheimer KB, Patel N, Richter F, Gorham J, Tai AC, Homsy J, Boskovski MT, Parfenov M, Goldmuntz E, Chung WK, Brueckner M, Tristani-Firouzi M, Srivastava D, Seidman JG, Seidman CE, Gelb BD, Sharp AJ
• Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration.
  Cell 2018 Mohamed TMA, Ang YS, Radzinsky E, Zhou P, Huang Y, Elfenbein A, Foley A, Magnitsky S, Srivastava D
• Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.
  Nature genetics 2017 Jin SC, Homsy J, Zaidi S, Lu Q, Morton S, DePalma SR, Zeng X, Qi H, Chang W, Sierant MC, Hung WC, Haider S, Zhang J, Knight J, Bjornson RD, Castaldi C, Tikhonoa IR, Bilguvar K, Mane SM, Sanders SJ, …
• A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.
  JCI insight 2017 Judge LM, Perez-Bermejo JA, Truong A, Ribeiro AJ, Yoo JC, Jensen CL, Mandegar MA, Huebsch N, Kaake RM, So PL, Srivastava D, Pruitt BL, Krogan NJ, Conklin BR
• BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure.
  Science translational medicine 2017 Duan Q, McMahon S, Anand P, Shah H, Thomas S, Salunga HT, Huang Y, Zhang R, Sahadevan A, Lemieux ME, Brown JD, Srivastava D, Bradner JE, McKinsey TA, Haldar SM
• Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes.
  Circulation research 2017 Ribeiro AJS, Schwab O, Mandegar MA, Ang YS, Conklin BR, Srivastava D, Pruitt BL
• Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency.
  The Journal of clinical investigation 2017 Theodoris CV, Mourkioti F, Huang Y, Ranade SS, Liu L, Blau HM, Srivastava D
• The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1.
  Journal of Cell Science 2017 Jun-yi Zhu, Amy Heidersbach, Irfan S. Kathiriya, Bayardo I. Garay, Kathryn N. Ivey, Deepak Srivastava, Zhe Han, Isabelle N. King
• The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1.
  Development (Cambridge, England) 2017 Zhu JY, Heidersbach A, Kathiriya IS, Garay BI, Ivey KN, Srivastava D, Han Z, King IN
• Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis.
  Cell 2016 Ang YS, Rivas RN, Ribeiro AJS, Srivas R, Rivera J, Stone NR, Pratt K, Mohamed TMA, Fu JD, Spencer CI, Tippens ND, Li M, Narasimha A, Radzinsky E, Moon-Grady AJ, Yu H, Pruitt BL, Snyder MP, Srivastava …
• Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming.
  Circulation 2016 Mohamed TM, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang YS, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D
• The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.
  Nature medicine 2016 Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y
• In Vivo Cellular Reprogramming: The Next Generation.
  Cell 2016 Srivastava D, DeWitt N
• The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling.
  Stem cell research & therapy 2016 Barruet E, Morales BM, Lwin W, White MP, Theodoris CV, Kim H, Urrutia A, Wong SA, Srivastava D, Hsiao EC
• Effect of biophysical cues on reprogramming to cardiomyocytes.
  Biomaterials 2016 Sia J, Yu P, Srivastava D, Li S
• Molecular Regulation of Cardiogenesis.
  Epstein\u0027s Inborn Errors of Development 2016 Deepak Srivastava, Joseph T. C. Shieh
• Sarcomeres and Cardiac Growth: Tension in the Relationship.
  Trends in molecular medicine 2016 Haldar SM, Srivastava D
• Conversion of human fibroblasts into functional cardiomyocytes by small molecules.
  Science (New York, N.Y.) 2016 Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H, Ma T, Xu T, Shi G, Srivastava D, Ding S
• Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses.
  Scientific reports 2016 Huebsch N, Loskill P, Deveshwar N, Spencer CI, Judge LM, Mandegar MA, Fox CB, Mohamed TM, Ma Z, Mathur A, Sheehan AM, Truong A, Saxton M, Yoo J, Srivastava D, Desai TA, So PL, Healy KE, Conklin BR
• Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.
  Cell stem cell 2016 Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S
• A Tuned Tension Regulates the Contractility of Cardiomyocytes Differentiated from Induced Pluripotent Stem Cells.
  Biophysical Journal 2016 Alexandre J. Ribeiro, Yen-Sin Ang, Robin E. Wilson, Renee N. Rivas, Deepak Srivastava, Beth L. Pruitt
• Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells.
  Current protocols in human genetics 2016 Kime C, Mandegar MA, Srivastava D, Yamanaka S, Conklin BR, Rand TA
• Heart disease modelling adds a Notch to its belt.
  Nature cell biology 2016 Gifford CA, Srivastava D
• Reprogramming Approaches to Cardiovascular Disease: From Developmental Biology to Regenerative Medicine.
  Etiology and Morphogenesis of Congenital Heart Disease 2016 Deepak Srivastava
• Recent advances in direct cardiac reprogramming.
  Current opinion in genetics & development 2015 Srivastava D, Yu P
• Practical Integration-Free Episomal Methods for Generating Human Induced Pluripotent Stem Cells.
  Current protocols in human genetics 2015 Kime C, Rand TA, Ivey KN, Srivastava D, Yamanaka S, Tomoda K
• Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Ribeiro AJ, Ang YS, Fu JD, Rivas RN, Mohamed TM, Higgs GC, Srivastava D, Pruitt BL
• microRNAs as Developmental Regulators.
  Cold Spring Harbor perspectives in biology 2015 Ivey KN, Srivastava D
• NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium.
  Journal of molecular and cellular cardiology 2015 White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, Meng X, Robbins RC, Ivey KN, Srivastava D
• Smyd1 facilitates heart development by antagonizing oxidative and ER stress responses.
  PloS one 2015 Rasmussen TL, Ma Y, Park CY, Harriss J, Pierce SA, Dekker JD, Valenzuela N, Srivastava D, Schwartz RJ, Stewart MD, Tucker HO
• Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency.
  Cell 2015 Theodoris CV, Li M, White MP, Liu L, He D, Pollard KS, Bruneau BG, Srivastava D
• Perfusion CT: can it predict the development of pancreatic necrosis in early stage of severe acute pancreatitis?
  Abdominal imaging 2015 Yadav AK, Sharma R, Kandasamy D, Bhalla AS, Gamanagatti S, Srivastava DN, Upadhyay AD, Garg PK
• RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells.
  Circulation research 2015 Vedantham V, Galang G, Evangelista M, Deo RC, Srivastava D
• Direct reprogramming of fibroblasts into cardiomyocytes for cardiac regenerative medicine.
  Circulation journal : official journal of the Japanese Circulation Society 2015 Fu JD, Srivastava D
• Oxygen: double-edged sword in cardiac function and repair.
  Circulation research 2014 Ang YS, Srivastava D
• Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia.
  Human molecular genetics 2014 Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H
• Specification of the mouse cardiac conduction system in the absence of Endothelin signaling.
  Developmental biology 2014 Hua LL, Vedantham V, Barnes RM, Hu J, Robinson AS, Bressan M, Srivastava D, Black BL
• A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data.
  Nature biotechnology 2014 Hu H, Roach JC, Coon H, Guthery SL, Voelkerding KV, Margraf RL, Durtschi JD, Tavtigian SV, Wu W, Scheet P, Wang S, Xing J, Glusman G, Hubley R, Li H, Garg V, Moore B, Hood L, Galas DJ, Srivastava D, …
• The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex.
  The Journal of biological chemistry 2014 King IN, Yartseva V, Salas D, Kumar A, Heidersbach A, Ando DM, Stallings NR, Elliott JL, Srivastava D, Ivey KN
• Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4.
  Cell reports 2014 Wang H, Cao N, Spencer CI, Nie B, Ma T, Xu T, Zhang Y, Wang X, Srivastava D, Ding S
• Congenital heart disease: entering a new era of human genetics.
  Circulation research 2014 Bruneau BG, Srivastava D
• microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart.
  eLife 2013 Heidersbach A, Saxby C, Carver-Moore K, Huang Y, Ang YS, de Jong PJ, Ivey KN, Srivastava D
• The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.
  Cell stem cell 2013 Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, Narita M, Srivastava D, Yamanaka S
• Direct cardiac reprogramming: from developmental biology to cardiac regeneration.
  Circulation research 2013 Qian L, Srivastava D
• Cardiac reprogramming: from mouse toward man.
  Current opinion in genetics & development 2013 Srivastava D, Berry EC
• Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state.
  Stem cell reports 2013 Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D
• Fibronectin mediates mesendodermal cell fate decisions.
  Development (Cambridge, England) 2013 Cheng P, Andersen P, Hassel D, Kaynak BL, Limphong P, Juergensen L, Kwon C, Srivastava D
• Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro.
  Nature protocols 2013 Qian L, Berry EC, Fu JD, Ieda M, Srivastava D
• Small solutions to big problems: microRNAs for cardiac regeneration.
  Circulation research 2013 Srivastava D, Heidersbach AJ
• AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy.
  PloS one 2013 Spindler MJ, Burmeister BT, Huang Y, Hsiao EC, Salomonis N, Scott MJ, Srivastava D, Carnegie GK, Conklin BR
• Fending for a Braveheart.
  The EMBO journal 2013 Srivastava D, Cordes Metzler KR
• Modeling human protein aggregation cardiomyopathy using murine induced pluripotent stem cells.
  Stem cells translational medicine 2013 Limphong P, Zhang H, Christians E, Liu Q, Riedel M, Ivey K, Cheng P, Mitzelfelt K, Taylor G, Winge D, Srivastava D, Benjamin I
• Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells.
  Stem cells (Dayton, Ohio) 2013 White MP, Rufaihah AJ, Liu L, Ghebremariam YT, Ivey KN, Cooke JP, Srivastava D
• Tam PPL, Nelson WJ, Rossant J, Eds. Mammalian Development: Networks, Switches, and Morphogenetic Processes
  MicroRNAs as developmental regulators 2013 Ivey KN Srivastava D
• Abstract 19764: Cardiac Disease Modeling of Familial Left Ventricular Noncompaction Cardiomyopathy Using Induced Pluripotent Stem Cells.
  Circulation 2012 Yen K Bui, Kimberly R Cordes, Samantha Hastie, Deepak Srivastava
• Stem cells in the land of the rising sun: ISSCR 2012.
  Cell stem cell 2012 Plath K, Srivastava D, Alvarez-Buylla A, Tanaka EM, Kriegstein AR
• Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning.
  Developmental biology 2012 Vedantham V, Evangelista M, Huang Y, Srivastava D
• A role for RNA post-transcriptional regulation in satellite cell activation.
  Skeletal muscle 2012 Farina NH, Hausburg M, Betta ND, Pulliam C, Srivastava D, Cornelison D, Olwin BB
• Cardiac repair with thymosin β4 and cardiac reprogramming factors.
  Annals of the New York Academy of Sciences 2012 Srivastava D, Ieda M, Fu J, Qian L
• Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage.
  Cell 2012 Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, Ding H, Wylie JN, Pico AR, Capra JA, Erwin G, Kattman SJ, Keller GM, Srivastava D, Levine SS, Pollard KS, Holloway AK, Boyer LA, …
• MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling.
  Circulation research 2012 Hassel D, Cheng P, White MP, Ivey KN, Kroll J, Augustin HG, Katus HA, Stainier DY, Srivastava D
• Social, communication, and cortical structural impairments in Epac2-deficient mice.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Srivastava DP, Jones KA, Woolfrey KM, Burgdorf J, Russell TA, Kalmbach A, Lee H, Yang C, Bradberry MM, Wokosin D, Moskal JR, Casanova MF, Waters J, Penzes P
• Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells.
  Cell stem cell 2012 Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S
• Critical factors for cardiac reprogramming.
  Circulation research 2012 Srivastava D, Ieda M
• In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.
  Nature 2012 Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D
• Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo.
  PLoS genetics 2012 Misra C, Sachan N, McNally CR, Koenig SN, Nichols HA, Guggilam A, Lucchesi PA, Pu WT, Srivastava D, Garg V
• A resource for the conditional ablation of microRNAs in the mouse.
  Cell reports 2012 Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus…
• microRNA regulation of cardiac cell fate, morphogenesis and function.
  The FASEB Journal 2012 Deepak Srivastava
• Genetics of human cardiovascular disease.
  Cell 2012 Kathiresan S, Srivastava D
• Tbx1 regulates oral epithelial adhesion and palatal development.
  Human molecular genetics 2012 Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H
• Stem cell therapy for cardiac disease.
  Pediatric research 2012 Bernstein HS, Srivastava D
• Allen HD, Driscoll DJ, Shaddy RE, Feltes TF, Eds. Moss and Adams' Heart Disease in Infants, Children and Adolescents
  Molecular determinants of cardiac development and disease 2012 Baldwin HS Srivastava D
• Abstract 10466: In Vivo Reprogramming of Murine Cardiac Fibroblasts into Induced Cardiomyocytes.
  Circulation 2011 Li Qian, Yu Huang, Amy Foley, Vasanth Vedantham, Ian Spencer, Simon J Conway, Jidong Fu, Deepak Srivastava
• Chromosomal haplotypes by genetic phasing of human families.
  American journal of human genetics 2011 Roach JC, Glusman G, Hubley R, Montsaroff SZ, Holloway AK, Mauldin DE, Srivastava D, Garg V, Pollard KS, Galas DJ, Hood L, Smit AF
• Notch post-translationally regulates β-catenin protein in stem and progenitor cells.
  Nature cell biology 2011 Kwon C, Cheng P, King IN, Andersen P, Shenje L, Nigam V, Srivastava D
• Monochorionic twins discordant for congenital heart disease: a referral center's experience and possible pathophysiologic mechanisms.
  Prenatal diagnosis 2011 AlRais F, Feldstein VA, Srivastava D, Gosnell K, Moon-Grady AJ
• Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.
  The Journal of cell biology 2011 Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin …
• Elevated miR-499 levels blunt the cardiac stress response.
  PloS one 2011 Shieh JT, Huang Y, Gilmore J, Srivastava D
• A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity.
  Developmental cell 2011 King IN, Qian L, Liang J, Huang Y, Shieh JT, Kwon C, Srivastava D
• A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish.
  Development (Cambridge, England) 2011 Fish JE, Wythe JD, Xiao T, Bruneau BG, Stainier DY, Srivastava D, Woo S
• miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes.
  The Journal of experimental medicine 2011 Qian L, Van Laake LW, Huang Y, Liu S, Wendland MF, Srivastava D
• The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2.
  Science (New York, N.Y.) 2011 Li Q, Kannan A, DeMayo FJ, Lydon JP, Cooke PS, Yamagishi H, Srivastava D, Bagchi MK, Bagchi IC
• The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling.
  Developmental dynamics : an official publication of the American Association of Anatomists 2011 Yu S, Crawford D, Tsuchihashi T, Behrens TW, Srivastava D
• <i>Rudplph's Pediatrics</i> (Rudolph C, Rudolph A, Lister G, First L, Gershon A, Eds)
  Control of embryologic cardiac development 2011 Srivastava D
• Hand2 function in second heart field progenitors is essential for cardiogenesis.
  Developmental biology 2010 Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D
• The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch.
  Development (Cambridge, England) 2010 Sheehy NT, Cordes KR, White MP, Ivey KN, Srivastava D
• skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Park CY, Pierce SA, von Drehle M, Ivey KN, Morgan JA, Blau HM, Srivastava D
• Identification of GATA6 sequence variants in patients with congenital heart defects.
  Pediatric research 2010 Maitra M, Koenig SN, Srivastava D, Garg V
• Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.
  Cell 2010 Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D
• A novel Slit–Robo–miR-218 signaling axis regulates VEGF-mediated heart tube formation in zebrafish.
  Developmental Biology 2010 Stephanie Woo, Jason E. Fish, Joshua D. Wythe, Benoit B. Bruneau, Didier Y. Stainier, Deepak Srivastava
• MicroRNAs as regulators of differentiation and cell fate decisions.
  Cell stem cell 2010 Ivey KN, Srivastava D
• Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves.
  The Journal of heart valve disease 2010 Nigam V, Sievers HH, Jensen BC, Sier HA, Simpson PC, Srivastava D, Mohamed SA
• Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance.
  Circulation research 2010 van Laake LW, Qian L, Cheng P, Huang Y, Hsiao EC, Conklin BR, Srivastava D
• Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones.
  Journal of Biological Chemistry 2010 Jason E. Fish, Matthew S. Yan, Charles C. Matouk, Rosanne St. Bernard, J. J. David Ho, Anna Gavryushova, Deepak Srivastava, Philip A. Marsden
• Thymosin beta4 and cardiac repair.
  Annals of the New York Academy of Sciences 2010 Shrivastava S, Srivastava D, Olson EN, DiMaio JM, Bock-Marquette I
• Monkeying around with cardiac progenitors: hope for the future.
  The Journal of clinical investigation 2010 Qian L, Srivastava D
• MicroRNAs in cardiac development.
  Pediatric cardiology 2010 Cordes KR, Srivastava D, Ivey KN
• Micrornas in bicuspid aortic valve: a comparison between stenosis and insufficiency aortic valve.
  The Thoracic and Cardiovascular Surgeon 2010 SA Mohamed, V Nigam, B Jensen, H Sier, P Simpson, D Srivastava, HH Sievers
• <i>Heart Development and Regeneration</i> (Rosenthal N, Harvey R, Eds)
  MicroRNA regulation of cardiac development and disease 2010 Cordes KR, Srivastava D
• <i>Paediatric Cardiology</i> (Anderson RH, Baker EJ, Penny D, Redington AN, Rigby ML, Wernovsky G, Eds)
  The Aetiology of Congenital Cardiac Disease 2010 Bruneau BG, Burn J, Srivastava D
• CHAPTER 9 Aetiology of Congenital Cardiac Disease.
  Paediatric Cardiology 2010 Benoit G. Bruneau, John Burn, Deepak Srivastava
• Chapter 10.3 MicroRNA Regulation of Cardiac Development and Disease.
  Heart Development and Regeneration 2010 Kimberly R. Cordes, Deepak Srivastava
• Chapter 309 Signaling Pathways Involved in Cardiogenesis.
  Handbook of Cell Signaling 2010 Deepak Srivastava, Chulan Kwon
• Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones.
  The Journal of biological chemistry 2009 Fish JE, Yan MS, Matouk CC, St Bernard R, Ho JJ, Ho JJ, Gavryushova A, Srivastava D, Marsden PA
• Notch1 represses osteogenic pathways in aortic valve cells.
  Journal of molecular and cellular cardiology 2009 Nigam V, Srivastava D
• A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate.
  Nature cell biology 2009 Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D
• Heart malformation: what are the chances it could happen again?
  Circulation 2009 Shieh JT, Srivastava D
• miR-145 and miR-143 regulate smooth muscle cell fate and plasticity.
  Nature 2009 Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D
• Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo.
  Journal of molecular and cellular cardiology 2009 Bock-Marquette I, Shrivastava S, Pipes GC, Thatcher JE, Blystone A, Shelton JM, Galindo CL, Melegh B, Srivastava D, Olson EN, DiMaio JM
• MicroRNA regulation of cardiovascular development.
  Circulation research 2009 Cordes KR, Srivastava D
• Alternative induced pluripotent stem cell characterization criteria for in vitro applications.
  Cell stem cell 2009 Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL
• Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling.
  Developmental cell 2009 Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D
• MicroRNAs: opening a new vein in angiogenesis research.
  Science signaling 2009 Fish JE, Srivastava D
• <i>Handbook of Cell Signaling</i> (Bradshaw RA, Dennis EA, Eds)
  Signaling pathways involved in cardiogenesis 2009 Srivastava D, Kwon C
• Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis.
  Cell cycle (Georgetown, Tex.) 2008 Kwon C, Cordes KR, Srivastava D
• Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.
  Developmental biology 2008 Maitra M, Schluterman MK, Nichols HA, Richardson JA, Lo CW, Srivastava D, Garg V
• Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Niu Z, Iyer D, Conway SJ, Martin JF, Ivey K, Srivastava D, Nordheim A, Schwartz RJ
• microRNA-138 modulates cardiac patterning during embryonic development.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Morton SU, Scherz PJ, Cordes KR, Ivey KN, Stainier DY, Srivastava D
• A rare human sequence variant reveals myocardin autoinhibition.
  The Journal of biological chemistry 2008 Ransom JF, King IN, Garg V, Srivastava D
• miR-126 regulates angiogenic signaling and vascular integrity.
  Developmental cell 2008 Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D
• Transcriptional regulation during development of the ductus arteriosus.
  Circulation research 2008 Ivey KN, Sutcliffe D, Richardson J, Clyman RI, Garcia JA, Srivastava D
• Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction.
  Circulation 2008 Saxena A, Fish JE, White MD, Yu S, Smyth JW, Shaw RM, DiMaio JM, Srivastava D
• MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.
  Cell stem cell 2008 Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D
• <i>Inborn Errors of Development</i> (Epstein CJ, Ed)
  Molecular regulation of cardiogenesis 2008 Nigam V, Srivastava D
• Nonlinear imaging study of extracellular matrix in chemical-induced, developmental dissecting aortic aneurysm: evidence for defective collagen type III.
  Birth defects research. Part A, Clinical and molecular teratology 2008 Gong B, Sun J, Vargas G, Chang Q, Xu Y, Srivastava D, Boor PJ
• Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Jia H, King IN, Chopra SS, Wan H, Ni TT, Jiang C, Guan X, Wells S, Srivastava D, Zhong TP
• Thymosin beta4 is cardioprotective after myocardial infarction.
  Annals of the New York Academy of Sciences 2007 Srivastava D, Saxena A, Michael Dimaio J, Bock-Marquette I
• Spectrum of heart disease associated with murine and human GATA4 mutation.
  Journal of molecular and cellular cardiology 2007 Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT
• Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D
• Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics.
  Circulation 2007 Pierpont ME, Basson CT, Benson DW, Gelb BD, Giglia TM, Goldmuntz E, McGee G, Sable CA, Srivastava D, Webb CL, American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular…
• Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Xin M, Small EM, van Rooij E, Qi X, Richardson JA, Srivastava D, Nakagawa O, Olson EN
• Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease.
  American journal of medical genetics. Part A 2007 Schluterman MK, Krysiak AE, Kathiriya IS, Abate N, Chandalia M, Srivastava D, Garg V
• Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2.
  Cell 2007 Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D
• A developmental view of microRNA function.
  Trends in biochemical sciences 2007 Zhao Y, Srivastava D
• <i>Advances in Developmental Biology</i> (Bodmer R, Ed)
  Role of microRNAs in Cardiovascular Biology 2007 Samal E, Srivastava D
• Role of microRNAs in Cardiovascular Biology.
  Cardiovascular Development 2007 Eva Samal, Deepak Srivastava
• The genetics of cardiac birth defects.
  Seminars in cell & developmental biology 2006 Ransom J, Srivastava D
• Erratum: Potential of stem-cell-based therapies for heart disease.
  Nature 2006 Deepak Srivastava, Kathryn N. Ivey
• The paradoxical patent ductus arteriosus.
  The Journal of clinical investigation 2006 Ivey KN, Srivastava D
• Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition.
  Circulation 2006 Ramana KV, Willis MS, White MD, Horton JW, DiMaio JM, Srivastava D, Bhatnagar A, Srivastava SK
• Making or breaking the heart: from lineage determination to morphogenesis.
  Cell 2006 Srivastava D
• Stretching to meet needs: integrin-linked kinase and the cardiac pump.
  Genes & development 2006 Srivastava D, Yu S
• Potential of stem-cell-based therapies for heart disease.
  Nature 2006 Srivastava D, Ivey KN
• Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.
  Development (Cambridge, England) 2006 Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L
• Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa.
  Biochemical and biophysical research communications 2006 King IN, Kathiriya IS, Murakami M, Nakagawa M, Gardner KA, Srivastava D, Nakagawa O
• Sonic hedgehog is essential for first pharyngeal arch development.
  Pediatric research 2006 Yamagishi C, Yamagishi H, Maeda J, Tsuchihashi T, Ivey K, Hu T, Srivastava D
• Tbx1 is regulated by forkhead proteins in the secondary heart field.
  Developmental dynamics : an official publication of the American Association of Anatomists 2006 Maeda J, Yamagishi H, McAnally J, Yamagishi C, Srivastava D
• Chemical-induced, nonlethal, developmental model of dissecting aortic aneurysm.
  Birth defects research. Part A, Clinical and molecular teratology 2006 Gong B, Trent MB, Srivastava D, Boor PJ
• Genetic regulation of cardiogenesis and congenital heart disease.
  Annual review of pathology 2006 Srivastava D
• Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.
  Nature genetics 2005 Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG
• MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Kwon C, Han Z, Olson EN, Srivastava D
• The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.
  Cell 2005 Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, …
• Mutations in NOTCH1 cause aortic valve disease.
  Nature 2005 Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Grossfeld PD, Srivastava D
• Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis.
  Nature 2005 Zhao Y, Samal E, Srivastava D
• Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype.
  Developmental biology 2005 Aiyer AR, Honarpour N, Herz J, Srivastava D
• <i>Principles of Molecular Cardiology</i> (Runge MS, Patterson C, Eds)
  Genetic underpinnings of cardiogenesis and congenital heart disease 2005 Garg V, Srivastava D
• Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease.
  Principles of Molecular Cardiology 2005 Vidu Garg, Deepak Srivastava
• The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.
  Development (Cambridge, England) 2004 McFadden DG, Barbosa AC, Richardson JA, Schneider MD, Srivastava D, Olson EN
• Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair.
  Nature 2004 Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D
• Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.
  The Journal of biological chemistry 2004 Kathiriya IS, King IN, Murakami M, Nakagawa M, Astle JM, Gardner KA, Gerard RD, Olson EN, Srivastava D, Nakagawa O
• Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors.
  Development (Cambridge, England) 2004 Hu T, Yamagishi H, Maeda J, McAnally J, Yamagishi C, Srivastava D
• Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development.
  Developmental biology 2004 Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M
• Heart disease: an ongoing genetic battle?
  Nature 2004 Srivastava D
• <i>Molecular Basis of Cardiovascular Disease: A Companion to Braunwald's Heart Disease</i> (Chien KR, Ed)
  Cardiac Development and Congenital Heart Disease 2004 Srivastava D, Olson EN
• Unraveling the genetic and developmental mysteries of 22q11 deletion syndrome.
  Trends in molecular medicine 2003 Yamagishi H, Srivastava D
• GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5.
  Nature 2003 Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D
• Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme.
  Developmental biology 2003 Ivey K, Tyson B, Ukidwe P, McFadden DG, Levi G, Olson EN, Srivastava D, Wilkie TM
• Functional attenuation of UFD1l, a 22q11.2 deletion syndrome candidate gene, leads to cardiac outflow septation defects in chicken embryos.
  Pediatric research 2003 Yamagishi C, Hierck BP, Gittenberger-De Groot AC, Yamagishi H, Srivastava D
• Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer.
  Genes & development 2003 Yamagishi H, Maeda J, Hu T, McAnally J, Conway SJ, Kume T, Meyers EN, Yamagishi C, Srivastava D
• <i>Handbook of Cell Signaling</i> (Bradshaw RA, Dennis EA, Eds)
  Signaling Pathways Involved in Cardiogenesis 2003 Srivastava D
• Building a heart: implications for congenital heart disease.
  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2003 Srivastava D
• Chapter 335 Signaling Pathways Involved in Cardiogenesis.
  Handbook of Cell Signaling 2003 Deepak Srivastava
• Genetic and comparative mapping of genes dysregulated in mouse hearts lacking the Hand2 transcription factor gene.
  Genomics 2002 Villanueva MP, Aiyer AR, Muller S, Pletcher MT, Liu X, Emanuel B, Srivastava D, Reeves RH
• Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis.
  Cell and tissue research 2002 Abe M, Tamamura Y, Yamagishi H, Maeda T, Kato J, Tabata MJ, Srivastava D, Wakisaka S, Kurisu K
• Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis.
  Nature genetics 2002 Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D
• <i>Neonatal Cardiology</i> (Artman M, Mahony L, Teitel DF, Eds)
  Molecular and morphogenetic cardiac embryology: Implications for congenital heart disease 2002 Srivastava D
• Molecular mechanisms of ventricular hypoplasia.
  Cold Spring Harbor symposia on quantitative biology 2002 Srivastava D, Gottlieb PD, Olson EN
• The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation.
  Developmental biology 2001 Yamagishi H, Yamagishi C, Nakagawa O, Harvey RP, Olson EN, Srivastava D
• A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L.
  Mechanisms of development 2001 Kunte A, Ivey K, Yamagishi C, Garg V, Yamagishi H, Srivastava D
• Human eHAND, but not dHAND, is down-regulated in cardiomyopathies.
  Journal of molecular and cellular cardiology 2001 Natarajan A, Yamagishi H, Ahmad F, Li D, Roberts R, Matsuoka R, Hill S, Srivastava D
• Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development.
  Developmental biology 2001 Garg V, Yamagishi C, Hu T, Kathiriya IS, Yamagishi H, Srivastava D
• CHAMP, a novel cardiac-specific helicase regulated by MEF2C.
  Developmental biology 2001 Liu ZP, Nakagawa O, Nakagawa M, Yanagisawa H, Passier R, Richardson JA, Srivastava D, Olson EN
• <i>Encyclopedia of Molecular Medicine</i> (Creighton TE and Kazazian HH, Eds)
  HAND transcription factors 2001 Olson EN, Srivastava D
• <i>Moss and Adams' Heart Disease in Infants, Children, and Adolescents</i> (Allen HD, Gutsgell HP, Clark EB, Driscoll DJ, Eds)
  Molecular determinants of cardiac development 2001 Srivastava D, Baldwin HS
• Genetic assembly of the heart: implications for congenital heart disease.
  Annual review of physiology 2001 Srivastava D
• Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN
• A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart.
  Development (Cambridge, England) 2000 McFadden DG, Charité J, Richardson JA, Srivastava D, Firulli AB, Olson EN
• Apoptosis during cardiovascular development.
  Circulation research 2000 Fisher SA, Langille BL, Srivastava D
• A genetic blueprint for cardiac development.
  Nature 2000 Srivastava D, Olson EN
• Conservation of sequence and expression of Xenopus and zebrafish dHAND during cardiac, branchial arch and lateral mesoderm development.
  Mechanisms of development 2000 Angelo S, Lohr J, Lee KH, Ticho BS, Breitbart RE, Hill S, Yost HJ, Srivastava D
• Congenital heart defects: trapping the genetic culprits.
  Circulation research 2000 Srivastava D
• Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway.
  Development (Cambridge, England) 2000 Fernandez-Teran M, Piedra ME, Kathiriya IS, Srivastava D, Rodriguez-Rey JC, Ros MA
• The basic helix-loop-helix transcription factor, dHAND, is required for vascular development.
  The Journal of clinical investigation 2000 Yamagishi H, Olson EN, Srivastava D
• <i>Etiology and Morphogenesis of Congenital Heart Disease</i> (Clark EB, Nakazawa M, Takao A, Eds)
  Role of the bHLH transcription factor, dHAND, in cranial/cardiac neural crest development 2000 Yamagishi H, Srivastava D
• <i>Etiology and Morphogenesis of Congenital Heart Disease</i> (Takao A, Nakazawa M, Clark EB, Eds)
  Understanding CHD through dissection of segmental cardiac molecular pathways 2000 Srivastava D
• DiGeorge syndrome: an enigma in mice and men.
  Molecular medicine today 2000 Srivastava D
• Left-right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease.
  American journal of medical genetics 2000 Kathiriya IS, Srivastava D
• HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments.
  Developmental biology 1999 Nakagawa O, Nakagawa M, Richardson JA, Olson EN, Srivastava D
• Developmental and genetic aspects of congenital heart disease.
  Current opinion in cardiology 1999 Srivastava D
• A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects.
  Science (New York, N.Y.) 1999 Yamagishi H, Garg V, Matsuoka R, Thomas T, Srivastava D
• 9 Segmental Regulation of Cardiac Development by the Basic Helix-Loop-Helix Transcription Factors dHAND and eHAND.
  Heart Development 1999 Deepak Srivastava
• <i>Heart Development</i> (Rosenthal N and Harvey R, Eds)
  Segmental regulation of cardiac development by the basic helix-loop-helix transcription factors dHAND and eHAND 1999 Srivastava D
• HAND proteins: molecular mediators of cardiac development and congenital heart disease.
  Trends in cardiovascular medicine 1999 Srivastava D
• A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme.
  Development (Cambridge, England) 1998 Thomas T, Kurihara H, Yamagishi H, Kurihara Y, Yazaki Y, Olson EN, Srivastava D
• The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness.
  Developmental biology 1998 Thomas T, Yamagishi H, Overbeek PA, Olson EN, Srivastava D
• Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1.
  Nature genetics 1998 Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN
• Role of the Transcription Factors dHAND and eHAND in Cardiac Morphogenesis.
  Pediatric Cardiology 1998 Deepak Srivastava
• Knowing in your heart what's right.
  Trends in cell biology 1997 Srivastava D, Olson EN
• Left, right ... which way to turn?
  Nature genetics 1997 Srivastava D
• Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND.
  Nature genetics 1997 Srivastava D, Thomas T, Lin Q, Kirby ML, Brown D, Olson EN
• <i>Genetic Control of Heart Development</i> (Harvey RP, Olson EN, Schulz RA, Altman JS, Eds)
  The bHLH proteins, dHAND and eHAND in cardiac development 1997 Srivastava D
• A transcriptional pathway for cardiac development.
  Cold Spring Harbor symposia on quantitative biology 1997 Lin Q, Srivastava D, Olson EN
• Neurotrophin-3 knocks heart off Trk.
  Nature medicine 1996 Srivastava D, Olson EN
• Molecular pathways controlling heart development.
  Science (New York, N.Y.) 1996 Olson EN, Srivastava D
• A subclass of bHLH proteins required for cardiac morphogenesis.
  Science (New York, N.Y.) 1995 Srivastava D, Cserjesi P, Olson EN
• Hepatic venous blood and the development of pulmonary arteriovenous malformations in congenital heart disease.
  Circulation 1995 Srivastava D, Preminger T, Lock JE, Mandell V, Keane JF, Mayer JE, Kozakewich H, Spevak PJ
• Two glucocorticoid binding sites on the human glucocorticoid receptor.
  Endocrinology 1990 Srivastava D, Thompson EB
• Interactions of the phenylpyrazolo steroid cortivazol with glucocorticoid receptors in steroid-sensitive and -resistant human leukemic cells.
  Cancer research 1989 Thompson EB, Srivastava D, Johnson BH