David Gardner, MD
Professor
Medicine
School of Medicine

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)

Grants and Projects

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• Regulation of ANP Receptor Activity in Vascular Cells, NIH, 1992-2013
• Expression and Regulation of Atrial Natriuretic Factor, NIH, 1985-2004
• Biomedical Research Support Grant, NIH, 1983-1991

Publications (53)

Top publication keywords:
Guanylate CyclaseDiacylglycerol O-AcyltransferaseCardiomegalyVitamin DMyocytes, Smooth MuscleNatriuretic Peptide, BrainMuscle, Smooth, VascularMyocytes, CardiacReceptors, Atrial Natriuretic FactorCalcitriolReceptors, CalcitriolKidney Tubules, CollectingCardiomyopathiesAtrial Natriuretic FactorEndothelins

• Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight.
  Diabetes 2016 Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA
• Amplification of lipotoxic cardiomyopathy in the VDR gene knockout mouse.
  The Journal of steroid biochemistry and molecular biology 2015 Glenn DJ, Cardema MC, Gardner DG
• Tie-2Cre mediated deletion of the vitamin D receptor gene leads to improved skeletal muscle insulin sensitivity and glucose tolerance.
  The Journal of steroid biochemistry and molecular biology 2015 Ni W, Glenn DJ, Gardner DG
• Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function.
  PloS one 2015 Jeffery LE, Qureshi OS, Gardner D, Hou TZ, Briggs Z, Soskic B, Baker J, Raza K, Sansom DM
• Cardiac steatosis potentiates angiotensin II effects in the heart.
  American journal of physiology. Heart and circulatory physiology 2014 Glenn DJ, Cardema MC, Ni W, Zhang Y, Yeghiazarians Y, Grapov D, Fiehn O, Gardner DG

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• Elimination of vitamin D receptor in vascular endothelial cells alters vascular function.
  Hypertension (Dallas, Tex. : 1979) 2014 Ni W, Watts SW, Ng M, Chen S, Glenn DJ, Gardner DG
• Vitamin D and the heart.
  American journal of physiology. Regulatory, integrative and comparative physiology 2013 Gardner DG, Chen S, Glenn DJ
• Vitamin D: beyond bone.
  Annals of the New York Academy of Sciences 2013 Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD
• Acute liver failure with thyrotoxicosis treated with liver transplantation.
  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2013 Cascino MD, McNabb B, Gardner DG, Woeber KA, Fox AN, Wang B, Fix OK
• Liganded vitamin D receptor displays anti-hypertrophic activity in the murine heart.
  The Journal of steroid biochemistry and molecular biology 2012 Chen S, Gardner DG
• Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide.
  Endocrine-related cancer 2012 Thompson IR, Chand AN, King PJ, Ansorge O, Karavitaki N, Jones CA, Rahmutula D, Gardner DG, Zivkovic V, Wheeler-Jones CP, McGonnell IM, Korbonits M, Anderson RA, Wass JA, McNeilly AS, Fowkes RC
• Effect of combining an ACE inhibitor and a VDR activator on glomerulosclerosis, proteinuria, and renal oxidative stress in uremic rats.
  American journal of physiology. Renal physiology 2011 Finch JL, Suarez EB, Husain K, Ferder L, Cardema MC, Glenn DJ, Gardner DG, Liapis H, Slatopolsky E
• Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy.
  Circulation 2011 Chen S, Law CS, Grigsby CL, Olsen K, Hong TT, Zhang Y, Yeghiazarians Y, Gardner DG
• A murine model of isolated cardiac steatosis leads to cardiomyopathy.
  Hypertension (Dallas, Tex. : 1979) 2011 Glenn DJ, Wang F, Nishimoto M, Cruz MC, Uchida Y, Holleran WM, Zhang Y, Yeghiazarians Y, Gardner DG
• Chapter 31 Vitamin D and the Cardiovascular System.
  Vitamin D 2011 David G. Gardner, Songcang Chen, Denis J. Glenn, Wei Ni
• A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation.
  The Journal of steroid biochemistry and molecular biology 2010 Chen S, Law CS, Grigsby CL, Olsen K, Gardner DG
• Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity.
  The Journal of steroid biochemistry and molecular biology 2009 Chen S, Law CS, Gardner DG
• Atrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblasts through a GATA4-dependent mechanism.
  Cardiovascular research 2009 Glenn DJ, Rahmutula D, Nishimoto M, Liang F, Gardner DG
• Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents.
  The Journal of clinical investigation 2009 Chen S, Grigsby CL, Law CS, Ni X, Nekrep N, Olsen K, Humphreys MH, Gardner DG
• Endothelin-stimulated human B-type natriuretic peptide gene expression is mediated by Yin Yang 1 in association with histone deacetylase 2.
  Hypertension (Dallas, Tex. : 1979) 2009 Glenn DJ, Wang F, Chen S, Nishimoto M, Gardner DG
• Expression of the vitamin d receptor is increased in the hypertrophic heart.
  Hypertension (Dallas, Tex. : 1979) 2008 Chen S, Glenn DJ, Ni W, Grigsby CL, Olsen K, Nishimoto M, Law CS, Gardner DG
• Lipids and the heart: neither feast nor famine.
  Hypertension (Dallas, Tex. : 1979) 2007 Glenn DJ, Gardner DG
• Molecular biology of the natriuretic peptide system: implications for physiology and hypertension.
  Hypertension (Dallas, Tex. : 1979) 2007 Gardner DG, Chen S, Glenn DJ, Grigsby CL
• Molecular aspects of the natriuretic peptide system.
  Molecular Mechanisms in Hypertension 2006 David Gardner, Songcang Chen, Dolkun Rahmutula, Feng Wang, Keith Olsen
• Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAH.
  Neurocritical care 2006 Fisher LA, Ko N, Miss J, Tung PP, Kopelnik A, Banki NM, Gardner D, Smith WS, Lawton MT, Zaroff JG
• A role for p38 mitogen-activated protein kinase and c-myc in endothelin-dependent rat aortic smooth muscle cell proliferation.
  Hypertension (Dallas, Tex. : 1979) 2005 Chen S, Qiong Y, Gardner DG
• C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells.
  Endocrinology 2005 Rahmutula D, Gardner DG
• 1,25-dihydroxyvitamin D inhibits human ANP gene promoter activity.
  Regulatory peptides 2005 Chen S, Nakamura K, Gardner DG
• 1,25 dihydroxyvitamin d amplifies type a natriuretic peptide receptor expression and activity in target cells.
  Journal of the American Society of Nephrology : JASN 2004 Chen S, Ni XP, Humphreys MH, Gardner DG
• Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems.
  American journal of physiology. Endocrinology and metabolism 2004 Xiang W, Kong J, Chen S, Cao LP, Qiao G, Zheng W, Liu W, Li X, Gardner DG, Li YC
• Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1.
  Hypertension (Dallas, Tex. : 1979) 2004 Rahmutula D, Cui J, Chen S, Gardner DG
• Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells.
  Hypertension (Dallas, Tex. : 1979) 2004 Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG
• Suppression of WEE1 and stimulation of CDC25A correlates with endothelin-dependent proliferation of rat aortic smooth muscle cells.
  The Journal of biological chemistry 2004 Chen S, Gardner DG
• Role of the epidermal growth factor receptor in signaling strain-dependent activation of the brain natriuretic peptide gene.
  The Journal of biological chemistry 2003 Anderson HD, Wang F, Gardner DG
• Natriuretic peptides: markers or modulators of cardiac hypertrophy?
  Trends in endocrinology and metabolism: TEM 2003 Gardner DG
• Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells.
  The Journal of biological chemistry 2003 Anderson HD, Rahmutula D, Gardner DG
• Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes.
  Endocrinology 2003 Liang F, Wang F, Zhang S, Gardner DG
• Brain natriuretic peptide: a marker for subclinical cardiovascular disease?
  The American journal of medicine 2003 Gardner DG
• Focal adhesion kinase is required for blood vessel morphogenesis.
  Circulation research 2003 Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner DG, Damsky CH
• Triiodothyronine increases brain natriuretic peptide (BNP) gene transcription and amplifies endothelin-dependent BNP gene transcription and hypertrophy in neonatal rat ventricular myocytes.
  The Journal of biological chemistry 2003 Liang F, Webb P, Marimuthu A, Zhang S, Gardner DG
• Endothelin inhibits NPR-A and stimulates eNOS gene expression in rat IMCD cells.
  Hypertension (Dallas, Tex. : 1979) 2002 Ye Q, Chen S, Gardner DG
• Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor.
  The Journal of biological chemistry 2002 Chen S, Cao L, Intengan HD, Humphreys M, Gardner DG
• Thyroid hormone export varies among primary cells and appears to differ from hormone uptake.
  Endocrinology 2002 Neves FA, Cavalieri RR, Simeoni LA, Gardner DG, Baxter JD, Scharschmidt BF, Lomri N, Ribeiro RC
• Requirements for the localization of p130 Cas to Z-lines in cardiac myocytes.
  Cellular & molecular biology letters 2002 Kovacic-Milivojevic B, Damsky CC, Gardner DG, Ilic D
• Osmoregulation of natriuretic peptide receptor signaling in inner medullary collecting duct. A requirement for p38 MAPK.
  The Journal of biological chemistry 2001 Chen S, Gardner DG
• Sp1 Dependence of Natriuretic Peptide Receptor A Gene Transcription in Rat Aortic Smooth Muscle Cells 1.
  Endocrinology 1999 Faquan Liang, Fred Schaufele, David G. Gardner
• Natriuretic Peptides and the Heart.
  Hormones and the Heart in Health and Disease 1999 David G. Gardner, Branka Kovacic-Milivojevic, Faquan Liang, Songcang Chen
• Cellular and Molecular Aspects of the A-Type Natriuretic Peptide.
  Natriuretic Peptides in Health and Disease 1997 David G. Gardner, Jianming Wu, Branka Kovacic-Milivojevic
• Divergent Regulation of the Human Atrial Natriuretic Peptide Gene by c-jun and c-fos.
  Molecular and Cellular Biology 1992 Branka Kovacic-Milivojevic, David G. Gardner
• Divergent regulation of the human atrial natriuretic peptide gene by c-jun and c-fos.
  Molecular and Cellular Biology 1992 B Kovacic-Milivojevic, D G Gardner
• 42 Extravascular shift of fluid and albumin induced by endothelin in binephrectomized rats.
  Journal of Hypertension 1991 J P Valentin, DG Gardner, J Ribstein, A Mimran, M.H Humphreys
• Atrial Natriuretic Peptide.
  Nature Biotechnology 1988 John D. Baxter, John A. Lewicki, David G. Gardner
• THE GROWTH HORMONE GENE FAMILY: STRUCTURE, EVOLUTION, EXPRESSION, AND REGULATION11This work was supported by NIH Grants AM19997 and AM18878 and NSF Grant 8004735.
  Gene Regulation 1982 Norman L. Eberhardt, Mark Selby, Guy Cathala, Michael Karin, Arthur Gutierrez-Hartmann, Synthia H. Mellon, Nancy C. Lan, David Gardner, John D. Baxter