Dean Sheppard, MD
Professor
Medicine
School of Medicine

The work began with basic investigation of how cells use members of the integrin family to detect, modify and respond to spatially restricted extracellular clues and how these responses contribute to the development of common lung diseases. Utilizing mice with global or conditional knockouts of the epithelial-restricted integrin, avß6, and the widely expressed integrins, a5ß1, a9ß1, avß5 and avß8, the lab has identified important roles for these integrins in models of each common lung disease and key steps upstream and downstream of the integrins that provide potential therapeutic targets. His lab identified the unique roles that 3 integrins, avß1, avß6 and avß8 play in activation of the growth factor, latent transforming growth factor beta (TGFß) and has identified critical roles for this process in acute lung injury, pulmonary fibrosis, post-natal brain development and immunosuppression in the setting of cancer. Current work is using single cell RNA sequencing to understand the heterogeneity of cells that contribute to tissue fibrosis and using these results to generate novel murine lines to establish the lineage, fate and functional importance of each of the new cell states identified. The lab is also collaborating with Wendell Lim to engineer cells that delivery genetically encoded therapeutics at sites of fibrosis and acute lung injury and to improve cell-based therapies for solid tumors.

• An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis.
  The Journal of clinical investigation 2024 Lee JY, Reyes NS, Ravishankar S, Zhou M, Krasilnikov M, Ringler C, Pohan G, Wilson C, Ang KK, Wolters PJ, Tsukui T, Sheppard D, Arkin MR, Peng T
• Mast cells help organize the Peyer's patch niche for induction of IgA responses.
  Science immunology 2024 De Giovanni M, Vykunta VS, Biram A, Chen KY, Taglinao H, An J, Sheppard D, Paidassi H, Cyster JG
• Challenges and Opportunities for Commercializing Technologies in the Pulmonary Arena: An Official American Thoracic Society Report.
  Annals of the American Thoracic Society 2024 Vukmirovic M, Benam KH, Rose JJ, Turner S, Magin CM, Lagares D, Cohen AH, Kaminski N, Hirota JA, Maher TM, Konigshoff M, Mallampalli RK, Sheppard D, Tarran R, Gomer RH, Kenyon NJ, Morris D, Hobbie S, …
• Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification.
  bioRxiv : the preprint server for biology 2023 Khan IS, Molina C, Ren X, Auyeung VC, Cohen M, Tsukui T, Atakilit A, Sheppard D
• APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.
  Nature immunology 2023 Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, …
• Radial glia promote microglial development through integrin αVβ8 -TGFβ1 signaling.
  bioRxiv : the preprint server for biology 2023 McKinsey GL, Santander N, Zhang X, Kleemann K, Tran L, Katewa A, Conant K, Barraza M, Waddell K, Lizama C, La Russa M, Koo HJ, Lee H, Mukherjee D, Paidassi H, Anton ES, Atabai K, Sheppard D, Butovsky …
• TGF-β signaling in health and disease.
  Cell 2023 Massagué J, Sheppard D
• An immune-based tool platform for in vivo cell clearance.
  Life science alliance 2023 Zhang J, Tsukui T, Wu X, Brito A, Trumble JM, Caraballo JC, Allen GM, Zavala-Solorio J, Zhang C, Paw J, Lim WA, Geng J, Kutskova Y, Freund A, Kolumam G, Sheppard D, Cohen RL
• An integrated cell atlas of the lung in health and disease.
  Nature medicine 2023 Sikkema L, Ramírez-Suástegui C, Strobl DC, Gillett TE, Zappia L, Madissoon E, Markov NS, Zaragosi LE, Ji Y, Ansari M, Arguel MJ, Apperloo L, Banchero M, Bécavin C, Berg M, Chichelnitskiy E, Chung MI, …
• Anti-Integrin αvβ6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis.
  Gastroenterology 2023 Livanos AE, Dunn A, Fischer J, Ungaro RC, Turpin W, Lee SH, Rui S, Del Valle DM, Jougon JJ, Martinez-Delgado G, Riddle MS, Murray JA, Laird RM, Torres J, Agrawal M, Magee JS, Dervieux T, Gnjatic S, …
• A stapled chromogranin A-derived peptide homes in on tumors that express αvβ6 or αvβ8 integrins.
  International journal of biological sciences 2023 Monieri M, Rainone P, Sacchi A, Gori A, Gasparri AM, Coliva A, Citro A, Ferrara B, Policardi M, Valtorta S, Pocaterra A, Alfano M, Sheppard D, Piemonti L, Moresco RM, Corti A, Curnis F
• Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
  Science (New York, N.Y.) 2022 Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T
• Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury.
  Frontiers in immunology 2022 Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M
• Obesity alters pathology and treatment response in inflammatory disease.
  Nature 2022 Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, …
• IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.
  American journal of physiology. Lung cellular and molecular physiology 2022 Auyeung VC, Downey MS, Thamsen M, Wenger TA, Backes BJ, Sheppard D, Papa FR
• αVβ8 integrin targeting to prevent posterior capsular opacification.
  JCI insight 2021 Shihan MH, Novo SG, Wang Y, Sheppard D, Atakilit A, Arnold TD, Rossi NM, Faranda AP, Duncan MK
• Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation.
  Nature communications 2021 Lainé A, Labiad O, Hernandez-Vargas H, This S, Sanlaville A, Léon S, Dalle S, Sheppard D, Travis MA, Paidassi H, Marie JC
• Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
  Cell reports 2021 Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal…
• Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.
  The Journal of clinical investigation 2021 Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB
• Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis?
  American journal of respiratory and critical care medicine 2021 Auyeung VC, Sheppard D
• Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis.
  The Journal of pathology 2021 Nishimichi N, Tsujino K, Kanno K, Sentani K, Kobayashi T, Chayama K, Sheppard D, Yokosaki Y
• KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice.
  JCI insight 2020 Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, …
• Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.
  Nature cell biology 2020 Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T
• Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.
  Bioorganic & medicinal chemistry letters 2020 Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H
• Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
  Science translational medicine 2020 Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R…
• Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier.
  The Journal of clinical investigation 2020 Santander N, Lizama CO, Meky E, McKinsey GL, Jung B, Sheppard D, Betsholtz C, Arnold TD
• Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking.
  Science advances 2020 Zhang Z, Bai M, Barbosa GO, Chen A, Wei Y, Luo S, Wang X, Wang B, Tsukui T, Li H, Sheppard D, Kornberg TB, Ma DK
• A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion.
  The Journal of biological chemistry 2019 Del Cid JS, Reed NI, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB
• Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction.
  The Journal of experimental medicine 2019 Arnold TD, Lizama CO, Cautivo KM, Santander N, Lin L, Qiu H, Huang EJ, Liu C, Mukouyama YS, Reichardt LF, Zovein AC, Sheppard D
• β6 -integrin serves as a novel serum tumor marker for colorectal carcinoma.
  International journal of cancer 2019 Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, Lang S, Atrott K, Mamie C, Vavricka SR, von Boehmer L, Knuth A, Tuomisto A, Mäkinen MJ, Hruz P, Turina M, Rickenbacher A, Petrowsky H…
• IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility.
  Journal of immunology (Baltimore, Md. : 1950) 2019 Bulek K, Chen X, Parron V, Sundaram A, Herjan T, Ouyang S, Liu C, Majors A, Zepp J, Gao J, Dongre A, Bodaszewska-Lubas M, Echard A, Aronica M, Carman J, Garantziotis S, Sheppard D, Li X
• Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.
  PloS one 2019 Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR
• Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration.
  The American journal of pathology 2018 Greenhalgh SN, Matchett KP, Taylor RS, Huang K, Li JT, Saeteurn K, Donnelly MC, Simpson EEM, Pollack JL, Atakilit A, Simpson KJ, Maher JJ, Iredale JP, Sheppard D, Henderson NC
• Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice.
  JCI insight 2018 Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD, Prakash YS, Bhattacharya M
• Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation.
  American journal of physiology. Lung cellular and molecular physiology 2018 Podolsky MJ, Gupta D, Ha A, Ta R, Khalifeh-Soltani A, McKleroy W, Datta R, Sheppard D, Atabai K
• TGF-β1 Signaling and Tissue Fibrosis.
  Cold Spring Harbor perspectives in biology 2018 Kim KK, Sheppard D, Chapman HA
• Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Stockis J, Liénart S, Colau D, Collignon A, Nishimura SL, Sheppard D, Coulie PG, Lucas S
• Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function.
  American journal of physiology. Lung cellular and molecular physiology 2017 Tsujino K, Li JT, Tsukui T, Ren X, Bakiri L, Wagner E, Sheppard D
• An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis.
  American journal of respiratory cell and molecular biology 2017 Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES, ATS …
• Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo.
  Journal of the American Society of Nephrology : JASN 2017 Chang Y, Lau WL, Jo H, Tsujino K, Gewin L, Reed NI, Atakilit A, Nunes ACF, DeGrado WF, Sheppard D
• Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma.
  The Journal of clinical investigation 2016 Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D
• Transforming growth factor-β plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma.
  American journal of physiology. Lung cellular and molecular physiology 2016 Tsujino K, Reed NI, Atakilit A, Ren X, Sheppard D
• Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors.
  ACS medicinal chemistry letters 2016 Reed NI, Tang YZ, McIntosh J, Wu Y, Molnar KS, Civitavecchia A, Sheppard D, DeGrado WF, Jo H
• An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens.
  PLoS pathogens 2016 Meliopoulos VA, Van de Velde LA, Van de Velde NC, Karlsson EA, Neale G, Vogel P, Guy C, Sharma S, Duan S, Surman SL, Jones BG, Johnson MD, Bosio C, Jolly L, Jenkins RG, Hurwitz JL, Rosch JW, Sheppard …
• Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome.
  Journal of immunology (Baltimore, Md. : 1950) 2016 McAleer JP, Nguyen NL, Chen K, Kumar P, Ricks DM, Binnie M, Armentrout RA, Pociask DA, Hein A, Yu A, Vikram A, Bibby K, Umesaki Y, Rivera A, Sheppard D, Ouyang W, Hooper LV, Kolls JK
• IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.
  Science (New York, N.Y.) 2016 Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG
• α-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFβ activation or collagen production across multiple models of organ fibrosis.
  American journal of physiology. Lung cellular and molecular physiology 2016 Sun KH, Chang Y, Reed NI, Sheppard D
• Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.
  Nature immunology 2016 Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, …
• Critical Appraisal of the Utility and Limitations of Animal Models of Scleroderma.
  Current rheumatology reports 2016 Tsujino K, Sheppard D
• Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis.
  Hepatology (Baltimore, Md.) 2015 Peng ZW, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Dixit R, Weinreb PH, Violette S, Sheppard D, Schuppan D, Popov Y
• Adaptive Immune Regulation of Mammary Postnatal Organogenesis.
  Developmental cell 2015 Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z
• Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D
• The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.
  Science translational medicine 2015 Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D
• Epithelial-mesenchymal interactions in fibrosis and repair. Transforming growth factor-β activation by epithelial cells and fibroblasts.
  Annals of the American Thoracic Society 2015 Sheppard D
• Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling.
  Molecular cell 2014 Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R
• Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain.
  Development (Cambridge, England) 2014 Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF
• IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.
  The Journal of clinical investigation 2014 Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D
• The cell biology of asthma.
  The Journal of cell biology 2014 Erle DJ, Sheppard D
• Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T
• Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis.
  American journal of physiology. Lung cellular and molecular physiology 2014 Madala SK, Korfhagen TR, Schmidt S, Davidson C, Edukulla R, Ikegami M, Violette SM, Weinreb PH, Sheppard D, Hardie WD
• Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.
  American journal of respiratory and critical care medicine 2014 Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty …
• TGF-β activation and function in immunity.
  Annual review of immunology 2013 Travis MA, Sheppard D
• Eosinophils secrete IL-4 to facilitate liver regeneration.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A
• The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.
  The Journal of clinical investigation 2013 Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A
• ROCKing pulmonary fibrosis.
  The Journal of clinical investigation 2013 Sheppard D
• Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5.
  Critical care medicine 2013 Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D
• Therapy for fibrotic diseases: nearing the starting line.
  Science translational medicine 2013 Friedman SL, Sheppard D, Duffield JS, Violette S
• Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Freimuth J, Clermont FF, Huang X, DeSapio A, Tokuyasu TA, Sheppard D, Akhurst RJ
• Integrin-mediated regulation of TGFβ in fibrosis.
  Biochimica et biophysica acta 2012 Henderson NC, Sheppard D
• Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR
• Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.
  The Journal of clinical investigation 2012 Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D
• Modulation of acute lung injury by integrins.
  Proceedings of the American Thoracic Society 2012 Sheppard D
• Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.
  The Journal of experimental medicine 2012 Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF
• IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.
  American journal of physiology. Lung cellular and molecular physiology 2012 Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D
• IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.
  Nature medicine 2012 Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D
• Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness.
  Journal of immunology (Baltimore, Md. : 1950) 2012 Doherty TA, Khorram N, Sugimoto K, Sheppard D, Rosenthal P, Cho JY, Pham A, Miller M, Croft M, Broide DH
• Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force.
  Experimental cell research 2012 Giacomini MM, Travis MA, Kudo M, Sheppard D
• The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.
  The Journal of clinical investigation 2012 Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D
• Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation.
  American journal of respiratory and critical care medicine 2012 Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D
• Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix.
  Cold Spring Harbor perspectives in biology 2011 Munger JS, Sheppard D
• Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Tatler AL, John AE, Jolly L, Habgood A, Porte J, Brightling C, Knox AJ, Pang L, Sheppard D, Huang X, Jenkins G
• Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease.
  International journal of rheumatology 2011 Katsumoto TR, Violette SM, Sheppard D
• Recommendations for the classification of diseases as CFTR-related disorders.
  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2011 Bombieri C, Claustres M, De Boeck K, Derichs N, Dodge J, Girodon E, Sermet I, Schwarz M, Tzetis M, Wilschanski M, Bareil C, Bilton D, Castellani C, Cuppens H, Cutting GR, Drevínek P, Farrell P, Elborn…
• Aspen Lung Conference 2010: systems biology of lung diseases--progress in the omics era.
  Proceedings of the American Thoracic Society 2011 Sheppard D
• Short form of α9 promotes α9β1 integrin-dependent cell adhesion by modulating the function of the full-length α9 subunit.
  Experimental cell research 2011 Kon S, Atakilit A, Sheppard D
• Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1.
  The Journal of biological chemistry 2011 Nishimichi N, Hayashita-Kinoh H, Chen C, Matsuda H, Sheppard D, Yokosaki Y
• Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling.
  Molecular and cellular biology 2010 Spassov DS, Wong CH, Sergina N, Ahuja D, Fried M, Sheppard D, Moasser MM
• Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.
  The Journal of clinical investigation 2010 Melton AC, Bailey-Bucktrout SL, Travis MA, Fife BT, Bluestone JA, Sheppard D
• Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages.
  The Journal of clinical investigation 2009 Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D
• beta6 Integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia.
  American journal of respiratory cell and molecular biology 2009 Hogmalm A, Sheppard D, Lappalainen U, Bry K
• Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.
  Developmental cell 2009 Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D, Makinen T
• Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
  The Journal of biological chemistry 2009 Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, …
• Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins.
  Blood 2009 Grassinger J, Haylock DN, Storan MJ, Haines GO, Williams B, Whitty GA, Vinson AR, Be CL, Li S, Sørensen ES, Tam PP, Denhardt DT, Sheppard D, Choong PF, Nilsson SK
• Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).
  The American journal of pathology 2009 Xu MY, Porte J, Knox AJ, Weinreb PH, Maher TM, Violette SM, McAnulty RJ, Sheppard D, Jenkins G
• Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing.
  The Journal of investigative dermatology 2008 Singh P, Chen C, Pal-Ghosh S, Stepp MA, Sheppard D, Van De Water L
• The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel.
  Proceedings of the National Academy of Sciences of the United States of America 2008 deHart GW, Jin T, McCloskey DE, Pegg AE, Sheppard D
• Dust mites' dirty dealings with dendritic cells.
  Nature medicine 2008 Sheppard D
• Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.
  The American journal of pathology 2008 Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L
• Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.
  Circulation research 2008 Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF
• An essential role for fibronectin extra type III domain A in pulmonary fibrosis.
  American journal of respiratory and critical care medicine 2007 Muro AF, Moretti FA, Moore BB, Yan M, Atrasz RG, Wilke CA, Flaherty KR, Martinez FJ, Tsui JL, Sheppard D, Baralle FE, Toews GB, White ES
• Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.
  The Journal of clinical investigation 2007 Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL
• Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.
  American journal of respiratory and critical care medicine 2007 Horan GS, Wood S, Ona V, Li DJ, Lukashev ME, Weinreb PH, Simon KJ, Hahm K, Allaire NE, Rinaldi NJ, Goyal J, Feghali-Bostwick CA, Matteson EL, O'Hara C, Lafyatis R, Davis GS, Huang X, Sheppard D, …
• Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.
  American journal of respiratory cell and molecular biology 2007 Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG
• Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Nandrot EF, Anand M, Almeida D, Atabai K, Sheppard D, Finnemann SC
• Genomics and proteomics of lung disease: conference summary.
  American journal of physiology. Lung cellular and molecular physiology 2007 Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, …
• Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis.
  The Journal of biological chemistry 2007 Vlahakis NE, Young BA, Atakilit A, Hawkridge AE, Issaka RB, Boudreau N, Sheppard D
• Roles of the innate immune system in mammary gland remodeling during involution.
  Journal of mammary gland biology and neoplasia 2007 Atabai K, Sheppard D, Werb Z
• Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.
  The American journal of pathology 2007 Hahm K, Lukashev ME, Luo Y, Yang WJ, Dolinski BM, Weinreb PH, Simon KJ, Chun Wang L, Leone DR, Lobb RR, McCrann DJ, Allaire NE, Horan GS, Fogo A, Kalluri R, Shield CF, Sheppard D, Gardner HA, Violette…
• Identification and molecular characterization of multiple phenotypes in integrin knockout mice.
  Methods in enzymology 2007 Chen C, Sheppard D
• Pulmonary emphysema: when more is less.
  Physiology (Bethesda, Md.) 2006 Morris DG, Sheppard D
• The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling.
  Immunity 2006 Chen C, Huang X, Atakilit A, Zhu QS, Corey SJ, Sheppard D
• Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function.
  American journal of respiratory cell and molecular biology 2006 Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF
• Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 Rao H, Lu G, Kajiya H, Garcia-Palacios V, Kurihara N, Anderson J, Patrene K, Sheppard D, Blair HC, Windle JJ, Choi SJ, Roodman GD
• ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice.
  Molecular and cellular biology 2006 Chen C, Huang X, Sheppard D
• Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA
• Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis.
  Proceedings of the American Thoracic Society 2006 Sheppard D
• Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.
  The Journal of clinical investigation 2006 Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D
• Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.
  American journal of respiratory cell and molecular biology 2006 Neurohr C, Nishimura SL, Sheppard D
• Population stratification confounds genetic association studies among Latinos.
  Human genetics 2005 Choudhry S, Coyle NE, Tang H, Salari K, Lind D, Clark SL, Tsai HJ, Naqvi M, Phong A, Ung N, Matallana H, Avila PC, Casal J, Torres A, Nazario S, Castro R, Battle NC, Perez-Stable EJ, Kwok PY, Sheppard…
• Mfge8 is critical for mammary gland remodeling during involution.
  Molecular biology of the cell 2005 Atabai K, Fernandez R, Huang X, Ueki I, Kline A, Li Y, Sadatmansoori S, Smith-Steinhart C, Zhu W, Pytela R, Werb Z, Sheppard D
• Integrin-mediated activation of latent transforming growth factor beta.
  Cancer metastasis reviews 2005 Sheppard D
• Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics.
  Genetic epidemiology 2005 Salari K, Choudhry S, Tang H, Naqvi M, Lind D, Avila PC, Coyle NE, Ung N, Nazario S, Casal J, Torres-Palacios A, Clark S, Phong A, Gomez I, Matallana H, Pérez-Stable EJ, Shriver MD, Kwok PY, Sheppard …
• ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7.
  The Biochemical journal 2005 Bridges LC, Sheppard D, Bowditch RD
• Characterization of integrin beta6 and thrombospondin-1 double-null mice.
  Journal of cellular and molecular medicine 2005 Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, Sheppard D, Lawler J
• Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway.
  The Journal of biological chemistry 2005 Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF
• Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma.
  The Journal of clinical investigation 2005 Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM
• Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin.
  The Journal of experimental medicine 2004 Nandrot EF, Kim Y, Brodie SE, Huang X, Sheppard D, Finnemann SC
• The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1.
  The Journal of biological chemistry 2004 Vlahakis NE, Young BA, Atakilit A, Sheppard D
• Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma.
  American journal of respiratory and critical care medicine 2004 Choudhry S, Ung N, Avila PC, Ziv E, Nazario S, Casal J, Torres A, Gorman JD, Salari K, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Castro RA, Salazar M, Gomez I, Fagan JK, Salas J, Clark S, …
• Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 Lane NE, Yao W, Nakamura MC, Humphrey MB, Kimmel D, Huang X, Sheppard D, Ross FP, Teitelbaum SL
• Fishing in the bloodstream: insights into the mechanisms of pulmonary hypertension?
  American journal of respiratory and critical care medicine 2004 Sheppard D
• Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration.
  The Journal of cell biology 2004 Chen C, Young BA, Coleman CS, Pegg AE, Sheppard D
• Roles of alphav integrins in vascular biology and pulmonary pathology.
  Current opinion in cell biology 2004 Sheppard D
• Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9.
  Journal of virology 2004 Williams CH, Kajander T, Hyypiä T, Jackson T, Sheppard D, Stanway G
• Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins.
  Biochemistry 2004 Bazan-Socha S, Kisiel DG, Young B, Theakston RD, Calvete JJ, Sheppard D, Marcinkiewicz C
• Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes.
  The Journal of biological chemistry 2004 Weinreb PH, Simon KJ, Rayhorn P, Yang WJ, Leone DR, Dolinski BM, Pearse BR, Yokota Y, Kawakatsu H, Atakilit A, Sheppard D, Violette SM
• Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma.
  American journal of respiratory and critical care medicine 2003 Burchard EG, Avila PC, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Salazar M, Gomez I, Fagan JK, Salas J, Lilly C, Matallana H, Ziv E, Castro R, Selman M, …
• Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3.
  Experimental cell research 2003 Tomczuk M, Takahashi Y, Huang J, Murase S, Mistretta M, Klaffky E, Sutherland A, Bolling L, Coonrod S, Marcinkiewicz C, Sheppard D, Stepp MA, White JM
• Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice.
  The American journal of pathology 2003 Ma LJ, Yang H, Gaspert A, Carlesso G, Barty MM, Davidson JM, Sheppard D, Fogo AB
• Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.
  American journal of respiratory cell and molecular biology 2003 Wu W, Samet JM, Silbajoris R, Dailey LA, Sheppard D, Bromberg PA, Graves LM
• ADAM33 is not associated with asthma in Puerto Rican or Mexican populations.
  American journal of respiratory and critical care medicine 2003 Lind DL, Choudhry S, Ung N, Ziv E, Avila PC, Salari K, Ha C, Lovins EG, Coyle NE, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Matallana H, Lilly CM, Salas J, Selman M, Boushey HA, Weiss ST, …
• Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism.
  The Journal of biological chemistry 2003 Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF
• Functions of pulmonary epithelial integrins: from development to disease.
  Physiological reviews 2003 Sheppard D
• The importance of race and ethnic background in biomedical research and clinical practice.
  The New England journal of medicine 2003 Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, Mountain JL, Pérez-Stable EJ, Sheppard D, Risch N
• Endothelial integrins and angiogenesis: not so simple anymore.
  The Journal of clinical investigation 2002 Sheppard D
• Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1.
  The American journal of pathology 2002 Knight PA, Wright SH, Brown JK, Huang X, Sheppard D, Miller HR
• Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.
  American journal of respiratory and critical care medicine 2002 Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King TE, Leinwand LA, Liotta L, Martin GR, Schwartz DA, Schultz GS, Wagner CR, Musson RA
• Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.
  Nature medicine 2002 Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ
• Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Zuo F, Kaminski N, Eugui E, Allard J, Yakhini Z, Ben-Dor A, Lollini L, Morris D, Kim Y, DeLustro B, Sheppard D, Pardo A, Selman M, Heller RA
• The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1.
  The Journal of cell biology 2002 Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL
• Killed by leukocytes that don't know when to leave.
  Nature immunology 2002 Sheppard D
• Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.
  The Journal of cell biology 2002 Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA
• Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.
  The Journal of biological chemistry 2002 Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon-McLaughlin W, Zhang XP, Sheppard D, Engvall E, Takada Y
• Roger S. Mitchell lecture. Uses of expression microarrays in studies of pulmonary fibrosis, asthma, acute lung injury, and emphysema.
  Chest 2002 Sheppard D
• Use of oligonucleotide microarrays to analyze gene expression patterns in pulmonary fibrosis reveals distinct patterns of gene expression in mice and humans.
  Chest 2002 Kaminski N, Zuo F, Cojocaro G, Yakhini Z, Ben-Dor A, Morris D, Sheppard D, Pardo A, Selman M, Heller RA
• The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing.
  The Journal of biological chemistry 2002 Liao YF, Gotwals PJ, Koteliansky VE, Sheppard D, Van De Water L
• Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus.
  Journal of virology 2002 Jackson T, Mould AP, Sheppard D, King AM
• Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins.
  Nature medicine 2002 Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM
• Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001 Ljubimov AV, Saghizadeh M, Pytela R, Sheppard D, Kenney MC
• Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.
  American journal of respiratory cell and molecular biology 2001 Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D
• The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner.
  Molecular biology of the cell 2001 Young BA, Taooka Y, Liu S, Askins KJ, Yokosaki Y, Thomas SM, Sheppard D
• Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells.
  The Journal of investigative dermatology 2001 Thomas GJ, Lewis MP, Whawell SA, Russell A, Sheppard D, Hart IR, Speight PM, Marshall JF
• Integrin-mediated activation of transforming growth factor-beta(1) in pulmonary fibrosis.
  Chest 2001 Sheppard D
• Pulmonary fibrosis: a cellular overreaction or a failure of communication?
  The Journal of clinical investigation 2001 Sheppard D
• TGF-beta is a critical mediator of acute lung injury.
  The Journal of clinical investigation 2001 Pittet JF, Griffiths MJ, Geiser T, Kaminski N, Dalton SL, Huang X, Brown LA, Gotwals PJ, Koteliansky VE, Matthay MA, Sheppard D
• Role of the cytoplasmic domain of the beta-subunit of integrin alpha(v)beta6 in infection by foot-and-mouth disease virus.
  Journal of virology 2001 Miller LC, Blakemore W, Sheppard D, Atakilit A, King AM, Jackson T
• Expression of the beta6 integrin subunit is associated with sites of neutrophil influx in lung epithelium.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001 Miller LA, Barnett NL, Sheppard D, Hyde DM
• RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction.
  The Journal of biological chemistry 2000 Eto K, Puzon-McLaughlin W, Sheppard D, Sehara-Fujisawa A, Zhang XP, Takada Y
• Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin.
  The Journal of biological chemistry 2000 Marcinkiewicz C, Taooka Y, Yokosaki Y, Calvete JJ, Marcinkiewicz MM, Lobb RR, Niewiarowski S, Sheppard D
• A primary culture model of differentiated murine tracheal epithelium.
  American journal of physiology. Lung cellular and molecular physiology 2000 Davidson DJ, Kilanowski FM, Randell SH, Sheppard DN, Dorin JR
• Functional genomics and expression profiling: be there or be square.
  American journal of respiratory cell and molecular biology 2000 Albelda SM, Sheppard D
• Tissue transglutaminase, coagulation factor XIII, and the pro-polypeptide of von Willebrand factor are all ligands for the integrins alpha 9beta 1 and alpha 4beta 1.
  The Journal of biological chemistry 2000 Takahashi H, Isobe T, Horibe S, Takagi J, Yokosaki Y, Sheppard D, Saito Y
• Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1.
  Molecular and cellular biology 2000 Huang XZ, Wu JF, Ferrando R, Lee JH, Wang YL, Farese RV, Sheppard D
• In vivo functions of integrins: lessons from null mutations in mice.
  Matrix biology : journal of the International Society for Matrix Biology 2000 Sheppard D
• The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus.
  Journal of virology 2000 Jackson T, Sheppard D, Denyer M, Blakemore W, King AM
• Mapping of the cryptic integrin-binding site in osteopontin suggests a new mechanism by which thrombin can regulate inflammation and tissue repair.
  Trends in cardiovascular medicine 2000 Yokasaki Y, Sheppard D
• Two mechanisms of genistein inhibition of cystic fibrosis transmembrane conductance regulator Cl- channels expressed in murine cell line.
  The Journal of physiology 2000 Lansdell KA, Cai Z, Kidd JF, Sheppard DN
• Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Kaminski N, Allard JD, Pittet JF, Zuo F, Griffiths MJ, Morris D, Huang X, Sheppard D, Heller RA
• Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice.
  Molecular and cellular biology 2000 Huang X, Griffiths M, Wu J, Farese RV, Sheppard D
• The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin.
  The Journal of biological chemistry 1999 Yokosaki Y, Matsuura N, Sasaki T, Murakami I, Schneider H, Higashiyama S, Saitoh Y, Yamakido M, Taooka Y, Sheppard D
• Analysis of gene expression in human bullous keratopathy corneas containing limiting amounts of RNA.
  Investigative ophthalmology & visual science 1999 Spirin KS, Ljubimov AV, Castellon R, Wiedoeft O, Marano M, Sheppard D, Kenney MC, Brown DJ
• Distinct roles for astrocyte alphavbeta5 and alphavbeta8 integrins in adhesion and migration.
  Journal of cell science 1999 Milner R, Huang X, Wu J, Nishimura S, Pytela R, Sheppard D, ffrench-Constant C
• Airway remodeling and repair.
  American journal of respiratory and critical care medicine 1999 Busse W, Elias J, Sheppard D, Banks-Schlegel S
• Inhibition of heterologously expressed cystic fibrosis transmembrane conductance regulator Cl- channels by non-sulphonylurea hypoglycaemic agents.
  British journal of pharmacology 1999 Cai Z, Lansdell KA, Sheppard DN
• Fibronectin and alpha5beta1 integrin mediate binding of Pseudomonas aeruginosa to repairing airway epithelium.
  The European respiratory journal 1999 Roger P, Puchelle E, Bajolet-Laudinat O, Tournier JM, Debordeaux C, Plotkowski MC, Cohen JH, Sheppard D, de Bentzmann S
• The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1.
  The Journal of cell biology 1999 Taooka Y, Chen J, Yednock T, Sheppard D
• Requirement for IL-13 independently of IL-4 in experimental asthma.
  Science (New York, N.Y.) 1998 Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB
• Regulated expression of the integrin alpha9beta1 in the epithelium of the developing human gut and in intestinal cell lines: relation with cell proliferation.
  Journal of cellular biochemistry 1998 Desloges N, Basora N, Perreault N, Bouatrouss Y, Sheppard D, Beaulieu JF
• Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice.
  American journal of respiratory cell and molecular biology 1998 Huang X, Wu J, Zhu W, Pytela R, Sheppard D
• Airway epithelial integrins: why so many?
  American journal of respiratory cell and molecular biology 1998 Sheppard D
• The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin.
  Journal of cell science 1998 Huang X, Wu J, Spong S, Sheppard D
• A novel peptide, PLAEIDGIELTY, for the targeting of alpha9beta1-integrins.
  FEBS letters 1998 Schneider H, Harbottle RP, Yokosaki Y, Kunde J, Sheppard D, Coutelle C
• Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C.
  The Journal of biological chemistry 1998 Yokosaki Y, Matsuura N, Higashiyama S, Murakami I, Obara M, Yamakido M, Shigeto N, Chen J, Sheppard D
• Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice.
  Molecular medicine (Cambridge, Mass.) 1998 Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM
• Comparison of the gating behaviour of human and murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in mammalian cells.
  The Journal of physiology 1998 Lansdell KA, Delaney SJ, Lunn DP, Thomson SA, Sheppard DN, Wainwright BJ
• Expression of the alpha9beta1 integrin in human colonic epithelial cells: resurgence of the fetal phenotype in a subset of colon cancers and adenocarcinoma cell lines.
  International journal of cancer 1998 Basora N, Desloges N, Chang Q, Bouatrouss Y, Gosselin J, Poisson J, Sheppard D, Beaulieu JF
• Epidermal integrin expression is upregulated rapidly in human fetal wound repair.
  Journal of pediatric surgery 1998 Cass DL, Bullard KM, Sylvester KG, Yang EY, Sheppard D, Herlyn M, Adzick NS
• Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells.
  Virology 1997 Agrez MV, Shafren DR, Gu X, Cox K, Sheppard D, Barry RD
• Stromal fibroblasts influence oral squamous-cell carcinoma cell interactions with tenascin-C.
  International journal of cancer 1997 Ramos DM, Chen BL, Boylen K, Stern M, Kramer RH, Sheppard D, Nishimura SL, Greenspan D, Zardi L, Pytela R
• Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin.
  The Journal of biological chemistry 1996 Smith LL, Cheung HK, Ling LE, Chen J, Sheppard D, Pytela R, Giachelli CM
• Differential regulation of airway epithelial integrins by growth factors.
  American journal of respiratory cell and molecular biology 1996 Wang A, Yokosaki Y, Ferrando R, Balmes J, Sheppard D
• Distinct structural requirements for interaction of the integrins alpha 5 beta 1, alpha v beta 5, and alpha v beta 6 with the central cell binding domain in fibronectin.
  Cell adhesion and communication 1996 Chen J, Maeda T, Sekiguchi K, Sheppard D
• Fibronectin and its alpha 5 beta 1-integrin receptor are involved in the wound-repair process of airway epithelium.
  The American journal of physiology 1996 Hérard AL, Pierrot D, Hinnrasky J, Kaplan H, Sheppard D, Puchelle E, Zahm JM
• Identification of a sequence within the integrin beta6 subunit cytoplasmic domain that is required to support the specific effect of alphavbeta6 on proliferation in three-dimensional culture.
  The Journal of biological chemistry 1996 Dixit RB, Chen A, Chen J, Sheppard D
• Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.
  The Journal of biological chemistry 1996 Yokosaki Y, Monis H, Chen J, Sheppard D
• Epithelial integrins.
  BioEssays : news and reviews in molecular, cellular and developmental biology 1996 Sheppard D
• Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.
  The Journal of cell biology 1996 Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D
• Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.
  British journal of cancer 1996 Agrez MV, Bates RC, Mitchell D, Wilson N, Ferguson N, Anseline P, Sheppard D
• Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells.
  Experimental cell research 1995 Kumar NM, Sigurdson SL, Sheppard D, Lwebuga-Mukasa JS
• Expression of the integrin subunit alpha 9 in the murine embryo.
  Developmental dynamics : an official publication of the American Association of Anatomists 1995 Wang A, Patrone L, McDonald JA, Sheppard D
• Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5.
  The Journal of clinical investigation 1995 Boylan AM, Sanan DA, Sheppard D, Broaddus VC
• The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.
  The Journal of biological chemistry 1995 Schnapp LM, Hatch N, Ramos DM, Klimanskaya IV, Sheppard D, Pytela R
• A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts.
  American journal of respiratory cell and molecular biology 1995 Huang XZ, Chen A, Agrez M, Sheppard D
• Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways.
  American journal of respiratory cell and molecular biology 1995 Weinacker A, Ferrando R, Elliott M, Hogg J, Balmes J, Sheppard D
• Localized distribution of alpha 9 integrin in the cornea and changes in expression during corneal epithelial cell differentiation.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995 Stepp MA, Zhu L, Sheppard D, Cranfill RL
• Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells.
  Journal of cell science 1995 Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R
• Localization of the alpha v subfamily of integrins and their putative ligands in synovial lining cell layer.
  The Journal of rheumatology 1995 Nikkari L, Haapasalmi K, Aho H, Torvinen A, Sheppard D, Larjava H, Heino J
• Staphylococcus aureus stimulates neutrophil recruitment by stimulating interleukin-8 production in dog trachea.
  The American journal of physiology 1995 Massion PP, Hébert CA, Leong S, Chan B, Inoue H, Grattan K, Sheppard D, Nadel JA
• Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.
  The Journal of biological chemistry 1994 Nishimura SL, Sheppard D, Pytela R
• The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin.
  The Journal of biological chemistry 1994 Yokosaki Y, Palmer EL, Prieto AL, Crossin KL, Bourdon MA, Pytela R, Sheppard D
• The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain.
  The Journal of cell biology 1994 Agrez M, Chen A, Cone RI, Pytela R, Sheppard D
• Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain.
  The Journal of biological chemistry 1994 Lukashev ME, Sheppard D, Pytela R
• Dominant negative mutants: tools for the study of protein function in vitro and in vivo.
  American journal of respiratory cell and molecular biology 1994 Sheppard D
• Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts.
  Cell adhesion and communication 1994 Cone RI, Weinacker A, Chen A, Sheppard D
• Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.
  The Journal of biological chemistry 1994 Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D
• Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules.
  Methods in enzymology 1994 Pytela R, Suzuki S, Breuss J, Erle DJ, Sheppard D
• Identification and characterization of novel airway epithelial integrins.
  The American review of respiratory disease 1993 Sheppard D
• Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle.
  The Journal of cell biology 1993 Palmer EL, Rüegg C, Ferrando R, Pytela R, Sheppard D
• Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1993 Breuss JM, Gillett N, Lu L, Sheppard D, Pytela R
• Occupational asthma in a pesticides manufacturing worker.
  Chest 1993 Royce S, Wald P, Sheppard D, Balmes J
• Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells.
  The Journal of biological chemistry 1992 Sheppard D, Cohen DS, Wang A, Busk M
• Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein.
  The Journal of biological chemistry 1992 Busk M, Pytela R, Sheppard D
• Identification of novel airway epithelial integrins using the homology-based polymerase chain reaction.
  Chest 1992 Sheppard D, Erle D, Busk M, Pytela R
• Airway oedema and obstruction in guinea pigs exposed to inhaled endotoxin.
  British journal of industrial medicine 1991 Gordon T, Balmes J, Fine J, Sheppard D
• Polarized regulation of fibronectin secretion and alternative splicing by transforming growth factor.
  The Journal of biological chemistry 1991 Wang A, Cohen DS, Palmer E, Sheppard D
• Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction.
  American journal of respiratory cell and molecular biology 1991 Erle DJ, Sheppard D, Breuss J, Rüegg C, Pytela R
• The response of guinea pig airway epithelial cells and alveolar macrophages to environmental stress.
  American journal of respiratory cell and molecular biology 1991 Cohen DS, Palmer E, Welch WJ, Sheppard D
• Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes.
  The Journal of biological chemistry 1991 Erle DJ, Rüegg C, Sheppard D, Pytela R
• Lack of bronchoconstrictor response to sulfuric acid aerosols and fogs.
  The American review of respiratory disease 1991 Aris R, Christian D, Sheppard D, Balmes JR
• The effects of sequential exposure to acidic fog and ozone on pulmonary function in exercising subjects.
  The American review of respiratory disease 1991 Aris R, Christian D, Sheppard D, Balmes JR
• Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.
  The Journal of biological chemistry 1990 Sheppard D, Rozzo C, Starr L, Quaranta V, Erle DJ, Pytela R
• Acid fog-induced bronchoconstriction. The role of hydroxymethanesulfonic acid.
  The American review of respiratory disease 1990 Aris R, Christian D, Sheppard D, Balmes JR
• Potential bronchoconstrictor stimuli in acid fog.
  Environmental health perspectives 1989 Balmes JR, Fine JM, Gordon T, Sheppard D
• Epithelium removal alters responsiveness of guinea pig trachea to substance P.
  Journal of applied physiology (Bethesda, Md. : 1985) 1989 Fine JM, Gordon T, Sheppard D
• Sulfur dioxide and asthma--a double-edged sword?
  The Journal of allergy and clinical immunology 1988 Sheppard D
• A tachykinin receptor antagonist inhibits and an inhibitor of tachykinin metabolism potentiates toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs.
  The American review of respiratory disease 1988 Sheppard D, Scypinski L
• Acidity potentiates bronchoconstriction induced by hypoosmolar aerosols.
  The American review of respiratory disease 1988 Balmes JR, Fine JM, Christian D, Gordon T, Sheppard D
• Arachidonic acid metabolites do not mediate toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs.
  Prostaglandins 1988 Gordon T, Thompson JE, Sheppard D
• Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase.
  The Journal of clinical investigation 1988 Sheppard D, Thompson JE, Scypinski L, Dusser D, Nadel JA, Borson DB
• Tumor necrosis factor inhibits a polymorphonuclear leukocyte-dependent airway edema in guinea pigs.
  Journal of applied physiology (Bethesda, Md. : 1985) 1988 Gordon T, Sheppard D
• Equivalence of continuous flow nebulizer and metered-dose inhaler with reservoir bag for treatment of acute airflow obstruction.
  Chest 1988 Turner JR, Corkery KJ, Eckman D, Gelb AM, Lipavsky A, Sheppard D
• Karyotypic analysis of the human monoblastic cell line U937.
  Cancer genetics and cytogenetics 1988 Shipley JM, Sheppard DM, Sheer D
• Phosphoramidon potentiates the increase in lung resistance mediated by tachykinins in guinea pigs.
  The American review of respiratory disease 1988 Thompson JE, Sheppard D
• Mechanisms of acute increases in airway responsiveness caused by environmental chemicals.
  The Journal of allergy and clinical immunology 1988 Sheppard D
• Symptomatic bronchoconstriction after short-term inhalation of sulfur dioxide.
  The American review of respiratory disease 1987 Balmes JR, Fine JM, Sheppard D
• The roles of pH and ionic species in sulfur dioxide- and sulfite-induced bronchoconstriction.
  The American review of respiratory disease 1987 Fine JM, Gordon T, Sheppard D
• What does exercise have to do with "exercise-induced" asthma?
  The American review of respiratory disease 1987 Sheppard D
• Tachykinins mediate the acute increase in airway responsiveness caused by toluene diisocyanate in guinea pigs.
  The American review of respiratory disease 1987 Thompson JE, Scypinski LA, Gordon T, Sheppard D
• Apparent effect of catalase on airway edema in guinea pigs. Role of endotoxin contamination.
  The American review of respiratory disease 1987 Gordon T, Milligan SA, Levin J, Thompson JE, Fine JM, Sheppard D
• The role of titratable acidity in acid aerosol-induced bronchoconstriction.
  The American review of respiratory disease 1987 Fine JM, Gordon T, Thompson JE, Sheppard D
• Physiology of the parasympathetic nervous system of the lung.
  Postgraduate medical journal 1987 Sheppard D
• Hydroxyurea inhibits airway hyperresponsiveness in guinea pigs by a granulocyte-independent mechanism.
  The American review of respiratory disease 1986 Thompson JE, Scypinski LA, Gordon T, Sheppard D
• Mechanisms of bronchoconstriction from nonimmunologic environmental stimuli.
  Chest 1986 Sheppard D
• Interaction of cromolyn and a muscarinic antagonist in inhibiting bronchial reactivity to sulfur dioxide and to eucapnic hyperpnea alone.
  The American review of respiratory disease 1986 Myers DJ, Bigby BG, Calvayrac P, Sheppard D, Boushey HA
• Granulocyte-mediated airway edema in guinea pigs.
  Journal of applied physiology (Bethesda, Md. : 1985) 1986 Sheppard D, Scypinski L, Horn J, Gordon T, Thompson JE
• The usefulness of induced sputum in the diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome.
  The American review of respiratory disease 1986 Bigby TD, Margolskee D, Curtis JL, Michael PF, Sheppard D, Hadley WK, Hopewell PC
• Effects of esmolol on airway function in patients with asthma.
  Journal of clinical pharmacology 1986 Sheppard D, DiStefano S, Byrd RC, Eschenbacher WL, Bell V, Steck J, Laddu A
• Acute effects of routine firefighting on lung function.
  American journal of industrial medicine 1986 Sheppard D, Distefano S, Morse L, Becker C
• Airway hyperresponsiveness and inflammation induced by toluene diisocyanate in guinea pigs.
  The American review of respiratory disease 1985 Gordon T, Sheppard D, McDonald DM, Distefano S, Scypinski L
• Effect of eucapnic hypoxia on bronchomotor tone and on the bronchomotor response to dry air in asthmatic subjects.
  The American review of respiratory disease 1985 Tam EK, Geffroy BA, Myers DJ, Seltzer J, Sheppard D, Boushey HA
• Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma.
  The American review of respiratory disease 1985 Siegel D, Sheppard D, Gelb A, Weinberg PF
• Respiratory heat loss is not the sole stimulus for bronchoconstriction induced by isocapnic hyperpnea with dry air.
  The American review of respiratory disease 1985 Eschenbacher WL, Sheppard D
• Pharmacotherapy of asthma.
  The Western journal of medicine 1985 Sheppard D
• Effect of 0.25 ppm sulfur dioxide on airway resistance in freely breathing, heavily exercising, asthmatic subjects.
  The American review of respiratory disease 1985 Bethel RA, Sheppard D, Geffroy B, Tam E, Nadel JA, Boushey HA
• Lack of bronchomotor response to up to 3 ppm formaldehyde in subjects with asthma.
  Environmental research 1984 Sheppard D, Eschenbacher WL, Epstein J
• Morphine sulfate inhibits bronchoconstriction in subjects with mild asthma whose responses are inhibited by atropine.
  The American review of respiratory disease 1984 Eschenbacher WL, Bethel RA, Boushey HA, Sheppard D
• Interaction of sulfur dioxide and dry cold air in causing bronchoconstriction in asthmatic subjects.
  Journal of applied physiology: respiratory, environmental and exercise physiology 1984 Bethel RA, Sheppard D, Epstein J, Tam E, Nadel JA, Boushey HA
• Magnitude of the interaction between the bronchomotor effects of sulfur dioxide and those of dry (cold) air.
  The American review of respiratory disease 1984 Sheppard D, Eschenbacher WL, Boushey HA, Bethel RA
• Respiratory water loss as a stimulus to exercise-induced bronchoconstriction.
  The Journal of allergy and clinical immunology 1984 Sheppard D, Eschenbacher WL
• Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone.
  The American review of respiratory disease 1984 Eschenbacher WL, Boushey HA, Sheppard D
• Variable inhibition of histamine-induced bronchoconstriction by atropine in subjects with asthma.
  The Journal of allergy and clinical immunology 1984 Sheppard D, Epstein J, Skoogh BE, Bethel RA, Nadel JA, Boushey HA
• Sulfur dioxide-induced bronchoconstriction in freely breathing, exercising, asthmatic subjects.
  The American review of respiratory disease 1983 Bethel RA, Epstein J, Sheppard D, Nadel JA, Boushey HA
• Antihistaminic versus anticholinergic effects of atropine on canine trachealis muscle.
  The American review of respiratory disease 1983 Skoogh BE, Nadel JA, Fabbri LM, Sheppard D, Holtzman MJ
• Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects.
  The American review of respiratory disease 1983 Bethel RA, Erle DJ, Epstein J, Sheppard D, Nadel JA, Boushey HA
• Purification of uroporphyrinogen decarboxylase from human erythrocytes. Immunochemical evidence for a single protein with decarboxylase activity in human erythrocytes and liver.
  The Biochemical journal 1983 Elder GH, Tovey JA, Sheppard DM
• Chest pain and hypoxemia from inhalation of a trichloroethane aerosol product.
  Journal of toxicology. Clinical toxicology 1983 Woo OF, Healey KM, Sheppard D, Tong TG
• Mechanism of cough and bronchoconstriction induced by distilled water aerosol.
  The American review of respiratory disease 1983 Sheppard D, Rizk NW, Boushey HA, Bethel RA
• Tolerance to sulfur dioxide-induced bronchoconstriction in subjects with asthma.
  Environmental research 1983 Sheppard D, Epstein J, Bethel RA, Nadel JA, Boushey HA
• Effect of route of atropine delivery on bronchospasm from cold air and methacholine.
  Journal of applied physiology: respiratory, environmental and exercise physiology 1983 Sheppard D, Epstein J, Holtzman MJ, Nadel JA, Boushey HA
• Intravenous versus inhaled atropine for inhibiting bronchoconstrictor responses in dogs.
  Journal of applied physiology: respiratory, environmental and exercise physiology 1983 Holtzman MJ, McNamara MP, Sheppard D, Fabbri LM, Hahn HL, Graf PD, Nadel JA
• Occupational asthma.
  The Western journal of medicine 1982 Sheppard D
• Effect of the oronasal breathing route on sulfur dioxide-induced bronchoconstriction in exercising asthmatic subjects.
  The American review of respiratory disease 1982 Kirkpatrick MB, Sheppard D, Nadel JA, Boushey HA
• Inhibition of sulfur dioxide-induced bronchoconstriction by disodium cromoglycate in asthmatic subjects.
  The American review of respiratory disease 1981 Sheppard D, Nadel JA, Boushey HA
• Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects.
  The American review of respiratory disease 1981 Sheppard D, Saisho A, Nadel JA, Boushey HA
• Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide.
  The American review of respiratory disease 1980 Sheppard D, Wong WS, Uehara CF, Nadel JA, Boushey HA