David Rowitch, MD, PhD
Professor
Pediatrics
School of Medicine

As a physician-scientist, I have investigated extensions of neuroscience that can impact our understanding of human neurological diseases, particularly cerebral palsy, multiple sclerosis and brain cancers. For over 15 years we have investigated the developmental genetics of the glial lineages of the brain and novel functions for astrocytes and oligodendrocytes. I helped establish the first “Neuro-NICU” in the USA at UCSF. This inter-disciplinary unit, focused on newborn neurological injuries, has improved standards of care and has facilitated basic and clinical research. I directed a first-in-man Phase I study of neural stem cell transplant into the human brain for leukodystrophy as an approach for demyelinating disorders. As a HHMI Investigator, I established a basic program of research in human neonatal brain development that has attracted support of an NINDS PO1. In 2016 I joined University of Cambridge as Head of Department of Paediatrics, where I have investigated application of whole genome sequencing in care of intensively ill children, supported by the UK National Institute for Health Research, Health Education England, Royal College of Paediatrics and Child Health, and the National Health Service (NHS). I am a Wellcome Trust Senior Investigator with a laboratory in the Cambridge Stem Cell Institute and Adjunct Professor of Pediatrics/Neonatology at UCSF, and I serve on the National Advisory Council Child Health and Development, National Institute of Child Health and Development.

• Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine.
  Trends in immunology 2024 Summers RA, Fagiani F, Rowitch DH, Absinta M, Reich DS
• Genetic investigations in cerebral palsy.
  Developmental medicine and child neurology 2024 Basu AP, Low K, Ratnaike T, Rowitch D
• Neuroinflammatory reactive astrocyte formation correlates with adverse outcomes in perinatal white matter injury.
  Glia 2024 Renz P, Steinfort M, Haesler V, Tscherrig V, Huang EJ, Chavali M, Liddelow S, Rowitch DH, Surbek D, Schoeberlein A, Brosius Lutz A
• Developmental origin of oligodendrocytes determines their function in the adult brain.
  Nature neuroscience 2024 Foerster S, Floriddia EM, van Bruggen D, Kukanja P, Hervé B, Cheng S, Kim E, Phillips BU, Heath CJ, Tripathi RB, Call C, Bartels T, Ridley K, Neumann B, López-Cruz L, Crawford AH, Lynch CJ, Serrano M,…
• A retroviral link to vertebrate myelination through retrotransposon-RNA-mediated control of myelin gene expression.
  Cell 2024 Ghosh T, Almeida RG, Zhao C, Mannioui A, Martin E, Fleet A, Chen CZ, Assinck P, Ellams S, Gonzalez GA, Graham SC, Rowitch DH, Stott K, Adams I, Zalc B, Goldman N, Lyons DA, Franklin RJM
• Time-resolved single-cell RNAseq profiling identifies a novel Fabp5+ subpopulation of inflammatory myeloid cells with delayed cytotoxic profile in chronic spinal cord injury.
  Heliyon 2023 Hamel R, Peruzzotti-Jametti L, Ridley K, Testa V, Yu B, Rowitch D, Marioni JC, Pluchino S
• Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination.
  The Journal of clinical investigation 2023 Kapell H, Fazio L, Dyckow J, Schwarz S, Cruz-Herranz A, Mayer C, Campos J, D'Este E, Möbius W, Cordano C, Pröbstel AK, Gharagozloo M, Zulji A, Narayanan Naik V, Delank A, Cerina M, Müntefering T, …
• Clinical and Neurophysiologic Phenotypes in Neonates With BRAT1 Encephalopathy.
  Neurology 2023 Carapancea E, Cornet MC, Milh M, De Cosmo L, Huang EJ, Granata T, Striano P, Ceulemans B, Stein A, Morris-Rosendahl D, Conti G, Mitra N, Raymond FL, Rowitch DH, Solazzi R, Vercellino F, De Liso P, D'…
• Publisher Correction: Brain charts for the human lifespan.
  Nature 2022 Bethlehem RAI, Seidlitz J, White SR, Vogel JW, Anderson KM, Adamson C, Adler S, Alexopoulos GS, Anagnostou E, Areces-Gonzalez A, Astle DE, Auyeung B, Ayub M, Bae J, Ball G, Baron-Cohen S, Beare R, …
• Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells.
  Neuron 2022 Bulstrode H, Girdler GC, Gracia T, Aivazidis A, Moutsopoulos I, Young AMH, Hancock J, He X, Ridley K, Xu Z, Stockley JH, Finlay J, Hallou C, Fajardo T, Fountain DM, van Dongen S, Joannides A, Morris R…
• Generation of functional human oligodendrocytes from dermal fibroblasts by direct lineage conversion.
  Development (Cambridge, England) 2022 Tanabe K, Nobuta H, Yang N, Ang CE, Huie P, Jordan S, Oldham MC, Rowitch DH, Wernig M
• Genetic correlates of phenotypic heterogeneity in autism.
  Nature genetics 2022 Warrier V, Zhang X, Reed P, Havdahl A, Moore TM, Cliquet F, Leblond CS, Rolland T, Rosengren A, EU-AIMS LEAP, iPSYCH-Autism Working Group, Spectrum 10K and APEX Consortia, Rowitch DH, Hurles ME, …
• Refinements and considerations for trio whole-genome sequence analysis when investigating Mendelian diseases presenting in early childhood.
  HGG advances 2022 French CE, Dolling H, Mégy K, Sanchis-Juan A, Kumar A, Delon I, Wakeling M, Mallin L, Agrawal S, Austin T, Walston F, Park SM, Parker A, Piyasena C, Bradbury K, Next Generation Children’s Project …
• Brain charts for the human lifespan.
  Nature 2022 Bethlehem RAI, Seidlitz J, White SR, Vogel JW, Anderson KM, Adamson C, Adler S, Alexopoulos GS, Anagnostou E, Areces-Gonzalez A, Astle DE, Auyeung B, Ayub M, Bae J, Ball G, Baron-Cohen S, Beare R, …
• Multicenter Consensus Approach to Evaluation of Neonatal Hypotonia in the Genomic Era: A Review.
  JAMA neurology 2022 Morton SU, Christodoulou J, Costain G, Muntoni F, Wakeling E, Wojcik MH, French CE, Szuto A, Dowling JJ, Cohn RD, Raymond FL, Darras BT, Williams DA, Lunke S, Stark Z, Rowitch DH, Agrawal PB
• MC3R links nutritional state to childhood growth and the timing of puberty.
  Nature 2021 Lam BYH, Williamson A, Finer S, Day FR, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P, Bedenbaugh MN, Porter DT, Melvin A, Ellacott KLJ, Lippert RN, Buller S, Rosmaninho-Salgado J, Dowsett GKC, …
• Optimising the health-care experiences of babies, children, and young people.
  Lancet (London, England) 2021 Ford T, Kusi-Mensah K, Newlove-Delgado T, Ramchandani P, Price-Kuehne F, Rowitch D
• Evidence for glutamine synthetase function in mouse spinal cord oligodendrocytes.
  Glia 2021 Ben Haim L, Schirmer L, Zulji A, Sabeur K, Tiret B, Ribon M, Chang S, Lamers WH, Boillée S, Chaumeil MM, Rowitch DH
• Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.
  Cell reports 2021 Kohnke S, Buller S, Nuzzaci D, Ridley K, Lam B, Pivonkova H, Bentsen MA, Alonge KM, Zhao C, Tadross J, Holmqvist S, Shimizu T, Hathaway H, Li H, Macklin W, Schwartz MW, Richardson WD, Yeo GSH, …
• On-chip perivascular niche supporting stemness of patient-derived glioma cells in a serum-free, flowable culture.
  Lab on a chip 2021 Gerigk M, Bulstrode H, Shi HH, Tönisen F, Cerutti C, Morrison G, Rowitch D, Huang YYS
• A classification of videoconferencing related illness: the Zoomnotic diseases.
  QJM : monthly journal of the Association of Physicians 2021 Rowitch DH, O'Rahilly S, Smith GCS
• Letter to Editor Response to: Is zoomnosis a human-driven human zoonosis? A call for action.
  QJM : monthly journal of the Association of Physicians 2021 Rowitch DH, O'Rahilly S, Smith GCS
• Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke.
  Pediatric research 2021 Nguyen V, Chavali M, Larpthaveesarp A, Kodali S, Gonzalez G, Franklin RJM, Rowitch DH, Gonzalez F
• Reactive astrocyte nomenclature, definitions, and future directions.
  Nature neuroscience 2021 Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt…
• Diversity and Function of Glial Cell Types in Multiple Sclerosis.
  Trends in immunology 2021 Schirmer L, Schafer DP, Bartels T, Rowitch DH, Calabresi PA
• Behaviorally consequential astrocytic regulation of neural circuits.
  Neuron 2020 Nagai J, Yu X, Papouin T, Cheong E, Freeman MR, Monk KR, Hastings MH, Haydon PG, Rowitch D, Shaham S, Khakh BS
• Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury.
  Neuron 2020 Chavali M, Ulloa-Navas MJ, Pérez-Borredá P, Garcia-Verdugo JM, McQuillen PS, Huang EJ, Rowitch DH
• Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.
  Cell 2020 Huang W, Bhaduri A, Velmeshev D, Wang S, Wang L, Rottkamp CA, Alvarez-Buylla A, Rowitch DH, Kriegstein AR
• Applying support-vector machine learning algorithms toward predicting host-guest interactions with cucurbit[7]uril.
  Physical chemistry chemical physics : PCCP 2020 Tabet A, Gebhart T, Wu G, Readman C, Pierson Smela M, Rana VK, Baker C, Bulstrode H, Anikeeva P, Rowitch DH, Scherman OA
• Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map.
  Nature neuroscience 2020 Bayraktar OA, Bartels T, Holmqvist S, Kleshchevnikov V, Martirosyan A, Polioudakis D, Ben Haim L, Young AMH, Batiuk MY, Prakash K, Brown A, Roberts K, Paredes MF, Kawaguchi R, Stockley JH, Sabeur K, …
• Oxygen Tension and the VHL-Hif1α Pathway Determine Onset of Neuronal Polarization and Cerebellar Germinal Zone Exit.
  Neuron 2020 Kullmann JA, Trivedi N, Howell D, Laumonnerie C, Nguyen V, Banerjee SS, Stabley DR, Shirinifard A, Rowitch DH, Solecki DJ
• An update on human astrocytes and their role in development and disease.
  Glia 2020 de Majo M, Koontz M, Rowitch D, Ullian EM
• Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.
  Neuron 2020 Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, Rowitch DH, Franklin RJM, Mallucci GR
• Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain.
  Brain : a journal of neurology 2019 Van Steenwinckel J, Schang AL, Krishnan ML, Degos V, Delahaye-Duriez A, Bokobza C, Csaba Z, Verdonk F, Montané A, Sigaut S, Hennebert O, Lebon S, Schwendimann L, Le Charpentier T, Hassan-Abdi R, Ball …
• Cucurbit[8]uril-Derived Graphene Hydrogels.
  ACS macro letters 2019 Rana VK, Tabet A, Vigil JA, Balzer CJ, Narkevicius A, Finlay J, Hallou C, Rowitch DH, Bulstrode H, Scherman OA
• Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.
  Cell stem cell 2019 Nobuta H, Yang N, Ng YH, Marro SG, Sabeur K, Chavali M, Stockley JH, Killilea DW, Walter PB, Zhao C, Huie P, Goldman SA, Kriegstein AR, Franklin RJM, Rowitch DH, Wernig M
• Author Correction: Niche stiffness underlies the ageing of central nervous system progenitor cells.
  Nature 2019 Segel M, Neumann B, Hill MFE, Weber IP, Viscomi C, Zhao C, Young A, Agley CC, Thompson AJ, Gonzalez GA, Sharma A, Holmqvist S, Rowitch DH, Franze K, Franklin RJM, Chalut KJ
• Niche stiffness underlies the ageing of central nervous system progenitor cells.
  Nature 2019 Segel M, Neumann B, Hill MFE, Weber IP, Viscomi C, Zhao C, Young A, Agley CC, Thompson AJ, Gonzalez GA, Sharma A, Holmqvist S, Rowitch DH, Franze K, Franklin RJM, Chalut KJ
• Challenges to curing primary brain tumours.
  Nature reviews. Clinical oncology 2019 Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, …
• Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease.
  Stem cell reports 2019 Gupta N, Henry RG, Kang SM, Strober J, Lim DA, Ryan T, Perry R, Farrell J, Ulman M, Rajalingam R, Gage A, Huhn SL, Barkovich AJ, Rowitch DH
• Reply to 'Assembling the brain trust: the multidisciplinary imperative in neuro-oncology'.
  Nature reviews. Clinical oncology 2019 Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, …
• Neuronal vulnerability and multilineage diversity in multiple sclerosis.
  Nature 2019 Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, Vistnes S, Stockley JH, Young A, Steindel M, Tung B, Goyal N, Bhaduri A, Mayer S, Engler JB, Bayraktar OA, Franklin RJM, …
• Single-cell genomics identifies cell type-specific molecular changes in autism.
  Science (New York, N.Y.) 2019 Velmeshev D, Schirmer L, Jung D, Haeussler M, Perez Y, Mayer S, Bhaduri A, Goyal N, Rowitch DH, Kriegstein AR
• Ferret brain possesses young interneuron collections equivalent to human postnatal migratory streams.
  The Journal of comparative neurology 2019 Ellis JK, Sorrells SF, Mikhailova S, Chavali M, Chang S, Sabeur K, Mcquillen P, Rowitch DH
• The neurointensive nursery: concept, development, and insights gained.
  Current opinion in pediatrics 2019 Glass HC, Ferriero DM, Rowitch DH, Shimotake TK
• Whole genome sequencing reveals that genetic conditions are frequent in intensively ill children.
  Intensive care medicine 2019 French CE, Delon I, Dolling H, Sanchis-Juan A, Shamardina O, Mégy K, Abbs S, Austin T, Bowdin S, Branco RG, Firth H, NIHR BioResource—Rare Disease, Next Generation Children Project, Rowitch DH, …
• Single-cell reconstruction of the early maternal-fetal interface in humans.
  Nature 2018 Vento-Tormo R, Efremova M, Botting RA, Turco MY, Vento-Tormo M, Meyer KB, Park JE, Stephenson E, Polanski K, Goncalves A, Gardner L, Holmqvist S, Henriksson J, Zou A, Sharkey AM, Millar B, Innes B, …
• Dlx1 and Dlx2 Promote Interneuron GABA Synthesis, Synaptogenesis, and Dendritogenesis.
  Cerebral cortex (New York, N.Y. : 1991) 2018 Pla R, Stanco A, Howard MA, Rubin AN, Vogt D, Mortimer N, Cobos I, Potter GB, Lindtner S, Price JD, Nord AS, Visel A, Schreiner CE, Baraban SC, Rowitch DH, Rubenstein JLR
• New Recipes for Myelinating Oligodendrocytes.
  Cell stem cell 2018 Nobuta H, Stockley JH, Rowitch DH
• Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity.
  eLife 2018 Schirmer L, Möbius W, Zhao C, Cruz-Herranz A, Ben Haim L, Cordano C, Shiow LR, Kelley KW, Sadowski B, Timmons G, Pröbstel AK, Wright JN, Sin JH, Devereux M, Morrison DE, Chang SM, Sabeur K, Green AJ, …
• A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.
  Cancer cell 2018 Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-…
• Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength.
  Neuron 2018 Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky AV, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH
• Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury.
  Cerebellum (London, England) 2018 Nguyen V, Sabeur K, Maltepe E, Ameri K, Bayraktar O, Rowitch DH
• Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.
  Stem cell reports 2017 Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, Horner PJ, Rowitch DH, Ullian EM
• Origin and dynamics of oligodendrocytes in the developing brain: Implications for perinatal white matter injury.
  Glia 2017 van Tilborg E, de Theije CGM, van Hal M, Wagenaar N, de Vries LS, Benders MJ, Rowitch DH, Nijboer CH
• Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.
  Neuron 2017 Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee…
• Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury.
  Glia 2017 Shiow LR, Favrais G, Schirmer L, Schang AL, Cipriani S, Andres C, Wright JN, Nobuta H, Fleiss B, Gressens P, Rowitch DH
• The role of prenatal steroids at 34-36 weeks of gestation.
  Archives of disease in childhood. Fetal and neonatal edition 2017 Smith GC, Rowitch D, Mol BW
• Olig1 is required for noggin-induced neonatal myelin repair.
  Annals of neurology 2017 Sabo JK, Heine V, Silbereis JC, Schirmer L, Levison SW, Rowitch DH
• A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2.
  Cell reports 2017 Zhou J, Tien AC, Alberta JA, Ficarro SB, Griveau A, Sun Y, Deshpande JS, Card JD, Morgan-Smith M, Michowski W, Hashizume R, James CD, Ligon KL, Snider WD, Sicinski P, Marto JA, Rowitch DH, Stiles CD
• Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone.
  Developmental neuroscience 2017 Dawes WJ, Zhang X, Fancy SPJ, Rowitch D, Marino S
• Neurotoxic reactive astrocytes are induced by activated microglia.
  Nature 2017 Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, …
• Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury.
  Nature communications 2016 Jablonska B, Gierdalski M, Chew LJ, Hawley T, Catron M, Lichauco A, Cabrera-Luque J, Yuen T, Rowitch D, Gallo V
• Functional diversity of astrocytes in neural circuit regulation.
  Nature reviews. Neuroscience 2016 Ben Haim L, Rowitch DH
• Concise Review: Stem Cell-Based Treatment of Pelizaeus-Merzbacher Disease.
  Stem cells (Dayton, Ohio) 2016 Osorio MJ, Rowitch DH, Tesar P, Wernig M, Windrem MS, Goldman SA
• Extensive migration of young neurons into the infant human frontal lobe.
  Science (New York, N.Y.) 2016 Paredes MF, James D, Gil-Perotin S, Kim H, Cotter JA, Ng C, Sandoval K, Rowitch DH, Xu D, McQuillen PS, Garcia-Verdugo JM, Huang EJ, Alvarez-Buylla A
• Lineage-Restricted OLIG2-RTK Signaling Governs the Molecular Subtype of Glioma Stem-like Cells.
  Cell reports 2016 Kupp R, Shtayer L, Tien AC, Szeto E, Sanai N, Rowitch DH, Mehta S
• The Role of the Neurointensive Care Nursery for Neonatal Encephalopathy.
  Clinics in perinatology 2016 Glass HC, Rowitch DH
• Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR
• Sustaining careers of physician-scientists in neonatology and pediatric critical care medicine: formulating supportive departmental policies.
  Pediatric research 2016 Christou H, Dizon ML, Farrow KN, Jadcherla SR, Leeman KT, Maheshwari A, Rubin LP, Stansfield BK, Rowitch DH
• Identification of proliferative progenitors associated with prominent postnatal growth of the pons.
  Nature communications 2016 Lindquist RA, Guinto CD, Rodas-Rodriguez JL, Fuentealba LC, Tate MC, Rowitch DH, Alvarez-Buylla A
• Astrocytes: The Final Frontier….
  Neuron 2016 Kelley KW, Rowitch DH
• Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome.
  Acta neuropathologica 2015 Nobuta H, Cilio MR, Danhaive O, Tsai HH, Tupal S, Chang SM, Murnen A, Kreitzer F, Bravo V, Czeisler C, Gokozan HN, Gygli P, Bush S, Weese-Mayer DE, Conklin B, Yee SP, Huang EJ, Gray PA, Rowitch D, …
• Dysregulation of astrocyte extracellular signaling in Costello syndrome.
  Science translational medicine 2015 Krencik R, Hokanson KC, Narayan AR, Dvornik J, Rooney GE, Rauen KA, Weiss LA, Rowitch DH, Ullian EM
• Disease specific therapies in leukodystrophies and leukoencephalopathies.
  Molecular genetics and metabolism 2015 Helman G, Van Haren K, Bonkowsky JL, Bernard G, Pizzino A, Braverman N, Suhr D, Patterson MC, Ali Fatemi S, Leonard J, van der Knaap MS, Back SA, Damiani S, Goldman SA, Takanohashi A, Petryniak M, …
• Postnatal growth of the human pons: a morphometric and immunohistochemical analysis.
  The Journal of comparative neurology 2014 Tate MC, Lindquist RA, Nguyen T, Sanai N, Barkovich AJ, Huang EJ, Rowitch DH, Alvarez-Buylla A
• Astrocyte development and heterogeneity.
  Cold Spring Harbor perspectives in biology 2014 Bayraktar OA, Fuentealba LC, Alvarez-Buylla A, Rowitch DH
• Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis.
  Cell 2014 Yuen TJ, Silbereis JC, Griveau A, Chang SM, Daneman R, Fancy SPJ, Zahed H, Maltepe E, Rowitch DH
• Hypomyelinating leukodystrophies: translational research progress and prospects.
  Annals of neurology 2014 Pouwels PJ, Vanderver A, Bernard G, Wolf NI, Dreha-Kulczewksi SF, Deoni SC, Bertini E, Kohlschütter A, Richardson W, Ffrench-Constant C, Köhler W, Rowitch D, Barkovich AJ
• An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Meijer DH, Sun Y, Liu T, Kane MF, Alberta JA, Adelmant G, Kupp R, Marto JA, Rowitch DH, Nakatani Y, Stiles CD, Mehta S
• Astrocyte-encoded positional cues maintain sensorimotor circuit integrity.
  Nature 2014 Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH
• Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer.
  Nature neuroscience 2014 Fancy SP, Harrington EP, Baranzini SE, Silbereis JC, Shiow LR, Yuen TJ, Huang EJ, Lomvardas S, Rowitch DH
• Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain.
  Neuron 2014 Silbereis JC, Nobuta H, Tsai HH, Heine VM, McKinsey GL, Meijer DH, Howard MA, Petryniak MA, Potter GB, Alberta JA, Baraban SC, Stiles CD, Rubenstein JL, Rowitch DH
• Cerebellar cortical lamination and foliation require cyclin A2.
  Developmental biology 2013 Otero JJ, Kalaszczynska I, Michowski W, Wong M, Gygli PE, Gokozan HN, Griveau A, Odajima J, Czeisler C, Catacutan FP, Murnen A, Schüller U, Sicinski P, Rowitch D
• Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years.
  Neuron 2013 Freeman MR, Rowitch DH
• A dramatic increase of C1q protein in the CNS during normal aging.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Stephan AH, Madison DV, Mateos JM, Fraser DA, Lovelett EA, Coutellier L, Kim L, Tsai HH, Huang EJ, Rowitch DH, Berns DS, Tenner AJ, Shamloo M, Barres BA
• The role of Tal2 and Tal1 in the differentiation of midbrain GABAergic neuron precursors.
  Biology open 2013 Achim K, Peltopuro P, Lahti L, Tsai HH, Zachariah A, Astrand M, Salminen M, Rowitch D, Partanen J
• Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions.
  Glia 2013 Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC
• Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress.
  PloS one 2013 Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi HJ, Tormos KV, Yeghiazarians Y, Jeffrey SS, Rinaudo PF, Rowitch DH, Aghi M, Maltepe E
• Missense mutation in mouse GALC mimics human gene defect and offers new insights into Krabbe disease.
  Human molecular genetics 2013 Potter GB, Santos M, Davisson MT, Rowitch DH, Marks DL, Bongarzone ER, Petryniak MA
• Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.
  Nature reviews. Neuroscience 2012 Meijer DH, Kane MF, Mehta S, Liu H, Harrington E, Taylor CM, Stiles CD, Rowitch DH
• Oligodendrocyte regeneration after neonatal hypoxia requires FoxO1-mediated p27Kip1 expression.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jablonska B, Scafidi J, Aguirre A, Vaccarino F, Nguyen V, Borok E, Horvath TL, Rowitch DH, Gallo V
• Neural stem cell engraftment and myelination in the human brain.
  Science translational medicine 2012 Gupta N, Henry RG, Strober J, Kang SM, Lim DA, Bucci M, Caverzasi E, Gaetano L, Mandelli ML, Ryan T, Perry R, Farrell J, Jeremy RJ, Ulman M, Huhn SL, Barkovich AJ, Rowitch DH
• STAT3-mediated astrogliosis protects myelin development in neonatal brain injury.
  Annals of neurology 2012 Nobuta H, Ghiani CA, Paez PM, Spreuer V, Dong H, Korsak RA, Manukyan A, Li J, Vinters HV, Huang EJ, Rowitch DH, Sofroniew MV, Campagnoni AT, de Vellis J, Waschek JA
• Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
  Genes & development 2012 Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY
• Evidence that nuclear factor IA inhibits repair after white matter injury.
  Annals of neurology 2012 Fancy SP, Glasgow SM, Finley M, Rowitch DH, Deneen B
• Regional astrocyte allocation regulates CNS synaptogenesis and repair.
  Science (New York, N.Y.) 2012 Tsai HH, Li H, Fuentealba LC, Molofsky AV, Taveira-Marques R, Zhuang H, Tenney A, Murnen AT, Fancy SP, Merkle F, Kessaris N, Alvarez-Buylla A, Richardson WD, Rowitch DH
• Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord.
  Development (Cambridge, England) 2012 Tien AC, Tsai HH, Molofsky AV, McMahon M, Foo LC, Kaul A, Dougherty JD, Heintz N, Gutmann DH, Barres BA, Rowitch DH
• Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH
• Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex.
  Cell 2012 Kwan KY, Lam MM, Johnson MB, Dube U, Shim S, Rašin MR, Sousa AM, Fertuzinhos S, Chen JG, Arellano JI, Chan DW, Pletikos M, Vasung L, Rowitch DH, Huang EJ, Schwartz ML, Willemsen R, Oostra BA, Rakic P,…
• Astrocytes and disease: a neurodevelopmental perspective.
  Genes & development 2012 Molofsky AV, Krencik R, Krenick R, Ullian EM, Ullian E, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH
• Identification of molecular compartments and genetic circuitry in the developing mammalian kidney.
  Development (Cambridge, England) 2012 Yu J, Valerius MT, Duah M, Staser K, Hansard JK, Guo JJ, McMahon J, Vaughan J, Faria D, Georgas K, Rumballe B, Ren Q, Krautzberger AM, Junker JP, Thiagarajan RD, Machanick P, Gray PA, van Oudenaarden …
• Olig1 function is required for remyelination potential of transplanted neural progenitor cells in a model of viral-induced demyelination.
  Experimental neurology 2012 Whitman LM, Blanc CA, Schaumburg CS, Rowitch DH, Lane TE
• Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem.
  Acta neuropathologica 2012 Grammel D, Warmuth-Metz M, von Bueren AO, Kool M, Pietsch T, Kretzschmar HA, Rowitch DH, Rutkowski S, Pfister SM, Schüller U
• Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma.
  The Journal of clinical investigation 2012 Phillips JJ, Huillard E, Robinson AE, Ward A, Lum DH, Polley MY, Rosen SD, Rowitch DH, Werb Z
• Ablation of NG2 proteoglycan leads to deficits in brown fat function and to adult onset obesity.
  PloS one 2012 Chang Y, She ZG, Sakimura K, Roberts A, Kucharova K, Rowitch DH, Stallcup WB
• Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Chong SY, Rosenberg SS, Fancy SP, Zhao C, Shen YA, Hahn AT, McGee AW, Xu X, Zheng B, Zhang LI, Rowitch DH, Franklin RJ, Lu QR, Chan JR
• Targeted therapy for BRAFV600E malignant astrocytoma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Nicolaides TP, Li H, Solomon DA, Hariono S, Hashizume R, Barkovich K, Baker SJ, Paugh BS, Jones C, Forshew T, Hindley GF, Hodgson JG, Kim JS, Rowitch DH, Weiss WA, Waldman TA, James CD
• A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury.
  Science translational medicine 2011 Heine VM, Griveau A, Chapin C, Ballard PL, Chen JK, Rowitch DH
• Myelin regeneration in multiple sclerosis: targeting endogenous stem cells.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2011 Huang JK, Fancy SP, Zhao C, Rowitch DH, Ffrench-Constant C, Franklin RJ
• Corridors of migrating neurons in the human brain and their decline during infancy.
  Nature 2011 Sanai N, Nguyen T, Ihrie RA, Mirzadeh Z, Tsai HH, Wong M, Gupta N, Berger MS, Huang E, Garcia-Verdugo JM, Rowitch DH, Alvarez-Buylla A
• Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases.
  Oncogene 2011 Papagiannakopoulos T, Friedmann-Morvinski D, Neveu P, Dugas JC, Gill RM, Huillard E, Liu C, Zong H, Rowitch DH, Barres BA, Verma IM, Kosik KS
• Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.
  Nature neuroscience 2011 Fancy SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C, Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R, Franklin RJ, Rowitch DH
• Myelin restoration: progress and prospects for human cell replacement therapies.
  Archivum immunologiae et therapiae experimentalis 2011 Potter GB, Rowitch DH, Petryniak MA
• Phosphorylation state of Olig2 regulates proliferation of neural progenitors.
  Neuron 2011 Sun Y, Meijer DH, Alberta JA, Mehta S, Kane MF, Tien AC, Fu H, Petryniak MA, Potter GB, Liu Z, Powers JF, Runquist IS, Rowitch DH, Stiles CD
• The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma.
  Cancer cell 2011 Mehta S, Huillard E, Kesari S, Maire CL, Golebiowski D, Harrington EP, Alberta JA, Kane MF, Theisen M, Ligon KL, Rowitch DH, Stiles CD
• Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Monje M, Mitra SS, Freret ME, Raveh TB, Kim J, Masek M, Attema JL, Li G, Haddix T, Edwards MS, Fisher PG, Weissman IL, Rowitch DH, Vogel H, Wong AJ, Beachy PA
• Role of academic medical centers in cell-based therapeutic clinical trials.
  Translational research : the journal of laboratory and clinical medicine 2011 Rowitch DH, Lo B
• NIH Consensus Development Conference statement: inhaled nitric-oxide therapy for premature infants.
  Pediatrics 2011 Cole FS, Alleyne C, Barks JD, Boyle RJ, Carroll JL, Dokken D, Edwards WH, Georgieff M, Gregory K, Johnston MV, Kramer M, Mitchell C, Neu J, Pursley DM, Robinson WM, Rowitch DH
• Myelin regeneration: a recapitulation of development?
  Annual review of neuroscience 2011 Fancy SP, Chan JR, Baranzini SE, Franklin RJ, Rowitch DH
• OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms.
  Journal of neuro-oncology 2010 Otero JJ, Rowitch D, Vandenberg S
• Developmental genetics of vertebrate glial-cell specification.
  Nature 2010 Rowitch DH, Kriegstein AR
• Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination.
  Annals of neurology 2010 Harrington EP, Zhao C, Fancy SP, Kaing S, Franklin RJ, Rowitch DH
• Towards improved animal models of neonatal white matter injury associated with cerebral palsy.
  Disease models & mechanisms 2010 Silbereis JC, Huang EJ, Back SA, Rowitch DH
• NIH consensus development conference: Inhaled nitric oxide therapy for premature infants.
  NIH consensus and state-of-the-science statements 2010 Cole FS, Alleyne C, Barks JD, Boyle RJ, Carroll JL, Dokken D, Edwards WH, Georgieff M, Gregory K, Johnston MV, Kramer M, Mitchell C, Neu J, Pursley DM, Robinson W, Rowitch DH
• Cerebellar abnormalities following hypoxia alone compared to hypoxic-ischemic forebrain injury in the developing rat brain.
  Neurobiology of disease 2010 Biran V, Heine VM, Verney C, Sheldon RA, Spadafora R, Vexler ZS, Rowitch DH, Ferriero DM
• Conserved role of intragenic DNA methylation in regulating alternative promoters.
  Nature 2010 Maunakea AK, Nagarajan RP, Bilenky M, Ballinger TJ, D'Souza C, Fouse SD, Johnson BE, Hong C, Nielsen C, Zhao Y, Turecki G, Delaney A, Varhol R, Thiessen N, Shchors K, Heine VM, Rowitch DH, Xing X, …
• Dexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-associated medulloblastoma.
  Cancer research 2010 Heine VM, Priller M, Ling J, Rowitch DH, Schüller U
• CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.
  Cell stem cell 2010 Zawadzka M, Rivers LE, Fancy SP, Zhao C, Tripathi R, Jamen F, Young K, Goncharevich A, Pohl H, Rizzi M, Rowitch DH, Kessaris N, Suter U, Richardson WD, Franklin RJ
• Neurocritical care for neonates.
  Neurocritical care 2010 Glass HC, Bonifacio SL, Peloquin S, Shimotake T, Sehring S, Sun Y, Sullivan J, Rogers E, Barkovich AJ, Rowitch D, Ferriero DM
• A FOXO-Pak1 transcriptional pathway controls neuronal polarity.
  Genes & development 2010 de la Torre-Ubieta L, Gaudillière B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S, Stegmüller J, Schüller U, Salih DA, Rowitch D, Brunet A, Bonni A
• Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas.
  Cancer research 2010 Schiffman JD, Hodgson JG, VandenBerg SR, Flaherty P, Polley MY, Yu M, Fisher PG, Rowitch DH, Ford JM, Berger MS, Ji H, Gutmann DH, James CD
• Overcoming remyelination failure in multiple sclerosis and other myelin disorders.
  Experimental neurology 2010 Fancy SP, Kotter MR, Harrington EP, Huang JK, Zhao C, Rowitch DH, Franklin RJ
• Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Zhang Y, Argaw AT, Gurfein BT, Zameer A, Snyder BJ, Ge C, Lu QR, Rowitch DH, Raine CS, Brosnan CF, John GR
• A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, Stiles CD
• Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK
• Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination.
  Cell 2009 Emery B, Agalliu D, Cahoy JD, Watkins TA, Dugas JC, Mulinyawe SB, Ibrahim A, Ligon KL, Rowitch DH, Barres BA
• Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.
  Genes & development 2009 Fancy SP, Baranzini SE, Zhao C, Yuk DI, Irvine KA, Kaing S, Sanai N, Franklin RJ, Rowitch DH
• Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanism.
  The Journal of clinical investigation 2009 Heine VM, Rowitch DH
• A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons.
  Cell 2009 Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, Rowitch D, Bonni A
• Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
  Cancer cell 2008 Schüller U, Heine VM, Mao J, Kho AT, Dillon AK, Han YG, Huillard E, Sun T, Ligon AH, Qian Y, Ma Q, Alvarez-Buylla A, McMahon AP, Rowitch DH, Ligon KL
• Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.
  Cancer cell 2008 Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, Schüller U, Machold R, Fishell G, Rowitch DH, Wainwright BJ, Wechsler-Reya RJ
• Glioma stem cells: a midterm exam.
  Neuron 2008 Stiles CD, Rowitch DH
• Expression and function of Nkx6.3 in vertebrate hindbrain.
  Brain research 2008 Hafler BP, Choi MY, Shivdasani RA, Rowitch DH
• Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia.
  Brain pathology (Zurich, Switzerland) 2008 Billiards SS, Haynes RL, Folkerth RD, Borenstein NS, Trachtenberg FL, Rowitch DH, Ligon KL, Volpe JJ, Kinney HC
• Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors.
  Molecular and cellular biology 2007 Schüller U, Zhao Q, Godinho SA, Heine VM, Medema RH, Pellman D, Rowitch DH
• A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.
  Development (Cambridge, England) 2007 Del Barrio MG, Taveira-Marques R, Muroyama Y, Yuk DI, Li S, Wines-Samuelson M, Shen J, Smith HK, Xiang M, Rowitch D, Richardson WD
• Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain.
  Neuron 2007 Petryniak MA, Potter GB, Rowitch DH, Rubenstein JL
• The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytes.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Parras CM, Hunt C, Sugimori M, Nakafuku M, Rowitch D, Guillemot F
• Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination.
  Glia 2007 Zeger M, Popken G, Zhang J, Xuan S, Lu QR, Schwab MH, Nave KA, Rowitch D, D'Ercole AJ, Ye P
• Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.
  Neuron 2007 Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH
• Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.
  Journal of neuropathology and experimental neurology 2006 Rousseau A, Nutt CL, Betensky RA, Iafrate AJ, Han M, Ligon KL, Rowitch DH, Louis DN
• A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway.
  Cancer research 2006 Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, McMahon AP
• Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis.
  Molecular and cellular neurosciences 2006 Schüller U, Kho AT, Zhao Q, Ma Q, Rowitch DH
• N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth.
  Cancer research 2006 Hatton BA, Knoepfler PS, Kenney AM, Rowitch DH, de Alborán IM, Olson JM, Eisenman RN
• Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma.
  Cancer research 2006 Chesler L, Schlieve C, Goldenberg DD, Kenney A, Kim G, McMillan A, Matthay KK, Rowitch D, Weiss WA
• Origin of oligodendrocytes in the subventricular zone of the adult brain.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Menn B, Garcia-Verdugo JM, Yaschine C, Gonzalez-Perez O, Rowitch D, Alvarez-Buylla A
• Beta-catenin function is required for cerebellar morphogenesis.
  Brain research 2006 Schüller U, Rowitch DH
• Olig gene function in CNS development and disease.
  Glia 2006 Ligon KL, Fancy SP, Franklin RJ, Rowitch DH
• Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord.
  Glia 2006 Kitada M, Rowitch DH
• Development of NG2 neural progenitor cells requires Olig gene function.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Ligon KL, Kesari S, Kitada M, Sun T, Arnett HA, Alberta JA, Anderson DJ, Stiles CD, Rowitch DH
• Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube.
  Developmental biology 2006 Sun T, Hafler BP, Kaing S, Kitada M, Ligon KL, Widlund HR, Yuk DI, Stiles CD, Rowitch DH
• Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Buffo A, Vosko MR, Ertürk D, Hamann GF, Jucker M, Rowitch D, Götz M
• Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube.
  Nature 2005 Muroyama Y, Fujiwara Y, Orkin SH, Rowitch DH
• Histology-based expression profiling yields novel prognostic markers in human glioblastoma.
  Journal of neuropathology and experimental neurology 2005 Dong S, Nutt CL, Betensky RA, Stemmer-Rachamimov AO, Denko NC, Ligon KL, Rowitch DH, Louis DN
• Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit.
  Developmental dynamics : an official publication of the American Association of Anatomists 2005 Matei V, Pauley S, Kaing S, Rowitch D, Beisel KW, Morris K, Feng F, Jones K, Lee J, Fritzsch B
• The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.
  Developmental cell 2005 Sjostrom SK, Finn G, Hahn WC, Rowitch DH, Kenney AM
• Olig2 expression, GFAP, p53 and 1p loss analysis contribute to glioma subclassification.
  Neuropathology and applied neurobiology 2005 Mokhtari K, Paris S, Aguirre-Cruz L, Privat N, Crinière E, Marie Y, Hauw JJ, Kujas M, Rowitch D, Hoang-Xuan K, Delattre JY, Sanson M
• Mouse brain organization revealed through direct genome-scale TF expression analysis.
  Science (New York, N.Y.) 2004 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles…
• bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.
  Science (New York, N.Y.) 2004 Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD
• Molecular diversity of astrocytes with implications for neurological disorders.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Bachoo RM, Kim RS, Ligon KL, Maher EA, Brennan C, Billings N, Chan S, Li C, Rowitch DH, Wong WH, DePinho RA
• Glial specification in the vertebrate neural tube.
  Nature reviews. Neuroscience 2004 Rowitch DH
• The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas.
  Journal of neuropathology and experimental neurology 2004 Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD, Rowitch DH
• Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Akiyama H, Chaboissier MC, Behringer RR, Rowitch DH, Schedl A, Epstein JA, de Crombrugghe B
• Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers.
  Genes & development 2004 Kho AT, Zhao Q, Cai Z, Butte AJ, Kim JY, Pomeroy SL, Rowitch DH, Kohane IS
• Synchronization of goat fibroblast cells at quiescent stage and determination of their transition from G0 to G1 by detection of cyclin D1 mRNA.
  Cloning and stem cells 2004 Memili E, Behboodi E, Overton SA, Kenney AM, O'Coin M, Zahedi A, Rowitch DH, Echelard Y
• Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors.
  Development (Cambridge, England) 2003 Kenney AM, Widlund HR, Rowitch DH
• Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice.
  Developmental biology 2003 Kim JY, Nelson AL, Algon SA, Graves O, Sturla LM, Goumnerova LC, Rowitch DH, Segal RA, Pomeroy SL
• Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Sun T, Dong H, Wu L, Kane M, Rowitch DH, Stiles CD
• Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Mori-Akiyama Y, Akiyama H, Rowitch DH, de Crombrugghe B
• Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia.
  Development (Cambridge, England) 2003 Ligon KL, Echelard Y, Assimacopoulos S, Danielian PS, Kaing S, Grove EA, McMahon AP, Rowitch DH
• Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors.
  Development (Cambridge, England) 2003 Kenney AM, Cole MD, Rowitch DH
• Development of mice expressing a single D-type cyclin.
  Genes & development 2002 Ciemerych MA, Kenney AM, Sicinska E, Kalaszczynska I, Bronson RT, Rowitch DH, Gardner H, Sicinski P
• An 'oligarchy' rules neural development.
  Trends in neurosciences 2002 Rowitch DH, Lu QR, Kessaris N, Richardson WD
• Medulloblastoma: a problem of developmental biology.
  Cancer cell 2002 Rubin JB, Rowitch DH
• Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Zhao Q, Kho A, Kenney AM, Yuk Di DI, Kohane I, Rowitch DH
• Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection.
  Cell 2002 Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD, Rowitch DH
• Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.
  Cancer cell 2002 Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA
• Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes.
  Mechanisms of development 2002 Heanue TA, Davis RJ, Rowitch DH, Kispert A, McMahon AP, Mardon G, Tabin CJ
• Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex.
  Nature neuroscience 2001 Lu QR, Cai L, Rowitch D, Cepko CL, Stiles CD
• Sonic hedgehog is required during an early phase of oligodendrocyte development in mammalian brain.
  Molecular and cellular neurosciences 2001 Alberta JA, Park SK, Mora J, Yuk D, Pawlitzky I, Iannarelli P, Vartanian T, Stiles CD, Rowitch DH
• Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube.
  Current biology : CB 2001 Sun T, Echelard Y, Lu R, Yuk DI, Kaing S, Stiles CD, Rowitch DH
• Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM
• Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon.
  Development (Cambridge, England) 2001 Tekki-Kessaris N, Woodruff R, Hall AC, Gaffield W, Kimura S, Stiles CD, Rowitch DH, Richardson WD
• Oligodendrocyte development in the spinal cord and telencephalon: common themes and new perspectives.
  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2001 Woodruff RH, Tekki-Kessaris N, Stiles CD, Rowitch DH, Richardson WD
• Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos.
  Developmental dynamics : an official publication of the American Association of Anatomists 2001 Lagutin O, Zhu CC, Furuta Y, Rowitch DH, McMahon AP, Oliver G
• Malignant glioma: genetics and biology of a grave matter.
  Genes & development 2001 Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA
• Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development.
  Development (Cambridge, England) 2001 Brault V, Moore R, Kutsch S, Ishibashi M, Rowitch DH, McMahon AP, Sommer L, Boussadia O, Kemler R
• Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase.
  The Journal of biological chemistry 2001 Chen L, Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S
• Characterization of Pax-2 regulatory sequences that direct transgene expression in the Wolffian duct and its derivatives.
  Developmental biology 2001 Kuschert S, Rowitch DH, Haenig B, McMahon AP, Kispert A
• Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors.
  Molecular and cellular biology 2000 Kenney AM, Rowitch DH
• Fate of the mammalian cardiac neural crest.
  Development (Cambridge, England) 2000 Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM
• Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis.
  Development (Cambridge, England) 2000 Chai Y, Jiang X, Ito Y, Bringas P, Han J, Rowitch DH, Soriano P, McMahon AP, Sucov HM
• Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system.
  Neuron 2000 Lu QR, Yuk D, Alberta JA, Zhu Z, Pawlitzky I, Chan J, McMahon AP, Stiles CD, Rowitch DH
• Pax-2 regulatory sequences that direct transgene expression in the developing neural plate and external granule cell layer of the cerebellum.
  Brain research. Developmental brain research 1999 Rowitch DH, Kispert A, McMahon AP
• Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Rowitch DH, S-Jacques B, Lee SM, Flax JD, Snyder EY, McMahon AP
• Cystic malformation of the posterior cerebellar vermis in transgenic mice that ectopically express Engrailed-1, a homeodomain transcription factor.
  Teratology 1999 Rowitch DH, Danielian PS, McMahon AP, Zec N
• Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase.
  Current biology : CB 1998 Danielian PS, Muccino D, Rowitch DH, Michael SK, McMahon AP
• Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence that governs Wnt-1 expression in the murine neural plate.
  Development (Cambridge, England) 1998 Rowitch DH, Echelard Y, Danielian PS, Gellner K, Brenner S, McMahon AP
• GDNF induces branching and increased cell proliferation in the ureter of the mouse.
  Developmental biology 1997 Pepicelli CV, Kispert A, Rowitch DH, McMahon AP
• Expression of the homeobox-containing genes EN1 and EN2 in human fetal midgestational medulla and cerebellum.
  Journal of neuropathology and experimental neurology 1997 Zec N, Rowitch DH, Bitgood MJ, Kinney HC
• Cell interactions in patterning the mammalian midbrain.
  Cold Spring Harbor symposia on quantitative biology 1997 Rowitch DH, Danielian PS, Lee SM, Echelard Y, McMahon AP
• Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips.
  Development (Cambridge, England) 1996 Kispert A, Vainio S, Shen L, Rowitch DH, McMahon AP
• Topical iodine and neonatal hypothyroidism.
  Archives of pediatrics & adolescent medicine 1995 Gordon CM, Rowitch DH, Mitchell ML, Kohane IS
• A single homeodomain binding site restricts spatial expression of Wnt-1 in the developing brain.
  Mechanisms of development 1995 Iler N, Rowitch DH, Echelard Y, McMahon AP, Abate-Shen C
• Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1.
  Mechanisms of development 1995 Rowitch DH, McMahon AP
• Neonatal herpes simplex virus infection presenting as fulminant liver failure.
  The Pediatric infectious disease journal 1995 Greenes DS, Rowitch D, Thorne GM, Perez-Atayde A, Lee FS, Goldmann D
• Effect of coat protein mutations in bacteriophage fd studied by sedimentation analysis.
  Biophysical journal 1992 Molina-Garcia AD, Harding SE, Diaz FG, de la Torre JG, Rowitch D, Perham RN
• Variable electrostatic interaction between DNA and coat protein in filamentous bacteriophage assembly.
  Journal of molecular biology 1988 Rowitch DH, Hunter GJ, Perham RN
• Cloning and expression of the filamentous bacteriophage Pf1 major coat protein gene in Escherichia coli. Membrane protein processing and virus assembly.
  Journal of molecular biology 1987 Rowitch DH, Perham RN
• Interactions between DNA and coat protein in the structure and assembly of filamentous bacteriophage fd.
  Nature 1987 Hunter GJ, Rowitch DH, Perham RN
• The metabolic defect of methionine dependence occurs frequently in human tumor cell lines.
  Biochemical and biophysical research communications 1983 Mecham JO, Rowitch D, Wallace CD, Stern PH, Hoffman RM
• Extent of DNA methylation in human tumor cells.
  Journal of the National Cancer Institute 1983 Diala ES, Cheah MS, Rowitch D, Hoffman RM