Davide Ruggero, PhD
Professor
Urology
School of Medicine

davide.ruggero@ucsf.edu 415-514-9755

Awards

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Co-Organizer, ACS “Expanding the Central Dogma to Fight Cancer” Symposium, 2020
Co-Organizer, QBI Cancer Cell Symposium, 2020
American Cancer Society (ACS) Research Professorship Award, 2019
Chair, NCI Special Workshop on Dysregulation of Ribosome Biogenesis & Protein Synthesis in Cancer, 2019
NCI Outstanding Investigator Award (R35), 2019
Co-Chair, 2018 Cold Spring Harbor Laboratories Meeting on Translational Control, 2018
Chair, Annual AACR Educational Session on "Translation Control in cancer: From Basic Science to Ther, 2017
Chair, Annual AACR Educational Session on "Translation Control in cancer: From Basic Science to Ther, 2017
Chair, Annual AACR Educational Session on "Translation Control in cancer: From Basic Science to Ther, 2017
Chair, Annual AACR Educational Session on "Translation Control in cancer: From Basic Science to Ther, 2017
Chair, Annual AACR Educational Session on "Translation Control in cancer: From Basic Science to Ther, 2017
Co-Chair and Organizer, AACR Special Conference on "Translating the cancer genome: a new frontier in, 2016
Chair, 2013 AACR Annual Meeting Major Symposium on "Stress Response Pathways in Cancer", 2013
Co-Organizer, AACR 3rd International Conference on Frontiers in Basic Cancer Research, 2013
Helen Diller Family Endowed Chair of Basic Cancer Research, 2011
Co-Chair and Organizer, 1st American Association for Cancer Research "Protein Translation and Cancer, 2010
Leukemia & Lymphoma Society Scholar Award, 2010
Phi Beta Psi Sorority National Project Research Award, 2010
UCSF Program for Breakthrough Biomedical Research Award, 2010
AACR Gertrude B. Elion Cancer Research Award, 2008
Pennsylvania Department of Health Merit Award (Commonwealth Universal Research Enhancement Program), 2006-2007
V Foundation Scholar Award, 2005-2007
Outstanding Research Fellow Award at MSKCC, 2003
American-Italian Cancer Foundation Fellowship, 1998-2000
Enichem Society Fellowship, 1994

Education & Training

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Ph.D. Molecular and Cell Biology University of Rome 1998
B.S. Biology University of Rome 1994

Websites

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Profile at urology.ucsf.edu (urology.ucsf.edu)

Grants and Projects

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Publications (144)

Top publication keywords:
PhosphoproteinsRibosomal ProteinsCarcinogenesisRibosomesRNA, Small NucleolarTOR Serine-Threonine KinasesProtein BiosynthesisProto-Oncogene Proteins c-mycCell Cycle ProteinsDyskeratosis CongenitaPseudouridineCell Transformation, Neoplastic5' Untranslated RegionsGenes, mycEukaryotic Initiation Factor-4E

Functional screen for mediators of onco-mRNA translation specificity.
bioRxiv : the preprint server for biology 2024 Kovalski JR, Sarioglu G, Subramanyam V, Hernandez G, Rademaker G, Oses-Prieto JA, Slota M, Mohan N, Yiakis K, Liu I, Wen KW, Kim GE, Miglani S, Burlingame AL, Goodarzi H, Perera RM, Ruggero D
Abstract A078: Functional screen for mediators of onco-mRNA translation specificity in pancreatic cancer.
Cancer Research 2024 Joanna R Kovalski, Goksu Sarioglu, Vishvak Subramanyam, Grace Hernandez, Gilles Rademaker, Juan A Oses-Prieto, Macey Slota, Kwun Wah Wen, Grace E Kim, Alma L Burlingame, Hani Goodarzi, Rushika M …
RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages.
Molecular cell 2024 Susanto TT, Hung V, Levine AG, Chen Y, Kerr CH, Yoo Y, Oses-Prieto JA, Fromm L, Zhang Z, Lantz TC, Fujii K, Wernig M, Burlingame AL, Ruggero D, Barna M
The crosstalk between metabolism and translation.
Cell metabolism 2024 Biffo S, Ruggero D, Santoro MM
snoRNAs in making "snoman" ribosomes.
Molecular cell 2024 Dabrowska A, Ruggero D

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Remodelling of the translatome controls diet and its impact on tumorigenesis.
Nature 2024 Yang H, Zingaro VA, Lincoff J, Tom H, Oikawa S, Oses-Prieto JA, Edmondson Q, Seiple I, Shah H, Kajimura S, Burlingame AL, Grabe M, Ruggero D
miR-217 Regulates Normal and Tumor Cell Fate Following Induction of Endoplasmic Reticulum Stress.
Molecular cancer research : MCR 2024 Dey N, Koumenis C, Ruggero D, Fuchs SY, Diehl JA
RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages.
bioRxiv : the preprint server for biology 2023 Susanto TT, Hung V, Levine AG, Kerr CH, Yoo Y, Chen Y, Oses-Prieto JA, Fromm L, Fujii K, Wernig M, Burlingame AL, Ruggero D, Barna M
Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer.
Nature communications 2023 Macaya I, Roman M, Welch C, Entrialgo-Cadierno R, Salmon M, Santos A, Feliu I, Kovalski J, Lopez I, Rodriguez-Remirez M, Palomino-Echeverria S, Lonfgren SM, Ferrero M, Calabuig S, Ludwig IA, Lara-…
Evolutionarily divergent mTOR remodels translatome for tissue regeneration.
Nature 2023 Zhulyn O, Rosenblatt HD, Shokat L, Dai S, Kuzuoglu-Öztürk D, Zhang Z, Ruggero D, Shokat KM, Barna M
Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates.
eLife 2023 Xu AF, Molinuevo R, Fazzari E, Tom H, Zhang Z, Menendez J, Casey KM, Ruggero D, Hinck L, Pritchard JK, Barna M
N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma.
Cancer research 2023 Kuzuoglu-Ozturk D, Aksoy O, Schmidt C, Lea R, Larson JD, Phelps RRL, Nasholm N, Holt M, Contreras A, Huang M, Wong-Michalak S, Shao H, Wechsler-Reya R, Phillips JJ, Gestwicki JE, Ruggero D, Weiss WA
Regulation of eIF4E guides a unique translational program to control erythroid maturation.
Science advances 2022 Forester CM, Oses-Prieto JA, Phillips NJ, Miglani S, Pang X, Byeon GW, DeMarco R, Burlingame A, Barna M, Ruggero D
Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3.
Nature chemistry 2022 Wang HY, Yang H, Holm M, Tom H, Oltion K, Al-Khdhairawi AAQ, Weber JF, Blanchard SC, Ruggero D, Taunton J
A tRF nucleator for Nucleolin in cancer metastasis.
Molecular cell 2022 Xu Y, Ruggero D
The promises and pitfalls of specialized ribosomes.
Molecular cell 2022 Barna M, Karbstein K, Tollervey D, Ruggero D, Brar G, Greer EL, Dinman JD
Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate.
Molecular cell 2022 Liedmann S, Liu X, Guy CS, Crawford JC, Rodriguez DA, Kuzuoglu-Öztürk D, Guo A, Verbist KC, Temirov J, Chen MJ, Ruggero D, Zhang H, Thomas PG, Green DR
Protein synthesis control in cancer: selectivity and therapeutic targeting.
The EMBO journal 2022 Kovalski JR, Kuzuoglu-Ozturk D, Ruggero D
ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance.
Cell 2021 Xu Y, Huangyang P, Wang Y, Xue L, Devericks E, Nguyen HG, Yu X, Oses-Prieto JA, Burlingame AL, Miglani S, Goodarzi H, Ruggero D
A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies.
Developmental cell 2021 Tiu GC, Kerr CH, Forester CM, Krishnarao PS, Rosenblatt HD, Raj N, Lantz TC, Zhulyn O, Bowen ME, Shokat L, Attardi LD, Ruggero D, Barna M
Releasing the brake on protein synthesis in hematopoietic stem cells.
Cell stem cell 2021 Forester CM, Ruggero D
Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome.
Cell reports 2021 Kuzuoglu-Ozturk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang GG, Worland ST, Brenner SE, Goodarzi H, Gilbert LA, Ruggero D
Reduced eIF4E function impairs B-cell leukemia without altering normal B-lymphocyte function.
iScience 2021 Chiu H, Buono R, Jackson LV, Herzog LO, Mallya S, Conn CS, Ruggero D, Fruman DA
OMIC-03. TRANSLATIONAL CONTROL IN MYC AND MYCN MEDULLOBLASTOMA.
Neuro-Oncology 2021 Christin Schmidt, Albertas Navickas, Frederique Zindy, Dana Farmer, Davide Ruggero, Hani Goodarzi, Martine F Roussel, Bjoern Schwer, William Weiss
The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity.
Nature metabolism 2021 Conn CS, Yang H, Tom HJ, Ikeda K, Oses-Prieto JA, Vu H, Oguri Y, Nair S, Gill RM, Kajimura S, DeBerardinis RJ, Burlingame AL, Ruggero D
Examining Myc-Dependent Translation Changes in Cellular Homeostasis and Cancer.
Methods in molecular biology (Clifton, N.J.) 2021 Kovalski JR, Xu Y, Ruggero D
Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2020 Zhao N, Huang Y, Wang YH, Muir RK, Chen YC, Wei J, Hooshdaran N, Viswanath P, Seo Y, Ruggero D, Renslo AR, Evans MJ
Abstract IA11: Translating the cancer genome one codon at a time and its therapeutic implications.
Molecular Cancer Research 2020 Davide Ruggero
Abstract IA17: Strategies to target the mTORC1/eIF4F axis in B-cell leukemia and lymphoma.
Molecular Cancer Research 2020 Lee-or Herzog, Bianca J. Lee, Thanh-Trang Vo, Honyin Chiu, Sharmila Mallya, Amos Fung, Mallika Singh, James Aggen, Nidhi Tibrewal, Jacqueline A.M. Smith, David Wildes, Ze'ev Ronai, Davide Ruggero, …
An Analysis of Isoclonal Antibody Formats Suggests a Role for Measuring PD-L1 with Low Molecular Weight PET Radiotracers.
Molecular imaging and biology 2020 Wei J, Wang YH, Lee CY, Truillet C, Oh DY, Xu Y, Ruggero D, Flavell RR, VanBrocklin HF, Seo Y, Craik CS, Fong L, Wang CI, Evans MJ
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Nature 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, …
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
bioRxiv : the preprint server for biology 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, …
The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications.
Annual Review of Cancer Biology 2020 Yichen Xu, Davide Ruggero
Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling.
Molecular & cellular proteomics : MCP 2019 Wei J, Leung K, Truillet C, Ruggero D, Wells JA, Evans MJ
Regulation of eIF4E Guides a Unique Translational Program to Steer Erythroid Maturation.
Blood 2019 Craig M Forester, Gun Woo-Byeon, Juan Oses-Prieto, Al Burlingame, Maria Barna, Davide M Ruggero
A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS.
eLife 2019 McMahon M, Contreras A, Holm M, Uechi T, Forester CM, Pang X, Jackson C, Calvert ME, Chen B, Quigley DA, Luk JM, Kelley RK, Gordan JD, Gill RM, Blanchard SC, Ruggero D
Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.
Nature cell biology 2019 Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salinas CS, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C
Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.
Molecular cell 2019 Fish L, Navickas A, Culbertson B, Xu Y, Nguyen HCB, Zhang S, Hochman M, Okimoto R, Dill BD, Molina H, Najafabadi HS, Alarcón C, Ruggero D, Goodarzi H
ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.
Nature cell biology 2019 Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salas Salinas C, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C
Translational Control in Cancer.
Cold Spring Harbor perspectives in biology 2019 Robichaud N, Sonenberg N, Ruggero D, Schneider RJ
Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography.
ACS central science 2019 Muir RK, Zhao N, Wei J, Wang YH, Moroz A, Huang Y, Chen YC, Sriram R, Kurhanewicz J, Ruggero D, Renslo AR, Evans MJ
A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis.
Cell host & microbe 2019 Moss SM, Taylor IR, Ruggero D, Gestwicki JE, Shokat KM, Mukherjee S
Translation control of the immune checkpoint in cancer and its therapeutic targeting.
Nature medicine 2019 Xu Y, Poggio M, Jin HY, Shi Z, Forester CM, Wang Y, Stumpf CR, Xue L, Devericks E, So L, Nguyen HG, Griselin A, Gordan JD, Umetsu SE, Reich SH, Worland ST, Asthana S, Barna M, Webster KR, Cunningham …
The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2018 Chiu H, Jackson LV, Oh KI, Mai A, Ronai ZA, Ruggero D, Fruman DA
A Translation Tuning HuDdle for Neurons.
Molecular cell 2018 McMahon M, Ruggero D
A wobbly road to drug resistance in melanoma: tRNA-modifying enzymes in translation reprogramming.
The EMBO journal 2018 McMahon M, Ruggero D
Abstract 3694: Measuring oncogene signaling with transferrin-based PET: From bench to bedside.
Clinical Research (Excluding Clinical Trials) 2018 Michael J. Evans, Charles Truillet, Davide Ruggero, Jason S. Lewis, Rahul Aggarwal, Spencer C. Behr
Development of a stress response therapy targeting aggressive prostate cancer.
Science translational medicine 2018 Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D
Revealing nascent proteomics in signaling pathways and cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2018 Forester CM, Zhao Q, Phillips NJ, Urisman A, Chalkley RJ, Oses-Prieto JA, Zhang L, Ruggero D, Burlingame AL
Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase.
Cancer cell 2018 Gwinn DM, Lee AG, Briones-Martin-Del-Campo M, Conn CS, Simpson DR, Scott AI, Le A, Cowan TM, Ruggero D, Sweet-Cordero EA
A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.
Nature cell biology 2017 Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA
CSIG-42. UNDERSTANDING THE ROLE OF TRANSLATIONAL CONTROL IN MYCN-DRIVEN MEDULLOBLASTOMA.
Neuro-Oncology 2017 Ozlem Aksoy, Qiwen Fan, Kevan Shokat, Davide Ruggero, William Weiss
New frontiers in translational control of the cancer genome.
Nature reviews. Cancer 2017 Truitt ML, Ruggero D
Editorial overview: Cell regulation: 1000 Flavors including chocolate and chili peppers.
Current opinion in cell biology 2017 Ruggero D, Shaw RJ
Abstract A25: Sensing stress in cancer: a novel therapy targeting protein synthesis through the unfolded protein response in prostate cancer development.
Translation Control: an Adaptive Response to Oncogenic Cellular Stress 2017 Crystal S. Conn, Hao G. Nguyen, Yae Kye, John T. Cunningham, Charles Truillet, Michael Evans, Tony L. Huynh, Peter Walters, Davide Ruggero
Abstract B11: Oncogenic KRAS regulates 4E-BP1, a repressor of cap-dependent translation, independently of growth factor activity.
Translation Control: an Adaptive Response to Oncogenic Cellular Stress 2017 Jillian M. Silva, Rachel K. Bagni, Davide Ruggero, Frank McCormick
Noninvasive Measurement of mTORC1 Signaling with 89Zr-Transferrin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Truillet C, Cunningham JT, Parker MFL, Huynh LT, Conn CS, Ruggero D, Lewis JS, Evans MJ
The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes.
Science signaling 2016 So L, Lee J, Palafox M, Mallya S, Woxland CG, Arguello M, Truitt ML, Sonenberg N, Ruggero D, Fruman DA
New frontiers in translational control of the cancer genome.
Nature reviews. Cancer 2016 Truitt ML, Ruggero D
Automated High-Throughput Quantification Reveals Morphological Heterogeneity in Mammalian Cell Populations.
Biophysical Journal 2016 Amy Y. Chang, Steven C. Chen, Morgan L. Truitt, Davide Ruggero, Wallace F. Marshall
A Tailor-Made Protein Synthesis Program Drives Erythroid Development and Disease.
Blood 2015 Craig M Forester, Zhen Shi, Maria Barna, Davide Ruggero
Cell type-specific abundance of 4EBP1 primes prostate cancer sensitivity or resistance to PI3K pathway inhibitors.
Science signaling 2015 Hsieh AC, Nguyen HG, Wen L, Edlind MP, Carroll PR, Kim W, Ruggero D
Abstract PR07: Myc-dependent translation makes an impact: Tailor-made protein expression for cancer development.
Therapeutic Translation 2015 Craig Stumpf, Tom Cunningham, Davide Ruggero
Differential Requirements for eIF4E Dose in Normal Development and Cancer.
Cell 2015 Truitt ML, Conn CS, Shi Z, Pang X, Tokuyasu T, Coady AM, Seo Y, Barna M, Ruggero D
Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions.
Cancer research 2015 Fujita-Sato S, Galeas J, Truitt M, Pitt C, Urisman A, Bandyopadhyay S, Ruggero D, McCormick F
YB-1 and MTA1 protein levels and not DNA or mRNA alterations predict for prostate cancer recurrence.
Oncotarget 2015 Sheridan CM, Grogan TR, Nguyen HG, Galet C, Rettig MB, Hsieh AC, Ruggero D
Targeting the eIF4F translation initiation complex: a critical nexus for cancer development.
Cancer research 2015 Pelletier J, Graff J, Ruggero D, Sonenberg N
38 Molecular Basis of Prostate Cancer.
2015 Long-Cheng Li, Andrew C. Hsieh, Davide Ruggero, Kirsten L. Greene, Peter R. Carroll
Early Hematopoietic Progenitors of Dkc1 Hypomorphic Mutant Mice Display Decreased Proliferation Rate and an Impaired Control of Serine/Arginine-Rich Splicing Factor 4 (Srsf4) Translation.
Blood 2014 Antonio R Lucena-Araujo, Bárbara A Santana-Lemos, Carol H Thome, Germano A Ferreira, Davide Ruggero, Vitor Marcel Faça, Eduardo M Rego
Small RNAs with big implications: new insights into H/ACA snoRNA function and their role in human disease.
Wiley interdisciplinary reviews. RNA 2014 McMahon M, Contreras A, Ruggero D
Abstract B78: Targeting the translational apparatus in MYCN-driven medulloblastoma.
Pediatric Oncology Translational Science and Clinical Trials 2014 Justin G. Meyerowitz, W. Clay Gustafson, Erin Nekritz, Fredrik Swartling, Kevan M. Shokat, Davide Ruggero, William A. Weiss
Marrow failure: a window into ribosome biology.
Blood 2014 Ruggero D, Shimamura A
Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer.
Cell 2014 John T. Cunningham, Melissa V. Moreno, Alessia Lodi, Sabrina M. Ronen, Davide Ruggero
Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.
Cell 2014 Cunningham JT, Moreno MV, Lodi A, Ronen SM, Ruggero D
Tailor made protein synthesis for HSCs.
Cell stem cell 2014 Barna M, Ruggero D
mTOR and Regulation of Translation.
Translation and Its Regulation in Cancer Biology and Medicine 2014 Yoshinori Tsukumo, Mathieu Laplante, Armen Parsyan, Davide Ruggero, Bruno Fonseca
Parallel measurement of dynamic changes in translation rates in single cells.
Nature methods 2013 Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T
The translational landscape of the mammalian cell cycle.
Molecular cell 2013 Stumpf CR, Moreno MV, Olshen AB, Taylor BS, Ruggero D
Abstract A46: Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers.
Cancer Signaling Networks 2013 Michael Pourdehnad, Morgan L. Truitt, Imran N. Siddiqi, Gregory S. Ducker, Kevan M. Shokat, Davide Ruggero
Abstract A57: Plasticity of the translational landscape during the mammalian cell cycle: Implications and new insights for cancer cell proliferation.
Post-Transcriptional Regulation 2013 Craig R. Stumpf, Melissa V. Moreno, Adam B. Olshen, Barry S. Taylor, Davide Ruggero
Abstract IA8: Novel insights into synthetic lethal interactions in cancer: Common nodes in protein synthesis control and nucleotide metabolism.
Cancer Research 2013 Davide Ruggero
New connections between old pathways: PDK1 signaling promotes cellular transformation through PLK1-dependent MYC stabilization.
Cancer discovery 2013 Cunningham JT, Ruggero D
Assessing gene-level translational control from ribosome profiling.
Bioinformatics (Oxford, England) 2013 Olshen AB, Hsieh AC, Stumpf CR, Olshen RA, Ruggero D, Taylor BS
Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers.
Proceedings of the National Academy of Sciences of the United States of America 2013 Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D
H/ACA small RNA dysfunctions in disease reveal key roles for noncoding RNA modifications in hematopoietic stem cell differentiation.
Cell reports 2013 Bellodi C, McMahon M, Contreras A, Juliano D, Kopmar N, Nakamura T, Maltby D, Burlingame A, Savage SA, Shimamura A, Ruggero D
Abstract SY32-04: The translation initiation factor elF2a regulates cytoprotective autophagy in Myc-dependent lymphoma.
Molecular and Cellular Biology 2013 Constantinos Koumenis, Lori S. Hart, Tom Cunningham, Souvik Dey, Feven Tameire, Ian Mills, Davide Ruggero, Alan J. Diehl, Serge Fuchs
Common variable immunodeficiency as the initial presentation of dyskeratosis congenita.
The Journal of allergy and clinical immunology 2013 Allenspach EJ, Bellodi C, Jeong D, Kopmar N, Nakamura T, Ochs HD, Ruggero D, Skoda-Smith S, Shimamura A, Torgerson TR
Translational control in cancer etiology.
Cold Spring Harbor perspectives in biology 2013 Ruggero D
Investigating Myc-dependent translational regulation in normal and cancer cells.
Methods in molecular biology (Clifton, N.J.) 2013 Cunningham JT, Pourdehnad M, Stumpf CR, Ruggero D
Exaggerated translation causes synaptic and behavioural aberrations associated with autism.
Nature 2012 Santini E, Huynh TN, MacAskill AF, Carter AG, Pierre P, Ruggero D, Kaphzan H, Klann E
Autism-related deficits via dysregulated eIF4E-dependent translational control.
Nature 2012 Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.
The Journal of clinical investigation 2012 Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG,…
Translational Control in Cancer Etiology.
Cold Spring Harbor Perspectives in Biology 2012 Davide Ruggero
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.
Science (New York, N.Y.) 2012 Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA
Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling.
Science signaling 2012 Ruggero D
Abstract 2347: Translational control and lung cancer: eIF4F activation promotes tumorigenesis in vivo.
Tumor Biology 2012 Joel A. McCauley, Kristen Evenson, Morgan Truitt, Robert Kratzke, Vitaly Polunovsky, Davide Ruggero, Peter BItterman, Jonathan D'Cunha
The translational landscape of mTOR signalling steers cancer initiation and metastasis.
Nature 2012 Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D
The “Fifth” RNA Nucleotide: A Role for Ribosomal RNA Pseudouridylation in Control of Gene Expression at the Translational Level.
Biophysical approaches to translational control of gene expression 2012 Mary McMahon, Cristian Bellodi, Davide Ruggero
rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells.
Molecular cell 2011 Jack K, Bellodi C, Landry DM, Niederer RO, Meskauskas A, Musalgaonkar S, Kopmar N, Krasnykh O, Dean AM, Thompson SR, Ruggero D, Dinman JD
Oncogenic AKTivation of translation as a therapeutic target.
British journal of cancer 2011 Hsieh AC, Truitt ML, Ruggero D
The cancerous translation apparatus.
Current opinion in genetics & development 2011 Stumpf CR, Ruggero D
Abstract 2078: PERK-mediated autophagy promotes Myc-induced transformation and tumorigenesis.
Cellular and Molecular Biology 2011 Lori S. Hart, Tom Cunningham, Tatini Datta, Huayi Liu, Albert C. Koong, Serge Fuchs, J. Alan Diehl, Davide Ruggero, Constantinos Koumenis
Abstract SY06-02: Activation of the UPR by c-Myc promotes transformation and tumorigenesis via cytoprotective autophagy.
Experimental and Molecular Therapeutics 2011 Constantinos Koumenis, Haiyan Zhang, Meixia Bi, Stacey L. Lehman, Tatini Datta, Huayi Liu, Andrei Thomas-Tikhonenko, Albert Koong, Serge Y. Fuchs, J. Alan Diehl, Davide Ruggero
Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Hsieh AC, Ruggero D
Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis.
Cancer research 2010 Bellodi C, Krasnykh O, Haynes N, Theodoropoulou M, Peng G, Montanaro L, Ruggero D
Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita.
The EMBO journal 2010 Bellodi C, Kopmar N, Ruggero D
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E.
Cancer cell 2010 Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, Meyuhas O, Shokat KM, Ruggero D
The role of Myc-induced protein synthesis in cancer.
Cancer research 2009 Ruggero D
Kaplan et al. reply.
Nature 2009 Rosandra N. Kaplan, Rebecca D. Riba, Stergios Zacharoulis, Anna H. Bramley, Loïc Vincent, Carla Costa, Daniel D. MacDonald, David K. Jin, Koji Shido, Scott A. Kerns, Zhenping Zhu, Daniel Hicklin, Yan …
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
PLoS biology 2009 Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.
Nature 2008 Barna M, Pusic A, Zollo O, Costa M, Kondrashov N, Rego E, Rao PH, Ruggero D
130 INVITED Novel insight into the pathogenesis of dyskeratosis congenita: how defective ribosome activity can cause cancer and disease.
European Journal of Cancer Supplements 2007 D. Ruggero, A. Yoon, G. Peng, O. Zollo, R. Adamo, N. Haynes, W. Xu, E. Rego
Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita.
Science (New York, N.Y.) 2006 Yoon A, Peng G, Brandenburger Y, Brandenburg Y, Zollo O, Xu W, Rego E, Ruggero D
Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha.
Oncogene 2006 Rego EM, Ruggero D, Tribioli C, Cattoretti G, Kogan S, Redner RL, Pandolfi PP
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche.
Nature 2005 Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, …
The Akt of translational control.
Oncogene 2005 Ruggero D, Sonenberg N
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.
Nature medicine 2004 Ruggero D, Montanaro L, Ma L, Xu W, Londei P, Cordon-Cardo C, Pandolfi PP
Does the ribosome translate cancer?
Nature reviews. Cancer 2003 Ruggero D, Pandolfi PP
Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification.
Science (New York, N.Y.) 2003 Ruggero D, Grisendi S, Piazza F, Rego E, Mari F, Rao PH, Cordon-Cardo C, Pandolfi PP
Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling.
Developmental cell 2002 Barna M, Merghoub T, Costoya JA, Ruggero D, Branford M, Bergia A, Samori B, Pandolfi PP
The puzzling multiple lives of PML and its role in the genesis of cancer.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000 Ruggero D, Wang ZG, Pandolfi PP
Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis.
The Journal of experimental medicine 2000 Zhong S, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi PP
Cis-acting signals controlling translational initiation in the thermophilic archaeon Sulfolobus solfataricus.
Molecular microbiology 1999 Condò I, Ciammaruconi A, Benelli D, Ruggero D, Londei P
PML is essential for multiple apoptotic pathways.
Nature genetics 1998 Wang ZG, Ruggero D, Ronchetti S, Zhong S, Gaboli M, Rivi R, Pandolfi PP
A novel aminopeptidase associated with the 60 kDa chaperonin in the thermophilic archaeon Sulfolobus solfataricus.
Molecular microbiology 1998 Condò I, Ruggero D, Reinhardt R, Londei P
The chaperonin of the archaeon Sulfolobus solfataricus is an RNA-binding protein that participates in ribosomal RNA processing.
The EMBO journal 1998 Ruggero D, Ciammaruconi A, Londei P
Differential antibiotic sensitivity determined by the large ribosomal subunit in thermophilic archaea.
Journal of bacteriology 1996 Ruggero D, Londei P
In vitro translation of archaeal natural mRNAs at high temperature.
FEMS Microbiology Letters 1993 Davide Ruggero, Roberta Creti, Paola Londei
Lithium and granulocytopenia during induction treatment of adult acute lymphoblastic leukemia.
Tumori 1982 Bandini G, Ricci P, Ruggero D, Cantore M, Visani G, Tura S
Treatment of severe aplastic anaemia with antilymphocyte globulin or bone-marrow transplantation.
British medical journal (Clinical research ed.) 1981 Speck B, Gratwohl A, Nissen C, Leibundgut U, Ruggero D, Osterwalder B, Burri HP, Cornu P, Jeannet M
[Experience with intensive plasma exchange].
Schweizerische medizinische Wochenschrift 1980 Gratwohl A, Cornu P, Nissen C, Ruggero D, Osterwalder B, Speck B
Serum lysozyme level in adult acute non-lymphoid leukaemia.
Haematologica 1979 Bandini G, Ricci P, Baccarani M, Ruggero D, Tura S
Adult acute lymphoblastic leukaemia: study of 32 patients and analysis of prognostic factors.
Scandinavian journal of haematology 1979 Ruggero D, Baccarani M, Gobbi M, Tura S
Sex and prognosis in adult acute lymphoblastic leukaemia.
British medical journal 1978 Baccarani M, Ruggero D, Gobbi M, Tura S
Ph1-positive chronic myeloid leukaemia presenting in blastic crisis: report of 12 cases.
Bollettino dell'Istituto sieroterapico milanese 1978 Zaccaria A, Ruggero D, Guolo ML, Guarini A, Frezza R, Baccarani M, Tura S
Therapy of chronic myeloid leukemia (CML): interim report on protocols CML/73 and CML/74.
Bollettino dell'Istituto sieroterapico milanese 1978 Baccarani M, Ruggero D, Tura S
Immunotherapy with BCG and leukemic blast cells during complete remission of acute myeloid leukemia.
Haematologica 1977 Gobbi M, Ruggero D, Baccarani M, Zaccaria A, Tomasini I, Tura S
Nervous system involvement in adult acute myeloid leukaemia: report of five cases.
Haematologica 1977 Ruggero D, Baccarani M, Zaccaria A, Gobbi M, Tomasini I, Tura S
Immunological study of patients with Hodgkin's disease in long-lasting not-maintained complete remission.
Bollettino dell'Istituto sieroterapico milanese 1977 Gobbi M, Fiacchini M, Tomasini I, Ruggero D, Lauria F, Tura S
Acute promyelocytic leukemia: results of therapy and analysis of 13 cases.
Acta haematologica 1977 Ruggero D, Baccarani M, Guarini A, Gugliotta L, Gobbi M, Ricci P, Zaccaria A, Lauria F, Tomasini I, Fiacchini M, Santucci MA, Tura S
[Progress and problems in the treatment of acute myeloid leukemia: analysis of 92 cases].
Giornale di clinica medica 1976 Ruggero D, Baccarani M, Tomasini I, Gobbi M, Santucci MA, Guarini A, Tura S
["Cured" Hodgkin's disease in a retrospective study of 147 cases].
Giornale di clinica medica 1976 Fiacchini M, Ruggero D, Tomasini I, Sciascia R, Emiliani E, Babini L
[Antibiotic therapy in the high risk patient (hematologic study)].
Giornale di clinica medica 1976 Tura S, Ruggero D
A simultaneous study of bone marrow, spleen, and liver in chronic myeloid leukemia: evidence for differences in cell composition and karyotypes.
Series haematologica (1968) 1975 Baccarani M, Zaccaria A, Santucci AM, Bagnara GP, Ricci P, Gobbi M, Ruggero D, Brunelli MA, Tura S

Davide Ruggero, PhDProfessorUrologySchool of Medicine