Deborah French, PhD
Professor
Laboratory Medicine
School of Medicine

Jude Children’s Research Hospital in Memphis, TN studying the pharmacogenetics of pediatric acute lymphoblastic leukemia with Dr Mary Relling. In July 2008 she began a ComACC Clinical Chemistry postdoctoral fellowship under the direction of Dr Alan Wu at the University of California San Francisco and in July 2010, Deborah became board certified in Clinical Chemistry by the American Board of Clinical Chemistry. In 2017, Deborah became certified in Toxicological Chemistry by the American Board of Clinical Chemistry.

• Reduced Immune Response and Neutralizing Antibody Activity to the SARS-CoV-2 Vaccination in Patients with a History of Solid Organ Transplant.
  Laboratory medicine 2022 French D, Ong CM, Patel P, Zuk M, Wu AHB
• Is the Best Drug Test the Enemy of the Good STAT Toxicology Screen?
  The journal of applied laboratory medicine 2022 Stone JA, French D
• Side-Effects of COVID-19 on Patient Care: An INR Story.
  The journal of applied laboratory medicine 2021 Pearson LN, Johnson SA, Greene DN, Chambliss AB, Farnsworth CW, French D, Herman DS, Kavsak PA, Merrill AE, Lo SM, Lyon ME, SoRelle JA, Schmidt RL
• The effect of the Covid-19 shutdown on glycemic testing and control.
  Clinica chimica acta; international journal of clinical chemistry 2021 Sharma A, Greene DN, Chambliss AB, Farnsworth CW, French D, Herman DS, Kavsak PA, Merrill AE, Margaret Lo SY, Lyon ME, Winston-McPherson G, Pearson LN, SoRelle JA, Waring AC, Schmidt RL
• Adding Value to Clinical Toxicology Testing.
  The journal of applied laboratory medicine 2020 French D
• The 2018 AACC/SYCL PhD Clinical Chemist Compensation Survey.
  The journal of applied laboratory medicine 2020 Bunch DR, El-Khoury JM, Colby J, Colon-Franco J, Hackenmueller SA, Olson KN, Cotten SW, Kampfrath T, Chittiprol S, Suh-Lailam B, French D, Isbell TS, Nerenz RD, Parnas ML, Tolan NV
• Serum 25-Hydroxyvitamin D Concentrations from Patient Groups at High Risk for Deficiency.
  The journal of applied laboratory medicine 2019 Wu AHB, Ghosh R, Mei Ong C, French D
• Development and validation of a LC-MS/MS assay for quantification of serum estradiol using calibrators with values assigned by the CDC reference measurement procedure.
  Clinica chimica acta; international journal of clinical chemistry 2019 Dowis J, Woroniecki W, French D
• Commentary.
  Clinical chemistry 2019 French D
• Comparison of four clinically validated testosterone LC-MS/MS assays: Harmonization is an attainable goal.
  Clinical mass spectrometry (Del Mar, Calif.) 2018 French D, Drees J, Stone JA, Holmes DT, van der Gugten JG
• A Practical First Step Using Needs Assessment and a Survey Approach to Implementing a Clinical Pharmacogenomics Consult Service.
  Journal of the American College of Clinical Pharmacy : JACCP 2018 Zakinova A, Long-Boyle JR, French D, Croci R, Wilson L, Phillips KA, Kroetz DL, Shin J, Tamraz B
• The (Sun)Light and Dark of 25-Hydroxyvitamin D Testing.
  The journal of applied laboratory medicine 2018 French D
• Quantification of Serum Voriconazole, Isavuconazole, and Posaconazole by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS).
  Current protocols in toxicology 2018 Smith A, Dowis J, French D
• A Case of Opioid Overdose? Or Is It?
  The journal of applied laboratory medicine 2018 French D, Gerona RR
• Advances in Clinical Mass Spectrometry.
  Advances in clinical chemistry 2016 French D
• Advances in bioanalytical techniques to measure steroid hormones in serum.
  Bioanalysis 2016 French D
• Population pharmacokinetics of busulfan in pediatric and young adult patients undergoing hematopoietic cell transplant: a model-based dosing algorithm for personalized therapy and implementation into routine clinical use.
  Therapeutic drug monitoring 2015 Long-Boyle JR, Savic R, Yan S, Bartelink I, Musick L, French D, Law J, Horn B, Cowan MJ, Dvorak CC
• Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay to quantify serum voriconazole.
  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2015 Mak J, Sujishi KK, French D
• Development and validation of a liquid chromatography-tandem mass spectrometry assay to quantify plasma busulfan.
  Therapeutic drug monitoring 2014 French D, Sujishi KK, Long-Boyle JR, Ritchie JC
• The challenges of LC-MS/MS analysis of opiates and opioids in urine.
  Bioanalysis 2013 French D
• Interpreting laboratory results in transgender patients on hormone therapy.
  The American journal of medicine 2013 Roberts TK, Kraft CS, French D, Ji W, Wu AH, Tangpricha V, Fantz CR
• The successful implementation of a licensed data management interface between a Sunquest(®) laboratory information system and an AB SCIEX™ mass spectrometer.
  Journal of pathology informatics 2013 French D, Terrazas E
• Direct total and free testosterone measurement by liquid chromatography tandem mass spectrometry across two different platforms.
  Clinical biochemistry 2013 Rhea JM, French D, Molinaro RJ
• Implementation of liquid chromatography/mass spectrometry into the clinical laboratory.
  Clinica chimica acta; international journal of clinical chemistry 2012 Wu AH, French D
• Development and validation of a serum total testosterone liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay calibrated to NIST SRM 971.
  Clinica chimica acta; international journal of clinical chemistry 2012 French D
• Role of liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology.
  Clinical toxicology (Philadelphia, Pa.) 2012 Wu AH, Gerona R, Armenian P, French D, Petrie M, Lynch KL
• A mixed (long- and medium-chain) triglyceride lipid emulsion extracts local anesthetic from human serum in vitro more effectively than a long-chain emulsion.
  Anesthesiology 2012 Ruan W, French D, Wong A, Drasner K, Wu AH
• Hydrophilic interaction LC-MS/MS analysis of opioids in urine: significance of glucuronide metabolites.
  Bioanalysis 2011 French D, Wu A, Lynch K
• Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies.
  Clinical toxicology (Philadelphia, Pa.) 2011 French D, Smollin C, Ruan W, Wong A, Drasner K, Wu AH
• PharmGKB summary: methotrexate pathway.
  Pharmacogenetics and genomics 2011 Mikkelsen TS, Thorn CF, Yang JJ, Ulrich CM, French D, Zaza G, Dunnenberger HM, Marsh S, McLeod HL, Giacomini K, Becker ML, Gaedigk R, Leeder JS, Kager L, Relling MV, Evans W, Klein TE, Altman RB
• KRAS mutation detection in colorectal cancer by a commercially available gene chip array compares well with Sanger sequencing.
  Clinica chimica acta; international journal of clinical chemistry 2011 French D, Smith A, Powers MP, Wu AH
• Serum verapamil concentrations before and after Intralipid® therapy during treatment of an overdose.
  Clinical toxicology (Philadelphia, Pa.) 2011 French D, Armenian P, Ruan W, Wong A, Drasner K, Olson KR, Wu AH
• A case of a rapid drop in lactate.
  The American journal of emergency medicine 2010 French D, Branch J, Wu AH, Winston L, Fiebig EW
• Vitamin D status of county hospital patients assessed by the DiaSorin LIAISON® 25-hydroxyvitamin D assay.
  Clinica chimica acta; international journal of clinical chemistry 2010 French D, Gorgi AW, Ihenetu KU, Weeks MA, Lynch KL, Wu AH
• Lack of gamma-hydroxybutyrate prevalence among an urban emergency department population.
  Journal of analytical toxicology 2010 Ureda N, Ruan W, French D, Wu AH
• Germline genomic variants associated with childhood acute lymphoblastic leukemia.
  Nature genetics 2009 Treviño LR, Yang W, French D, Hunger SP, Carroll WL, Devidas M, Willman C, Neale G, Downing J, Raimondi SC, Pui CH, Evans WE, Relling MV
• Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
  JAMA 2009 Yang JJ, Cheng C, Yang W, Pei D, Cao X, Fan Y, Pounds SB, Neale G, Treviño LR, French D, Campana D, Downing JR, Evans WE, Pui CH, Devidas M, Bowman WP, Camitta BM, Willman CL, Davies SM, Borowitz MJ, …
• Lab Medicine
  Choosing the right benzodiazepine assay: impact on clinical decision making 2009 French D, Stone JA, Chang JS and Wu AH.
• Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.
  Blood 2008 French D, Yang W, Cheng C, Raimondi SC, Mullighan CG, Downing JR, Evans WE, Pui CH, Relling MV
• Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia.
  Clinical pharmacology and therapeutics 2008 Stocco G, Cheok MH, Crews KR, Dervieux T, French D, Pei D, Yang W, Cheng C, Pui CH, Relling MV, Evans WE
• Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs.
  PloS one 2008 French D, Yang W, Hamilton LH, Neale G, Fan Y, Downing JR, Cox NJ, Pui CH, Evans WE, Relling MV
• A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.
  Blood 2008 French D, Hamilton LH, Mattano LA, Sather HN, Devidas M, Nachman JB, Relling MV, Children's Oncology Group
• Ancestry and pharmacogenetics of antileukemic drug toxicity.
  Blood 2007 Kishi S, Cheng C, French D, Pei D, Das S, Cook EH, Hijiya N, Rizzari C, Rosner GL, Frudakis T, Pui CH, Evans WE, Relling MV
• Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada.
  Environmental health perspectives 2007 Steinberg KK, Relling MV, Gallagher ML, Greene CN, Rubin CS, French D, Holmes AK, Carroll WL, Koontz DA, Sampson EJ, Satten GA
• Genome-wide approach to identify risk factors for therapy-related myeloid leukemia.
  Leukemia 2006 Bogni A, Cheng C, Liu W, Yang W, Pfeffer J, Mukatira S, French D, Downing JR, Pui CH, Relling MV
• Global gene expression as a function of germline genetic variation.
  Human molecular genetics 2005 French D, Wilkinson MR, Yang W, de Chaisemartin L, Cook EH, Das S, Ratain MJ, Evans WE, Downing JR, Pui CH, Relling MV
• A preliminary evaluation of the functional significance of alpha-1-acid glycoprotein glycosylation on wound healing.
  Biomedical chromatography : BMC 2002 French D, Watson J, McCahill B, Taggart I, Smith KD