David Raleigh, PhD, MD
Associate Professor
Radiation Oncology
School of Medicine

Raleigh's research focuses on understanding the biological processes that cause brain tumors to grow. His goals are to uncover new measures of brain cancer and to identify cells for drugs to target.

Raleigh earned a bachelor's degree in molecular and cell biology as well as a bachelor's degree in cognitive science from the University of California, Berkeley. He earned his doctoral degree in molecular pathogenesis – how disease develops at the molecular level – from the University of Chicago, followed by his medical degree from the Pritzker School of Medicine at the University of Chicago. He completed a residency in radiation oncology at UCSF.

Raleigh is a member of the American Society of Clinical Oncology, American Society for Radiation Oncology, Pacific Pediatric Neuro-Oncology Consortium, Children's Oncology Group, Society for Neuro-Oncology, International Meningioma Society and North American Skull Base Society.

At the UCSF Brain Tumor Center, Raleigh is a principal investigator with the Wolfe Meningioma Program Project.

• A 34-gene expression biomarker predicts meningioma outcomes and radiotherapy responses.
  Neuro-oncology 2024 Raleigh DR, Preusser M
• Epigenetic reprogramming shapes the cellular landscape of schwannoma.
  Nature communications 2024 Liu SJ, Casey-Clyde T, Cho NW, Swinderman J, Pekmezci M, Dougherty MC, Foster K, Chen WC, Villanueva-Meyer JE, Swaney DL, Vasudevan HN, Choudhury A, Pak J, Breshears JD, Lang UE, Eaton CD, Hiam-Galvez…
• Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance.
  Nature communications 2024 Vasudevan HN, Payne E, Delley CL, John Liu S, Mirchia K, Sale MJ, Lastella S, Nunez MS, Lucas CG, Eaton CD, Casey-Clyde T, Magill ST, Chen WC, Braunstein SE, Perry A, Jacques L, Reddy AT, Pekmezci M, …
• Pan-cancer copy number variant analysis identifies optimized size thresholds and co-occurrence models for individualized risk-stratification.
  Research square 2024 Raleigh D, Nguyen M, Chen W, Zakimi N, Mirchia K, Lucas CH
• Epidemiology, Genetics, and DNA Methylation Grouping of Hyperostotic Meningiomas.
  Operative neurosurgery (Hagerstown, Md.) 2024 Umbach G, Tran EB, Eaton CD, Choudhury A, Morshed R, Villanueva-Meyer JE, Theodosopoulos PV, Magill ST, McDermott MW, Raleigh DR, Goldschmidt E
• Radiotherapy dose escalation for high-risk meningiomas after subtotal resection.
  Neuro-oncology 2023 Raleigh DR
• "De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.
  Acta neuropathologica 2023 Hadad S, Gupta R, Oberheim Bush NA, Taylor JW, Villanueva-Meyer JE, Young JS, Wu J, Ravindranathan A, Zhang Y, Warrier G, McCoy L, Shai A, Pekmezci M, Perry A, Bollen AW, Phillips JJ, Braunstein SE, …
• Multiomic screening of invasive GBM cells reveals targetable transsulfuration pathway alterations.
  The Journal of clinical investigation 2023 Garcia JH, Akins EA, Jain S, Wolf KJ, Zhang J, Choudhary N, Lad M, Shukla P, Rios J, Seo K, Gill SA, Carson WH, Carette LR, Zheng AC, Raleigh DR, Kumar S, Aghi MK
• Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.
  Nature medicine 2023 Chen WC, Choudhury A, Youngblood MW, Polley MC, Lucas CG, Mirchia K, Maas SLN, Suwala AK, Won M, Bayley JC, Harmanci AS, Harmanci AO, Klisch TJ, Nguyen MP, Vasudevan HN, McCortney K, Yu TJ, Bhave V, …
• A Prospective Registry Study of 68Ga-DOTATATE PET/CT Incorporation Into Treatment Planning of Intracranial Meningiomas.
  International journal of radiation oncology, biology, physics 2023 Perlow HK, Nalin AP, Handley D, Gokun Y, Blakaj DM, Beyer SJ, Thomas EM, Raval RR, Boulter D, Kleefisch C, Bovi J, Chen WC, Braunstein SE, Raleigh DR, Knisely JPS, Ivanidze J, Palmer JD
• Glioma-neuronal circuit remodeling induces regional immunosuppression.
  bioRxiv : the preprint server for biology 2023 Nejo T, Krishna S, Jimenez C, Yamamichi A, Young JS, Lakshmanachetty S, Chen T, Phyu SSS, Ogino H, Watchmaker P, Diebold D, Choudhury A, Daniel AGS, Raleigh DR, Hervey-Jumper SL, Okada H
• Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma.
  Research square 2023 Daggubati V, Vykunta A, Choudhury A, Qadeer Z, Mirchia K, Saulnier O, Zakimi N, Hines K, Paul M, Wang L, Jura N, Xu L, Reiter J, Taylor M, Weiss W, Raleigh D
• Molecular Features of Resected Melanoma Brain Metastases, Clinical Outcomes, and Responses to Immunotherapy.
  JAMA network open 2023 Vasudevan HN, Delley C, Chen WC, Mirchia K, Pan S, Shukla P, Aabedi AA, Nguyen MP, Morshed RA, Young JS, Boreta L, Fogh SE, Nakamura JL, Theodosopoulos PV, Phillips J, Hervey-Jumper SL, Daras M, Pike …
• Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis.
  Research square 2023 Raleigh D, Mirchia K, Choudhury A, Joseph T, Birrueta J, Phillips J, Bhaduri A, Crouch E, Perry A
• NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy.
  bioRxiv : the preprint server for biology 2023 Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, Bush NAO, Hervey-Jumper SL, Klein OD, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, …
• Correction: Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas.
  Acta neuropathologica 2023 Wang JZ, Patil V, Liu J, Dogan H, Tabatabai G, Yefet LS, Behling F, Hoffman E, Bunda S, Yakubov R, Kaloti R, Brandner S, Gao A, Cohen-Gadol A, Barnholtz-Sloan J, Skardelly M, Tatagiba M, Raleigh DR, …
• Post-Surgical Prognosis of Patients with Pineoblastoma: A Systematic Review and Individual Patient Data Analysis with Trends over Time.
  Cancers 2023 Nandoliya KR, Sadagopan NS, Thirunavu V, Houskamp EJ, Karras CL, Chaliparambil RK, Sriram N, Jamshidi P, Raleigh DR, Lukas RV, Magill ST
• Radiotherapy and radiosurgery for meningiomas.
  Neuro-oncology advances 2023 Chen WC, Lucas CG, Magill ST, Rogers CL, Raleigh DR
• Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution.
  Research square 2023 Lucas CH, Mirchia K, Seo K, Najem H, Chen W, Zakimi N, Choudhury A, Liu SJ, Phillips J, Magill S, Horbinski C, Solomon D, Perry A, Vasudevan H, Heimberger A, Raleigh D
• Glioblastoma remodelling of human neural circuits decreases survival.
  Nature 2023 Krishna S, Choudhury A, Keough MB, Seo K, Ni L, Kakaizada S, Lee A, Aabedi A, Popova G, Lipkin B, Cao C, Nava Gonzales C, Sudharshan R, Egladyous A, Almeida N, Zhang Y, Molinaro AM, Venkatesh HS, …
• Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas.
  Acta neuropathologica 2023 Wang JZ, Patil V, Liu J, Dogan H, Tabatabai G, Yefet LS, Behling F, Hoffman E, Bunda S, Yakubov R, Kaloti R, Brandner S, Gao A, Cohen-Gadol A, Barnholtz-Sloan J, Skardelly M, Tatagiba M, Raleigh DR, …
• Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.
  Research square 2023 Raleigh D, Chen W, Choudhury A, Youngblood M, Polley MY, Lucas CH, Mirchia K, Maas S, Suwala A, Won M, Bayley J, Harmanci A, Harmanci A, Klisch T, Nguyen M, Vasudevan H, McCortney K, Yu T, Bhave V, …
• Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features.
  Neuro-oncology 2023 Choudhury A, Chen WC, Lucas CG, Bayley JC, Harmanci AS, Maas SLN, Santagata S, Klisch T, Perry A, Bi WL, Sahm F, Patel AJ, Magill ST, Raleigh DR
• MerlinS13 phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features.
  Research square 2023 Eaton C, Avalos L, Liu SJ, Casey-Clyde T, Bisignano P, Lucas CH, Stevenson E, Choudhury A, Vasudevan H, Magill S, Krogan N, Villanueva-Meyer J, Swaney D, Raleigh D
• Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma.
  Acta neuropathologica 2023 Khan AB, English CW, Chen WC, Athukuri P, Bayley JC, Brandt VL, Shetty A, Hadley CC, Choudhury A, Lu HC, Harmanci AO, Harmanci AS, Magill ST, Raleigh DR, Klisch TJ, Patel AJ
• Loss of p16 expression is a sensitive marker of CDKN2A homozygous deletion in malignant meningiomas.
  Acta neuropathologica 2023 Tang V, Lu R, Mirchia K, Van Ziffle J, Devine P, Lee J, Phillips JJ, Perry A, Raleigh DR, Lucas CG, Solomon DA
• Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling.
  The Journal of clinical investigation 2023 Lee D, Gimple RC, Wu X, Prager BC, Qiu Z, Wu Q, Daggubati V, Mariappan A, Gopalakrishnan J, Sarkisian MR, Raleigh DR, Rich JN
• Radiotherapy for Meningioma.
  Advances in experimental medicine and biology 2023 Susko MS, Raleigh DR
• A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets.
  Nature cancer 2022 Wang L, Jung J, Babikir H, Shamardani K, Jain S, Feng X, Gupta N, Rosi S, Chang S, Raleigh D, Solomon D, Phillips JJ, Diaz AA
• Mutational Status and Clinical Outcomes Following Systemic Therapy with or without Focal Radiation for Resected Melanoma Brain Metastases.
  World neurosurgery 2022 Vasudevan HN, Susko MS, Ma L, Nakamura JL, Raleigh DR, Boreta L, Fogh S, Theodosopoulos PV, McDermott MW, Tsai KK, Sneed PK, Braunstein SE
• Radiotherapy for meningiomas.
  Journal of neuro-oncology 2022 Chen WC, Perlow HK, Choudhury A, Nguyen MP, Mirchia K, Youngblood MW, Lucas CG, Palmer JD, Magill ST, Raleigh DR
• A case (report) for mechanistic validation of meningioma molecular therapies.
  Neuro-oncology advances 2022 Nguyen MP, Seo K, Eaton CD, Lucas CG, Chen WC, Choudhury A, Young JS, Raleigh DR
• Gene expression analysis during progression of malignant meningioma compared to benign meningioma.
  Journal of neurosurgery 2022 Maier AD, Meddis A, Mirian C, Haslund-Vinding J, Bartek J, Krog SM, Nguyen TUP, Areškeviciute A, Melchior LC, Heegaard S, Kristensen BW, Munch TN, Fugleholm K, Ziebell M, Raleigh DR, Poulsen FR, Gerds…
• Miat and interacting protein Metadherin maintain a stem-like niche to promote medulloblastoma tumorigenesis and treatment resistance.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Peng KL, Vasudevan HN, Lockney DT, Baum R, Hendrickson RC, Raleigh DR, Schmitt AM
• Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1.
  Acta neuropathologica 2022 Lucas CG, Sloan EA, Gupta R, Wu J, Pratt D, Vasudevan HN, Ravindranathan A, Barreto J, Williams EA, Shai A, Whipple NS, Bruggers CS, Maher O, Nabors B, Rodriguez M, Samuel D, Brown M, Carmichael J, Lu…
• CDK 4/6 inhibitors for the treatment of meningioma.
  Frontiers in oncology 2022 Young JS, Kidwell RL, Zheng A, Haddad AF, Aghi MK, Raleigh DR, Schulte JD, Butowski NA
• Intrinsically Disordered Protein Micelles as Vehicles for Convection-Enhanced Drug Delivery to Glioblastoma Multiforme.
  ACS applied bio materials 2022 Gleason JM, Klass SH, Huang P, Ozawa T, Santos RA, Fogarty MM, Raleigh DR, Berger MS, Francis MB
• Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma.
  Journal of neuropathology and experimental neurology 2022 Lucas CG, Davidson CJ, Alashari M, Putnam AR, Whipple NS, Bruggers CS, Mendez JS, Cheshier SH, Walker JB, Ramani B, Cadwell CR, Sullivan DV, Lu R, Mirchia K, Van Ziffle J, Devine P, Goldschmidt E, …
• 68Ga-DOTATATE PET: The Future of Meningioma Treatment.
  International journal of radiation oncology, biology, physics 2022 Prasad RN, Perlow HK, Bovi J, Braunstein SE, Ivanidze J, Kalapurakal JA, Kleefisch C, Knisely JPS, Mehta MP, Prevedello DM, Raleigh DR, Mishra MV, Roberge D, Rogers CL, Palmer JD
• Intratumor and informatic heterogeneity influence meningioma molecular classification.
  Acta neuropathologica 2022 Vasudevan HN, Choudhury A, Hilz S, Villanueva-Meyer JE, Chen WC, Lucas CG, Braunstein SE, Oberheim Bush NA, Butowski N, Pekmezci M, McDermott MW, Perry A, Solomon DA, Magill ST, Raleigh DR
• Supervised machine learning algorithms demonstrate proliferation index correlates with long-term recurrence after complete resection of WHO grade I meningioma.
  Journal of neurosurgery 2022 Nguyen MP, Morshed RA, Dalle Ore CL, Cummins DD, Saggi S, Chen WC, Choudhury A, Ravi A, Raleigh DR, Magill ST, McDermott MW, Theodosopoulos PV
• Adverse radiation effect and freedom from progression following repeat stereotactic radiosurgery for brain metastases.
  Journal of neurosurgery 2022 Sneed PK, Chan JW, Ma L, Braunstein SE, Theodosopoulos PV, Fogh SE, Nakamura JL, Boreta L, Raleigh DR, Ziemer BP, Morin O, Hervey-Jumper SL, McDermott MW
• Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities.
  Nature genetics 2022 Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW,…
• A molecularly integrated grade for meningioma.
  Neuro-oncology 2022 Driver J, Hoffman SE, Tavakol S, Woodward E, Maury EA, Bhave V, Greenwald NF, Nassiri F, Aldape K, Zadeh G, Choudhury A, Vasudevan HN, Magill ST, Raleigh DR, Abedalthagafi M, Aizer AA, Alexander BM, …
• CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids.
  Nature communications 2022 Lo M, Sharir A, Paul MD, Torosyan H, Agnew C, Li A, Neben C, Marangoni P, Xu L, Raleigh DR, Jura N, Klein OD
• Pediatric pineoblastoma: A pooled outcome study of North American and Australian therapeutic data.
  Neuro-oncology advances 2022 Hansford JR, Huang J, Endersby R, Dodgshun AJ, Li BK, Hwang E, Leary S, Gajjar A, Von Hoff K, Wells O, Wray A, Kotecha RS, Raleigh DR, Stoller S, Mueller S, Schild SE, Bandopadhayay P, Fouladi M, …
• Resection with intraoperative cesium-131 brachytherapy as salvage therapy for recurrent brain tumors.
  Journal of neurosurgery 2022 Chen WC, Lafreniere M, Phuong C, Liu SJ, Baal JD, Lometti M, Morin O, Ziemer B, Vasudevan HN, Lucas CG, Hervey-Jumper SL, Theodosopoulos PV, Magill ST, Fogh S, Nakamura JL, Boreta L, Sneed PK, …
• ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma.
  Genome biology 2021 Babikir H, Wang L, Shamardani K, Catalan F, Sudhir S, Aghi MK, Raleigh DR, Phillips JJ, Diaz AA
• Synthesis and Preliminary Biological Assessment of Carborane-Loaded Theranostic Nanoparticles to Target Prostate-Specific Membrane Antigen.
  ACS applied materials & interfaces 2021 Meher N, Seo K, Wang S, Bidkar AP, Fogarty M, Dhrona S, Huang X, Tang R, Blaha C, Evans MJ, Raleigh DR, Jun YW, VanBrocklin HF, Desai TA, Wilson DM, Ozawa T, Flavell RR
• Mouse models of glioblastoma for the evaluation of novel therapeutic strategies.
  Neuro-oncology advances 2021 Haddad AF, Young JS, Amara D, Berger MS, Raleigh DR, Aghi MK, Butowski NA
• Efficacy and Safety of Stereotactic Radiosurgery for Brainstem Metastases: A Systematic Review and Meta-analysis.
  JAMA oncology 2021 Chen WC, Baal UH, Baal JD, Pai JS, Boreta L, Braunstein SE, Raleigh DR
• Residents-as-Teachers Curriculum for Radiation Oncology: A Targeted Needs Assessment.
  International journal of radiation oncology, biology, physics 2021 Ni L, Thomas HR, Raleigh DR, Boreta LC, Park CC, Braunstein SE
• Letter: Patterns of Intermediate- and High-Risk Meningioma Recurrence After Treatment With Postoperative External Beam Radiotherapy.
  Neurosurgery 2021 Susko MS, Chen WC, Vasudevan HN, Magill ST, Lucas CG, Oberheim Bush NA, Solomon DA, Theodosopoulos PV, McDermott MW, Villanueva-Meyer JE, Boreta L, Nakamura JL, Sneed PK, Braunstein SE, Raleigh DR
• A single institution retrospective analysis on survival based on treatment paradigms for patients with anaplastic oligodendroglioma.
  Journal of neuro-oncology 2021 Bush NAO, Young JS, Zhang Y, Dalle Ore CL, Molinaro AM, Taylor J, Clarke J, Prados M, Braunstein SE, Raleigh DR, Chang SM, Berger MS, Butowski NA
• Sterol regulation of developmental and oncogenic Hedgehog signaling.
  Biochemical pharmacology 2021 Daggubati V, Raleigh DR, Sever N
• Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models.
  The Journal of clinical investigation 2021 Daggubati V, Hochstelter J, Bommireddy A, Choudhury A, Krup AL, Kaur P, Tong P, Li A, Xu L, Reiter JF, Raleigh DR
• Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer.
  Neurosurgery 2021 Vasudevan HN, Lucas CG, Villanueva-Meyer JE, Theodosopoulos PV, Raleigh DR
• Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway.
  The Journal of cell biology 2021 Findakly S, Daggubati V, Garcia G, LaStella SA, Choudhury A, Tran C, Li A, Tong P, Garcia JQ, Puri N, Reiter JF, Xu L, Raleigh DR
• A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection.
  Neurosurgery 2020 Chen WC, Vasudevan HN, Choudhury A, Pekmezci M, Lucas CG, Phillips J, Magill ST, Susko MS, Braunstein SE, Oberheim Bush NA, Boreta L, Nakamura JL, Villanueva-Meyer JE, Sneed PK, Perry A, McDermott MW,…
• Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival.
  Neuro-oncology advances 2020 Lucas CG, Vasudevan HN, Chen WC, Magill ST, Braunstein SE, Jacques L, Dahiya S, Rodriguez FJ, Horvai AE, Perry A, Pekmezci M, Raleigh DR
• Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.
  Nature communications 2020 Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, …
• WHO Grade I Meningioma Recurrence: Identifying High Risk Patients Using Histopathological Features and the MIB-1 Index.
  Frontiers in oncology 2020 Haddad AF, Young JS, Kanungo I, Sudhir S, Chen JS, Raleigh DR, Magill ST, McDermott MW, Aghi MK
• The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.
  Cancer discovery 2020 Prager BC, Vasudevan HN, Dixit D, Bernatchez JA, Wu Q, Wallace LC, Bhargava S, Lee D, King BH, Morton AR, Gimple RC, Pekmezci M, Zhu Z, Siqueira-Neto JL, Wang X, Xie Q, Chen C, Barnett GH, Vogelbaum …
• Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals.
  Acta neuropathologica communications 2020 Findakly S, Choudhury A, Daggubati V, Pekmezci M, Lang UE, Raleigh DR
• DNA methylation profiling demonstrates superior diagnostic classification to RNA-sequencing in a case of metastatic meningioma.
  Acta neuropathologica communications 2020 Vasudevan HN, Castro MRH, Lee JC, Villanueva-Meyer JE, Bush NAO, McDermott MW, Solomon DA, Perry A, Magill ST, Raleigh DR
• CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.
  Genome biology 2020 Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, …
• Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma.
  Cell reports 2020 Liu SJ, Magill ST, Vasudevan HN, Hilz S, Villanueva-Meyer JE, Lastella S, Daggubati V, Spatz J, Choudhury A, Orr BA, Demaree B, Seo K, Ferris SP, Abate AR, Oberheim Bush NA, Bollen AW, McDermott MW, …
• Clinical Implications of Primary Cilia in Skin Cancer.
  Dermatology and therapy 2020 Choudhury A, Neumann NM, Raleigh DR, Lang UE
• Stereotactic Body Radiation Therapy of Adrenal Metastases: A Pooled Meta-Analysis and Systematic Review of 39 Studies with 1006 Patients.
  International journal of radiation oncology, biology, physics 2020 Chen WC, Baal JD, Baal U, Pai J, Gottschalk A, Boreta L, Braunstein SE, Raleigh DR
• Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.
  Cell stem cell 2020 Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, …
• Preclinical models of meningioma: Cell culture and animal systems.
  Handbook of clinical neurology 2020 Choudhury A, Raleigh DR
• Stereotactic Radiosurgery to More Than 10 Brain Metastases: Evidence to Support the Role of Radiosurgery for Ideal Hippocampal Sparing in the Treatment of Multiple Brain Metastases.
  World neurosurgery 2019 Susko MS, Garcia MA, Ma L, Nakamura JL, Raleigh DR, Fogh S, Theodosopoulos P, McDermott M, Sneed PK, Braunstein SE
• Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas.
  Acta neuropathologica 2019 Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, …
• Integrated models incorporating radiologic and radiomic features predict meningioma grade, local failure, and overall survival.
  Neuro-oncology advances 2019 Morin O, Chen WC, Nassiri F, Susko M, Magill ST, Vasudevan HN, Wu A, Vallières M, Gennatas ED, Valdes G, Pekmezci M, Alcaide-Leon P, Choudhury A, Interian Y, Mortezavi S, Turgutlu K, Bush NAO, Solberg…
• Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.
  Molecular pharmaceutics 2019 Wang S, Blaha C, Santos R, Huynh T, Hayes TR, Beckford-Vera DR, Blecha JE, Hong AS, Fogarty M, Hope TA, Raleigh DR, Wilson DM, Evans MJ, VanBrocklin HF, Ozawa T, Flavell RR
• Clinical, radiological, and histopathological predictors for long-term prognosis after surgery for atypical meningiomas.
  Acta neurochirurgica 2019 Streckert EMS, Hess K, Sporns PB, Adeli A, Brokinkel C, Kriz J, Holling M, Eich HT, Paulus W, Spille DC, van Eck ATCJ, Raleigh DR, McDermott MW, Stummer W, Brokinkel B
• Reirradiation of recurrent high-grade glioma and development of prognostic scores for progression and survival.
  Neuro-oncology practice 2019 Chapman CH, Hara JH, Molinaro AM, Clarke JL, Oberheim Bush NA, Taylor JW, Butowski NA, Chang SM, Fogh SE, Sneed PK, Nakamura JL, Raleigh DR, Braunstein SE
• Meningioma metastases: incidence and proposed screening paradigm.
  Journal of neurosurgery 2019 Dalle Ore CL, Magill ST, Yen AJ, Shahin MN, Lee DS, Lucas CG, Chen WC, Viner JA, Aghi MK, Theodosopoulos PV, Raleigh DR, Villanueva-Meyer JE, McDermott MW
• Temozolomide Treatment Induces lncRNA MALAT1 in an NF-κB and p53 Codependent Manner in Glioblastoma.
  Cancer research 2019 Voce DJ, Bernal GM, Wu L, Crawley CD, Zhang W, Mansour NM, Cahill KE, Szymura SJ, Uppal A, Raleigh DR, Spretz R, Nunez L, Larsen G, Khodarev NN, Weichselbaum RR, Yamini B
• Preoperative Dural Contact and Recurrence Risk After Surgical Cavity Stereotactic Radiosurgery for Brain Metastases: New Evidence in Support of Consensus Guidelines.
  Advances in radiation oncology 2019 Susko M, Yu Y, Ma L, Nakamura J, Fogh S, Raleigh DR, Golden E, Theodosopoulos PV, McDermott MW, Sneed PK, Braunstein SE
• Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma.
  Acta neuropathologica 2019 Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS, Thangaraj N, Wendelsdorf K, Samuel D, Kline CN, Banerjee A, Auguste K, Raffel C, Gupta N, Berger M, Raleigh DR, Shai A, Phillips JJ, Bollen AW, Tihan…
• Preoperative MR Imaging to Differentiate Chordoid Meningiomas from Other Meningioma Histologic Subtypes.
  AJNR. American journal of neuroradiology 2019 Baal JD, Chen WC, Solomon DA, Pai JS, Lucas CH, Hara JH, Oberheim Bush NA, McDermott MW, Raleigh DR, Villanueva-Meyer JE
• Misactivation of Hedgehog signaling causes inherited and sporadic cancers.
  The Journal of clinical investigation 2019 Raleigh DR, Reiter JF
• Advances in multidisciplinary therapy for meningiomas.
  Neuro-oncology 2019 Brastianos PK, Galanis E, Butowski N, Chan JW, Dunn IF, Goldbrunner R, Herold-Mende C, Ippen FM, Mawrin C, McDermott MW, Sloan A, Snyder J, Tabatabai G, Tatagiba M, Tonn JC, Wen PY, Aldape K, Nassiri …
• Erratum: "Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers" [Med. Phys. 45 (7), 3449-3459 (2018)].
  Medical physics 2019 Deist TM, Dankers FJWM, Valdes G, Wijsman R, Hsu IC, Oberije C, Lustberg T, van Soest J, Hoebers F, Jochems A, El Naqa I, Wee L, Morin O, Raleigh DR, Bots W, Kaanders JH, Belderbos J, Kwint M, Solberg…
• The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma.
  Acta neuropathologica 2018 Fritchie K, Jensch K, Moskalev EA, Caron A, Jenkins S, Link M, Brown PD, Rodriguez FJ, Guajardo A, Brat D, Velázquez Vega JE, Perry A, Wu A, Raleigh DR, Santagata S, Louis DN, Brastianos PK, Kaplan A,…
• Surgical outcomes after reoperation for recurrent non-skull base meningiomas.
  Journal of neurosurgery 2018 Magill ST, Dalle Ore CL, Diaz MA, Jalili DD, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW
• Cilia-Associated Oxysterols Activate Smoothened.
  Molecular cell 2018 Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald …
• Preoperative and postoperative prediction of long-term meningioma outcomes.
  PloS one 2018 Gennatas ED, Wu A, Braunstein SE, Morin O, Chen WC, Magill ST, Gopinath C, Villaneueva-Meyer JE, Perry A, McDermott MW, Solberg TD, Valdes G, Raleigh DR
• Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers.
  Medical physics 2018 Deist TM, Dankers FJWM, Valdes G, Wijsman R, Hsu IC, Oberije C, Lustberg T, van Soest J, Hoebers F, Jochems A, El Naqa I, Wee L, Morin O, Raleigh DR, Bots W, Kaanders JH, Belderbos J, Kwint M, Solberg…
• Clinical Applications of Quantitative 3-Dimensional MRI Analysis for Pediatric Embryonal Brain Tumors.
  International journal of radiation oncology, biology, physics 2018 Hara JH, Wu A, Villanueva-Meyer JE, Valdes G, Daggubati V, Mueller S, Solberg TD, Braunstein SE, Morin O, Raleigh DR
• Surgical Outcomes, Complications, and Management Strategies for Foramen Magnum Meningiomas.
  Journal of neurological surgery. Part B, Skull base 2018 Magill ST, Shahin MN, Lucas CG, Yen AJ, Lee DS, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW
• Surgical outcomes after reoperation for recurrent skull base meningiomas.
  Journal of neurosurgery 2018 Magill ST, Lee DS, Yen AJ, Lucas CG, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW
• How the Ciliary Membrane Is Organized Inside-Out to Communicate Outside-In.
  Current biology : CB 2018 Garcia G, Raleigh DR, Reiter JF
• Histopathological features predictive of local control of atypical meningioma after surgery and adjuvant radiotherapy.
  Journal of neurosurgery 2018 Chen WC, Magill ST, Wu A, Vasudevan HN, Morin O, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Braunstein SE, Raleigh DR
• Petrous Face Meningiomas: Classification, Clinical Syndromes, and Surgical Outcomes.
  World neurosurgery 2018 Magill ST, Rick JW, Chen WC, Haase DA, Raleigh DR, Aghi MK, Theodosopoulos PV, McDermott MW
• Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation.
  Cell reports 2018 Vasudevan HN, Braunstein SE, Phillips JJ, Pekmezci M, Tomlin BA, Wu A, Reis GF, Magill ST, Zhang J, Feng FY, Nicholaides T, Chang SM, Sneed PK, McDermott MW, Berger MS, Perry A, Raleigh DR
• Salvage therapy outcomes for atypical meningioma.
  Journal of neuro-oncology 2018 Chen WC, Hara J, Magill ST, Wu A, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Raleigh DR, Braunstein SE
• Resection Cavity Contraction Effects in the Use of Radioactive Sources (1-25 versus Cs-131) for Intra-Operative Brain Implants.
  Cureus 2018 Han DY, Ma L, Braunstein S, Raleigh D, Sneed PK, McDermott M
• Presenting Symptoms and Prognostic Factors for Symptomatic Outcomes Following Resection of Meningioma.
  World neurosurgery 2017 Wu A, Garcia MA, Magill ST, Chen W, Vasudevan HN, Perry A, Theodosopoulos PV, McDermott MW, Braunstein SE, Raleigh DR
• Hedgehog signaling drives medulloblastoma growth via CDK6.
  The Journal of clinical investigation 2017 Raleigh DR, Choksi PK, Krup AL, Mayer W, Santos N, Reiter JF
• Multiple myeloma and a mischievous pacemaker: A teaching case involving irradiation of a cardiovascular implantable electronic device.
  Practical radiation oncology 2017 Lloyd S, Morin O, Whitman I, Raleigh D, Fogh S, Menzel P
• Case-based review: pediatric medulloblastoma.
  Neuro-oncology practice 2017 Kline CN, Packer RJ, Hwang EI, Raleigh DR, Braunstein S, Raffel C, Bandopadhayay P, Solomon DA, Aboian M, Cha S, Mueller S
• Management of Chordoma and Chondrosarcoma with Fractionated Stereotactic Radiotherapy.
  Frontiers in surgery 2017 Vasudevan HN, Raleigh DR, Johnson J, Garsa AA, Theodosopoulos PV, Aghi MK, Ames C, McDermott MW, Barani IJ, Braunstein SE
• Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy.
  Neuro-oncology 2017 Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, …
• Pediatric high-grade glioma: current molecular landscape and therapeutic approaches.
  Journal of neuro-oncology 2017 Braunstein S, Raleigh D, Bindra R, Mueller S, Haas-Kogan D
• Surgical Resection and Interstitial Iodine-125 Brachytherapy for High-Grade Meningiomas: A 25-Year Series.
  Neurosurgery 2017 Magill ST, Lau D, Raleigh DR, Sneed PK, Fogh SE, McDermott MW
• Survival after chemotherapy and stem cell transplant followed by delayed craniospinal irradiation is comparable to upfront craniospinal irradiation in pediatric embryonal brain tumor patients.
  Journal of neuro-oncology 2016 Raleigh DR, Tomlin B, Buono BD, Roddy E, Sear K, Byer L, Felton E, Banerjee A, Torkildson J, Samuel D, Horn B, Braunstein SE, Haas-Kogan DA, Mueller S
• Educational Impact of a Structured Radiation Oncology Clerkship Curriculum: An Interinstitutional Comparison.
  Journal of the American College of Radiology : JACR 2016 Oskvarek JJ, Brower JV, Mohindra P, Raleigh DR, Chmura SJ, Golden DW
• Discovery of additional brain metastases on the day of stereotactic radiosurgery: risk factors and outcomes.
  Journal of neurosurgery 2016 Garcia MA, Lazar A, Duriseti S, Raleigh DR, Hess CP, Fogh SE, Barani IJ, Nakamura JL, Larson DA, Theodosopoulos P, McDermott M, Sneed PK, Braunstein S
• Resection and brain brachytherapy with permanent iodine-125 sources for brain metastasis.
  Journal of neurosurgery 2016 Raleigh DR, Seymour ZA, Tomlin B, Theodosopoulos PV, Berger MS, Aghi MK, Geneser SE, Krishnamurthy D, Fogh SE, Sneed PK, McDermott MW
• Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome.
  Neuro-oncology 2016 Raleigh DR, Solomon DA, Lloyd SA, Lazar A, Garcia MA, Sneed PK, Clarke JL, McDermott MW, Berger MS, Tihan T, Haas-Kogan DA
• Parameters influencing local control of meningiomas treated with radiosurgery.
  Journal of neuro-oncology 2016 Kaprealian T, Raleigh DR, Sneed PK, Nabavizadeh N, Nakamura JL, McDermott MW
• Meningiomas With Rhabdoid Features Lacking Other Histologic Features of Malignancy: A Study of 44 Cases and Review of the Literature.
  Journal of neuropathology and experimental neurology 2015 Vaubel RA, Chen SG, Raleigh DR, Link MJ, Chicoine MR, Barani I, Jenkins SM, Aleff PA, Rodriguez FJ, Burger PC, Dahiya S, Perry A, Giannini C
• Somatostatin receptor 2a is a more sensitive diagnostic marker of meningioma than epithelial membrane antigen.
  Acta neuropathologica 2015 Menke JR, Raleigh DR, Gown AM, Thomas S, Perry A, Tihan T
• Patient- and treatment-specific predictors of genitourinary function after high-dose-rate monotherapy for favorable prostate cancer.
  Brachytherapy 2015 Raleigh DR, Chang AJ, Tomlin B, Cunha JA, Braunstein SE, Shinohara K, Gottschalk AR, Roach M, Hsu IC
• Induction Hedgehog pathway inhibition followed by combined-modality radiotherapy for basal cell carcinoma.
  The British journal of dermatology 2015 Raleigh DR, Algazi A, Arron ST, Neuhaus IM, Yom SS
• S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability.
  Cell cycle (Georgetown, Tex.) 2015 Crawley CD, Kang S, Bernal GM, Wahlstrom JS, Voce DJ, Cahill KE, Garofalo A, Raleigh DR, Weichselbaum RR, Yamini B
• The management of central neurocytoma: radiotherapy.
  Neurosurgery clinics of North America 2015 Barani IJ, Raleigh DR, Larson D
• Bladder wall recurrence of prostate cancer after high-dose-rate brachytherapy.
  Brachytherapy 2014 Raleigh DR, Hsu IC, Braunstein S, Chang AJ, Simko JP, Roach M
• Toward an improved understanding of the ionizing radiation induced DNA damage/response networks in human malignancies.
  Frontiers in oncology 2014 Haas-Kogan DA, Raleigh DR, Dicker AP
• Non-Muscle Myosin IIa Heavy Chain Links Squamous-Cell Carcinoma of the Head and Neck to the DNA Damage Response.
  Frontiers in oncology 2014 Raleigh DR, Haas-Kogan DA
• A national radiation oncology medical student clerkship survey: didactic curricular components increase confidence in clinical competency.
  International journal of radiation oncology, biology, physics 2014 Jagadeesan VS, Raleigh DR, Koshy M, Howard AR, Chmura SJ, Golden DW
• Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux.
  Molecular biology of the cell 2013 Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley EM, Breskin LA, Wu L, Anderson K, Turner JR, Weber CR
• Molecular targets and mechanisms of radiosensitization using DNA damage response pathways.
  Future oncology (London, England) 2013 Raleigh DR, Haas-Kogan DA
• DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-κB p50 and a single nucleotide in the κB-site.
  Nucleic acids research 2012 Crawley CD, Raleigh DR, Kang S, Voce DJ, Schmitt AM, Weichselbaum RR, Yamini B
• A genome-wide transgenic resource for conditional expression of Drosophila microRNAs.
  Development (Cambridge, England) 2012 Bejarano F, Bortolamiol-Becet D, Dai Q, Sun K, Saj A, Chou YT, Raleigh DR, Kim K, Ni JQ, Duan H, Yang JS, Fulga TA, Van Vactor D, Perrimon N, Lai EC
• Radiation oncology fourth-year medical student clerkships: a targeted needs assessment.
  International journal of radiation oncology, biology, physics 2012 Golden DW, Raleigh DR, Chmura SJ, Koshy M, Howard AR
• p50 (NF-κB1) is an effector protein in the cytotoxic response to DNA methylation damage.
  Molecular cell 2011 Schmitt AM, Crawley CD, Kang S, Raleigh DR, Yu X, Wahlstrom JS, Voce DJ, Darga TE, Weichselbaum RR, Yamini B
• Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function.
  The Journal of cell biology 2011 Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JR
• Tight junction pore and leak pathways: a dynamic duo.
  Annual review of physiology 2011 Shen L, Weber CR, Raleigh DR, Yu D, Turner JR
• MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Yu D, Marchiando AM, Weber CR, Raleigh DR, Wang Y, Shen L, Turner JR
• Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo.
  The Journal of cell biology 2010 Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JR
• Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity.
  The Journal of biological chemistry 2010 Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR
• Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions.
  Molecular biology of the cell 2010 Raleigh DR, Marchiando AM, Zhang Y, Shen L, Sasaki H, Wang Y, Long M, Turner JR