David Lovett, MD
Professor Emeritus
Medicine
School of Medicine

A.B. Indiana University, Zoology and Chemistry, Highest Distinction M.D. Indiana University, Highest Distinction Resident in Internal Medicine, Yale University Chief Resident in Internal Medicine, Yale University Fellow in Nephrology, Yale University Fellow, Alexander von Humboldt Stiftung, Medizinische Hochschule Hannover Germany

Clinical and Academic Activities: Professor of Medicine in Residence, Step 9, emeritus 2020 Chief, Nephrology Section SFVAMC, 1995-2019

University/Public Service: Principal Investigator UCSF T32 Academic Training Program in Nephrology 2006-2016 Member, UCSF Committee on Academic Personnel 2016-2017 Vice Chair, UCSF Committee on Academic Personnel 2017-2018 Chair, UCSF Committee on Academic Personnel 2018-2019

Scholarly Activity: Our laboratory has primarily focused in recent years on an examination of the role of matrix metalloproteinase 2 in progressive cardiac and renal failure. These studies have included determinations of transcriptional regulatory networks, impact of promoter haplotypes on gene expression and generation of a series of transgenic mice to directly test the significance of MMP-2 expression on renal and cardiac disease. We have demonstrated that MMP-2 alone is sufficient to trigger the entire process of progressive renal disease seen in humans, including glomerulosclerosis, tubular atrophy and interstitial fibrosis without the requirement for superimposed injury. In the heart we have published a series of studies demonstrating that MMP-2 directly mediates cardiomyocyte apoptosis and contractile failure. More recently we have characterized (Lovett, et al., PLoS One 2012) a novel intracelllular isoform of MMP-2 that activates innate immunity. The isoform is generated by oxidative stress mediated activation of an alternative promoter in the first intron of the MMP-2 gene, thereby generating an intracellular, active N-terminal truncated enzyme. Transgenic mice expressing this isoform in the heart develop severe cardiomyocyte hypertrophy, inflammation and sytolic failure. Transgenic mice expressing this isoform in the kidney develop progressive tubular atrophy due mitochondrial damage mediated regulated necrosis. We are currently determining the extent of expression of this MMP-2 isoform in clinical specimens of cardiac and renal tissue using a combination of histochemical and epigenetic approaches. In addition, we are studying the epigenetic regulation of the MMP-2 intronic promoter using a novel series of transgenic reporter mice and epigenetic techniques. We believe that both isoforms of MMP-2 represent appealing therapeutic targets and we are currently developing antibody and siRNA-based strategies to selectively inhibit the MMP-2 isoforms in models of cardiac and renal disease.

• Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility.
  Journal of biomedical materials research. Part A 2020 Spaulding KA, Zhu Y, Takaba K, Ramasubramanian A, Badathala A, Haraldsson H, Collins A, Aguayo E, Shah C, Wallace AW, Ziats NP, Lovett DH, Baker AJ, Healy KE, Ratcliffe MB
• Nonsurgical Periodontal Therapy in CKD: Findings of the Kidney and Periodontal Disease (KAPD) Pilot Randomized Controlled Trial.
  Kidney medicine 2019 Grubbs V, Garcia F, Vittinghoff E, Jue BL, Ryder M, Lovett DH, Offenbacher S, Taylor G, Ganz P, Bibbins-Domingo K, Powe NR
• Enhanced cardiac expression of two isoforms of matrix metalloproteinase-2 in experimental diabetes mellitus.
  PloS one 2019 Lee HW, Lee SJ, Lee MY, Park MW, Kim SS, Shin N, Lovett DH, Bae SS, Ahn J, Park JS, Oh JH, Choi JH, Lee HC, Cha KS, Hong TJ, Song SH
• Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse.
  Muscles Ligaments and Tendons Journal 2019 Q. Zhang, S.K. Joshi, D.H. Lovett, G. Manzano, H.T. Kim, X. Liu
• Reversal of right ventricular failure by chronic α1A-subtype adrenergic agonist therapy.
  American journal of physiology. Heart and circulatory physiology 2018 Cowley PM, Wang G, Swigart PM, Raghunathan A, Reddy N, Dulam P, Lovett DH, Simpson PC, Baker AJ
• The expression of two isoforms of matrix metalloproteinase-2 in aged mouse models of diabetes mellitus and chronic kidney disease.
  Kidney research and clinical practice 2018 Rhee H, Han M, Kim SS, Kim IY, Lee HW, Bae SS, Ha HK, Jung ES, Lee MY, Seong EY, Lee DW, Lee SB, Lovett DH, Song SH
• The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus.
  BMC nephrology 2018 Kim IY, Kim SS, Lee HW, Bae SS, Ha HK, Jung ES, Lee MY, Han M, Rhee H, Seong EY, Lee DW, Lee SB, Lovett DH, Song SH
• Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility.
  PloS one 2018 Spaulding K, Takaba K, Collins A, Faraji F, Wang G, Aguayo E, Ge L, Saloner D, Wallace AW, Baker AJ, Lovett DH, Ratcliffe MB
• α1A-Subtype adrenergic agonist therapy for the failing right ventricle.
  American journal of physiology. Heart and circulatory physiology 2017 Cowley PM, Wang G, Joshi S, Swigart PM, Lovett DH, Simpson PC, Baker AJ
• Hyperpolarized 13 C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model.
  NMR in biomedicine 2017 Baligand C, Qin H, True-Yasaki A, Gordon JW, von Morze C, Santos JD, Wilson DM, Raffai R, Cowley PM, Baker AJ, Kurhanewicz J, Lovett DH, Wang ZJ
• Clear Cell Renal Cell Carcinoma is linked to Epithelial-to-Mesenchymal Transition and to Fibrosis.
  Physiological reports 2017 Landolt L, Eikrem Ø, Strauss P, Scherer A, Lovett DH, Beisland C, Finne K, Osman T, Ibrahim MM, Gausdal G, Ahmed L, Lorens JB, Thiery JP, Tan TZ, Sekulic M, Marti HP
• MP501A SPATIAL DISTRIBUTION OF TWO ISOFORMS OF MATRIX METALLOPROTEINASE-2 IN DIABETIC KIDNEY ACCORDING TO THE TIME OF DIABETIC MILIEU.
  Nephrology,Dialysis and Transplantation 2017 Sang Heon Song, Harin Rhee, Il Young Kim, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Min Young Lee, Soo Young Bang, David H Lovett
• a1A-Subtype Adrenergic Agonist Therapy for Failing Right Ventricle.
  The FASEB Journal 2017 Patrick M Cowley, Guanying Wang, Philip M Swigart, David H Lovett, Paul C Simpson, Anthony J Baker
• Enhanced expression of two discrete isoforms of matrix metalloproteinase-2 in experimental and human diabetic nephropathy.
  PloS one 2017 Kim SS, Shin N, Bae SS, Lee MY, Rhee H, Kim IY, Seong EY, Lee DW, Lee SB, Kwak IS, Lovett DH, Song SH
• The Kidney and Periodontal Disease (KAPD) study: A pilot randomized controlled trial testing the effect of non-surgical periodontal therapy on chronic kidney disease.
  Contemporary clinical trials 2016 Grubbs V, Garcia F, Jue BL, Vittinghoff E, Ryder M, Lovett D, Carrillo J, Offenbacher S, Ganz P, Bibbins-Domingo K, Powe NR
• a1A-Subtype Adrenergic Therapy is Beneficial for Failing Right Ventricle (RV).
  The FASEB Journal 2016 Patrick M Cowley, Guanying Wang, Sunil Joshi, David H Lovett, Paul C Simpson, Anthony J Baker
• Immunosuppression With FTY720 Reverses Cardiac Dysfunction in Hypomorphic ApoE Mice Deficient in SR-BI Expression That Survive Myocardial Infarction Caused by Coronary Atherosclerosis.
  Journal of cardiovascular pharmacology 2016 Luk FS, Kim RY, Li K, Ching D, Wong DK, Joshi SK, Imhof I, Honbo N, Hoover H, Zhu BQ, Lovett DH, Karliner JS, Raffai RL
• Abstract 17311: Molecular Memory and the Epigenetic Regulation of Cardiac Intracellular Matrix Metalloproteinase-2.
  Circulation 2015 David H Lovett, Stanley Luk, Lalita Uttarwar, Sunil Joshi, Robert L RAffai
• Novel intracellular N-terminal truncated matrix metalloproteinase-2 isoform in skeletal muscle ischemia-reperfusion injury.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2015 Joshi SK, Lee L, Lovett DH, Kang H, Kim HT, Delgado C, Liu X
• The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium.
  American journal of physiology. Heart and circulatory physiology 2015 Cowley PM, Wang G, Chang AN, Makwana O, Swigart PM, Lovett DH, Stull JT, Simpson PC, Baker AJ
• RR15. Renal Progression in the Advanced Chronic Kidney Disease Populations: Creation of the ESRD Prediction Scorecard.
  Journal of Vascular Surgery 2015 Marcos K. Lau, Joy L. Meier, Warren Gasper, David H. Lovett, Pauline M. Velez, Christopher D. Owens
• Abstract 23: Immunosuppression with FTY720 Reverses Cardiac Dysfunction to Prevent Chronic Heart Failure in Mice that Survive Diet-induced Myocardial Infarction.
  Arteriosclerosis Thrombosis and Vascular Biology 2015 Fu Sang Luk, Roy Y Kim, Kang Li, Daniel Ching, Sunil Joshi, Norman Honbo, Isabella Imhof, Bo-qing Zhu, David Lovett, Joel S Karliner, Robert L Raffai
• FP458THE EXPRESSION OF FULL LENGTH MMP-2 AND INTRACELLULAR N-TERMINAL TRUNCATED MMP-2 ISOFORM IN DIABETIC KIDNEY DISEASE.
  Nephrology,Dialysis and Transplantation 2015 Sangheon Song, Ihm Soo Kwak, Min Young Lee, Eun Young Seong, Harin Rhee, Il Young Kim, Dong Won Lee, Soo Bong Lee, David H Lovett
• The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts.
  Journal of cell science 2015 Alam SG, Lovett D, Kim DI, Roux KJ, Dickinson RB, Lele TP
• Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy.
  Muscles, ligaments and tendons journal 2015 Zhang Q, Joshi SK, Lovett DH, Zhang B, Bodine S, Kim HT, Liu X
• Upregulation of a1A-Subtype Adrenergic Signaling is Beneficial in Failing Right Ventricle (RV).
  Biophysical Journal 2015 Patrick M. Cowley, Guanying Wang, Audrey N. Chang, David H. Lovett, James T. Stull, Paul C. Simpson, Anthony J. Baker
• Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy.
  Muscles, ligaments and tendons journal 2014 Zhang Q, Joshi SK, Lovett DH, Zhang B, Bodine S, Kim H, Liu X
• Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone.
  American journal of physiology. Heart and circulatory physiology 2014 Shimkunas R, Makwana O, Spaulding K, Bazargan M, Khazalpour M, Takaba K, Soleimani M, Myagmar BE, Lovett DH, Simpson PC, Ratcliffe MB, Baker AJ
• Abstract 363: Prolonged Upregulation of Proinflammatory and Profibrotic Genes is Characteristic of Successful Arteriovenous Fistula Maturation.
  Arteriosclerosis Thrombosis and Vascular Biology 2014 Joy Walker, Robert Toy, Sean Thomas, Michael S Conte, Charles M Eichler, David Lovett, Warren J Gasper, Christopher D Owens
• Vitamin D deficiency is associated with mortality and adverse vascular access outcomes in patients with end-stage renal disease.
  Journal of vascular surgery 2014 Walker JP, Hiramoto JS, Gasper WJ, Auyang P, Conte MS, Rapp JH, Lovett DH, Owens CD
• Original article Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse.
  Muscles, ligaments and tendons journal 2013 Zhang Q, Joshi SK, Manzano G, Lovett DH, Kim HT, Liu X
• Vitamin D Deficiency Is Associated With Mortality and Adverse Vascular Access Outcomes in the ESRD Population.
  Journal of Vascular Surgery 2013 Joy Walker, Jade S. Hiramoto, Philip Auyang, Hugh Alley, Michael Conte, David Lovett, Joseph Rapp, Christopher D. Owens
• Intraventricular and interventricular cellular heterogeneity of inotropic responses to α(1)-adrenergic stimulation.
  American journal of physiology. Heart and circulatory physiology 2013 Chu C, Thai K, Park KW, Wang P, Makwana O, Lovett DH, Simpson PC, Baker AJ
• mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012 Joshi SK, Liu X, Samagh SP, Lovett DH, Bodine SC, Kim HT, Feeley BT
• Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene.
  The Journal of biological chemistry 2012 Chintala H, Liu H, Parmar R, Kamalska M, Kim YJ, Lovett D, Grant MB, Chaqour B
• The safety of an adenosine A(1)-receptor antagonist, rolofylline, in patients with acute heart failure and renal impairment: findings from PROTECT.
  Drug safety 2012 Teerlink JR, Iragui VJ, Mohr JP, Carson PE, Hauptman PJ, Lovett DH, Miller AB, Piña IL, Thomson S, Varosy PD, Zile MR, Cleland JG, Givertz MM, Metra M, Ponikowski P, Voors AA, Davison BA, Cotter G, …
• Evaluation of Akt/mTOR activity in muscle atrophy after rotator cuff tears in a rat model.
  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012 Liu X, Joshi SK, Samagh SP, Dang YX, Laron D, Lovett DH, Bodine SC, Kim HT, Feeley BT
• Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype.
  Carcinogenesis 2011 Mahimkar R, Alfonso-Jaume MA, Cape LM, Dahiya R, Lovett DH
• Telomerase deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation.
  Arteriosclerosis, thrombosis, and vascular biology 2010 Findeisen HM, Gizard F, Zhao Y, Cohn D, Heywood EB, Jones KL, Lovett DH, Howatt DA, Daugherty A, Bruemmer D
• Transgenic expression of matrix metalloproteinase-2 induces coronary artery ectasia.
  International journal of experimental pathology 2010 Dahi S, Karliner JS, Sarkar R, Lovett DH
• YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis.
  Biochemical and biophysical research communications 2010 Lovett DH, Cheng S, Cape L, Pollock AS, Mertens PR
• Role of AP-1 and RE-1 binding sites in matrix metalloproteinase-2 transcriptional regulation in skeletal muscle atrophy.
  Biochemical and biophysical research communications 2010 Liu X, Manzano G, Lovett DH, Kim HT
• Mechanisms of matrix metalloproteinase-2 (mmp-2) transcriptional repression by progesterone in jar choriocarcinoma cells.
  Reproductive biology and endocrinology : RB&E 2009 Goldman S, Lovett DH, Shalev E
• Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease.
  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2008 Mahimkar R, Nguyen A, Mann M, Yeh CC, Zhu BQ, Karliner JS, Lovett DH
• Associations of interleukin-6, C-reactive protein and serum amyloid A with mortality in haemodialysis patients.
  Nephrology (Carlton, Vic.) 2008 Wetmore JB, Lovett DH, Hung AM, Cook-Wiens G, Mahnken JD, Sen S, Johansen KL
• Inhibition of MMP2/MMP9 after spinal cord trauma reduces apoptosis.
  Spine 2008 Dang AB, Tay BK, Kim HT, Nauth A, Alfonso-Jaume MA, Lovett DH
• Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy.
  American journal of physiology. Heart and circulatory physiology 2007 McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson RA, Karliner JS, Baker AJ
• Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction.
  Biochemical and biophysical research communications 2007 Zhou HZ, Ma X, Gray MO, Zhu BQ, Nguyen AP, Baker AJ, Simonis U, Cecchini G, Lovett DH, Karliner JS
• Regulation of MMP-2 gene transcription in dermal wounds.
  The Journal of investigative dermatology 2007 Jansen PL, Rosch R, Jansen M, Binnebösel M, Junge K, Alfonso-Jaume A, Klinge U, Lovett DH, Mertens PR
• Polymeric meshes induce zonal regulation of matrix metalloproteinase-2 gene expression by macrophages and fibroblasts.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007 Jansen PL, Kever M, Rosch R, Krott E, Jansen M, Alfonso-Jaume A, Dooley S, Klinge U, Lovett DH, Mertens PR
• Biomaterials: Disturbing Factors in Cell Cross-Talk and Gene Regulation.
  Recurrent Hernia 2007 P. Lynen-Jansen, U. Klinge, D. H. Lovett, P. R. Mertens
• Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction.
  American journal of physiology. Heart and circulatory physiology 2006 Bergman MR, Teerlink JR, Mahimkar R, Li L, Zhu BQ, Nguyen A, Dahi S, Karliner JS, Lovett DH
• Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Cheng S, Pollock AS, Mahimkar R, Olson JL, Lovett DH
• An angiotensin converting enzyme haplotype predicts survival in patients with end stage renal disease.
  Human genetics 2006 Wetmore JB, Johansen KL, Sen S, Hung AM, Lovett DH
• Selective spatiotemporal induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 transcription after myocardial infarction.
  American journal of physiology. Heart and circulatory physiology 2006 Mukherjee R, Mingoia JT, Bruce JA, Austin JS, Stroud RE, Escobar GP, McClister DM, Allen CM, Alfonso-Jaume MA, Fini ME, Lovett DH, Spinale FG
• Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB.
  American journal of physiology. Heart and circulatory physiology 2006 Alfonso-Jaume MA, Bergman MR, Mahimkar R, Cheng S, Jin ZQ, Karliner JS, Lovett DH
• Intronic regulation mediates ischemia-induced MMP-2 transcription.
  Journal of Surgical Research 2006 J.G. Lee, D.H. Lovett, S. Dahi
• Response element 1 reguliert die Expression der MMP-2 in der Wundheilung Ergebnisse aus dem transgenen Mausmodell.
  Chirurgisches Forum 2006 2006 P. Lynen Jansen, M. Hungol, E. Krott, M. Jansen, D. Lovett, U. Klinge, P. R. Mertens
• Intronic regulation of matrix metalloproteinase-2 revealed by in vivo transcriptional analysis in ischemia.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Lee JG, Dahi S, Mahimkar R, Tulloch NL, Alfonso-Jaume MA, Lovett DH, Sarkar R
• Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility.
  Cardiovascular research 2005 Wang GY, Bergman MR, Nguyen AP, Turcato S, Swigart PM, Rodrigo MC, Simpson PC, Karliner JS, Lovett DH, Baker AJ
• Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin.
  Journal of vascular surgery 2005 Dahi S, Lee JG, Lovett DH, Sarkar R
• Interleukin-1 gene cluster polymorphisms predict risk of ESRD.
  Kidney international 2005 Wetmore JB, Hung AM, Lovett DH, Sen S, Quershy O, Johansen KL
• Renin-angiotensin system gene polymorphisms predict the progression to renal insufficiency among Asians with lupus nephritis.
  Genes and immunity 2005 Parsa A, Lovett DH, Peden EA, Zhu L, Seldin MF, Criswell LA
• The disintegrin domain of ADAM9: a ligand for multiple beta1 renal integrins.
  The Biochemical journal 2005 Mahimkar RM, Visaya O, Pollock AS, Lovett DH
• Alloplastische Netzmaterialien induzieren die MMP-2 Promotoraktivität — Ergebnisse aus dem transgenen Mausmodell.
  Chirurgisches Forum 2005 2005 Petra Lynen Jansen, M. Jansen, M. Hungol, E. Krott, D. Lovett, P. R. Mertens, U. Klinge
• Transcription factor YB-1 mediates DNA polymerase alpha gene expression.
  The Journal of biological chemistry 2004 En-Nia A, Yilmaz E, Klinge U, Lovett DH, Stefanidis I, Mertens PR
• P53, YB-1 and the AP-1 family of transcription factors mediate MMP-2 transcription induced by skeletal muscle ischemia.
  Journal of the American College of Surgeons 2004 Rajabrata Sarkar, Jackie Lee, Rajeev Mahimkar, David Lovett
• Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells.
  The Biochemical journal 2004 Alfonso-Jaume MA, Mahimkar R, Lovett DH
• Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation.
  The American journal of pathology 2003 Cheng S, Lovett DH
• Linked common polymorphisms in the gelatinase a promoter are associated with diminished transcriptional response to estrogen and genetic fitness.
  The Journal of biological chemistry 2003 Harendza S, Lovett DH, Panzer U, Lukacs Z, Kuhnl P, Stahl RA
• A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers.
  The Biochemical journal 2003 Bergman MR, Cheng S, Honbo N, Piacentini L, Karliner JS, Lovett DH
• The prodomain of interleukin 1alpha interacts with elements of the RNA processing apparatus and induces apoptosis in malignant cells.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Pollock AS, Turck J, Lovett DH
• Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1).
  The Biochemical journal 2002 Cheng S, Alfonso-Jaume MA, Mertens PR, Lovett DH
• Transcription factor Ets-1 regulates gelatinase a gene expression in mesangial cells.
  Journal of the American Society of Nephrology : JASN 2002 Reisdorff J, En-Nia A, Stefanidis I, Floege J, Lovett DH, Mertens PR
• Combinatorial interactions of p53, activating protein-2, and YB-1 with a single enhancer element regulate gelatinase A expression in neoplastic cells.
  The Journal of biological chemistry 2002 Mertens PR, Steinmann K, Alfonso-Jaume MA, En-Nia A, Sun Y, Lovett DH
• Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen.
  The Journal of biological chemistry 2002 Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng FJ, Labrador P, Klein R, Lovett D, Yancopoulos GD, Friedman SL, Lin HC
• Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2.
  The Journal of biological chemistry 2001 Olaso E, Labrador JP, Wang L, Ikeda K, Eng FJ, Klein R, Lovett DH, Lin HC, Friedman SL
• The hematopoietic transcription factor PU.1 represses gelatinase A transcription in glomerular mesangial cells.
  The Journal of biological chemistry 2000 Harendza S, Lovett DH, Stahl RA
• Identification, cellular distribution and potential function of the metalloprotease-disintegrin MDC9 in the kidney.
  Journal of the American Society of Nephrology : JASN 2000 Mahimkar RM, Baricos WH, Visaya O, Pollock AS, Lovett DH
• YB-1 regulation of the human and rat gelatinase A genes via similar enhancer elements.
  Journal of the American Society of Nephrology : JASN 1999 Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH
• A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription.
  The Journal of biological chemistry 1998 Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH
• Regulated expression of matrix metalloproteinases and TIMP in nephrogenesis.
  Developmental dynamics : an official publication of the American Association of Anatomists 1998 Tanney DC, Feng L, Pollock AS, Lovett DH
• Glomerular mesangial cell-specific transactivation of matrix metalloproteinase 2 transcription is mediated by YB-1.
  The Journal of biological chemistry 1997 Mertens PR, Harendza S, Pollock AS, Lovett DH
• Gelatinase A is a glomerular mesangial cell growth and differentiation factor.
  Kidney international 1997 Turck J, Pollock AS, Lovett DH
• The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Stevenson FT, Turck J, Locksley RM, Lovett DH
• Pharmacological inhibition of gelatinase B induction and tumor cell invasion.
  International journal of cancer 1996 McMillan JI, Weeks R, West JW, Bursten S, Rice GC, Lovett DH
• Matrix metalloproteinase 2 (gelatinase A) regulates glomerular mesangial cell proliferation and differentiation.
  The Journal of biological chemistry 1996 Turck J, Pollock AS, Lee LK, Marti HP, Lovett DH
• Characterization of a glomerular epithelial cell metalloproteinase as matrix metalloproteinase-9 with enhanced expression in a model of membranous nephropathy.
  The Journal of clinical investigation 1996 McMillan JI, Riordan JW, Couser WG, Pollock AS, Lovett DH
• Tissue-specific enhancer-promoter interactions regulate high level constitutive expression of matrix metalloproteinase 2 by glomerular mesangial cells.
  The Journal of biological chemistry 1995 Harendza S, Pollock AS, Mertens PR, Lovett DH
• Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney.
  The Journal of clinical investigation 1995 Lee LK, Meyer TW, Pollock AS, Lovett DH
• Immunologic glomerular disease--new prospects for specific therapy.
  The Western journal of medicine 1994 Lovett DH
• Role of oxidants and proteases in glomerular injury.
  Kidney international 1994 Johnson RJ, Lovett D, Lehrer RI, Couser WG, Klebanoff SJ
• Structure and expression of the human gene for the matrix metalloproteinase matrilysin.
  The Journal of biological chemistry 1994 Gaire M, Magbanua Z, McDonnell S, McNeil L, Lovett DH, Matrisian LM
• Transforming growth factor-beta 1 stimulates glomerular mesangial cell synthesis of the 72-kd type IV collagenase.
  The American journal of pathology 1994 Marti HP, Lee L, Kashgarian M, Lovett DH
• In vivo gene transfer, Koch's postulates, and renal disease.
  The Journal of clinical investigation 1993 Johnson RJ, Lovett D
• Asymmetric origins of the mature glomerular basement membrane.
  Journal of cellular physiology 1993 Lee LK, Pollock AS, Lovett DH
• The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece.
  Proceedings of the National Academy of Sciences of the United States of America 1993 Stevenson FT, Bursten SL, Fanton C, Locksley RM, Lovett DH
• Homology cloning of rat 72 kDa type IV collagenase: cytokine and second-messenger inducibility in glomerular mesangial cells.
  The Biochemical journal 1993 Marti HP, McNeil L, Davies M, Martin J, Lovett DH
• [Current aspects in the pathogenesis and therapy of glomerulonephritis: significance of glomerular metalloproteinases].
  Schweizerische medizinische Wochenschrift 1992 Marti HP, Lovett DH
• Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues.
  The Journal of experimental medicine 1992 Stevenson FT, Bursten SL, Locksley RM, Lovett DH
• Interleukin 1: the patterns of translation and intracellular distribution support alternative secretory mechanisms.
  Journal of cellular physiology 1992 Stevenson FT, Torrano F, Locksley RM, Lovett DH
• Molecular characterization of a low-molecular-mass matrix metalloproteinase secreted by glomerular mesangial cells as PUMP-1.
  The Biochemical journal 1992 Marti HP, McNeil L, Thomas G, Davies M, Lovett DH
• Structural characterization of the mesangial cell type IV collagenase and enhanced expression in a model of immune complex-mediated glomerulonephritis.
  The American journal of pathology 1992 Lovett DH, Johnson RJ, Marti HP, Martin J, Davies M, Couser WG
• Expression of phosphoenolpyruvate carboxykinase (PEPCK) chimeras in renal epithelial cells. Retention of appropriate physiological responsiveness using enhancerless retroviral vectors.
  The Biochemical journal 1992 Pollock AS, Lovett DH
• Glomerular epithelial cells secrete a glomerular basement membrane-degrading metalloproteinase.
  Journal of the American Society of Nephrology : JASN 1992 Johnson R, Yamabe H, Chen YP, Campbell C, Gordon K, Baker P, Lovett D, Couser WG
• Proteinases and glomerular matrix turnover.
  Kidney international 1992 Davies M, Martin J, Thomas GJ, Lovett DH
• Lipid A activation of glomerular mesangial cells: mimicry of the bioactive lipid, phosphatidic acid.
  The American journal of physiology 1992 Bursten SL, Harris WE, Resch K, Lovett DH
• Interleukin-1 rapidly stimulates lysophosphatidate acyltransferase and phosphatidate phosphohydrolase activities in human mesangial cells.
  The Journal of biological chemistry 1991 Bursten SL, Harris WE, Bomsztyk K, Lovett D
• Mesangial cell activation by bacterial endotoxin. Induction of rapid cytoskeletal reorganization and gene expression.
  The American journal of pathology 1991 Bursten SL, Stevenson F, Torrano F, Lovett DH
• Proteinases and the glomerulus: their role in glomerular diseases.
  Klinische Wochenschrift 1990 Davies M, Coles GA, Thomas GJ, Martin J, Lovett DH
• Particles from dialysis tubing stimulate interleukin-1 secretion by macrophages.
  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1990 Bommer J, Weinreich T, Lovett DH, Bouillon R, Ritz E, Gemsa D
• Human mesangial cells secrete a GBM-degrading neutral proteinase and a specific inhibitor.
  Kidney international 1989 Martin J, Davies M, Thomas G, Lovett DH
• Characterization of the interleukin-1-induced tyrosine phosphorylation of a 41-kDa plasma membrane protein of the human tumor cell line K 562.
  European journal of biochemistry 1989 Martin M, Lovett DH, Szamel M, Resch K
• Activation of glomerular mesangial cells by gram-negative bacterial cell wall components.
  The American journal of pathology 1988 Lovett DH, Bursten SL, Gemsa D, Bessler W, Resch K, Ryan JL
• Modulation of mesangial cell migration by extracellular matrix components. Inhibition by heparinlike glycosaminoglycans.
  The American journal of pathology 1988 Person JM, Lovett DH, Raugi GJ
• Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors.
  The Journal of clinical investigation 1988 Bursten SL, Locksley RM, Ryan JL, Lovett DH
• Insulin and insulin-like growth factor I binding to cultured rat glomerular mesangial cells.
  Endocrinology 1988 Abrass CK, Raugi GJ, Gabourel LS, Lovett DH
• Cell cycle-dependent interleukin 1 gene expression by cultured glomerular mesangial cells.
  The Journal of clinical investigation 1988 Lovett DH, Larsen A
• Interleukin 1 and the glomerular mesangium. III. IL-1-dependent stimulation of mesangial cell protein kinase activity.
  Kidney international 1988 Lovett DH, Martin M, Bursten S, Szamel M, Gemsa D, Resch K
• The purification and characterization of a glomerular-basement-membrane-degrading neutral proteinase from rat mesangial cells.
  The Biochemical journal 1988 Davies M, Thomas GJ, Martin J, Lovett DH
• Interleukin I and the glomerular mesangium. II. Monokine stimulation of mesangial cell prostanoid secretion.
  The American journal of pathology 1987 Lovett DH, Resch K, Gemsa D
• Thrombospondin secretion by cultured human glomerular mesangial cells.
  The American journal of pathology 1987 Raugi GJ, Lovett DH
• Activation of glomerular mesangial cells by the terminal membrane attack complex of complement.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Lovett DH, Haensch GM, Goppelt M, Resch K, Gemsa D
• Mesangial cell hillocks. Nodular foci of exaggerated growth of cells and matrix in prolonged culture.
  The American journal of pathology 1986 Sterzel RB, Lovett DH, Foellmer HG, Perfetto M, Biemesderfer D, Kashgarian M
• The receptor for interleukin 1 in plasma membranes of the human leukemia cell K 562: biological and biochemical characterization.
  Immunobiology 1986 Resch K, Martin M, Lovett DH, Kyas U, Gemsa D
• Cell culture approaches to the analysis of glomerular inflammation.
  Kidney international 1986 Lovett DH, Sterzel RB
• Enhancement of glomerular mesangial cell neutral proteinase secretion by macrophages: role of interleukin 1.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Martin J, Lovett DH, Gemsa D, Sterzel RB, Davies M
• Interleukin 1 and the glomerular mesangium. I. Purification and characterization of a mesangial cell-derived autogrowth factor.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Lovett DH, Szamel M, Ryan JL, Sterzel RB, Gemsa D, Resch K
• Interleukin 1 induces specific phosphorylation of a 41 kDa plasma membrane protein from the human tumor cell line K 562.
  Immunobiology 1986 Martin M, Lovett D, Resch K
• Macrophage cytotoxicity: interleukin 1 as a mediator of tumor cytostasis.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Lovett D, Kozan B, Hadam M, Resch K, Gemsa D
• Measurement of interleukin-1 by growth inhibition of the human tumor cell K562; receptor studies.
  Lymphokine research 1986 Resch K, Martin M, Lovett DH, Gemsa D
• Release of Prostaglandins and Modulation of Leukocyte Functions.
  Advances in Immunopharmacology 1986 D. GEMSA, M. NAIN, G.M. HÄNSCH, D. LOVETT, P.H. KRAMMER, K. RESCH
• Production of an endogenous pyrogen by glomerular mesangial cells.
  Journal of immunology (Baltimore, Md. : 1950) 1985 Lovett DH, Sterzel RB, Ryan JL, Atkins E
• Studies on the mechanism whereby cyclosporin A inhibits T-lymphocyte activation.
  Immunobiology 1985 Stoeck M, Wildhagen K, Szamel M, Lovett D, Resch K
• Stimulation of rat mesangial cell proliferation by macrophage interleukin 1.
  Journal of immunology (Baltimore, Md. : 1950) 1983 Lovett DH, Ryan JL, Sterzel RB
• A thymocyte-activating factor derived from glomerular mesangial cells.
  Journal of immunology (Baltimore, Md. : 1950) 1983 Lovett DH, Ryan JL, Sterzel RB
• Neutral proteinase activity produced in vitro by cells of the glomerular mesangium.
  Kidney international 1983 Lovett DH, Sterzel RB, Kashgarian M, Ryan JL
• The mesangium and glomerulonephritis.
  Klinische Wochenschrift 1982 Sterzel RB, Lovett DH, Stein HD, Kashgarian M
• Lysosomal enzymes in glomerular cells of the rat.
  The American journal of pathology 1982 Lovett DH, Ryan JL, Kashgarian M, Sterzel RB
• Angioimmunoblastic lymphadenopathy evolution to a Burkitt-like lymphoma.
  The American journal of medicine 1979 Mazur EM, Lovett DH, Enriquez RE, Breg WR, Papac RJ