David Killilea, PhD
MLK Core Manager
Vice Chanc Research
Chancellor/EVC/FAS
Education & Training
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- Diversity, Equity, and Inclusion Champion Training University of California 2022
- Visiting Scholar University of California, Berkeley 2011
- Participating Guest Scientist Lawrence Livermore National Laboratory 2008
- Post-doctoral Molecular and Cellular Biology University of California, Berkeley 2003
- Ph.D. Pharmacology University of South Alabama 2000
- B.S. Molecular and Cellular Biology Rhodes College 1994
Websites
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- UCSF Summer Student Research Program YouTube Channel (youtube.com)
- MLK Research Building Cores (mlkcores.ucsf.edu)
- ResearchGate Profile for David Killilea (researchgate.net)
- UCSF Summer Student Research Program (summerstudents.ucsf.edu)
- MLK Cores iLab Reservation System (ucsf.ilab.agilent.com)
Grants and Projects
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- Supporting Underrepresented Students Adapting to Change: Summer Program to Accelerate Regenerative Medicine Knowledge (SUSTAIN-a-SPARK), California Institute for Regenerative Medicine, 2022-2026
- STIMULUS – Science Technology Immersion for Underrepresented Learners in the US, NIH/NHLBI, 2021-2025
- Summer Training for Underrepresented and Diverse Youth in STEM (STUDY STEM), Doris Duke Charitable Foundation, 2024-2025
- SSRP Supporting Underrepresented STEM Adapting to Change (SUSTAIN), Doris Duke Charitable Foundation, 2021-2023
- Clinical Research Continuum: High School to College, Doris Duke Charitable Foundation, 2017-2020
- Determining Optimal Blood Processing and Handling Parameters, Bill & Melinda Gates Foundation, 2018-2020
Publications (60)
Top publication keywords:
MineralsUrinary CalculiLongevityFlourZincVeinsWheat Germ AgglutininsHematologic TestsIronMalnutritionPlasmaTriticumMagnesium DeficiencyNutrition AssessmentCellular Senescence
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Increasing STEM Skills, Knowledge and Interest Among Diverse Students: Results from an Intensive Summer Research Program at the University of California, San Francisco
Innovative Higher Education 2024 Galvez G, Killilea DW, Berry S, Narayanaswami V, and Fung E -
Pre-analytical variables influence zinc measurement in blood samples.
PloS one 2023 Killilea DW, Schultz K -
Change in Metabolomic Profile Associated with an Average Increase in Plain Water Intake of >+ 1 L/Day, Sustained Over 4 Weeks, in Healthy Young Men with Initial Total Water Intake Below 2 L/Day.
Paracelsus proceedings of experimental medicine 2023 Stookey JD, Paulweber B, Felder TK, Lang F, Häussinger D, Killilea DW, Kuypers FA, Ritter M -
Nutritional Anemia. Nutrition and Health
The Role of Zinc in the Etiology of Anemia 2022 Killilea DW, Siekmann JH -
Blood draw site and analytic device influence hemoglobin measurements.
PloS one 2022 Killilea DW, Kuypers FA, Larkin SK, Schultz K
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Kidney Stones in Transfusion-Dependent Thalassemia: Prevalence and Risk Factors
Open Journal of Urology 2022 Sayani FA, Lal A, Tasian GE, Al Mukaddam M, Killilea DW, Wasserstein A, and Fung EB -
Mineral requirements for mitochondrial function: A connection to redox balance and cellular differentiation.
Free radical biology & medicine 2022 Killilea DW, Killilea AN -
Success of Distance Learning During 2020 COVID-19 Restrictions: A Report from Five STEM Training Programs for Underrepresented High School and Undergraduate Learners.
Journal of STEM outreach 2021 Fung EB, Frey MR, Valmont ME, Caffey-Fleming DE, Fraser M, Williams J, Killilea DW, Bogenmann E, Livshits S, Boone DN -
Zinc deficiency and its association with treatment-related toxicity in children with cancer.
Pediatric blood & cancer 2021 Chung JH, Phalke N, Hastings C, Killilea DW, Feusner JH, Fung EB -
Zinc supplementation improves markers of glucose homeostasis in thalassaemia.
British journal of haematology 2020 Fung EB, Ahmad T, Killilea DW, Hussain R, Lal A -
Plasma and Nail Zinc Concentrations, But Not Hair Zinc, Respond Positively to Two Different Forms of Preventive Zinc Supplementation in Young Laotian Children: a Randomized Controlled Trial.
Biological trace element research 2020 Wessells KR, Brown KH, Arnold CD, Barffour MA, Hinnouho GM, Killilea DW, Kounnavong S, Hess SY -
Wheat germ agglutinin is a biomarker of whole grain content in wheat flour and pasta.
Journal of food science 2020 Killilea DW, McQueen R, Abegania JR -
Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.
Cell stem cell 2019 Nobuta H, Yang N, Ng YH, Marro SG, Sabeur K, Chavali M, Stockley JH, Killilea DW, Walter PB, Zhao C, Huie P, Goldman SA, Kriegstein AR, Franklin RJM, Rowitch DH, Wernig M -
A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.
PLoS genetics 2019 Lang S, Hilsabeck TA, Wilson KA, Sharma A, Bose N, Brackman DJ, Beck JN, Chen L, Watson MA, Killilea DW, Ho S, Kahn A, Giacomini K, Stoller ML, Chi T, Kapahi P -
Monitoring of the National Oil and Wheat Flour Fortification Program in Cameroon Using a Program Impact Pathway Approach.
Current developments in nutrition 2019 Mark HE, Assiene JG, Luo H, Nankap M, Ndjebayi A, Ngnie-Teta I, Tarini A, Pattar A, Killilea DW, Brown KH, Engle-Stone R -
Early maturing spring wheat in Nordic wildtype NAM-B1 germplasm for short-duration alternative wheat producing regions
Plant Genetic Resources 2019 Econopouly BF, Van Veldhuizen BM, Lyon SR, Killilea DW, Zhang M, and Jones SS -
Potassium restriction boosts vacuolar acidity and extends lifespan in yeast.
Experimental gerontology 2019 Sasikumar AN, Killilea DW, Kennedy BK, Brem RB -
Editorial: Metal Biology Takes Flight: The Study of Metal Homeostasis and Detoxification in Insects.
Frontiers in genetics 2018 Mohr SE, Killilea DW -
Change in hydration indices associated with an increase in total water intake of more than 0.5 L/day, sustained over 4 weeks, in healthy young men with initial total water intake below 2 L/day.
Physiological reports 2017 Stookey JD, Hamer J, Killilea DW -
Iron, Zinc, Folate, and Vitamin B-12 Status Increased among Women and Children in Yaoundé and Douala, Cameroon, 1 Year after Introducing Fortified Wheat Flour.
The Journal of nutrition 2017 Engle-Stone R, Nankap M, Ndjebayi AO, Allen LH, Shahab-Ferdows S, Hampel D, Killilea DW, Gimou MM, Houghton LA, Friedman A, Tarini A, Stamm RA, Brown KH -
Flame retardant tris(1,3-dichloro-2-propyl)phosphate (TDCPP) toxicity is attenuated by N-acetylcysteine in human kidney cells.
Toxicology reports 2017 Killilea DW, Chow D, Xiao SQ, Li C, Stoller ML -
Identification of a Hemolysis Threshold That Increases Plasma and Serum Zinc Concentration.
The Journal of nutrition 2017 Killilea DW, Rohner F, Ghosh S, Otoo GE, Smith L, Siekmann JH, King JC -
α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria.
Nature medicine 2017 Zee T, Bose N, Zee J, Beck JN, Yang S, Parihar J, Yang M, Damodar S, Hall D, O'Leary MN, Ramanathan A, Gerona RR, Killilea DW, Chi T, Tischfield J, Sahota A, Kahn A, Stoller ML, Kapahi P -
A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing plasma zinc concentrations.
The American journal of clinical nutrition 2016 Zyba SJ, Shenvi SV, Killilea DW, Holland TC, Kim E, Moy A, Sutherland B, Gildengorin V, Shigenaga MK, King JC -
A genome-wide screen of bacterial mutants that enhance dauer formation in C. elegans.
Scientific reports 2016 Khanna A, Kumar J, Vargas MA, Barrett L, Katewa S, Li P, McCloskey T, Sharma A, Naudé N, Nelson C, Brem R, Killilea DW, Mooney SD, Gill M, Kapahi P -
Dietary Zinc and Incident Calcium Kidney Stones in Adolescence.
The Journal of urology 2016 Tasian GE, Ross ME, Song L, Grundmeier RW, Massey J, Denburg MR, Copelovitch L, Warner S, Chi T, Killilea DW, Stoller ML, Furth SL -
Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans.
PloS one 2016 Kumar J, Barhydt T, Awasthi A, Lithgow GJ, Killilea DW, Kapahi P -
Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.
Science translational medicine 2016 Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, … -
Acute changes in cellular zinc alters zinc uptake rates prior to zinc transporter gene expression in Jurkat cells.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2015 Holland TC, Killilea DW, Shenvi SV, King JC -
The elementome of calcium-based urinary stones and its role in urolithiasis.
Nature reviews. Urology 2015 Ramaswamy K, Killilea DW, Kapahi P, Kahn AJ, Chi T, Stoller ML -
Fertility in transfusion-dependent thalassemia men: effects of iron burden on the reproductive axis.
American journal of hematology 2015 Singer ST, Killilea D, Suh JH, Wang ZJ, Yuan Q, Ivani K, Evans P, Vichinsky E, Fischer R, Smith JF -
Changes in Mineral Micronutrient Status During and After Pulmonary Exacerbation in Adults With Cystic Fibrosis.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2015 Lee MJ, Alvarez JA, Smith EM, Killilea DW, Chmiel JF, Joseph PM, Grossmann RE, Gaggar A, Ziegler TR, Tangpricha V, Vitamin D for Enhancing the Immune System in Cystic Fibrosis Investigators -
Elemental Content of Calcium Oxalate Stones from a Canine Model of Urinary Stone Disease.
PloS one 2015 Killilea DW, Westropp JL, Shiraki R, Mellema M, Larsen J, Kahn AJ, Kapahi P, Chi T, Stoller ML -
A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease.
PloS one 2015 Chi T, Kim MS, Lang S, Bose N, Kahn A, Flechner L, Blaschko SD, Zee T, Muteliefu G, Bond N, Kolipinski M, Fakra SC, Mandel N, Miller J, Ramanathan A, Killilea DW, Brückner K, Kapahi P, Stoller ML -
Iron promotes protein insolubility and aging in C. elegans.
Aging 2014 Klang IM, Schilling B, Sorensen DJ, Sahu AK, Kapahi P, Andersen JK, Swoboda P, Killilea DW, Gibson BW, Lithgow GJ -
Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans.
Metallomics : integrated biometal science 2014 Angeli S, Barhydt T, Jacobs R, Killilea DW, Lithgow GJ, Andersen JK -
Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels.
Respiratory research 2014 Hassan F, Xu X, Nuovo G, Killilea DW, Tyrrell J, Da Tan C, Tarran R, Diaz P, Jee J, Knoell D, Boyaka PN, Cormet-Boyaka E -
Stunting prevalence, plasma zinc concentrations, and dietary zinc intakes in a nationally representative sample suggest a high risk of zinc deficiency among women and young children in Cameroon.
The Journal of nutrition 2014 Engle-Stone R, Ndjebayi AO, Nankap M, Killilea DW, Brown KH -
Altered transition metal homeostasis in Niemann-Pick disease, type C1.
Metallomics : integrated biometal science 2013 Hung YH, Faux NG, Killilea DW, Yanjanin N, Firnkes S, Volitakis I, Ganio G, Walterfang M, Hastings C, Porter FD, Ory DS, Bush AI -
Zinc deficiency augments leptin production and exacerbates macrophage infiltration into adipose tissue in mice fed a high-fat diet.
The Journal of nutrition 2013 Liu MJ, Bao S, Bolin ER, Burris DL, Xu X, Sun Q, Killilea DW, Shen Q, Ziouzenkova O, Belury MA, Failla ML, Knoell DL -
ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB.
Cell reports 2013 Liu MJ, Bao S, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, Knoell DL -
Aluminium exposure disrupts elemental homeostasis in Caenorhabditis elegans.
Metallomics : integrated biometal science 2012 Page KE, White KN, McCrohan CR, Killilea DW, Lithgow GJ -
A connection between magnesium deficiency and aging: new insights from cellular studies.
Magnesium research 2008 Killilea DW, Maier JA -
Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2008 Killilea DW, Ames BN -
Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts.
Redox report : communications in free radical research 2008 Lal A, Atamna W, Killilea DW, Suh JH, Ames BN -
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans.
The Journal of biological chemistry 2007 McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow GJ -
Zinc deficiency reduces paclitaxel efficacy in LNCaP prostate cancer cells.
Cancer letters 2007 Killilea AN, Downing KH, Killilea DW -
N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007 Voloboueva LA, Killilea DW, Atamna H, Ames BN -
Steady-state asymmetric nanospray dual ion source for accurate mass determination within a chromatographic separation.
Analytical chemistry 2007 Young NL, Sisto MC, Young MN, Grant PG, Killilea DW, LaMotte L, Wu KJ, Lebrilla CB -
Dialyzability of minerals in corn masa gruel (atole) fortified with different iron compounds: effects of ascorbic acid, disodium EDTA, and phytic acid.
Food and nutrition bulletin 2007 De-Regil LM, Casanueva E, Killilea DW, Viteri FE -
Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease.
British journal of haematology 2006 Walter PB, Fung EB, Killilea DW, Jiang Q, Hudes M, Madden J, Porter J, Evans P, Vichinsky E, Harmatz P -
Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging.
Molecular aspects of medicine 2005 Ames BN, Atamna H, Killilea DW -
Iron accumulation during cellular senescence.
Annals of the New York Academy of Sciences 2004 Killilea DW, Wong SL, Cahaya HS, Atamna H, Ames BN -
Iron accumulation during cellular senescence in human fibroblasts in vitro.
Antioxidants & redox signaling 2003 Killilea DW, Atamna H, Liao C, Ames BN -
Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging.
Proceedings of the National Academy of Sciences of the United States of America 2002 Atamna H, Killilea DW, Killilea AN, Ames BN -
Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid.
Proceedings of the National Academy of Sciences of the United States of America 2002 Liu J, Killilea DW, Ames BN -
Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001 Grishko V, Solomon M, Breit JF, Killilea DW, Ledoux SP, Wilson GL, Gillespie MN -
Free radical production in hypoxic pulmonary artery smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology 2000 Killilea DW, Hester R, Balczon R, Babal P, Gillespie MN -
Hypoxia causes oxidant lesions in the rat pulmonary artery smooth muscle cell VEGF gene: potential link to VEGF mRNA expression.
Chest 1998 Gillespie MN, Killilea DW, Solomon M, Babal P, LeDoux SP, Wilson GL -
Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic-3',5'-guanosine monophosphate-stimulated phosphodiesterase to reverse hypoxic pulmonary vasoconstriction in the perfused rat lung.
The Journal of pharmacology and experimental therapeutics 1996 Haynes J, Killilea DW, Peterson PD, Thompson WJ