David Wilson, MD, PhD
Professor
Radiology
School of Medicine

Dr. Wilson’s subsequent clinical training was in radiology and neuroradiology at University of California, San Francisco (UCSF), where he trained further in the laboratory of Professor John Kurhanewicz and subsequently became a faculty member in 2010. He has since established a basic science laboratory investigating the detection and characterization of cancer via analyte sensing, and developing probes for positron emission tomography (PET) and hyperpolarized 13C spectroscopy. His laboratory has most recently studied imaging infection using bacteria-specific metabolic pathways, and ways to detect ACE2 suppression in SARS-CoV-2.

Dr. Wilson’s research interest is the development of new molecular probes for brain and tumor imaging. He is mainly interested in molecular imaging approaches where structural and biochemical insight is required. Recently, Dr. Wilson’s research consist of the development of new agents for hyperpolarized 13C spectroscopy, and his goal is to identify positron emission tomography (PET) that correlates for imaging in animal models.

Dr. Wilson is a physician-scientist dedicated to exploring a variety of metabolic and biochemical phenomena using new imaging techniques. His laboratory is currently focusing on comparing hyperpolarized (HP) 13C MRS and positron emission tomography (PET) in a variety of disease processes. Expertise: Neuroradiology

Specialty: Positron emission tomography (PET)

Professional Interests: Molecular imaging, MR spectroscopy, Redox chemistry, Vitamin C

Education and Training:

• Medical School: Columbia University, New York
• Internship: University of Hawaii Residency Program - Transitional Program
• Residency: University of California, San Francisco - Diagnostic Radiology
• Fellowship: University of California, San Francisco - Neuroradiology
• Doctor of Philosophy: Columbia University, New York

• In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.
  ACS Central Science 2021 Ning Zhao, Conner Bardine, Andre´ Luiz Lourenc¸o, Yung-hua Wang, Yangjie Huang, Simon J. Cleary, David M. Wilson, David Y. Oh, Lawrence Fong, Mark R. Looney, Michael J. Evans, Charles S. Craik
• Deuterium Metabolic Imaging—Rediscovery of a Spectroscopic Tool.
  Metabolites 2021 Ilona Polvoy, Hecong Qin, Robert R. Flavell, Jeremy Gordon, Pavithra Viswanath, Renuka Sriram, Michael A. Ohliger, David M. Wilson
• Synthesis of N-trifluoromethyl amides from carboxylic acids.
  Chem 2021 Jianbo Liu, Matthew F.L. Parker, Sinan Wang, Robert R. Flavell, F. Dean Toste, David M. Wilson
• Introduction: MRI/MRS as Metabolic Imaging Tools.
  Imaging and Metabolism 2018 David Wilson, Michael Ohliger
• Bacterial Imaging.
  Imaging Infections 2017 Alvaro A. Ordonez, Lauren E. Bambarger, Niren Murthy, David M. Wilson, Sanjay K. Jain
• Recent Developments in Combined PET/MRI.
  Current Radiology Reports 2016 Robert R. Flavell, David M. Wilson, Spencer C. Behr
• [(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography.
  Chemical communications (Cambridge, England) 2016 Carroll VN, Truillet C, Shen B, Flavell RR, Shao X, Evans MJ, VanBrocklin HF, Scott PJ, Chin FT, Wilson DM
• Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging.
  Chemical communications (Cambridge, England) 2016 Korenchan DE, Flavell RR, Baligand C, Sriram R, Neumann K, Sukumar S, VanBrocklin H, Vigneron DB, Wilson DM, Kurhanewicz J
• Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI.
  Chemical communications (Cambridge, England) 2015 Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson PE, Kurhanewicz J, Wilson DM
• Abstract B37: Patient-derived tissue culture model systems of renal cell carcinoma for development of clinically translatable metabolic biomarkers.
  Preclinical Studies 2014 Renuka Sriram, Kayvan R. Keshari, Mark Van Criekinge, John Kurhanewicz, David M. Wilson, Donna M. Peehl, Robert Bok, Wang J. Zhen
• ChemInform Abstract: Chemistry and Biochemistry of 13C Hyperpolarized Magnetic Resonance Using Dynamic Nuclear Polarization.
  ChemInform 2014 Kayvan R. Keshari, David M. Wilson
• Case report: glioblastoma multiforme complicating familial cavernous malformations.
  Clinical neuroradiology 2013 Wilson DM, Cohen B, Keshari K, Vogel H, Steinberg G, Dillon W
• Solid phase synthesis of hydroxamate peptides for histone deacetylase inhibition.
  Tetrahedron Letters 2013 David M. Wilson, Lisa N. Silverman, Markus Bergauer, Kayvan R. Keshari
• Metabolic Profiling of CNS Lymphoma and Its Microenvironment.
  Blood 2011 Anna Bet-Lachin, Frank Jiang, Lingjing Chen, Keyvan Keshari, David Wilson, John Kurhanewicz, James L. Rubenstein
• Cyclodextrin dimers as cleavable carriers of photodynamic sensitizers.
  Journal of the American Chemical Society 2001 Baugh SD, Yang Z, Leung DK, Wilson DM, Breslow R