David Soleimani-Meigooni, MD
Assistant Professor
Neurology
School of Medicine

In research, Soleimani-Meigooni focuses on advancing precision-medicine approaches to diagnosing Alzheimer's disease and other neurodegenerative diseases. He looks at using positron emission tomography (PET) to image amyloid-beta and tau (protein fragments that accumulate in the brains of people with the condition).

Soleimani-Meigooni earned his medical degree at UCSF. He completed a residency in neurology at Washington University School of Medicine in St. Louis, followed by a fellowship in cognitive and behavioral neurology at UCSF.

• Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer's disease.
  Brain communications 2023 Llibre-Guerra JJ, Iaccarino L, Coble D, Edwards L, Li Y, McDade E, Strom A, Gordon B, Mundada N, Schindler SE, Tsoy E, Ma Y, Lu R, Fagan AM, Benzinger TLS, Soleimani-Meigooni D, Aschenbrenner AJ, …
• The Sporadic Early-onset Alzheimer's Disease Signature Of Atrophy: Preliminary Findings From The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) Cohort.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Touroutoglou A, Katsumi Y, Brickhouse M, Zaitsev A, Eckbo R, Aisen P, Beckett L, Dage JL, Eloyan A, Foroud T, Ghetti B, Griffin P, Hammers D, Jack CR, Kramer JH, Iaccarino L, Joie R, Mundada NS, …
• Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment.
  Alzheimer's research & therapy 2023 Mundada NS, Rojas JC, Vandevrede L, Thijssen EH, Iaccarino L, Okoye OC, Shankar R, Soleimani-Meigooni DN, Lago AL, Miller BL, Teunissen CE, Heuer H, Rosen HJ, Dage JL, Jagust WJ, Rabinovici GD, Boxer …
• Amyloid and tau-PET in early-onset AD: Baseline data from the Longitudinal Early-onset Alzheimer's Disease Study (LEADS).
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Cho H, Mundada NS, Apostolova LG, Carrillo MC, Shankar R, Amuiri AN, Zeltzer E, Windon CC, Soleimani-Meigooni DN, Tanner JA, Heath CL, Lesman-Segev OH, Aisen P, Eloyan A, Lee HS, Hammers DB, Kirby K, …
• Influence of amyloid and diagnostic syndrome on non-traditional memory scores in early-onset Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Bushnell J, Hammers DB, Aisen P, Dage JL, Eloyan A, Foroud T, Grinberg LT, Iaccarino L, Jack CR, Kirby K, Kramer J, Koeppe R, Kukull WA, La Joie R, Mundada NS, Murray ME, Nudelman K, Rumbaugh M, …
• Sex and APOE ε4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Nemes S, Logan PE, Manchella MK, Mundada NS, La Joie R, Polsinelli AJ, Hammers DB, Koeppe RA, Foroud TM, Nudelman KN, Eloyan A, Iaccarino L, Dorsant-Ardón V, Taurone A, Thangarajah M, Dage JL, Aisen P…
• Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Dage JL, Eloyan A, Thangarajah M, Hammers DB, Fagan AM, Gray JD, Schindler SE, Snoddy C, Nudelman KNH, Faber KM, Foroud T, Aisen P, Griffin P, Grinberg LT, Iaccarino L, Kirby K, Kramer J, Koeppe R, …
• White matter hyperintensities are higher among early-onset Alzheimer's disease participants than their cognitively normal and early-onset nonAD peers: Longitudinal Early-onset Alzheimer's Disease Study (LEADS).
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Eloyan A, Thangarajah M, An N, Borowski BJ, Reddy AL, Aisen P, Dage JL, Foroud T, Ghetti B, Griffin P, Hammers D, Iaccarino L, Jack CR, Kirby K, Kramer J, Koeppe R, Kukull WA, La Joie R, Mundada NS, …
• Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Polsinelli AJ, Wonderlin RJ, Hammers DB, Garcia AP, Eloyan A, Taurone A, Thangarajah M, Beckett L, Gao S, Wang S, Kirby K, Logan PE, Aisen P, Dage JL, Foroud T, Griffin P, Iaccarino L, Kramer JH, …
• Profiling baseline performance on the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort near the midpoint of data collection.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Hammers DB, Eloyan A, Taurone A, Thangarajah M, Beckett L, Gao S, Kirby K, Aisen P, Dage JL, Foroud T, Griffin P, Grinberg LT, Jack CR, Kramer J, Koeppe R, Kukull WA, Mundada NS, La Joie R, Soleimani-…
• Amyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer's disease.
  Brain : a journal of neurology 2022 Tanner JA, Iaccarino L, Edwards L, Asken BM, Gorno-Tempini ML, Kramer JH, Pham J, Perry DC, Possin K, Malpetti M, Mellinger T, Miller BL, Miller Z, Mundada NS, Rosen HJ, Soleimani-Meigooni DN, Strom A…
• Tau PET Visual Reads: Research and Clinical Applications and Future Directions.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2022 Soleimani-Meigooni DN, Rabinovici GD
• The Role of Amyloid PET in Imaging Neurodegenerative Disorders: A Review.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2022 Chapleau M, Iaccarino L, Soleimani-Meigooni D, Rabinovici GD
• Plasma P-tau181 and P-tau217 in Patients With Traumatic Encephalopathy Syndrome With and Without Evidence of Alzheimer Disease Pathology.
  Neurology 2022 Asken BM, Tanner JA, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, La Joie R, Iaccarino L, Soleimani-Meigooni D, Rojas JC, Gardner RC, Miller BL, Grinberg LT, Boxer AL, Kramer JH, Rabinovici …
• Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease.
  Brain : a journal of neurology 2022 Strom A, Iaccarino L, Edwards L, Lesman-Segev OH, Soleimani-Meigooni DN, Pham J, Baker SL, Landau SM, Jagust WJ, Miller BL, Rosen HJ, Gorno-Tempini ML, Rabinovici GD, La Joie R, Alzheimer’s Disease …
• Pharmacokinetics of 38 Percent Silver Diamine Fluoride in Children.
  Pediatric dentistry 2022 Ellenikiotis H, Chen KF, Soleimani-Meigooni DN, Rothen ML, Thompson B, Lin YS, Milgrom P
• Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease: A Head-to-Head Comparison Against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging.
  JAMA neurology 2021 Ossenkoppele R, Smith R, Mattsson-Carlgren N, Groot C, Leuzy A, Strandberg O, Palmqvist S, Olsson T, Jögi J, Stormrud E, Cho H, Ryu YH, Choi JY, Boxer AL, Gorno-Tempini ML, Miller BL, Soleimani-…
• Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females.
  Neurobiology of aging 2021 Edwards L, La Joie R, Iaccarino L, Strom A, Baker SL, Casaletto KB, Cobigo Y, Grant H, Kim M, Kramer JH, Mellinger TJ, Pham J, Possin KL, Rosen HJ, Soleimani-Meigooni DN, Wolf A, Miller BL, Rabinovici…
• Comparing ATN-T designation by tau PET visual reads, tau PET quantification, and CSF PTau181 across three cohorts.
  European journal of nuclear medicine and molecular imaging 2021 Provost K, Iaccarino L, Soleimani-Meigooni DN, Baker S, Edwards L, Eichenlaub U, Hansson O, Jagust W, Janabi M, La Joie R, Lesman-Segev O, Mellinger TJ, Miller BL, Ossenkoppele R, Pham J, Smith R, …
• Spatial Relationships between Molecular Pathology and Neurodegeneration in the Alzheimer's Disease Continuum.
  Cerebral cortex (New York, N.Y. : 1991) 2021 Iaccarino L, La Joie R, Edwards L, Strom A, Schonhaut DR, Ossenkoppele R, Pham J, Mellinger T, Janabi M, Baker SL, Soleimani-Meigooni D, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD
• 18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases.
  Brain : a journal of neurology 2020 Soleimani-Meigooni DN, Iaccarino L, La Joie R, Baker S, Bourakova V, Boxer AL, Edwards L, Eser R, Gorno-Tempini ML, Jagust WJ, Janabi M, Kramer JH, Lesman-Segev OH, Mellinger T, Miller BL, Pham J, …
• Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET.
  Neurology 2020 La Joie R, Visani AV, Lesman-Segev OH, Baker SL, Edwards L, Iaccarino L, Soleimani-Meigooni DN, Mellinger T, Janabi M, Miller ZA, Perry DC, Pham J, Strom A, Gorno-Tempini ML, Rosen HJ, Miller BL, …
• The impact of demographic, clinical, genetic, and imaging variables on tau PET status.
  European journal of nuclear medicine and molecular imaging 2020 Ossenkoppele R, Leuzy A, Cho H, Sudre CH, Strandberg O, Smith R, Palmqvist S, Mattsson-Carlgren N, Olsson T, Jögi J, Stormrud E, Ryu YH, Choi JY, Alzheimer’s Disease Neuroimaging Initiative, PREVENT-…
• Symptomatic amyloid-related imaging abnormalities in an APOE ε4/ε4 patient treated with aducanumab.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2020 VandeVrede L, Gibbs DM, Koestler M, La Joie R, Ljubenkov PA, Provost K, Soleimani-Meigooni D, Strom A, Tsoy E, Rabinovici GD, Boxer AL
• Tau Positron Emission Tomographic Findings in a Former US Football Player With Pathologically Confirmed Chronic Traumatic Encephalopathy.
  JAMA neurology 2020 Mantyh WG, Spina S, Lee A, Iaccarino L, Soleimani-Meigooni D, Tsoy E, Mellinger TJ, Grant H, Vandevrede L, La Joie R, Lesman-Segev O, Gaus S, Possin KL, Grinberg LT, Miller BL, Seeley WW, Rabinovici …
• The Oxford Handbook of Adult Cognitive Disorders
  Rapidly Progressive Dementia: Human Prion Diseases and an Approach for Evaluating Non-Prion Etiologies 2019 Soleimani-Meigooni DN and Geschwind MD
• Structural signature of sporadic Creutzfeldt-Jakob disease.
  European journal of neurology 2019 Navid J, Day GS, Strain J, Perrin RJ, Bucelli RC, Dincer A, Wisch JK, Soleimani-Meigooni D, Morris JC, Benzinger TLS, Ances BM
• JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7.
  Journal of neurovirology 2016 Soleimani-Meigooni DN, Schwetye KE, Angeles MR, Ryschkewitsch CF, Major EO, Dang X, Koralnik IJ, Schmidt RE, Clifford DB, Kuhlmann FM, Bucelli RC
• Cylindrical coordinate based TG-43U1 parameters for dose calculation around elongated brachytherapy sources.
  Journal of applied clinical medical physics 2008 Awan SB, Dini SA, Hussain M, Soleimani-Meigooni D, Meigooni AS
• Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3.
  Oncogene 2004 Chendil D, Ranga RS, Meigooni D, Sathishkumar S, Ahmed MM