David Morgan, PhD
Professor
Physiology
School of Medicine
Education & Training
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- Ph.D. Graduate Division (Endocrinology) University of California, San Francisco 1986
- B.Sc. Animal Biology University of Calgary 1980
Websites
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- Lab website (morganlab.ucsf.edu)
- Profile at physio.ucsf.edu (physio.ucsf.edu)
Grants and Projects
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- Regulatory Enzymes and Systems in Cell Cycle Control, NIH, 2016-2026
- Cell Biology, Genetics, and Biochemistry Training Grant, NIH, 1979-2021
- Cell Cycle Control by Cyclin-Dependent Kinases, NIH, 2004-2017
- Molecular Control of Cell Proliferation, NIH, 1990-2016
- Regulation of chromosome segregation, NIH, 2010-2015
- Quantitative studies of cell cycle checkpoints and switches, NIH, 2011-2015
- Molecular Control of Cell Proliferation, NIH, 1990-2011
- Structure/function of Cyclin Dependent Kinases, NIH, 1994-2003
- Molecular Cell Biology Conference, NIH, 1996-1997
- Molecular Control of Cell Proliferation, NIH, 1990-1995
Publications (57)
Top publication keywords:
Chromosome SegregationCell Cycle ProteinsCDC2 Protein KinaseUbiquitinationAnaphase-Promoting Complex-CyclosomeUbiquitin-Conjugating EnzymesCyclin BUbiquitin-Protein Ligase ComplexesCdc20 ProteinsSecurinAcetyltransferasesMitosisSaccharomyces cerevisiae ProteinsAnaphaseSaccharomyces cerevisiae
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Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing.
bioRxiv : the preprint server for biology 2024 Ng HY, Adly AN, Whelpley DH, Suhandynata RT, Zhou H, Morgan DO -
Assembly of SARS-CoV-2 ribonucleosomes by truncated N∗ variant of the nucleocapsid protein.
The Journal of biological chemistry 2023 Adly AN, Bi M, Carlson CR, Syed AM, Ciling A, Doudna JA, Cheng Y, Morgan DO -
The molecular mechanisms of human separase regulation.
Biochemical Society transactions 2023 Yu J, Morgan DO, Boland A -
Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation.
The Journal of biological chemistry 2022 Carlson CR, Adly AN, Bi M, Howard CJ, Frost A, Cheng Y, Morgan DO -
Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation.
bioRxiv : the preprint server for biology 2022 Carlson CR, Adly AN, Bi M, Cheng Y, Morgan DO
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Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C.
Nature communications 2022 Hartooni N, Sung J, Jain A, Morgan DO -
Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription.
Current biology : CB 2021 Asfaha JB, Örd M, Carlson CR, Faustova I, Loog M, Morgan DO -
Structural basis of human separase regulation by securin and CDK1-cyclin B1.
Nature 2021 Yu J, Raia P, Ghent CM, Raisch T, Sadian Y, Cavadini S, Sabale PM, Barford D, Raunser S, Morgan DO, Boland A -
Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions.
Molecular cell 2020 Carlson CR, Asfaha JB, Ghent CM, Howard CJ, Hartooni N, Safari M, Frankel AD, Morgan DO -
Phosphorylation modulates liquid-liquid phase separation of the SARS-CoV-2 N protein.
bioRxiv : the preprint server for biology 2020 Carlson CR, Asfaha JB, Ghent CM, Howard CJ, Hartooni N, Morgan DO -
Polyanions provide selective control of APC/C interactions with the activator subunit.
Nature communications 2019 Mizrak A, Morgan DO -
Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site.
Nature communications 2019 Rosen LE, Klebba JE, Asfaha JB, Ghent CM, Campbell MG, Cheng Y, Morgan DO -
The pseudosubstrate inhibitor Acm1 inhibits the anaphase-promoting complex/cyclosome by combining high-affinity activator binding with disruption of Doc1/Apc10 function.
The Journal of biological chemistry 2019 Qin L, Mizrak A, Guimarães DSPSF, Tambrin HM, Morgan DO, Hall MC -
Firing of Replication Origins Frees Dbf4-Cdc7 to Target Eco1 for Destruction.
Current biology : CB 2017 Seoane AI, Morgan DO -
Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex.
Molecular cell 2016 Davey NE, Morgan DO -
Cell Size Determines the Strength of the Spindle Assembly Checkpoint during Embryonic Development.
Developmental cell 2016 Galli M, Morgan DO -
Quantitative framework for ordered degradation of APC/C substrates.
BMC biology 2015 Lu D, Girard JR, Li W, Mizrak A, Morgan DO -
An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition.
The Journal of biological chemistry 2015 Girard JR, Tenthorey JL, Morgan DO -
Multiple mechanisms determine the order of APC/C substrate degradation in mitosis.
The Journal of cell biology 2014 Lu D, Hsiao JY, Davey NE, Van Voorhis VA, Foster SA, Tang C, Morgan DO -
Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation during mitosis.
Journal of cell science 2014 Eshleman HD, Morgan DO -
Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency.
Current biology : CB 2014 Van Voorhis VA, Morgan DO -
Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis.
Journal of cell science 2014 Naylor SG, Morgan DO -
The D box meets its match.
Molecular cell 2013 Morgan DO -
Sequential primed kinases create a damage-responsive phosphodegron on Eco1.
Nature structural & molecular biology 2013 Lyons NA, Fonslow BR, Diedrich JK, Yates JR, Morgan DO -
The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.
Molecular cell 2012 Foster SA, Morgan DO -
Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation.
Developmental cell 2012 Yaakov G, Thorn K, Morgan DO -
Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism.
Current biology : CB 2011 Foe IT, Foster SA, Cheung SK, DeLuca SZ, Morgan DO, Toczyski DP -
Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes.
The Journal of biological chemistry 2011 Schaefer JB, Morgan DO -
Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase.
Nature 2011 Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Balog ER, Rubin SM, Morgan DO, Loog M -
Dynamics of Cdk1 substrate specificity during the cell cycle.
Molecular cell 2011 Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Morgan DO, Loog M -
Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase.
Molecular cell 2011 Lyons NA, Morgan DO -
Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin.
Molecular cell 2010 Rodrigo-Brenni MC, Foster SA, Morgan DO -
The hidden rhythms of the dividing cell.
Cell 2010 Morgan DO -
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Science (New York, N.Y.) 2009 Holt LJ, Tuch BB, Villén J, Johnson AD, Gygi SP, Morgan DO -
Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.
Molecular cell 2009 Matyskiela ME, Morgan DO -
Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis.
Molecular cell 2009 Benanti JA, Matyskiela ME, Morgan DO, Toczyski DP -
Mechanisms of ubiquitin transfer by the anaphase-promoting complex.
Journal of biology 2009 Matyskiela ME, Rodrigo-Brenni MC, Morgan DO -
The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast.
Molecular biology of the cell 2008 Tully GH, Nishihama R, Pringle JR, Morgan DO -
SnapShot: Cell-cycle regulators II.
Cell 2008 Morgan DO -
SnapShot: cell-cycle regulators I.
Cell 2008 Morgan DO -
Cyclin-specific control of ribosomal DNA segregation.
Molecular and cellular biology 2008 Sullivan M, Holt L, Morgan DO -
Positive feedback sharpens the anaphase switch.
Nature 2008 Holt LJ, Krutchinsky AN, Morgan DO -
Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.
Molecular cell 2008 Enquist-Newman M, Sullivan M, Morgan DO -
Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates.
Proceedings of the National Academy of Sciences of the United States of America 2008 Blethrow JD, Glavy JS, Morgan DO, Shokat KM -
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration.
Chemistry & biology 2007 Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM -
Finishing mitosis, one step at a time.
Nature reviews. Molecular cell biology 2007 Sullivan M, Morgan DO -
Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis.
Molecular biology of the cell 2007 Ko N, Nishihama R, Tully GH, Ostapenko D, Solomon MJ, Morgan DO, Pringle JR -
Sequential E2s drive polyubiquitin chain assembly on APC targets.
Cell 2007 Rodrigo-Brenni MC, Morgan DO -
A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I.
The Journal of biological chemistry 2007 Sullivan M, Morgan DO -
Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis.
Molecular cell 2007 Holt LJ, Hutti JE, Cantley LC, Morgan DO -
Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase.
Nature cell biology 2006 Woodbury EL, Morgan DO -
An architectural map of the anaphase-promoting complex.
Genes & development 2006 Thornton BR, Ng TM, Matyskiela ME, Carroll CW, Morgan DO, Toczyski DP -
Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates.
Nature 2005 Loog M, Morgan DO -
The APC subunit Doc1 promotes recognition of the substrate destruction box.
Current biology : CB 2005 Carroll CW, Enquist-Newman M, Morgan DO -
Enzymology of the anaphase-promoting complex.
Methods in enzymology 2005 Carroll CW, Morgan DO -
Targets of the cyclin-dependent kinase Cdk1.
Nature 2003 Ubersax JA, Woodbury EL, Quang PN, Paraz M, Blethrow JD, Shah K, Shokat KM, Morgan DO -
Oscillation sensation.
Nature 2002 Morgan DO, Roberts JM