Davide Verotta, PhD
Professor Emeritus
Clinical Pharmacy
School of Pharmacy

In PKPD, his main areas of interest are: mechanistic modeling (where prior knowledge about parts of a PKPD system is embedded in the model describing it); the development of empirical models (where no prior knowledge is embedded in the model) to analyze, simulate and control; population PKPD modeling with particular regard to empirical methods for population data analysis. In MS modeling, his main interests are in linear and non-linear system analysis, control, and experimental design. He is involved in collaborative research with scientists and different investigators in PKPD and clinical therapy (notably HIV therapy) modeling. Additional areas of investigation are the use of Bayesian methods, in particular applied to pharmacogenomics and mechanistic modeling, fractional differential equations, and applications of functional data analysis to population PKPD.

• Determination of meropenem in bacterial media by LC-MS/MS.
  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2014 Huang L, Haagensen J, Verotta D, Lizak P, Aweeka F, Yang K
• Every 36-h gentamicin dosing in neonates with hypoxic-ischemic encephalopathy receiving hypothermia.
  Journal of perinatology : official journal of the California Perinatal Association 2013 Frymoyer A, Lee S, Bonifacio SL, Meng L, Lucas SS, Guglielmo BJ, Sun Y, Verotta D
• Gentamicin pharmacokinetics and dosing in neonates with hypoxic ischemic encephalopathy receiving hypothermia.
  Pharmacotherapy 2013 Frymoyer A, Meng L, Bonifacio SL, Verotta D, Guglielmo BJ
• Population pharmacokinetics of unbound mycophenolic acid in adult allogeneic haematopoietic cell transplantation: effect of pharmacogenetic factors.
  British journal of clinical pharmacology 2013 Frymoyer A, Verotta D, Jacobson P, Long-Boyle J
• Nevirapine pharmacokinetics and risk of rash and hepatitis among HIV-infected sub-Saharan African women.
  AIDS (London, England) 2012 Dong BJ, Zheng Y, Hughes MD, Frymoyer A, Verotta D, Lizak P, Sawe F, Currier JS, Lockman S, Aweeka FT, AIDS Clinical Trials Group Study 5208 Team
• A method to quantify illicit intake of drugs from urine: methamphetamine.
  The Journal of pharmacology and experimental therapeutics 2011 Li L, Galloway GP, Verotta D, Everhart ET, Baggott MJ, Coyle JR, Lopez JC, Mendelson J
• Fractional dynamics pharmacokinetics-pharmacodynamic models.
  Journal of pharmacokinetics and pharmacodynamics 2010 Verotta D
• Fractional compartmental models and multi-term Mittag-Leffler response functions.
  Journal of pharmacokinetics and pharmacodynamics 2010 Verotta D
• Population analyses of atorvastatin clearance in patients living in the community and in nursing homes.
  Clinical pharmacology and therapeutics 2009 Schwartz JB, Verotta D
• Oral heroin in opioid-dependent patients: pharmacokinetic comparison of immediate and extended release tablets.
  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008 Perger L, Rentsch KM, Kullak-Ublick GA, Verotta D, Fattinger K
• A mechanistic model for the sex-specific response to nalbuphine and naloxone in postoperative pain.
  Journal of pharmacokinetics and pharmacodynamics 2007 Kshirsagar S, Gear R, Levine J, Verotta D
• Reversible jump Markov chain Monte Carlo for deconvolution.
  Journal of pharmacokinetics and pharmacodynamics 2007 Kang D, Verotta D
• Improving data reliability using a non-compliance detection method versus using pharmacokinetic criteria.
  Journal of pharmacokinetics and pharmacodynamics 2006 Kshirsagar SA, Blaschke TF, Sheiner LB, Krygowski M, Acosta EP, Verotta D
• A non-linear mixed effect dynamic model incorporating prior exposure and adherence to treatment to describe long-term therapy outcome in HIV-patients.
  Journal of pharmacokinetics and pharmacodynamics 2006 Labbé L, Verotta D
• Pharmacokinetic-pharmacodynamic modelling: history and perspectives.
  Journal of pharmacokinetics and pharmacodynamics 2006 Csajka C, Verotta D
• Population analyses of amlodipine in patients living in the community and patients living in nursing homes.
  Clinical pharmacology and therapeutics 2006 Kang D, Verotta D, Schwartz JB
• Sample size computations for PK/PD population models.
  Journal of pharmacokinetics and pharmacodynamics 2005 Kang D, Schwartz JB, Verotta D
• The use of a sum of inverse Gaussian functions to describe the absorption profile of drugs exhibiting complex absorption.
  Pharmaceutical research 2005 Csajka C, Drover D, Verotta D
• A predictive model for exemestane pharmacokinetics/pharmacodynamics incorporating the effect of food and formulation.
  British journal of clinical pharmacology 2005 Valle M, Di Salle E, Jannuzzo MG, Poggesi I, Rocchetti M, Spinelli R, Verotta D
• Mechanistic pharmacokinetic modelling of ephedrine, norephedrine and caffeine in healthy subjects.
  British journal of clinical pharmacology 2005 Csajka C, Haller CA, Benowitz NL, Verotta D
• Mechanistic pharmacokinetic and pharmacodynamic modeling of CHF3381 (2-[(2,3-dihydro-1H-inden-2-yl)amino]acetamide monohydrochloride), a novel N-methyl-D-aspartate antagonist and monoamine oxidase-A inhibitor in healthy subjects.
  The Journal of pharmacology and experimental therapeutics 2005 Csajka C, Imbimbo BP, Piccinno A, Dostert P, Verotta D
• A sample size computation method for non-linear mixed effects models with applications to pharmacokinetics models.
  Statistics in medicine 2004 Kang D, Schwartz JB, Verotta D
• CSF quinolinic acid levels are determined by local HIV infection: cross-sectional analysis and modelling of dynamics following antiretroviral therapy.
  Brain : a journal of neurology 2004 Valle M, Price RW, Nilsson A, Heyes M, Verotta D
• Volterra series in pharmacokinetics and pharmacodynamics.
  Journal of pharmacokinetics and pharmacodynamics 2003 Verotta D
• Population analyses of sustained-release verapamil in patients: effects of sex, race, and smoking.
  Clinical pharmacology and therapeutics 2003 Kang D, Verotta D, Krecic-Shepard ME, Modi NB, Gupta SK, Schwartz JB
• Modeling nicotine arterial-venous differences to predict arterial concentrations and input based on venous measurements: application to smokeless tobacco and nicotine gum.
  Journal of pharmacokinetics and pharmacodynamics 2002 Pitsiu M, Gries JM, Benowitz N, Gourlay SG, Verotta D
• Non-linear dynamics models characterizing long-term virological data from AIDS clinical trials.
  Mathematical biosciences 2002 Verotta D, Schaedeli F
• A semiparametric deconvolution model to establish in vivo-in vitro correlation applied to OROS oxybutynin.
  Journal of pharmaceutical sciences 2001 Pitsiu M, Sathyan G, Gupta S, Verotta D
• Linear mixed-effect multivariate adaptive regression splines applied to nonlinear pharmacokinetics data.
  Journal of biopharmaceutical statistics 2000 Gries JM, Verotta D
• Nasal mucosal versus gastrointestinal absorption of nasally administered cocaine.
  European journal of clinical pharmacology 2000 Fattinger K, Benowitz NL, Jones RT, Verotta D
• Additive inhibition of nicotinic acetylcholine receptors by corticosteroids and the neuromuscular blocking drug vecuronium.
  Anesthesiology 2000 Kindler CH, Verotta D, Gray AT, Gropper MA, Yost CS
• Down-regulation models and modeling of testosterone production induced by recombinant human choriogonadotropin.
  The Journal of pharmacology and experimental therapeutics 1999 Gries JM, Munafo A, Porchet HC, Verotta D
• A general solution for nonparametric control of a linear system using computer-controlled infusion pumps.
  IEEE transactions on bio-medical engineering 1999 Verotta D
• Characterizing the variability of system kernel and input estimates.
  Annals of biomedical engineering 1998 Verotta D
• Use of a pharmacokinetic/pharmacodynamic model to design an optimal dose input profile.
  Journal of pharmacokinetics and biopharmaceutics 1998 Park K, Verotta D, Gupta SK, Sheiner LB
• Importance of chronopharmacokinetics in design and evaluation of transdermal drug delivery systems.
  The Journal of pharmacology and experimental therapeutics 1998 Gries JM, Benowitz N, Verotta D
• Passive versus electrotransport-facilitated transdermal absorption of ketorolac.
  Clinical pharmacology and therapeutics 1998 Park K, Verotta D, Gupta SK, Sheiner LB
• Age effects on interrelationships between lung volume and heart rate during standing.
  The American journal of physiology 1997 Stanley G, Verotta D, Craft N, Siegel RA, Schwartz JB
• Exposure-response relationships for saquinavir, zidovudine, and zalcitabine in combination therapy.
  Antimicrobial agents and chemotherapy 1997 Vanhove GF, Gries JM, Verotta D, Sheiner LB, Coombs R, Collier AC, Blaschke TF
• Pharmacokinetics of saquinavir, zidovudine, and zalcitabine in combination therapy.
  Antimicrobial agents and chemotherapy 1997 Vanhove GF, Kastrissios H, Gries JM, Verotta D, Park K, Collier AC, Squires K, Sheiner LB, Blaschke TF
• A semiparametric method for describing noisy population pharmacokinetic data.
  Journal of pharmacokinetics and biopharmaceutics 1997 Park K, Verotta D, Blaschke TF, Sheiner LB
• Pharmacodynamics of acute tolerance to multiple nicotinic effects in humans.
  The Journal of pharmacology and experimental therapeutics 1997 Fattinger K, Verotta D, Benowitz NL
• A general framework for non-parametric subject-specific and population deconvolution methods for in vivo-in vitro correlation.
  Advances in experimental medicine and biology 1997 Verotta D
• A pooled analysis of CD4 response to zidovudine and zalcitabine treatment in patients with AIDS and AIDS-related complex.
  Clinical pharmacology and therapeutics 1997 Gries JM, Troconiz IF, Verotta D, Jacobson M, Sheiner LB
• Chronopharmacokinetics of nicotine.
  Clinical pharmacology and therapeutics 1996 Gries JM, Benowitz N, Verotta D
• Modeling a bivariate control system: LH and testosterone response to the GnRH antagonist antide.
  The American journal of physiology 1996 Fattinger KE, Verotta D, Porchet HC, Munafo A, Le Cotonnec JY, Sheiner LB
• Age and autonomic effects on interrelationships between lung volume and heart rate.
  The American journal of physiology 1996 Stanley G, Verotta D, Craft N, Siegel RA, Schwartz JB
• A descriptive tool to characterize nonlinear kinetics, with applications to meperidine and lidocaine.
  Journal of pharmaceutical sciences 1996 Gries JM, Upton R, Huang YF, Verotta D
• Concepts, properties, and applications of linear systems to describe distribution, identify input, and control endogenous substances and drugs in biological systems.
  Critical reviews in biomedical engineering 1996 Verotta D
• A new method to explore the distribution of interindividual random effects in non-linear mixed effects models.
  Biometrics 1995 Fattinger KE, Sheiner LB, Verotta D
• A nonparametric subject-specific population method for deconvolution: I. Description, internal validation, and real data examples.
  Journal of pharmacokinetics and biopharmaceutics 1995 Fattinger KE, Verotta D
• A nonparametric subject-specific population method for deconvolution: II. External validation.
  Journal of pharmacokinetics and biopharmaceutics 1995 Fattinger KE, Verotta D
• Estimating bioavailability when clearance changes in time: the effect of model misspecification.
  Clinical pharmacology and therapeutics 1995 Fattinger KE, Verotta D
• Further notes on physiologic indirect response models.
  Clinical pharmacology and therapeutics 1995 Sheiner LB, Verotta D
• A general conceptual model for non-steady state pharmacokinetic/pharmacodynamic data.
  Journal of pharmacokinetics and biopharmaceutics 1995 Verotta D, Sheiner LB
• Pharmacokinetic-pharmacodynamic (PK-PD) modelling in non-steady-state studies and arterio-venous drug concentration differences.
  British journal of clinical pharmacology 1994 Gumbleton M, Oie S, Verotta D
• Semiparametric models for antagonistic drug interactions.
  Journal of applied physiology (Bethesda, Md. : 1985) 1994 Troconiz IF, Sheiner LB, Verotta D
• Estimation and model selection in constrained deconvolution.
  Annals of biomedical engineering 1993 Verotta D
• Two constrained deconvolution methods using spline functions.
  Journal of pharmacokinetics and biopharmaceutics 1993 Verotta D
• Aging effects on stereoselective pharmacokinetics and pharmacodynamics of verapamil.
  The Journal of pharmacology and experimental therapeutics 1993 Schwartz JB, Troconiz IF, Verotta D, Liu S, Capili H
• Building population pharmacokinetic--pharmacodynamic models. I. Models for covariate effects.
  Journal of pharmacokinetics and biopharmaceutics 1992 Mandema JW, Verotta D, Sheiner LB
• Elderly, conscious patients have an accentuated hypotensive response to nitroglycerin.
  Anesthesiology 1992 Cahalan MK, Hashimoto Y, Aizawa K, Verotta D, Ionescu P, Balea M, Eger EI, Benet LZ, Ehrenfeld WK, Goldstone J
• Comparing responses when each response is a curve.
  The American journal of physiology 1992 Verotta D, Sheiner LB
• Effects of interleukin 3 and interleukin 6 on platelet recovery in mice treated with 5-fluorouracil.
  Experimental hematology 1992 Carrington PA, Hill RJ, Levin J, Verotta D
• Reversal of neuromuscular blockade in humans by neostigmine and edrophonium: a mathematical model.
  Journal of pharmacokinetics and biopharmaceutics 1991 Verotta D, Kitts J, Rodriguez R, Coldwell J, Miller RD, Sheiner LB
• Semiparametric analysis of non-steady-state pharmacodynamic data.
  Journal of pharmacokinetics and biopharmaceutics 1991 Verotta D, Sheiner LB
• Mean time parameters for generalized physiological flow models (semihomogeneous linear systems).
  Journal of pharmacokinetics and biopharmaceutics 1991 Verotta D, Sheiner LB, Beal SL
• An application of the D-optimal criterion to define the experimental design for a particular class of semi-parametric models.
  Computer methods and programs in biomedicine 1990 Verotta D
• Comments on two recent deconvolution methods.
  Journal of pharmacokinetics and biopharmaceutics 1990 Verotta D
• Comparative tissue concentration profiles of fentanyl and alfentanil in humans predicted from tissue/blood partition data obtained in rats.
  Anesthesiology 1990 Björkman S, Stanski DR, Verotta D, Harashima H
• Pharmacodynamic modeling of verapamil effects under steady-state and nonsteady-state conditions.
  The Journal of pharmacology and experimental therapeutics 1989 Schwartz JB, Verotta D, Sheiner LB
• The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose.
  Clinical pharmacology and therapeutics 1989 Boyd RA, Chin SK, Don-Pedro O, Verotta D, Sheiner LB, Williams RL, Giacomini KM
• A semiparametric approach to physiological flow models.
  Journal of pharmacokinetics and biopharmaceutics 1989 Verotta D, Sheiner LB, Ebling WF, Stanski DR
• An inequality-constrained least-squares deconvolution method.
  Journal of pharmacokinetics and biopharmaceutics 1989 Verotta D
• Pharmacokinetic and pharmacodynamic modelling of metoprolol in rabbits with liver failure.
  European journal of drug metabolism and pharmacokinetics 1989 Bortolotti A, Castelli D, Verotta D, Bonati M
• Semiparametric approach to pharmacokinetic-pharmacodynamic data.
  The American journal of physiology 1989 Verotta D, Beal SL, Sheiner LB
• A new criterion for selection of pharmacokinetic multiexponential equations.
  Journal of pharmaceutical sciences 1988 Imbimbo BP, Imbimbo E, Daniotti S, Verotta D, Bassotti G
• Software for experimental design: the computer program EXCAD.
  Computer methods and programs in biomedicine 1988 Verotta D
• D-optimal design applied to binding saturation curves of an enkephalin analog in rat brain.
  Life sciences 1988 Verotta D, Petrillo P, La Regina A, Rocchetti M, Tavani A
• Simultaneous modeling of pharmacokinetics and pharmacodynamics: an improved algorithm.
  Computer applications in the biosciences : CABIOS 1987 Verotta D, Sheiner LB
• Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man.
  Journal of pharmacokinetics and biopharmaceutics 1987 Schüttler J, Stanski DR, White PF, Trevor AJ, Horai Y, Verotta D, Sheiner LB
• Differential postnatal development of mu-, delta- and kappa-opioid binding sites in rat brain.
  Brain research 1987 Petrillo P, Tavani A, Verotta D, Robson LE, Kosterlitz HW
• MODDIS: a microcomputer program for model discrimination.
  Computer methods and programs in biomedicine 1986 Verotta D, Recchia M, Urso R
• Allosteric inhibition as a model to explain flatter displacement curves in binding experiments: application to "heterogeneous" serotonin receptors.
  Journal of receptor research 1986 Gobbi M, Barone D, Dagnino G, Verotta D, Mennini T
• Non-linear fitting program for biological data.
  International journal of bio-medical computing 1986 Bartosek I, Verotta D