David Ziegler, PhD
Associate Professor
Neurology
School of Medicine

Education & Training

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• Postdoc Neurology UCSF 2016
• PhD Systems Neuroscience MIT 2011
• BS Psychobiology Denison University 1999

Websites

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• Neuroscape (neuroscape.ucsf.edu)

Grants and Projects

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• Optimizing a closed-loop digital meditation intervention for remediating cognitive decline and reducing stress in older adults, NIH, 2022-2028
• Optimizing a closed-loop digital meditation intervention for remediating cognitive decline and reducing stress in older adults, NIH/NIA, 2022-2028
• A Pilot Study of the Impact of Personalized Digital Meditation on Improving Cognition and Sleep and Reducing Stress in MCI, NIH/NIA, 2023-2026
• Accelerating Cognitive Gains from Digital Meditation with Noninvasive Brain Stimulation: A Pilot Study in MCI, NIH/NIA, 2023-2026
• A Pilot Study of the Impact of Personalized Digital Meditation on Improving Cognition and Sleep and Reducing Stress in MCI, NIH, 2023-2025
• Accelerating Cognitive Gains from Digital Meditation with Noninvasive Brain Stimulation: A Pilot Study in MCI, NIH, 2023-2025

Publications (29)

Top publication keywords:
TechnologyCognitionEvent-Related Potentials, P300MindfulnessReceptors, Dopamine D2AttentionImpulsive BehaviorCorpus StriatumParietal LobeCatechol O-MethyltransferaseSubstantia NigraMeditationNeurofeedbackMemory, Short-TermAging

• Closed-Loop Systems and Real-Time Neurofeedback in Mindfulness Meditation Research.
  Biological psychiatry. Cognitive neuroscience and neuroimaging 2024 Chen JCC, Ziegler DA
• Closed-loop digital meditation improves sustained attention in young adults.
  Nature human behaviour 2019 Ziegler DA, Simon AJ, Gallen CL, Skinner S, Janowich JR, Volponi JJ, Rolle CE, Mishra J, Kornfield J, Anguera JA, Gazzaley A
• Substantia nigra volume loss before basal forebrain degeneration in early Parkinson disease.
  JAMA neurology 2013 Ziegler DA, Wonderlick JS, Ashourian P, Hansen LA, Young JC, Murphy AJ, Koppuzha CK, Growdon JH, Corkin S
• Localization of white matter volume increase in autism and developmental language disorder.
  Annals of neurology 2004 Herbert MR, Ziegler DA, Makris N, Filipek PA, Kemper TL, Normandin JJ, Sanders HA, Kennedy DN, Caviness VS
• Quantifying attention span across the lifespan.
  Frontiers in cognition 2023 Simon AJ, Gallen CL, Ziegler DA, Mishra J, Marco EJ, Anguera JA, Gazzaley A

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• Leveraging technology to personalize cognitive enhancement methods in aging.
  Nature aging 2022 Ziegler DA, Anguera JA, Gallen CL, Hsu WY, Wais PE, Gazzaley A
• The Generation of Involuntary Mental Imagery in an Ecologically-Valid Task.
  Frontiers in psychology 2021 Velasquez AG, Gazzaley A, Toyoda H, Ziegler DA, Morsella E
• Reconfiguration of Electroencephalography Microstate Networks after Breath-Focused, Digital Meditation Training.
  Brain connectivity 2021 Bréchet L, Ziegler DA, Simon AJ, Brunet D, Gazzaley A, Michel CM
• Focus on the Breath: Brain Decoding Reveals Internal States of Attention During Meditation.
  Frontiers in human neuroscience 2020 Weng HY, Lewis-Peacock JA, Hecht FM, Uncapher MR, Ziegler DA, Farb NAS, Goldman V, Skinner S, Duncan LG, Chao MT, Gazzaley A
• β-amyloid and tau drive early Alzheimer's disease decline while glucose hypometabolism drives late decline.
  Communications biology 2020 Hammond TC, Xing X, Wang C, Ma D, Nho K, Crane PK, Elahi F, Ziegler DA, Liang G, Cheng Q, Yanckello LM, Jacobs N, Lin AL
• Closed-loop digital meditation for neurocognitive and behavioral development in adolescents with childhood neglect.
  Translational psychiatry 2020 Mishra J, Sagar R, Parveen S, Kumaran S, Modi K, Maric V, Ziegler D, Gazzaley A
• Differential Impact of Interference on Internally- and Externally-Directed Attention.
  Scientific reports 2018 Ziegler DA, Janowich JR, Gazzaley A
• Training Working Memory: Anatomy Matters.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Simon AJ, Skinner SN, Ziegler DA
• Motor impulsivity in Parkinson disease: associations with COMT and DRD2 polymorphisms.
  Scandinavian journal of psychology 2014 Ziegler DA, Ashourian P, Wonderlick JS, Sarokhan AK, Prelec D, Scherzer CR, Corkin S
• Harnessing advances in structural MRI to enhance research on Parkinson's disease.
  Imaging in medicine 2013 Ziegler DA, Augustinack JC
• A cognitive framework for understanding and improving interference resolution in the brain.
  Progress in brain research 2013 Mishra J, Anguera JA, Ziegler DA, Gazzaley A
• New MRI Biomarkers Advance the Characterization of Parkinson Disease.
  European neurological review 2013 Ziegler DA, Corkin S
• Statistical adjustments for brain size in volumetric neuroimaging studies: some practical implications in methods.
  Psychiatry research 2011 O'Brien LM, Ziegler DA, Deutsch CK, Frazier JA, Herbert MR, Locascio JJ
• Transformations in oscillatory activity and evoked responses in primary somatosensory cortex in middle age: a combined computational neural modeling and MEG study.
  NeuroImage 2010 Ziegler DA, Pritchett DL, Hosseini-Varnamkhasti P, Corkin S, Hämäläinen M, Moore CI, Jones SR
• Cognition in healthy aging is related to regional white matter integrity, but not cortical thickness.
  Neurobiology of aging 2008 Ziegler DA, Piguet O, Salat DH, Prince K, Connally E, Corkin S
• Reliability of MRI-derived cortical and subcortical morphometric measures: effects of pulse sequence, voxel geometry, and parallel imaging.
  NeuroImage 2008 Wonderlick JS, Ziegler DA, Hosseini-Varnamkhasti P, Locascio JJ, Bakkour A, van der Kouwe A, Triantafyllou C, Corkin S, Dickerson BC
• Amygdala volume associated with alcohol abuse relapse and craving.
  The American journal of psychiatry 2008 Wrase J, Makris N, Braus DF, Mann K, Smolka MN, Kennedy DN, Caviness VS, Hodge SM, Tang L, Albaugh M, Ziegler DA, Davis OC, Kissling C, Schumann G, Breiter HC, Heinz A
• Adjustment for whole brain and cranial size in volumetric brain studies: a review of common adjustment factors and statistical methods.
  Harvard review of psychiatry 2006 O'Brien LM, Ziegler DA, Deutsch CK, Kennedy DN, Goldstein JM, Seidman LJ, Hodge S, Makris N, Caviness V, Frazier JA, Herbert MR
• Volumetric neuroimaging and low-dose early-life exposures: loose coupling of pathogenesis-brain-behavior links.
  Neurotoxicology 2005 Herbert MR, Ziegler DA
• Language-association cortex asymmetry in autism and specific language impairment.
  Annals of neurology 2004 De Fossé L, Hodge SM, Makris N, Kennedy DN, Caviness VS, McGrath L, Steele S, Ziegler DA, Herbert MR, Frazier JA, Tager-Flusberg H, Harris GJ
• Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis.
  Brain : a journal of neurology 2004 Herbert MR, Ziegler DA, Deutsch CK, O'Brien LM, Kennedy DN, Filipek PA, Bakardjiev AI, Hodgson J, Takeoka M, Makris N, Caviness VS
• Decreased absolute amygdala volume in cocaine addicts.
  Neuron 2004 Makris N, Gasic GP, Seidman LJ, Goldstein JM, Gastfriend DR, Elman I, Albaugh MD, Hodge SM, Ziegler DA, Sheahan FS, Caviness VS, Tsuang MT, Kennedy DN, Hyman SE, Rosen BR, Breiter HC
• Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys.
  Brain : a journal of neurology 2003 Herbert MR, Ziegler DA, Deutsch CK, O'Brien LM, Lange N, Bakardjiev A, Hodgson J, Adrien KT, Steele S, Makris N, Kennedy D, Harris GJ, Caviness VS
• Abnormal asymmetry in language association cortex in autism.
  Annals of neurology 2002 Herbert MR, Harris GJ, Adrien KT, Ziegler DA, Makris N, Kennedy DN, Lange NT, Chabris CF, Bakardjiev A, Hodgson J, Takeoka M, Tager-Flusberg H, Caviness VS