David Erle, MD
Professor
Medicine
School of Medicine
Dr. Erle received an A.B. degree (Biochemistry) from Harvard College in 1980 and an M.D. degree from UCSF in 1984. He was trained in internal medicine and in pulmonary disease at UCSF. As a CVRI research fellow training at the UCSF Lung Biology Center, he studied leukocyte integrins with Robert Pytela and Dean Sheppard. He joined the Lung Biology Center faculty in 1990.
Show full bio (340 words) Hide full bio
His academic activities include laboratory research and clinical teaching. He founded the UCSF Functional Genomics Core Facility. He is a member of the Bakar ImmunoX Program, the Cardiovascular Research Institute, and the Institute for Human Genetics.
Research Interests:
Asthma affects ~300 million people and causes ~250,000 deaths annually. The long-term overall vision of our research program is that fundamental insights into the biology of the airway epithelium will allow us to better understand asthma and other airway diseases and provide a firm foundation for developing new approaches to prevention, cure, or treatment of these diseases.
The concept that the airway epithelium plays a central role in asthma pathogenesis represents a relatively recent paradigm shift. We showed that direct effects of the type 2 cytokine IL-13 on resident airway cells were sufficient to induce airway hyperreactivity (AHR) and mucus overproduction. Our most important early contribution was the demonstration that IL-13-driven activation of the transcription factor (TF) STAT6 in airway epithelial cells causes AHR and mucus overproduction in mice. More recently, our studies of primary human bronchial epithelial (HBE) cells showed that IL-13 induces changes in expression, organization, and function of airway mucus glycoproteins (MUC5AC and MUC5B mucins). These changes lead to attachment (tethering) of mucus to the epithelium, prevent normal mucus clearance, and promote formation of obstructive mucus plugs that are a prominent feature of fatal asthma.
Completed and ongoing studies in the lab are intended to help reach a deeper understanding of the molecular mechanisms underlying airway epithelial dysfunction in asthma. We study the mechanisms of gene regulation in the airway epithelium and determine the contributions of specific gene expression changes to changes in airway epithelial function. We use a variety of approaches from cell and molecular biology, genomics, and computational biology. We have adapted powerful new methods, including single cell RNA-seq (scRNA-seq), ChIP-seq, and CRISPR, for use with HBE cells as well as with cells obtained directly from individuals with asthma. We collaborate extensively with experts in asthma clinical studies, genetics and genomics, and computational biology.
Awards
Show all (5) Hide
- Outstanding Investigator Award, National Heart Lung and Blood Institute, 2019
- Elected member, Association of American Physicians (AAP), 2018
- Trudeau Award, American Lung Association, 1990
- Alpha Omega Alpha, University of California San Francisco, 1983
- Magna cum laude, Harvard College, 1980
Education & Training
Show all (5) Hide
- Diversity, Equity, and Inclusion Champion Training University of California 2018
- Pulmonary Medicine University of California 06/1990
- Internal Medicine (Residency) University of California 06/1987
- MD Medicine University of California 06/1984
- AB Biochemistry Harvard College 06/1980
Websites
Show all (5) Hide
- Biomedical Sciences Graduate Program (bms.ucsf.edu)
- Institute for Human Genetics (humangenetics.ucsf.edu)
- UCSF CoLabs (colabs.ucsf.edu)
- Erle lab (erlelab.ucsf.edu)
- Cardiovascular Research Institute (cvri.ucsf.edu)
Grants and Projects
Show all (19) Hide
- Airway epithelial cell gene regulation: new mechanisms and therapeutic strategies, NIH, 2019-2026
- Understanding Asthma Endotypes, NIH, 2008-2023
- Multidisciplinary Training Program in Lung Disease, NIH, 1976-2022
- Airway Epithelial Reprogramming in Asthma, NIH, 2017-2021
- Defining A Comprehensive Reference Profile of Circulating Human Extracellular RNA, NIH, 2014-2020
- UCSF Career Development Program in Omics of Lung Diseases, NIH, 2013-2019
- Massively parallel identification of functional 3' UTR variants in asthma, NIH, 2014-2019
- Empiric deconvolution of functional RNA elements, NIH, 2014-2019
- Combined Transcriptomics and Genomics to Find Asthma Genes in Admixed Populations, NIH, 2014-2018
- Specialized molecules with essential roles in mucus production, NIH, 2010-2014
- Micro-RNAs in airway epithelial differentiation and asthma, NIH, 2011-2014
- Airway Epithelial Responses to Allergic Inflammation, NIH, 2006-2012
- Tools for high-throughput functional analysis of 3'UTR cis-regulatory elements, NIH, 2008-2010
- Shared Microarray Facility, NIH, 2002-2007
- Interactions of Lymphocytes, Cytokines and Airway Cells, NIH, 1996-2006
- Integrin Alpha 4 Beta 7 and Regulation of Gut Immunity, NIH, 1999-2005
- Chemokines as Regulators of Leukocyte Integrin Activity, NIH, 1994-2004
- Multipurpose Arthritis and Musculoskeletal Diseases Ctr, NIH, 1977-2003
- Mechanisms of Persistent Airway Inflammation in Asthma, NIH, 1996-2001
Publications (159)
Top publication keywords:
Gene Expression RegulationRespiratory SystemEpithelial CellsRespiratory MucosaIntegrinsMucin 5ACInterleukin-13Th2 CellsMucoproteinsAsthmaMucociliary ClearanceRNA StabilityMucusAllergens3' Untranslated Regions
-
Large Differences in Small RNA Composition Between Human Biofluids.
Cell reports 2018 Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ -
CRISPR-Cas9-mediated functional dissection of 3'-UTRs.
Nucleic acids research 2017 Zhao W, Siegel D, Biton A, Tonqueze OL, Zaitlen N, Ahituv N, Erle DJ -
Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma.
The Journal of clinical investigation 2016 Bonser LR, Zlock L, Finkbeiner W, Erle DJ -
Massively parallel functional annotation of 3' untranslated regions.
Nature biotechnology 2014 Zhao W, Pollack JL, Blagev DP, Zaitlen N, McManus MT, Erle DJ -
Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.
American journal of respiratory and critical care medicine 2009 Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ -
The protein disulfide isomerase AGR2 is essential for production of intestinal mucus.
Proceedings of the National Academy of Sciences of the United States of America 2009 Park SW, Zhen G, Verhaeghe C, Nakagami Y, Nguyenvu LT, Barczak AJ, Killeen N, Erle DJ -
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.
Nature medicine 2002 Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ
Show all (152 more) Hide
-
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.
Nature communications 2024 Ozonoff A, Jayavelu ND, Liu S, Melamed E, Milliren CE, Qi J, Geng LN, McComsey GA, Cairns CB, Baden LR, Schaenman J, Shaw AC, Samaha H, Seyfert-Margolis V, Krammer F, Rosen LB, Steen H, Syphurs C, … -
GCLiPP: global crosslinking and protein purification method for constructing high-resolution occupancy maps for RNA binding proteins.
Genome biology 2023 Zhu WS, Litterman AJ, Sekhon HS, Kageyama R, Arce MM, Taylor KE, Zhao W, Criswell LA, Zaitlen N, Erle DJ, Ansel KM -
Corrigendum to "Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study" [eBioMedicine 83 (2022) 104208].
EBioMedicine 2023 Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein … -
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
iScience 2023 Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, … -
Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
Research square 2023 Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK -
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.
Stem cell reports 2023 Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, … -
Fluorogenic reporter enables identification of compounds that inhibit SARS-CoV-2.
Nature microbiology 2023 Yang J, Xiao Y, Lidsky PV, Wu CT, Bonser LR, Peng S, Garcia-Knight MA, Tassetto M, Chung CI, Li X, Nakayama T, Lee IT, Nayak JV, Ghias K, Hargett KL, Shoichet BK, Erle DJ, Jackson PK, Andino R, Shu X -
Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma.
Cell genomics 2022 Koh KD, Bonser LR, Eckalbar WL, Yizhar-Barnea O, Shen J, Zeng X, Hargett KL, Sun DI, Zlock LT, Finkbeiner WE, Ahituv N, Erle DJ -
COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.
American journal of respiratory and critical care medicine 2022 Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COVID… -
Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.
Critical care (London, England) 2022 Wick KD, Leligdowicz A, Willmore A, Carrillo SA, Ghale R, Jauregui A, Chak SS, Nguyen V, Lee D, Jones C, Dewar R, Lane HC, Kangelaris KN, Hendrickson CM, Liu KD, Sinha P, Erle DJ, Langelier CR, … -
Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study.
EBioMedicine 2022 Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein … -
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.
Immunity 2022 Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Munoz Sandoval P, Willmore A, UCSF COMET Consortium, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Calfee CS, Erle DJ… -
Immediate myeloid depot for SARS-CoV-2 in the human lung.
Research square 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, … -
Immediate myeloid depot for SARS-CoV-2 in the human lung.
bioRxiv : the preprint server for biology 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, … -
The Type 2 Asthma Mediator IL-13 Inhibits Severe Acute Respiratory Syndrome Coronavirus 2 Infection of Bronchial Epithelium.
American journal of respiratory cell and molecular biology 2022 Bonser LR, Eckalbar WL, Rodriguez L, Shen J, Koh KD, Ghias K, Zlock LT, Christenson S, Woodruff PG, Finkbeiner WE, Erle DJ -
A conserved immune trajectory of recovery in hospitalized COVID-19 patients.
bioRxiv : the preprint server for biology 2022 Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Sandoval PM, UCSF COMET Consortium, Calfee CS, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Erle DJ, Ansel KM, … -
Massively parallel analysis of human 3' UTRs reveals that AU-rich element length and registration predict mRNA destabilization.
G3 (Bethesda, Md.) 2022 Siegel DA, Le Tonqueze O, Biton A, Zaitlen N, Erle DJ -
Discovering dominant tumor immune archetypes in a pan-cancer census.
Cell 2021 Combes AJ, Samad B, Tsui J, Chew NW, Yan P, Reeder GC, Kushnoor D, Shen A, Davidson B, Barczak AJ, Adkisson M, Edwards A, Naser M, Barry KC, Courau T, Hammoudi T, Argüello RJ, Rao AA, Olshen AB, … -
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
medRxiv : the preprint server for health sciences 2021 Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, … -
Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
EClinicalMedicine 2021 Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J,… -
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
Nature communications 2021 Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, … -
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
Science translational medicine 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, … -
Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.
Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, … -
SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.
bioRxiv : the preprint server for biology 2021 Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, … -
Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
Research square 2021 Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson… -
Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface protein in PBMCs.
bioRxiv : the preprint server for biology 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, … -
Epithelial miR-141 regulates IL-13-induced airway mucus production.
JCI insight 2021 Siddiqui S, Johansson K, Joo A, Bonser LR, Koh KD, Le Tonqueze O, Bolourchi S, Bautista RA, Zlock L, Roth TL, Marson A, Bhakta NR, Ansel KM, Finkbeiner WE, Erle DJ, Woodruff PG -
Flow-Cytometric Analysis and Purification of Airway Epithelial-Cell Subsets.
American journal of respiratory cell and molecular biology 2021 Bonser LR, Koh KD, Johansson K, Choksi SP, Cheng D, Liu L, Sun DI, Zlock LT, Eckalbar WL, Finkbeiner WE, Erle DJ -
The type 2 asthma mediator IL-13 inhibits SARS-CoV-2 infection of bronchial epithelium.
bioRxiv : the preprint server for biology 2021 Bonser LR, Eckalbar WL, Rodriguez L, Shen J, Koh KD, Zlock LT, Christenson S, Woodruff PG, Finkbeiner WE, Erle DJ -
Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans.
American journal of respiratory and critical care medicine 2021 Gui H, Levin AM, Hu D, Sleiman P, Xiao S, Mak ACY, Yang M, Barczak AJ, Huntsman S, Eng C, Hochstadt S, Zhang E, Whitehouse K, Simons S, Cabral W, Takriti S, Abecasis G, Blackwell TW, Kang HM, … -
Global absence and targeting of protective immune states in severe COVID-19.
Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, … -
COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
Research square 2021 Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, … -
Asthma and its relationship to mitochondrial copy number: Results from the Asthma Translational Genomics Collaborative (ATGC) of the Trans-Omics for Precision Medicine (TOPMed) program.
PloS one 2020 Cocco MP, White E, Xiao S, Hu D, Mak A, Sleiman P, Yang M, Bobbitt KR, Gui H, Levin AM, Hochstadt S, Whitehouse K, Rynkowski D, Barczak AJ, Abecasis G, Blackwell TW, Kang HM, Nickerson DA, Germer S, … -
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.
Cell stem cell 2020 Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W,… -
Global Absence and Targeting of Protective Immune States in Severe COVID-19.
bioRxiv : the preprint server for biology 2020 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, … -
Global Absence and Targeting of Protective Immune States in Severe COVID-19.
Research square 2020 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, … -
Whole-Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth.
American journal of respiratory and critical care medicine 2020 Lee EY, Mak ACY, Hu D, Sajuthi S, White MJ, Keys KL, Eckalbar W, Bonser L, Huntsman S, Urbanek C, Eng C, Jain D, Abecasis G, Kang HM, Germer S, Zody MC, Nickerson DA, Erle D, Ziv E, Rodriguez-Santana … -
Steps toward Cell Therapy for Cystic Fibrosis.
American journal of respiratory cell and molecular biology 2020 Koh KD, Erle DJ -
Development of allergic airway immunity depends on MARCH1-mediated ubiquitination of MHCII and CD86 in dendritic cells.
The Journal of Immunology 2020 Carlos A Castellanos, Xin Ren, Hong-Erh Liang, Brian J Laidlaw, Andrea Barczak, Joshua Rudolph, Walter L Eckalbar, Xiaozhu Huang, Jason G Cyster, Richard M Locksley, David J Erle, Satoshi Ishido, … -
Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis.
American journal of respiratory cell and molecular biology 2020 Koh KD, Siddiqui S, Cheng D, Bonser LR, Sun DI, Zlock LT, Finkbeiner WE, Woodruff PG, Erle DJ -
Comparison of Reproducibility, Accuracy, Sensitivity, and Specificity of miRNA Quantification Platforms.
Cell reports 2019 Godoy PM, Barczak AJ, DeHoff P, Srinivasan S, Etheridge A, Galas D, Das S, Erle DJ, Laurent LC -
The airway epithelium in asthma.
Advances in immunology 2019 Bonser LR, Erle DJ -
The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses.
The Journal of experimental medicine 2019 Sin JH, Zuckerman C, Cortez JT, Eckalbar WL, Erle DJ, Anderson MS, Waterfield MR -
A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization.
Genome research 2019 Litterman AJ, Kageyama R, Le Tonqueze O, Zhao W, Gagnon JD, Goodarzi H, Erle DJ, Ansel KM -
Singling out Th2 cells in eosinophilic esophagitis.
The Journal of clinical investigation 2019 Eckalbar WL, Erle DJ -
Putting Mucins on the Map.
American journal of respiratory and critical care medicine 2019 Bonser LR, Erle DJ -
An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.
The Journal of clinical investigation 2018 Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS,… -
Integrative approach identifies corticosteroid response variant in diverse populations with asthma.
The Journal of allergy and clinical immunology 2018 Levin AM, Gui H, Hernandez-Pacheco N, Yang M, Xiao S, Yang JJ, Hochstadt S, Barczak AJ, Eckalbar WL, Rynkowski D, Samedy LA, Kwok PY, Pino-Yanes M, Erle DJ, Lanfear DE, Burchard EG, Williams LK -
Tissue signals imprint ILC2 identity with anticipatory function.
Nature immunology 2018 Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM -
Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.
Nature biotechnology 2018 Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Hoen ENMN, Jiang H, Wang… -
Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
Nature 2018 Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, … -
Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.
Immunity 2018 Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J -
Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.
Nature biotechnology 2018 Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, De Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Nolte-'t Hoen ENM, … -
Widespread Effects of Chemokine 3' Untranslated Regions on mRNA Degradation and Protein Production in Human Cells.
Journal of immunology (Baltimore, Md. : 1950) 2018 Zhao W, Erle DJ -
IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.
American journal of respiratory and critical care medicine 2018 Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG -
CD40 Mediates Maturation of Thymic Dendritic Cells Driven by Self-Reactive CD4+ Thymocytes and Supports Development of Natural Regulatory T Cells.
Journal of immunology (Baltimore, Md. : 1950) 2018 Oh J, Wu N, Barczak AJ, Barbeau R, Erle DJ, Shin JS -
Airway Mucus and Asthma: The Role of MUC5AC and MUC5B.
Journal of clinical medicine 2017 Bonser LR, Erle DJ -
Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD.
The European respiratory journal 2017 Naz S, Kolmert J, Yang M, Reinke SN, Kamleh MA, Snowden S, Heyder T, Levänen B, Erle DJ, Sköld CM, Wheelock ÅM, Wheelock CE -
Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.
Cell reports 2017 Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP -
Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.
Cell 2017 Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM -
Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.
Mucosal immunology 2017 Yi L, Cheng D, Zhang K, Huo X, Mo Y, Shi H, Di H, Zou Y, Zhang H, Zhao J, Xu Y, Erle DJ, Zhen G -
A tissue checkpoint regulates type 2 immunity.
Nature immunology 2016 Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM -
Chitin-Induced Airway Epithelial Cell Innate Immune Responses Are Inhibited by Carvacrol/Thymol.
PloS one 2016 Khosravi AR, Erle DJ -
miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis.
PloS one 2016 Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ -
Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD.
The European respiratory journal 2016 Balgoma D, Yang M, Sjödin M, Snowden S, Karimi R, Levänen B, Merikallio H, Kaarteenaho R, Palmberg L, Larsson K, Erle DJ, Dahlén SE, Dahlén B, Sköld CM, Wheelock ÅM, Wheelock CE -
Massively Parallel Identification of Regulatory Variants in Asthma.
Annals of the American Thoracic Society 2016 Biton A, Torgerson D, Letonqueze O, Zhao W, Zaitlen N, Erle DJ -
MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production.
Immunity 2016 Pua HH, Steiner DF, Patel S, Gonzalez JR, Ortiz-Carpena JF, Kageyama R, Chiou NT, Gallman A, de Kouchkovsky D, Jeker LT, McManus MT, Erle DJ, Ansel KM -
Abstract B65: Dissecting the tumor myeloid compartment reveals rare activating antigen presenting cells, critical for T cell immunity.
Tumor Microenvironment 2015 Miranda Broz, Mikhail Binnewies, Bijan Boldajipour, Amanda Nelson, Joshua Pollock, David Erle, Andrea Barczak, Michael Rosenblum, Adil Daud, Diane Barber, Sebastian Amigorena, Laura J. van 't Veer, … -
The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway.
American journal of respiratory cell and molecular biology 2015 Bonser LR, Schroeder BW, Ostrin LA, Baumlin N, Olson JL, Salathe M, Erle DJ -
Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells.
PloS one 2015 Khan IS, Park CY, Mavropoulos A, Shariat N, Pollack JL, Barczak AJ, Erle DJ, McManus MT, Anderson MS, Jeker LT -
Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
American journal of physiology. Lung cellular and molecular physiology 2015 Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS -
Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity.
Cancer cell 2014 Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF -
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.
Cancer cell 2014 Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF -
Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma.
American journal of respiratory and critical care medicine 2014 Cheng D, Xue Z, Yi L, Shi H, Zhang K, Huo X, Bonser LR, Zhao J, Xu Y, Erle DJ, Zhen G -
Erratum: Corrigendum: The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
Nature Immunology 2014 Michael Waterfield, Imran S Khan, Jessica T Cortez, Una Fan, Todd Metzger, Alexandra Greer, Kayla Fasano, Marc Martinez-Llordella, Joshua L Pollack, David J Erle, Maureen Su, Mark S Anderson -
IL-17 and "TH2-high" asthma: Adding fuel to the fire?
The Journal of allergy and clinical immunology 2014 Bhakta NR, Erle DJ -
Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.
Science translational medicine 2014 Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ… -
The cell biology of asthma.
The Journal of cell biology 2014 Erle DJ, Sheppard D -
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
Nature immunology 2014 Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS -
Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa.
Genome medicine 2014 McErlean P, Berdnikovs S, Favoreto S, Shen J, Biyasheva A, Barbeau R, Eisley C, Barczak A, Ward T, Schleimer RP, Erle DJ, Boushey HA, Avila PC -
Hands-on workshops as an effective means of learning advanced technologies including genomics, proteomics and bioinformatics.
Genomics, proteomics & bioinformatics 2013 Reisdorph N, Stearman R, Kechris K, Phang TL, Reisdorph R, Prenni J, Erle DJ, Coldren C, Schey K, Nesvizhskii A, Geraci M -
S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus.
Cytokine 2013 Jean Publicover, Anuj Gaggar, Stephen Nishimura, Christine M. Van Horn, Amanda Goodsell, Marcus O. Muench, R. Lee Reinhardt, Nico van Rooijen, Adil E. Wakil Marion Peters, Jason G. Cyster, David J. … -
Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.
The Journal of clinical investigation 2013 Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL -
Apolipoprotein A1 potentiates lipoxin A4 synthesis and recovery of allergen-induced disrupted tight junctions in the airway epithelium.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2013 Park SW, Lee EH, Lee EJ, Kim HJ, Bae DJ, Han S, Kim D, Jang AS, Uh ST, Kim YH, Erle DJ, Park CS -
Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1.
Cardiovascular research 2013 Rahmutula D, Marcus GM, Wilson EE, Ding CH, Xiao Y, Paquet AC, Barbeau R, Barczak AJ, Erle DJ, Olgin JE -
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.
The Journal of Cell Biology 2013 Yelena Bronevetsky, Alejandro V. Villarino, Christopher J. Eisley, Rebecca Barbeau, Andrea J. Barczak, Gitta A. Heinz, Elisabeth Kremmer, Vigo Heissmeyer, Michael T. McManus, David J. Erle, Anjana Rao… -
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.
The Journal of experimental medicine 2013 Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM -
Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients.
The Journal of allergy and clinical immunology 2013 Levänen B, Bhakta NR, Torregrosa Paredes P, Barbeau R, Hiltbrunner S, Pollack JL, Sköld CM, Svartengren M, Grunewald J, Gabrielsson S, Eklund A, Larsson BM, Woodruff PG, Erle DJ, Wheelock ÅM -
An integrated nano-scale approach to profile miRNAs in limited clinical samples.
American journal of clinical and experimental immunology 2012 Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM -
Airway epithelial miRNA expression is altered in asthma.
American journal of respiratory and critical care medicine 2012 Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG -
Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics.
BMC medical genomics 2012 Diez D, Goto S, Fahy JV, Erle DJ, Woodruff PG, Wheelock ÅM, Wheelock CE -
AGR2 is induced in asthma and promotes allergen-induced mucin overproduction.
American journal of respiratory cell and molecular biology 2012 Schroeder BW, Verhaeghe C, Park SW, Nguyenvu LT, Huang X, Zhen G, Erle DJ -
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.
The Journal of clinical investigation 2012 Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D -
The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.
Proceedings of the National Academy of Sciences of the United States of America 2011 Wang BT, Ducker GS, Barczak AJ, Barbeau R, Erle DJ, Shokat KM -
Toward a systematic understanding of mRNA 3' untranslated regions.
Proceedings of the American Thoracic Society 2011 Zhao W, Blagev D, Pollack JL, Erle DJ -
An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors.
PloS one 2011 Ritner C, Wong SS, King FW, Mihardja SS, Liszewski W, Erle DJ, Lee RJ, Bernstein HS -
Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma.
The Journal of allergy and clinical immunology 2010 Kirstein F, Horsnell WG, Kuperman DA, Huang X, Erle DJ, Lopata AL, Brombacher F -
Systemically dispersed innate IL-13-expressing cells in type 2 immunity.
Proceedings of the National Academy of Sciences of the United States of America 2010 Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley RM -
Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation.
American journal of physiology. Lung cellular and molecular physiology 2009 Gu N, Kang G, Jin C, Xu Y, Zhang Z, Erle DJ, Zhen G -
Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking.
PloS one 2009 Kim JK, Klinger M, Benjamin J, Xiao Y, Erle DJ, Littman DR, Killeen N -
Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands.
Journal of immunology (Baltimore, Md. : 1950) 2009 Klinger M, Kim JK, Chmura SA, Barczak A, Erle DJ, Killeen N -
CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2009 Medoff BD, Seung E, Hong S, Thomas SY, Sandall BP, Duffield JS, Kuperman DA, Erle DJ, Luster AD -
The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model.
Journal of immunology (Baltimore, Md. : 1950) 2008 Nakagami Y, Favoreto S, Zhen G, Park SW, Nguyenvu LT, Kuperman DA, Dolganov GM, Huang X, Boushey HA, Avila PC, Erle DJ -
Disease-specific gene expression profiling in multiple models of lung disease.
American journal of respiratory and critical care medicine 2007 Lewis CC, Yang JY, Huang X, Banerjee SK, Blackburn MR, Baluk P, McDonald DM, Blackwell TS, Nagabhushanam V, Peters W, Voehringer D, Erle DJ -
Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.
The Journal of clinical investigation 2007 Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL -
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids.
Proceedings of the National Academy of Sciences of the United States of America 2007 Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV -
Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.
American journal of respiratory cell and molecular biology 2007 Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG -
Progress toward a systems biology approach to acute lung injury.
American journal of physiology. Lung cellular and molecular physiology 2007 Frank JA, Erle DJ -
Genomics and proteomics of lung disease: conference summary.
American journal of physiology. Lung cellular and molecular physiology 2007 Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, … -
Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signals.
Journal of immunology (Baltimore, Md. : 1950) 2007 Chang WL, Coro ES, Rau FC, Xiao Y, Erle DJ, Baumgarth N -
Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice.
PLoS pathogens 2007 Horsnell WG, Cutler AJ, Hoving JC, Hoving CJ, Mearns H, Myburgh E, Arendse B, Finkelman FD, Owens GK, Erle D, Brombacher F -
Microarray analysis of a mouse model of transfusion-related acute lung injury (TRALI) reveals prominent increased expression of neutrophil-derived chemokines.
The FASEB Journal 2007 Mark R Looney, Rebecca Barbeau, Andrea Barczak, Yuanyuan Xiao, Clifford A Lowell, David J Erle, Michael A Matthay -
IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production.
American journal of respiratory cell and molecular biology 2006 Zhen G, Park SW, Nguyenvu LT, Rodriguez MW, Barbeau R, Paquet AC, Erle DJ -
The asthma channel? Stay tuned . . .
American journal of respiratory and critical care medicine 2006 Erle DJ, Zhen G -
A distinctive alveolar macrophage activation state induced by cigarette smoking.
American journal of respiratory and critical care medicine 2005 Woodruff PG, Koth LL, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ -
IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production.
Journal of immunology (Baltimore, Md. : 1950) 2005 Kuperman DA, Huang X, Nguyenvu L, Hölscher C, Brombacher F, Erle DJ -
Dissecting asthma using focused transgenic modeling and functional genomics.
The Journal of allergy and clinical immunology 2005 Kuperman DA, Lewis CC, Woodruff PG, Rodriguez MW, Yang YH, Dolganov GM, Fahy JV, Erle DJ -
Increased DNA microarray hybridization specificity using sscDNA targets.
BMC genomics 2005 Barker CS, Griffin C, Dolganov GM, Hanspers K, Yang JY, Erle DJ -
Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005 Wolters PJ, Mallen-St Clair J, Lewis CC, Villalta SA, Baluk P, Erle DJ, Caughey GH -
Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2.
Respiratory research 2004 Koth LL, Rodriguez MW, Bernstein XL, Chan S, Huang X, Charo IF, Rollins BJ, Erle DJ -
Differential gene expression by integrin beta 7+ and beta 7- memory T helper cells.
BMC immunology 2004 Rodriguez MW, Paquet AC, Yang YH, Erle DJ -
Asthma investigators begin to reap the fruits of genomics.
Genome biology 2003 Erle DJ, Yang YH -
Abnormal alveolar development associated with elevated adenine nucleosides.
American journal of respiratory cell and molecular biology 2003 Banerjee SK, Young HW, Barczak A, Erle DJ, Blackburn MR -
Spotted long oligonucleotide arrays for human gene expression analysis.
Genome research 2003 Barczak A, Rodriguez MW, Hanspers K, Koth LL, Tai YC, Bolstad BM, Speed TP, Erle DJ -
Activated alpha4 integrins are preferentially expressed on immature thymocytes and activated T cells.
Developmental immunology 2002 Shu F, Holzmann B, Seibold F, Erle D, Kearney JF -
Use of spotted oligonucleotide arrays for large-scale analysis of mammalian gene expression.
Chest 2002 Erle DJ, Koth L, Abramson O, Rodriguez MW, Barczak A -
The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells.
American journal of respiratory cell and molecular biology 2002 Venkayya R, Lam M, Willkom M, Grünig G, Corry DB, Erle DJ -
Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.
American journal of respiratory cell and molecular biology 2001 Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D -
Preferential production of interferon-gamma by CD4+ T cells expressing the homing receptor integrin alpha4/beta7.
Immunology 2001 Abramson O, Qiu S, Erle DJ -
Effect of serial-day exposure to nitrogen dioxide on airway and blood leukocytes and lymphocyte subsets.
The European respiratory journal 2000 Solomon C, Christian DL, Chen LL, Welch BS, Kleinman MT, Dunham E, Erle DJ, Balmes JR -
Intraepithelial lymphocytes in the lung: a neglected lymphocyte population.
American journal of respiratory cell and molecular biology 2000 Erle DJ, Pabst R -
Recent advances in molecular biological techniques and their relevance to pulmonary research.
Thorax 2000 Robinson BW, Erle DJ, Jones DA, Shapiro S, Metzger WJ, Albelda SM, Parks WC, Boylan A -
Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow.
Journal of immunology (Baltimore, Md. : 1950) 1998 Pachynski RK, Wu SW, Gunn MD, Erle DJ -
Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins.
The Journal of biological chemistry 1998 Pfaff M, Liu S, Erle DJ, Ginsberg MH -
Presentation of integrins on leukocyte microvilli: a role for the extracellular domain in determining membrane localization.
The Journal of cell biology 1997 Abitorabi MA, Pachynski RK, Ferrando RE, Tidswell M, Erle DJ -
Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1.
Journal of immunology (Baltimore, Md. : 1950) 1997 Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ -
Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph.
Journal of immunology (Baltimore, Md. : 1950) 1996 Abitorabi MA, Mackay CR, Jerome EH, Osorio O, Butcher EC, Erle DJ -
Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.
The Journal of cell biology 1996 Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D -
Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.
The Journal of experimental medicine 1996 Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM -
Intraepithelial lymphocytes. Scratching the surface.
Current biology : CB 1995 Erle DJ -
Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes.
Journal of immunology (Baltimore, Md. : 1950) 1994 Erle DJ, Briskin MJ, Butcher EC, Garcia-Pardo A, Lazarovits AI, Tidswell M -
Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression.
American journal of respiratory cell and molecular biology 1994 Erle DJ, Brown T, Christian D, Aris R -
Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules.
Methods in enzymology 1994 Pytela R, Suzuki S, Breuss J, Erle DJ, Sheppard D -
Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism.
Journal of immunology (Baltimore, Md. : 1950) 1993 Schweighoffer T, Tanaka Y, Tidswell M, Erle DJ, Horgan KJ, Luce GE, Lazarovits AI, Buck D, Shaw S -
Characterization of the leukocyte integrin subunit beta 7.
Chest 1993 Rüegg C, Pytela R, Erle DJ -
How do integrins integrate? The role of cell adhesion receptors in differentiation and development.
American journal of respiratory cell and molecular biology 1992 Erle DJ, Pytela R -
Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering.
The Journal of cell biology 1992 Rüegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ -
Identification of novel airway epithelial integrins using the homology-based polymerase chain reaction.
Chest 1992 Sheppard D, Erle D, Busk M, Pytela R -
Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction.
American journal of respiratory cell and molecular biology 1991 Erle DJ, Sheppard D, Breuss J, Rüegg C, Pytela R -
Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes.
The Journal of biological chemistry 1991 Erle DJ, Rüegg C, Sheppard D, Pytela R -
Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.
The Journal of biological chemistry 1990 Sheppard D, Rozzo C, Starr L, Quaranta V, Erle DJ, Pytela R -
Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects.
The American review of respiratory disease 1983 Bethel RA, Erle DJ, Epstein J, Sheppard D, Nadel JA, Boushey HA