David Sretavan, MD, PhD
Professor Emeritus
Ophthalmology
School of Medicine

Education & Training

Show all (5) Hide

• Postdoctoral Research HHMI University of California San Francisco 1992
• Postdoctoral Research Laboratory of Neurobiology Rockefeller University 1990
• M.D. Medicine Stanford University 1987
• Ph.D. Neurobiology Stanford University 1987
• B.Sc. Honors Physiology McGill University 1980

Interests

Show all (3) Hide

• Miniaturized technology for Ophthalmic diagnosis and treatments
• Glaucoma disease mechanisms
• Axon injury & response

Websites

Show all (1) Hide

• Profile at ucsf.edu (vision.ucsf.edu)

Grants and Projects

Show all (6) Hide

• P30 - Core Grant for Vision Research, NIH, 1977-2024
• Intraocular Pressure Sensing Using Light, NIH, 2015-2019
• Enhanced Axon Sparing In Glaucoma Through Augmentation Of EphB/ephrin B Signaling, NIH, 1994-2017
• California National Primate Research Center, NIH, 1975-2015
• Microscale Axon Repair As A Novel Paradigm For Nerve Injuries, NIH, 2008-2012
• Axon Guidance Molecules and Optic Nerve Disease, NIH, 2005-2008

Publications (53)

Top publication keywords:
Lenses, IntraocularOptic ChiasmLens Capsule, CrystallineRetinal Ganglion CellsCataract ExtractionGrowth ConesEphrin-B3AxonsPosterior CapsulotomyEphrin-B2CapsulorhexisCataractCapsule OpacificationPhacoemulsificationOptic Nerve

• Endothelial Cell Loss Following Cataract Surgery Using Continuous Curvilinear Capsulorhexis or Precision Pulse Capsulotomy.
  Clinical ophthalmology (Auckland, N.Z.) 2023 Vital MC, Jong KY, Trinh CE, Starck T, Sretavan D
• Automated precision pulse capsulotomy vs manual capsulorhexis in white cataracts: reduction in procedural time and resource utilization.
  Journal of cataract and refractive surgery 2022 Ifantides C, Sretavan D
• Use of P1-P4 Purkinje reflections as a surrogate sign for intraoperative patient fixation.
  Journal of cataract and refractive surgery 2021 Thompson V, Holladay J, Sretavan D
• Precision pulse capsulotomy: performance metrics and utility in routine and complex cases.
  Journal of cataract and refractive surgery 2020 Ifantides C, Lee J, Rouweyha R, Vital M, Sretavan D
• Fabry-Pérot optical sensor and portable detector for monitoring high-resolution ocular hemodynamics.
  IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society 2019 Lee JO, Narasimhan V, Balakrishna A, Smith MR, Du J, Sretavan D, Choo H

Show all (48 more) Hide

• Multifunctional biophotonic nanostructures inspired by the longtail glasswing butterfly for medical devices.
  Nature nanotechnology 2018 Narasimhan V, Siddique RH, Lee JO, Kumar S, Ndjamen B, Du J, Hong N, Sretavan D, Choo H
• A microscale optical implant for continuous in vivo monitoring of intraocular pressure.
  Microsystems & nanoengineering 2017 Lee JO, Park H, Du J, Balakrishna A, Chen O, Sretavan D, Choo H
• Real-Time In Vivo Intraocular Pressure Monitoring using an Optomechanical Implant and an Artificial Neural Network.
  IEEE sensors journal 2017 Kim KH, Lee JO, Du J, Sretavan D, Choo H
• Intraocular Sensors: Biocompatible Multifunctional Black-Silicon for Implantable Intraocular Sensor (Adv. Healthcare Mater. 4/2017).
  Advanced Healthcare Materials 2017 Jeong Oen Lee, Vinayak Narasimhan, Juan Du, Blaise Ndjamen, David Sretavan, Hyuck Choo
• Biocompatible Multifunctional Black-Silicon for Implantable Intraocular Sensor.
  Advanced healthcare materials 2017 Lee JO, Narasimhan V, Du J, Ndjamen B, Sretavan D, Choo H
• Regulation of axon regeneration by the RNA repair and splicing pathway.
  Nature neuroscience 2015 Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN
• Ectopic vesicular glutamate release at the optic nerve head and axon loss in mouse experimental glaucoma.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Fu CT, Sretavan DW
• Rabbit models for continuous curvilinear capsulorhexis instruction.
  Journal of cataract and refractive surgery 2012 Ruggiero J, Keller C, Porco T, Naseri A, Sretavan DW
• Involvement of EphB/Ephrin-B signaling in axonal survival in mouse experimental glaucoma.
  Investigative ophthalmology & visual science 2012 Fu CT, Sretavan D
• Axon repair: surgical application at a subcellular scale.
  Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2010 Chang WC, Hawkes E, Keller CG, Sretavan DW
• Axonal/glial upregulation of EphB/ephrin-B signaling in mouse experimental ocular hypertension.
  Investigative ophthalmology & visual science 2009 Fu CT, Tran T, Sretavan D
• Laser-induced ocular hypertension in albino CD-1 mice.
  Investigative ophthalmology & visual science 2009 Fu CT, Sretavan D
• Single cell and neural process experimentation using laterally applied electrical fields between pairs of closely apposed microelectrodes with vertical sidewalls.
  Biosensors & bioelectronics 2009 Chang WC, Sretavan DW
• Microtechnology and nanotechnology in nerve repair.
  Neurological research 2008 Chang WC, Kliot M, Sretavan DW
• Novel high-resolution micropatterning for neuron culture using polylysine adsorption on a cell repellant, plasma-polymerized background.
  Langmuir : the ACS journal of surfaces and colloids 2008 Chang WC, Sretavan DW
• Upregulation of EphB2 and ephrin-B2 at the optic nerve head of DBA/2J glaucomatous mice coincides with axon loss.
  Investigative ophthalmology & visual science 2007 Du J, Tran T, Fu C, Sretavan DW
• In vivo use of a nanoknife for axon microsurgery.
  Neurosurgery 2007 Chang WC, Hawkes EA, Kliot M, Sretavan DW
• Eph/ephrin signaling as a potential therapeutic target after central nervous system injury.
  Current pharmaceutical design 2007 Du J, Fu C, Sretavan DW
• Microtechnology in medicine: the emergence of surgical microdevices.
  Clinical neurosurgery 2007 Chang WC, Sretavan DW
• EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Liu X, Hawkes E, Ishimaru T, Tran T, Sretavan DW
• Optic nerve formation.
  Retinal Development 2006 David W. Sretavan
• Isolation of neuronal substructures and precise neural microdissection using a nanocutting device.
  Journal of neuroscience methods 2005 Chang WC, Keller CG, Sretavan DW
• Microscale Surgery on Single Axons.
  Neurosurgery 2005 David W. Sretavan, Wesley Chang, Elizabeth Hawkes, Christopher Keller, Michel Kliot
• Microscale surgery on single axons.
  Neurosurgery 2005 Sretavan DW, Chang W, Hawkes E, Keller C, Kliot M
• Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans.
  Neuron 2004 Kantor DB, Chivatakarn O, Peer KL, Oster SF, Inatani M, Hansen MJ, Flanagan JG, Yamaguchi Y, Sretavan DW, Giger RJ, Kolodkin AL
• An oligodendrocyte lineage-specific semaphorin, Sema5A, inhibits axon growth by retinal ganglion cells.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Goldberg JL, Vargas ME, Wang JT, Mandemakers W, Oster SF, Sretavan DW, Barres BA
• L1/Laminin modulation of growth cone response to EphB triggers growth pauses and regulates the microtubule destabilizing protein SCG10.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Suh LH, Oster SF, Soehrman SS, Grenningloh G, Sretavan DW
• Ganglion cell axon pathfinding in the retina and optic nerve.
  Seminars in cell & developmental biology 2004 Oster SF, Deiner M, Birgbauer E, Sretavan DW
• FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies.
  Neuron 2003 Beggs HE, Schahin-Reed D, Zang K, Goebbels S, Nave KA, Gorski J, Jones KR, Sretavan D, Reichardt LF
• Connecting the eye to the brain: the molecular basis of ganglion cell axon guidance.
  The British journal of ophthalmology 2003 Oster SF, Sretavan DW
• Invariant Sema5A inhibition serves an ensheathing function during optic nerve development.
  Development (Cambridge, England) 2003 Oster SF, Bodeker MO, He F, Sretavan DW
• GAP-43 mediates retinal axon interaction with lateral diencephalon cells during optic tract formation.
  Development (Cambridge, England) 2000 Zhang F, Lu C, Severin C, Sretavan DW
• Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina.
  Development (Cambridge, England) 2000 Birgbauer E, Cowan CA, Sretavan DW, Henkemeyer M
• Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Deiner MS, Sretavan DW
• Domains of regulatory gene expression and the developing optic chiasm: correspondence with retinal axon paths and candidate signaling cells.
  The Journal of comparative neurology 1999 Marcus RC, Shimamura K, Sretavan D, Lai E, Rubenstein JL, Mason CA
• Randomized retinal ganglion cell axon routing at the optic chiasm of GAP-43-deficient mice: association with midline recrossing and lack of normal ipsilateral axon turning.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Sretavan DW, Kruger K
• Retinal ganglion cell axon progression from the optic chiasm to initiate optic tract development requires cell autonomous function of GAP-43.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Kruger K, Tam AS, Lu C, Sretavan DW
• Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia.
  Neuron 1997 Deiner MS, Kennedy TE, Fazeli A, Serafini T, Tessier-Lavigne M, Sretavan DW
• Disruption of retinal axon ingrowth by ablation of embryonic mouse optic chiasm neurons.
  Science (New York, N.Y.) 1995 Sretavan DW, Puré E, Siegel MW, Reichardt LF
• Embryonic neurons of the developing optic chiasm express L1 and CD44, cell surface molecules with opposing effects on retinal axon growth.
  Neuron 1994 Sretavan DW, Feng L, Puré E, Reichardt LF
• Time-lapse video analysis of retinal ganglion cell axon pathfinding at the mammalian optic chiasm: growth cone guidance using intrinsic chiasm cues.
  Neuron 1993 Sretavan DW, Reichardt LF
• Pathfinding at the mammalian optic chiasm.
  Current opinion in neurobiology 1993 Sretavan DW
• Adhesive interactions that regulate development of the retina and primary visual projection.
  Cold Spring Harbor symposia on quantitative biology 1992 Reichardt LF, Bossy B, de Curtis I, Neugebauer KM, Venstrom K, Sretavan D
• Specific routing of retinal ganglion cell axons at the mammalian optic chiasm during embryonic development.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1990 Sretavan DW
• Modification of retinal ganglion cell axon morphology by prenatal infusion of tetrodotoxin.
  Nature 1988 Sretavan DW, Shatz CJ, Stryker MP
• Axon arbors of X and Y retinal ganglion cells are differentially affected by prenatal disruption of binocular inputs.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Garraghty PE, Shatz CJ, Sretavan DW, Sur M
• Prenatal development of cat retinogeniculate axon arbors in the absence of binocular interactions.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1986 Sretavan DW, Shatz CJ
• Prenatal development of retinal ganglion cell axons: segregation into eye-specific layers within the cat's lateral geniculate nucleus.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1986 Sretavan DW, Shatz CJ