David Pearce, MD
Professor
Medicine
School of Medicine

College: University of California, Berkeley BA (Mathematics) Medical School: University of Chicago, Pritzker School of Medicine, MD Internal Medicine Residency: Harbor-UCLA Medical Center Nephrology Fellowship: University of California, San Francisco

Dr. Pearce's research focuses on understanding the cellular and molecular mechanisms underlying hormone-regulated ion transport in the kidney tubules. His lab has cloned and characterized several key regulatory proteins involved in the control of epithelial Na+ and K+ transport. Notably, SGK1 is a serine-threonine signaling kinase, which mediates the effects of multiple hormones, and is necessary for normal Na+ and K+ homeostasis. Defects in SGK1 result in pseudohypoaldosteronism (Na+ wasting and inability to excrete K+ despite high aldosterone levels).

His group has made seminal contributions to our understanding of how the effects of SGK1 and other signaling proteins are integrated to achieve specific regulation of ion transport. Recently, his lab identified a large multiprotein complex, which integrates manifold inputs that impact on Na+ transport in kidney tubule cells. The principal goal of this basic research is to identify points of entry for treatment of diseases such as hypertension and metabolic syndrome. Already, SGK1 inhibitors are in preclinical testing for the treatment of salt sensitive hypertension.

Dr. Pearce's research is funded by two R01's from the NIDDK, and several Foundation awards.

Dr. Pearce is Professor of Medicine and Cellular & Molecular Pharmacology at UCSF, and Chief of Nephrology at San Francisco General Hospital, one of the core teaching hospitals affiliated with UCSF.

• Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate Epithelial Sodium Channel: Role in Rapid Renal Responses to Dietary Potassium.
  Journal of the American Society of Nephrology : JASN 2023 Saha B, Shabbir W, Takagi E, Duan XP, Leite Dellova DCA, Demko J, Manis A, Loffing-Cueni D, Loffing J, Sørensen MV, Wang WH, Pearce D
• WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport.
  Journal of cell science 2022 Saha B, Leite-Dellova DCA, Demko J, Sørensen MV, Takagi E, Gleason CE, Shabbir W, Pearce D
• Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls.
  Journal of the Endocrine Society 2022 Parikh NI, Arowolo F, Durstenfeld MS, Nah G, Njoroge J, Vittinghoff E, Long CS, Ganz P, Pearce D, Hsue P, Wu AHS, Hajizadeh N, Liu KD, Lynch KL
• Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
  The Journal of biological chemistry 2022 Yu Z, Chen J, Takagi E, Wang F, Saha B, Liu X, Joubert LM, Gleason CE, Jin M, Li C, Nowotny C, Agard D, Cheng Y, Pearce D
• Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology.
  Pflugers Archiv : European journal of physiology 2022 Pearce D, Manis AD, Nesterov V, Korbmacher C
• Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold.
  The Journal of biological chemistry 2021 Allu PKR, Paulo E, Bertholet AM, Situ G, Lee SH, Wu Y, Gleason CE, Saha B, Chawla A, Wang B, Pearce D
• Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19.
  Medical hypotheses 2020 Stookey JD, Allu PKR, Chabas D, Pearce D, Lang F
• Regulation of ENaC by aldosterone and potassium.
  The FASEB Journal 2020 Deise C. A. Leite Dellova, Bidisha Saha, Enzo Takagi, Waheed Shabbir, David Pearce
• mTOR Modulates Sodium and Potassium Conduction in Heterologous Expression System.
  The FASEB Journal 2020 Waheed Shabbir, Catherine E. Gleason, Bidisha Saha, Deise C. A. Leite Dellova, David Pearce
• Association of Urinary Plasminogen-Plasmin with Edema and Epithelial Sodium Channel Activation in Patients with Nephrotic Syndrome.
  American journal of nephrology 2019 Chen JL, Wang L, Yao XM, Zang YJ, Wang Y, Li ZJ, Pearce D, Wang H
• Potassium acts through mTOR to regulate its own secretion.
  JCI insight 2019 Sørensen MV, Saha B, Jensen IS, Wu P, Ayasse N, Gleason CE, Svendsen SL, Wang WH, Pearce D
• Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt.
  Journal of cell science 2019 Gleason CE, Oses-Prieto JA, Li KH, Saha B, Situ G, Burlingame AL, Pearce D
• The mTORC2-SGK1 Signaling Module Mediates Local Sensing of Potassium in Kidney Tubule Principal Cells to Activate ENaC and Promote Potassium Secretion.
  The FASEB Journal 2019 Bidisha Saha, Catherine Gleason, Peng Wu, Wen-Hui Wang, David Pearce
• The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex.
  Cell death & disease 2018 Yuan YP, Zhao H, Peng LQ, Li ZF, Liu S, Yuan CY, Mwamunyi MJ, Pearce D, Yao LJ
• Potassium Can Regulate Its Own Excretion in Collecting Duct Cells: Role of mTORC2, SGK1 and ENaC.
  The FASEB Journal 2018 Bidisha Saha, Peng Wu, Catherine E. Gleason, Wenhui Wang, David Pearce
• Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance in vivo.
  Scientific reports 2018 Morze CV, Allu PKR, Chang GY, Marco-Rius I, Milshteyn E, Wang ZJ, Ohliger MA, Gleason CE, Kurhanewicz J, Vigneron DB, Pearce D
• Lack of serum- and glucocorticoid-inducible kinase 3 leads to podocyte dysfunction.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Peng LQ, Zhao H, Liu S, Yuan YP, Yuan CY, Mwamunyi MJ, Pearce D, Yao LJ
• Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate.
  Magnetic resonance in medicine 2018 von Morze C, Ohliger MA, Marco-Rius I, Wilson DM, Flavell RR, Pearce D, Vigneron DB, Kurhanewicz J, Wang ZJ
• Lack of specificity of antibodies raised against CLN3, the lysosomal/endosomal transmembrane protein mutated in juvenile Batten disease.
  Bioscience reports 2017 Nelson T, Pearce DA, Kovács AD
• Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron.
  Kidney international 2017 Rashmi P, Colussi G, Ng M, Wu X, Kidwai A, Pearce D
• Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone.
  Magnetic resonance in medicine 2016 Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M
• Decreased sensitivity of palmitoyl protein thioesterase 1-deficient neurons to chemical anoxia.
  Metabolic brain disease 2016 Meyer M, Kovács AD, Pearce DA
• Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13 C-lactate and 13 C-pyruvate in kidney and liver.
  Magnetic resonance in medicine 2016 von Morze C, Chang GY, Larson PE, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB
• Detecting Metabolism of Gluconeogenic Precursors Lactate and Pyruvate in Kidney & Liver with Hyperpolarized 13 C MRI.
  The FASEB Journal 2016 Cornelius von Morze, Gene-Yuan Chang, Peder E Larson, Hong Shang, Prasanna KR Allu, Robert A Bok, Jason C Crane, Marram P Olson, Chou T Tan, Irene Marco-Rius, Sarah J Nelson, John Kurhanewicz, David …
• Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies.
  Magnetic resonance in medicine 2016 Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB
• Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway.
  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2015 Lang F, Pearce D
• mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity.
  The Journal of clinical investigation 2014 Gleason CE, Frindt G, Cheng CJ, Ng M, Kidwai A, Rashmi P, Lang F, Baum M, Palmer LG, Pearce D
• The novel Cln1(R151X) mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy.
  Human molecular genetics 2014 Miller JN, Kovács AD, Pearce DA
• Collecting duct principal cell transport processes and their regulation.
  Clinical journal of the American Society of Nephrology : CJASN 2014 Pearce D, Soundararajan R, Trimpert C, Kashlan OB, Deen PM, Kohan DE
• Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription.
  American journal of physiology. Renal physiology 2013 Zhang X, Zhou Q, Chen L, Berger S, Wu H, Xiao Z, Pearce D, Zhou X, Zhang W
• Osmotic stress changes the expression and subcellular localization of the Batten disease protein CLN3.
  PloS one 2013 Getty A, Kovács AD, Lengyel-Nelson T, Cardillo A, Hof C, Chan CH, Pearce DA
• The role of nonsense-mediated decay in neuronal ceroid lipofuscinosis.
  Human molecular genetics 2013 Miller JN, Chan CH, Pearce DA
• Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival.
  The Journal of cell biology 2012 Kim HJ, Prasad V, Hyung SW, Lee ZH, Lee SW, Bhargava A, Pearce D, Lee Y, Kim HH
• SGK3 regulates Ca(2+) entry and migration of dendritic cells.
  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012 Schmid E, Bhandaru M, Nurbaeva MK, Yang W, Szteyn K, Russo A, Leibrock C, Tyan L, Pearce D, Shumilina E, Lang F
• Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex.
  The Journal of biological chemistry 2012 Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D
• Age-dependent therapeutic effect of memantine in a mouse model of juvenile Batten disease.
  Neuropharmacology 2012 Kovács AD, Saje A, Wong A, Ramji S, Cooper JD, Pearce DA
• The Glucocorticoid-induced leucine zipper (GILZ) Is essential for spermatogonial survival and spermatogenesis.
  Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2012 Romero Y, Vuandaba M, Suarez P, Grey C, Calvel P, Conne B, Pearce D, de Massy B, Hummler E, Nef S
• The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility.
  Molecular endocrinology (Baltimore, Md.) 2012 Suarez PE, Rodriguez EG, Soundararajan R, Mérillat AM, Stehle JC, Rotman S, Roger T, Voirol MJ, Wang J, Gross O, Pétrilli V, Nadra K, Wilson A, Beermann F, Pralong FP, Maillard M, Pearce D, Chrast R, …
• Organization of the ENaC-regulatory machinery.
  Critical reviews in biochemistry and molecular biology 2012 Soundararajan R, Lu M, Pearce D
• Chapter 6 Aldosterone Regulation of Ion Transport.
  Brenner and Rector\u0027s The Kidney 2012 David Pearce, Vivek Bhalla, John W. Funder, John B. Stokes
• The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport.
  Molecular and cellular endocrinology 2011 Soundararajan R, Pearce D, Ziera T
• Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.
  Molecular endocrinology (Baltimore, Md.) 2011 Yao LJ, McCormick JA, Wang J, Yang KY, Kidwai A, Colussi GL, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D
• Altered glutamate receptor function in the cerebellum of the Ppt1-/- mouse, a murine model of infantile neuronal ceroid lipofuscinosis.
  Journal of neuroscience research 2011 Finn R, Kovács AD, Pearce DA
• mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.
  The Journal of biological chemistry 2011 Lu M, Wang J, Ives HE, Pearce D
• Identification of CNK3 in the Aldosterone-regulated ENaC Regulatory Complex.
  The FASEB Journal 2011 Tim Ziera, Eric Koo, Rama Soundararajan, David Pearce
• Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3.
  Kidney international 2011 Bhandaru M, Kempe DS, Rotte A, Capuano P, Pathare G, Sopjani M, Alesutan I, Tyan L, Huang DY, Siraskar B, Judenhofer MS, Stange G, Pichler BJ, Biber J, Quintanilla-Martinez L, Wagner CA, Pearce D, …
• Altered sensitivity of cerebellar granule cells to glutamate receptor overactivation in the Cln3(Δex7/8)-knock-in mouse model of juvenile neuronal ceroid lipofuscinosis.
  Neurochemistry international 2011 Finn R, Kovács AD, Pearce DA
• Cardiovascular effects of melanocortins.
  European journal of pharmacology 2011 Humphreys MH, Ni XP, Pearce D
• Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3.
  Journal of gastroenterology 2010 Pasham V, Rotte A, Bhandaru M, Eichenmüller M, Fröhlich H, Mack AF, Bobbala D, Yang W, Pearce D, Lang F
• Temporary inhibition of AMPA receptors induces a prolonged improvement of motor performance in a mouse model of juvenile Batten disease.
  Neuropharmacology 2010 Kovács AD, Saje A, Wong A, Szénási G, Kiricsi P, Szabó E, Cooper JD, Pearce DA
• Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization.
  The Journal of biological chemistry 2010 Soundararajan R, Wang J, Melters D, Pearce D
• Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney.
  American journal of physiology. Renal physiology 2010 Pao AC, Bhargava A, Di Sole F, Quigley R, Shao X, Wang J, Thomas S, Zhang J, Shi M, Funder JW, Moe OW, Pearce D
• Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3.
  American journal of physiology. Cell physiology 2010 Zemtsova IM, Heise N, Fröhlich H, Qadri SM, Kucherenko Y, Boini KM, Pearce D, Shumilina E, Lang F
• Role of epithelial sodium channels and their regulators in hypertension.
  The Journal of biological chemistry 2010 Soundararajan R, Pearce D, Hughey RP, Kleyman TR
• Regulation of gastric acid secretion by PKB/Akt2.
  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010 Rotte A, Pasham V, Bhandaru M, Eichenmüller M, Yang W, Qadri SM, Kempe DS, Puchchakayala G, Pearce D, Birnbaum MJ, Lang F
• Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel.
  The Journal of biological chemistry 2010 Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D
• Akt/PKB-sensitive proximal tubular glucose and phosphate transport.
  The FASEB Journal 2010 Michael Föller, Daniela S. Kempe, Gulab Siraskar, Henning Fröhlich, Teresa F. Ackermann, Balasaheb Siraskar, Harald Völkl, Martin Judenhofer, Bernd Pichler, Karla F. Leavens, Morris J. Birnbaum, David…
• GILZ1: a key molecular determinant of intracellular signaling specificity governing epithelial sodium transport.
  The FASEB Journal 2010 Rama Soundararajan, Jian Wang, Daniel Melters, I-Chia Shih, David Pearce
• Phosphopeptide Screen Uncovers JNK1 as a Potentiator of Nedd4-2-Mediated Epithelial Na+ Channel Inhibition.
  The FASEB Journal 2010 Vivek Bhalla, Nicholas M Oyster, Marjolein Wijngaarden, Jeffrey Lee, Hui Li, Xiaoyu Xia, Zhirong Huang, Robert Chalkley, Alma Burlingame, David Pearce, Ken Hallows
• mTOR complex-2 activates ENaC by phosphorylating SGK1.
  Journal of the American Society of Nephrology : JASN 2010 Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D
• Akt2/PKBbeta-sensitive regulation of renal phosphate transport.
  Acta physiologica (Oxford, England) 2010 Kempe DS, Ackermann TF, Boini KM, Klaus F, Umbach AT, Dërmaku-Sopjani M, Judenhofer MS, Pichler BJ, Capuano P, Stange G, Wagner CA, Birnbaum MJ, Pearce D, Föller M, Lang F
• Regulation of renal tubular glucose reabsorption by Akt2/PKBβ.
  American journal of physiology. Renal physiology 2010 Kempe DS, Siraskar G, Fröhlich H, Umbach AT, Stübs M, Weiss F, Ackermann TF, Völkl H, Birnbaum MJ, Pearce D, Föller M, Lang F
• Akt2 and SGK3 are both determinants of postnatal hair follicle development.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Mauro TM, McCormick JA, Wang J, Boini KM, Ray L, Monks B, Birnbaum MJ, Lang F, Pearce D
• Evidence for a noradrenergic mechanism causing hypertension and abnormal glucose metabolism in rats with relative deficiency of gamma-melanocyte-stimulating hormone.
  Experimental physiology 2009 Ni XP, van Dijk C, Pearce D, Humphreys MH
• Epithelial sodium channel regulated by differential composition of a signaling complex.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Soundararajan R, Melters D, Shih IC, Wang J, Pearce D
• Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1.
  PLoS biology 2009 Jones KT, Greer ER, Pearce D, Ashrafi K
• Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport.
  American journal of physiology. Renal physiology 2008 Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D
• Differential activities of glucocorticoid-induced leucine zipper protein isoforms.
  The Journal of biological chemistry 2007 Soundararajan R, Wang J, Melters D, Pearce D
• NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions.
  American journal of physiology. Renal physiology 2007 Pao AC, McCormick JA, Li H, Siu J, Govaerts C, Bhalla V, Soundararajan R, Pearce D
• Salt, sodium channels, and SGK1.
  The Journal of clinical investigation 2007 Pearce D, Kleyman TR
• AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2.
  The Journal of biological chemistry 2006 Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR
• Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ.
  American journal of physiology. Renal physiology 2006 Bhalla V, Soundararajan R, Pao AC, Li H, Pearce D
• Renal function of gene-targeted mice lacking both SGK1 and SGK3.
  American journal of physiology. Regulatory, integrative and comparative physiology 2006 Grahammer F, Artunc F, Sandulache D, Rexhepaj R, Friedrich B, Risler T, McCormick JA, Dawson K, Wang J, Pearce D, Wulff P, Kuhl D, Lang F
• Inhibition of the Epithelial Sodium Channel by AMP-Activated Kinase Involves Modulation of Nedd4-2 Activity.
  The FASEB Journal 2006 Kenneth R Hallows, Nicholas M Oyster, Vivek Bhalla, David Pearce
• Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouse.
  Behavioural brain research 2005 Lang UE, Wolfer DP, Grahammer F, Strutz-Seebohm N, Seebohm G, Lipp HP, McCormick JA, Hellweg R, Dawson K, Wang J, Pearce D, Lang F
• A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport.
  The Journal of biological chemistry 2005 Soundararajan R, Zhang TT, Wang J, Vandewalle A, Pearce D
• Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney.
  American journal of physiology. Regulatory, integrative and comparative physiology 2005 Ni XP, Bhargava A, Pearce D, Humphreys MH
• Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.
  Molecular endocrinology (Baltimore, Md.) 2005 Bhalla V, Daidié D, Li H, Pao AC, LaGrange LP, Wang J, Vandewalle A, Stockand JD, Staub O, Pearce D
• Decreased intestinal glucose transport in the sgk3-knockout mouse.
  Pflugers Archiv : European journal of physiology 2005 Sandu C, Rexhepaj R, Grahammer F, McCormick JA, Henke G, Palmada M, Nammi S, Lang U, Metzger M, Just L, Skutella T, Dawson K, Wang J, Pearce D, Lang F
• SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption.
  Physiology (Bethesda, Md.) 2005 McCormick JA, Bhalla V, Pao AC, Pearce D
• Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3.
  The Journal of physiology 2005 Strutz-Seebohm N, Seebohm G, Mack AF, Wagner HJ, Just L, Skutella T, Lang UE, Henke G, Striegel M, Hollmann M, Rouach N, Nicoll RA, McCormick JA, Wang J, Pearce D, Lang F
• Enhanced mitochondrial degradation of yeast cytochrome c with amphipathic structures.
  Current genetics 2004 Chen X, Moerschell RP, Pearce DA, Ramanan DD, Sherman F
• Steroid receptor coactivator-1 splice variants differentially affect corticosteroid receptor signaling.
  Endocrinology 2004 Meijer OC, Kalkhoven E, van der Laan S, Steenbergen PJ, Houtman SH, Dijkmans TF, Pearce D, de Kloet ER
• Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development.
  Molecular biology of the cell 2004 McCormick JA, Feng Y, Dawson K, Behne MJ, Yu B, Wang J, Wyatt AW, Henke G, Grahammer F, Mauro TM, Lang F, Pearce D
• Long double-stranded RNA-mediated RNA interference as a tool to achieve site-specific silencing of hypothalamic neuropeptides.
  Brain research. Brain research protocols 2004 Bhargava A, Dallman MF, Pearce D, Choi S
• Mechanisms of mineralocorticoid action: determinants of receptor specificity and actions of regulated gene products.
  Trends in endocrinology and metabolism: TEM 2004 Bhargava A, Pearce D
• Regulation of epithelial ion transport by aldosterone through changes in gene expression.
  Molecular and cellular endocrinology 2004 Bhargava A, Wang J, Pearce D
• Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells.
  Hypertension (Dallas, Tex. : 1979) 2004 Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG
• Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants.
  Molecular endocrinology (Baltimore, Md.) 2003 Adams M, Meijer OC, Wang J, Bhargava A, Pearce D
• Multiple corticosteroid receptors in a teleost fish: distinct sequences, expression patterns, and transcriptional activities.
  Endocrinology 2003 Greenwood AK, Butler PC, White RB, DeMarco U, Pearce D, Fernald RD
• Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse.
  The Journal of clinical investigation 2003 Ni XP, Pearce D, Butler AA, Cone RD, Humphreys MH
• The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC.
  Pflugers Archiv : European journal of physiology 2003 Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, Wang J, Pearce D, Lang F
• Aldosterone: its receptor, target genes, and actions.
  Vitamins and hormones 2003 Pearce D, Bhargava A, Cole TJ
• SGK1 regulation of epithelial sodium transport.
  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2003 Pearce D
• The serum and glucocorticoid-inducible kinase SGK1 and the Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1.
  Journal of the American Society of Nephrology : JASN 2002 Yun CC, Palmada M, Embark HM, Fedorenko O, Feng Y, Henke G, Setiawan I, Boehmer C, Weinman EJ, Sandrasagra S, Korbmacher C, Cohen P, Pearce D, Lang F
• Effect of immunosuppressive agents on glucocorticoid receptor function in A6 cells.
  American journal of physiology. Renal physiology 2002 Edinger RS, Watkins SC, Pearce D, Johnson JP
• Glucocorticoids prolong Ca(2+) transients in hippocampal-derived H19-7 neurons by repressing the plasma membrane Ca(2+)-ATPase-1.
  Molecular endocrinology (Baltimore, Md.) 2002 Bhargava A, Mathias RS, McCormick JA, Dallman MF, Pearce D
• Hypotonic induction of SGK1 and Na+ transport in A6 cells.
  American journal of physiology. Renal physiology 2002 Rozansky DJ, Wang J, Doan N, Purdy T, Faulk T, Bhargava A, Dawson K, Pearce D
• Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.
  The EMBO journal 2001 Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Münster C, Chraïbi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O
• Determinants of subnuclear organization of mineralocorticoid receptor characterized through analysis of wild type and mutant receptors.
  The Journal of biological chemistry 2001 Pearce D, Náray-Fejes-Tóth A, Fejes-Tóth G
• The role of SGK1 in hormone-regulated sodium transport.
  Trends in endocrinology and metabolism: TEM 2001 Pearce D
• Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.
  American journal of physiology. Renal physiology 2001 Loffing J, Zecevic M, Féraille E, Kaissling B, Asher C, Rossier BC, Firestone GL, Pearce D, Verrey F
• The Serum- and Glucocorticoid-Induced Kinase Is a Physiological Mediator of Aldosterone Action*.
  Endocrinology 2001 Aditi Bhargava, Meryl J. Fullerton, Kathy Myles, Timothy M. Purdy, John W. Funder, David Pearce, Timothy J. Cole
• The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action.
  Endocrinology 2001 Bhargava A, Fullerton MJ, Myles K, Purdy TM, Funder JW, Pearce D, Cole TJ
• SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport.
  American journal of physiology. Renal physiology 2001 Wang J, Barbry P, Maiyar AC, Rozansky DJ, Bhargava A, Leong M, Firestone GL, Pearce D
• Human immunodeficiency virus type 1 Vpr contains two leucine-rich helices that mediate glucocorticoid receptor coactivation independently of its effects on G(2) cell cycle arrest.
  Journal of virology 2000 Sherman MP, de Noronha CM, Pearce D, Greene WC
• A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy.
  Molecular and cellular biology 2000 Iñiguez-Lluhí JA, Pearce D
• Plasma membrane calcium pump isoform 1 gene expression is repressed by corticosterone and stress in rat hippocampus.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 Bhargava A, Meijer OC, Dallman MF, Pearce D
• Pleiotropic action of aldosterone in epithelia mediated by transcription and post-transcription mechanisms.
  Kidney international 2000 Verrey F, Pearce D, Pfeiffer R, Spindler B, Mastroberardino L, Summa V, Zecevic M
• Role of SGK in mineralocorticoid-regulated sodium transport.
  Kidney international 2000 Pearce D, Verrey F, Chen SY, Mastroberardino L, Meijer OC, Wang J, Bhargava A
• Transcriptional repression of the 5-HT1A receptor promoter by corticosterone via mineralocorticoid receptors depends on the cellular context.
  Journal of neuroendocrinology 2000 Meijer OC, Williamson A, Dallman MF, Pearce D
• Regulation of the rat serotonin-1A receptor gene by corticosteroids.
  The Journal of biological chemistry 2000 Wissink S, Meijer O, Pearce D, van Der Burg B, van Der Saag PT
• Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae.
  Journal of bacteriology 1999 Pearce DA, Sherman F
• Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids.
  Molecular and cellular biology 1999 Rogatsky I, Hittelman AB, Pearce D, Garabedian MJ
• Epithelial sodium channel regulated by aldosterone-induced protein sgk.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, Pearce D
• Glucocorticoid receptor transcriptional activity determined by spacing of receptor and nonreceptor DNA sites.
  The Journal of biological chemistry 1998 Pearce D, Matsui W, Miner JN, Yamamoto KR
• Subcellular localization of mineralocorticoid receptors in living cells: effects of receptor agonists and antagonists.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Fejes-Tóth G, Pearce D, Náray-Fejes-Tóth A
• Aldosterone responsiveness of A6 cells is restored by cloned rat mineralocorticoid receptor.
  The American journal of physiology 1998 Chen SY, Wang J, Liu W, Pearce D
• Androgen and glucocorticoid receptor heterodimer formation. A possible mechanism for mutual inhibition of transcriptional activity.
  The Journal of biological chemistry 1997 Chen Sy, Wang J, Yu Gq, Liu W, Pearce D
• The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of their products to form a haem or apo- c-type cytochrome transporter.
  Microbiology (Reading, England) 1997 Page MD, Pearce DA, Norris HAC, Ferguson SJ
• Steroid receptor transcriptional synergy is potentiated by disruption of the DNA-binding domain dimer interface.
  Molecular endocrinology (Baltimore, Md.) 1996 Liu W, Wang J, Yu G, Pearce D
• Steroid receptor heterodimerization demonstrated in vitro and in vivo.
  Proceedings of the National Academy of Sciences of the United States of America 1995 Liu W, Wang J, Sauter NK, Pearce D
• A mechanistic basis for distinct mineralocorticoid and glucocorticoid receptor transcriptional specificities.
  Steroids 1994 Pearce D
• Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element.
  Science (New York, N.Y.) 1993 Pearce D, Yamamoto KR
• Expression of rat renal Na/H antiporter mRNA levels in response to respiratory and metabolic acidosis.
  The Journal of clinical investigation 1991 Krapf R, Pearce D, Lynch C, Xi XP, Reudelhuber TL, Pouysségur J, Rector FC
• NaCl reflection coefficients in proximal tubule apical and basolateral membrane vesicles. Measurement by induced osmosis and solvent drag.
  Biophysical journal 1989 Pearce D, Verkman AS
• Membrane water and solute permeability determined quantitatively by self-quenching of an entrapped fluorophore.
  Biochemistry 1988 Chen PY, Pearce D, Verkman AS