David Perry, MD
Associate Professor
Neurology
School of Medicine

Perry's research centers on understanding behavioral changes in dementia, particularly those related to reward and motivation. By linking these behavioral changes to specific brain abnormalities, he seeks to improve diagnostic accuracy.

After earning his medical degree at the Georgetown University School of Medicine, Perry completed a residency in neurology at the Mayo Clinic in Rochester, Minnesota. He then completed a fellowship in behavioral neurology at the UCSF Memory and Aging Center.

Perry belongs to the American Academy of Neurology.

• Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia.
  Brain : a journal of neurology 2022 Younes K, Borghesani V, Montembeault M, Spina S, Mandelli ML, Welch AE, Weis E, Callahan P, Elahi FM, Hua AY, Perry DC, Karydas A, Geschwind D, Huang E, Grinberg LT, Kramer JH, Boxer AL, Rabinovici GD…
• A systematic review of digital technology to evaluate motor function and disease progression in motor neuron disease.
  Journal of neurology 2022 Beswick E, Fawcett T, Hassan Z, Forbes D, Dakin R, Newton J, Abrahams S, Carson A, Chandran S, Perry D, Pal S
• Enhanced positive emotional reactivity in frontotemporal dementia reflects left-lateralized atrophy in the temporal and frontal lobes.
  Cortex; a journal devoted to the study of the nervous system and behavior 2022 Shdo SM, Roy ARK, Datta S, Sible IJ, Lukic S, Perry DC, Rankin KP, Kramer JH, Rosen HJ, Miller BL, Seeley WW, Holley SR, Gorno-Tempini ML, Sturm VE
• Multi-Modal Biomarkers of Repetitive Head Impacts and Traumatic Encephalopathy Syndrome: A Clinicopathological Case Series.
  Journal of neurotrauma 2022 Asken BM, Tanner JA, VandeVrede L, Casaletto KB, Staffaroni AM, Mundada N, Fonseca C, Iaccarino L, La Joie R, Tsuei T, Mladinov M, Grant H, Shankar R, Wang KKW, Xu H, Cobigo Y, Rosen H, Gardner RC, …
• Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration.
  JAMA network open 2022 Illán-Gala I, Nigro S, VandeVrede L, Falgàs N, Heuer HW, Painous C, Compta Y, Martí MJ, Montal V, Pagonabarraga J, Kulisevsky J, Lleó A, Fortea J, Logroscino G, Quattrone A, Quattrone A, Perry DC, …
• Late-Onset Alcohol Abuse as a Presenting Symptom of Neurodegenerative Diseases.
  Journal of Alzheimer's disease : JAD 2022 de Paula França Resende E, Ketelle R, Karydas A, Allen I, Grinberg LT, Spina S, Seeley WW, Perry DC, Miller B, Naasan G
• Diagnostic Utility of Measuring Cerebral Atrophy in the Behavioral Variant of Frontotemporal Dementia and Association With Clinical Deterioration.
  JAMA network open 2021 Illán-Gala I, Falgàs N, Friedberg A, Castro-Suárez S, Keret O, Rogers N, Oz D, Nigro S, Quattrone A, Quattrone A, Wolf A, Younes K, Santos-Santos M, Borrego-Écija S, Cobigo Y, Dols-Icardo O, Lladó A, …
• Sex differences in the behavioral variant of frontotemporal dementia: A new window to executive and behavioral reserve.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2021 Illán-Gala I, Casaletto KB, Borrego-Écija S, Arenaza-Urquijo EM, Wolf A, Cobigo Y, Goh SYM, Staffaroni AM, Alcolea D, Fortea J, Blesa R, Clarimon J, Iulita MF, Brugulat-Serrat A, Lladó A, Grinberg LT,…
• Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET.
  Neurology 2020 La Joie R, Visani AV, Lesman-Segev OH, Baker SL, Edwards L, Iaccarino L, Soleimani-Meigooni DN, Mellinger T, Janabi M, Miller ZA, Perry DC, Pham J, Strom A, Gorno-Tempini ML, Rosen HJ, Miller BL, …
• Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease.
  Neurology 2020 Illán-Gala I, Lleo A, Karydas A, Staffaroni AM, Zetterberg H, Sivasankaran R, Grinberg LT, Spina S, Kramer JH, Ramos EM, Coppola G, La Joie R, Rabinovici GD, Perry DC, Gorno-Tempini ML, Seeley WW, …
• Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example.
  American journal of speech-language pathology 2020 Europa E, Iaccarino L, Perry DC, Weis E, Welch AE, Rabinovici GD, Miller BL, Gorno-Tempini ML, Henry ML
• Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders.
  Brain : a journal of neurology 2020 Ducharme S, Dols A, Laforce R, Devenney E, Kumfor F, van den Stock J, Dallaire-Théroux C, Seelaar H, Gossink F, Vijverberg E, Huey E, Vandenbulcke M, Masellis M, Trieu C, Onyike C, Caramelli P, de …
• Profiles of neurobehavior and their associations with brain abnormalities on MRI in infants born preterm.
  Early human development 2020 Kennedy E, Wouldes T, Perry D, Deib G, Alsweiler J, Crowther C, Harding J, MagNUM Study Group
• Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET.
  Science translational medicine 2020 La Joie R, Visani AV, Baker SL, Brown JA, Bourakova V, Cha J, Chaudhary K, Edwards L, Iaccarino L, Janabi M, Lesman-Segev OH, Miller ZA, Perry DC, O'Neil JP, Pham J, Rojas JC, Rosen HJ, Seeley WW, …
• Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy.
  NeuroImage. Clinical 2019 Lesman-Segev OH, La Joie R, Stephens ML, Sonni I, Tsai R, Bourakova V, Visani AV, Edwards L, O'Neil JP, Baker SL, Gardner RC, Janabi M, Chaudhary K, Perry DC, Kramer JH, Miller BL, Jagust WJ, …
• Relationship Turmoil and Emotional Empathy in Frontotemporal Dementia.
  Alzheimer disease and associated disorders 2019 Takeda A, Sturm VE, Rankin KP, Ketelle R, Miller BL, Perry DC
• Factors that predict diagnostic stability in neurodegenerative dementia.
  Journal of neurology 2019 Perry DC, Datta S, Miller ZA, Rankin KP, Gorno-Tempini ML, Kramer JH, Rosen HJ, Seeley WW, Miller BL
• Dopamine receptor D4 (DRD4) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia.
  NeuroImage. Clinical 2019 Butler PM, Chiong W, Perry DC, Miller ZA, Gennatas ED, Brown JA, Pasquini L, Karydas A, Dokuru D, Coppola G, Sturm VE, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW
• 18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes.
  Alzheimer's research & therapy 2019 Tsai RM, Bejanin A, Lesman-Segev O, LaJoie R, Visani A, Bourakova V, O'Neil JP, Janabi M, Baker S, Lee SE, Perry DC, Bajorek L, Karydas A, Spina S, Grinberg LT, Seeley WW, Ramos EM, Coppola G, Gorno-…
• Resting parasympathetic dysfunction predicts prosocial helping deficits in behavioral variant frontotemporal dementia.
  Cortex; a journal devoted to the study of the nervous system and behavior 2018 Sturm VE, Sible IJ, Datta S, Hua AY, Perry DC, Kramer JH, Miller BL, Seeley WW, Rosen HJ
• Enhanced Positive Emotional Reactivity Undermines Empathy in Behavioral Variant Frontotemporal Dementia.
  Frontiers in neurology 2018 Hua AY, Sible IJ, Perry DC, Rankin KP, Kramer JH, Miller BL, Rosen HJ, Sturm VE
• Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration.
  Neurology 2018 Seo SW, Thibodeau MP, Perry DC, Hua A, Sidhu M, Sible I, Vargas JNS, Gaus SE, Rabinovici GD, Rankin KD, Boxer AL, Kramer JH, Rosen HJ, Gorno-Tempini ML, Grinberg LT, Huang EJ, DeArmond SJ, Trojanowski…
• AAV5-Factor VIII Gene Transfer in Severe Hemophilia A.
  The New England journal of medicine 2017 Rangarajan S, Walsh L, Lester W, Perry D, Madan B, Laffan M, Yu H, Vettermann C, Pierce GF, Wong WY, Pasi KJ
• Clinicopathological correlations in behavioural variant frontotemporal dementia.
  Brain : a journal of neurology 2017 Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel…
• Reward deficits in behavioural variant frontotemporal dementia include insensitivity to negative stimuli.
  Brain : a journal of neurology 2017 Perry DC, Datta S, Sturm VE, Wood KA, Zakrzewski J, Seeley WW, Miller BL, Kramer JH, Rosen HJ
• Prosocial deficits in behavioral variant frontotemporal dementia relate to reward network atrophy.
  Brain and behavior 2017 Sturm VE, Perry DC, Wood K, Hua AY, Alcantar O, Datta S, Rankin KP, Rosen HJ, Miller BL, Kramer JH
• Precipitous Deterioration of Motor Function, Cognition, and Behavior.
  JAMA neurology 2017 Fernández-Fournier M, Perry DC, Tartaglia MC, de May M, Boxer A, Coppola G, Christine CW, Huang EJ, Seeley WW, Miller BL, DeArmond SJ, Grinberg LT, Geschwind MD
• Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL…
• Frontotemporal dementia with the V337M MAPT mutation: Tau-PET and pathology correlations.
  Neurology 2017 Spina S, Schonhaut DR, Boeve BF, Seeley WW, Ossenkoppele R, O'Neil JP, Lazaris A, Rosen HJ, Boxer AL, Perry DC, Miller BL, Dickson DW, Parisi JE, Jagust WJ, Murray ME, Rabinovici GD
• Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke.
  Stroke 2016 Mair G, von Kummer R, Adami A, White PM, Adams ME, Yan B, Demchuk AM, Farrall AJ, Sellar RJ, Sakka E, Palmer J, Perry D, Lindley RI, Sandercock PA, Wardlaw JM, IST-3 Collaborative Group
• Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration.
  JAMA neurology 2016 Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W,…
• Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage.
  Neurology 2016 Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, Christine You S, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A,…
• Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis.
  Journal of neurosurgery 2015 Perry DC, Sturm VE, Peterson MJ, Pieper CF, Bullock T, Boeve BF, Miller BL, Guskiewicz KM, Berger MS, Kramer JH, Welsh-Bohmer KA
• Regulation of α4β2α5 nicotinic acetylcholinergic receptors in rat cerebral cortex in early and late adolescence: Sex differences in response to chronic nicotine.
  Neuropharmacology 2015 Hoegberg BG, Lomazzo E, Lee NH, Perry DC
• The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features.
  Brain : a journal of neurology 2015 Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, La Joie R, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel …
• Amyloid in dementia associated with familial FTLD: not an innocent bystander.
  Neurocase 2015 Naasan G, Rabinovici GD, Ghosh P, Elofson JD, Miller BL, Coppola G, Karydas A, Fong J, Perry D, Lee SE, Yokoyama JS, Seeley WW, Kramer JH, Weiner MW, Schuff N, Jagust WJ, Grinberg LT, Pribadi M, Yang …
• Divergent processing of monetary and social reward in behavioral variant frontotemporal dementia and Alzheimer disease.
  Alzheimer disease and associated disorders 2015 Perry DC, Sturm VE, Wood KA, Miller BL, Kramer JH
• Criminal behavior in frontotemporal dementia and Alzheimer disease.
  JAMA neurology 2015 Liljegren M, Naasan G, Temlett J, Perry DC, Rankin KP, Merrilees J, Grinberg LT, Seeley WW, Englund E, Miller BL
• High volume image-guided Injections for patellar tendinopathy: a combined retrospective and prospective case series.
  Muscles, ligaments and tendons journal 2014 Morton S, Chan O, King J, Perry D, Crisp T, Maffulli N, Morrissey D
• Anatomical correlates of reward-seeking behaviours in behavioural variant frontotemporal dementia.
  Brain : a journal of neurology 2014 Perry DC, Sturm VE, Seeley WW, Miller BL, Kramer JH, Rosen HJ
• Reward processing in neurodegenerative disease.
  Neurocase 2014 Perry DC, Kramer JH
• Frontotemporal dementia.
  Seminars in neurology 2013 Perry DC, Miller BL
• [¹²⁵I]AT-1012, a new high affinity radioligand for the α3β4 nicotinic acetylcholine receptors.
  Neuropharmacology 2013 Wu J, Perry DC, Bupp JE, Jiang F, Polgar WE, Toll L, Zaveri NT
• Eligibility for randomized trials of treatments specifically for intracerebral hemorrhage: community-based study.
  Stroke 2013 Fonville AF, Samarasekera N, Hutchison A, Perry D, Roos YB, Al-Shahi Salman R
• A randomized clinical trial of trans-dermal nicotine replacement in pregnant African-American smokers.
  Maternal and child health journal 2013 El-Mohandes AA, Windsor R, Tan S, Perry DC, Gantz MG, Kiely M
• Progranulin mutations as risk factors for Alzheimer disease.
  JAMA neurology 2013 Perry DC, Lehmann M, Yokoyama JS, Karydas A, Lee JJ, Coppola G, Grinberg LT, Geschwind D, Seeley WW, Miller BL, Rosen H, Rabinovici G
• Interrater reliability of the new criteria for behavioral variant frontotemporal dementia.
  Neurology 2013 Lamarre AK, Rascovsky K, Bostrom A, Toofanian P, Wilkins S, Sha SJ, Perry DC, Miller ZA, Naasan G, Laforce R, Hagen J, Takada LT, Tartaglia MC, Kang G, Galasko D, Salmon DP, Farias ST, Kaur B, …
• Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.
  The Journal of pharmacology and experimental therapeutics 2012 Hussmann GP, Turner JR, Lomazzo E, Venkatesh R, Cousins V, Xiao Y, Yasuda RP, Wolfe BB, Perry DC, Rezvani AH, Levin ED, Blendy JA, Kellar KJ
• Voxel-based morphometry in patients with obsessive-compulsive behaviors in behavioral variant frontotemporal dementia.
  European journal of neurology 2012 Perry DC, Whitwell JL, Boeve BF, Pankratz VS, Knopman DS, Petersen RC, Jack CR, Josephs KA
• Relationships between self-reported smoking, household environmental tobacco smoke exposure and depressive symptoms in a pregnant minority population.
  Maternal and child health journal 2011 Tan S, Courtney LP, El-Mohandes AA, Gantz MG, Blake SM, Thornberry J, El-Khorazaty MN, Perry D, Kiely M
• Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization.
  The Journal of physiology 2011 Othman NA, Gallacher M, Deeb TZ, Baptista-Hon DT, Perry DC, Hales TG
• Thorough work-up and new diagnostic criteria needed for CJD.
  Nature reviews. Neurology 2011 Perry DC, Geschwind MD
• Effects of chronic nicotine on heteromeric neuronal nicotinic receptors in rat primary cultured neurons.
  Journal of neurochemistry 2011 Lomazzo E, Hussmann GP, Wolfe BB, Yasuda RP, Perry DC, Kellar KJ
• Dipstick tests for secondhand smoke exposure.
  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2010 Best D, Green EM, Smith JH, Perry DC
• Development of an undergraduate pharmacogenomics curriculum.
  Pharmacogenomics 2009 O'Brien TJ, Goodsaid F, Plack M, Harralson A, Harrouk W, Hales TG, Mandel HG, Perry DC, Kennedy K, Sarvazyan N, Chiappinelli VA
• Evaluation of the immediate impact of the Washington, D.C., smoke-free indoor air policy on bar employee environmental tobacco smoke exposure.
  Public health reports (Washington, D.C. : 1974) 2009 Pearson J, Windsor R, El-Mohandes A, Perry DC
• Prenatal exposure of rats to nicotine causes persistent alterations of nicotinic cholinergic receptors.
  Brain research 2008 Gold AB, Keller AB, Perry DC
• Effects of nicotine on sensorimotor gating impairment induced by long-term treatment with neurotoxic NMDA antagonism.
  Neurotoxicity research 2008 Rasmussen BA, Perry DC, O'Neil J, Manaye KF, Tizabi Y
• Adult and periadolescent rats differ in expression of nicotinic cholinergic receptor subtypes and in the response of these subtypes to chronic nicotine exposure.
  Brain research 2008 Doura MB, Gold AB, Keller AB, Perry DC
• Transport of multiple nicotinic acetylcholine receptors in the rat optic nerve: high densities of receptors containing alpha6 and beta3 subunits.
  Journal of neurochemistry 2008 Cox BC, Marritt AM, Perry DC, Kellar KJ
• The alpha4beta2alpha5 nicotinic cholinergic receptor in rat brain is resistant to up-regulation by nicotine in vivo.
  Journal of neurochemistry 2007 Mao D, Perry DC, Yasuda RP, Wolfe BB, Kellar KJ
• Chronic nicotine differentially regulates alpha6- and beta3-containing nicotinic cholinergic receptors in rat brain.
  The Journal of pharmacology and experimental therapeutics 2007 Perry DC, Mao D, Gold AB, McIntosh JM, Pezzullo JC, Kellar KJ
• Long-term effects of developmental PCP administration on sensorimotor gating in male and female rats.
  Psychopharmacology 2006 Rasmussen BA, O'Neil J, Manaye KF, Perry DC, Tizabi Y
• An autoradiographic analysis of [125I]alpha-bungarotoxin binding in rat brain after chronic nicotine exposure.
  Neuroscience letters 2006 Rasmussen BA, Perry DC
• Detection of erosions in the rheumatoid hand; a comparative study of multidetector computerized tomography versus magnetic resonance scanning.
  The Journal of rheumatology 2005 Perry D, Stewart N, Benton N, Robinson E, Yeoman S, Crabbe J, McQueen F
• Beliefs, death, anxiety, denial, and treatment preferences in end-of-life care: a comparison of social work students, community residents, and medical students.
  Journal of social work in end-of-life & palliative care 2005 Reese DJ, Chan CL, Perry DC, Wiersgalla D, Schlinger JM
• Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long-term but not short-term nicotine treatment.
  Journal of neurochemistry 2004 Nguyen HN, Rasmussen BA, Perry DC
• Subtype-selective up-regulation by chronic nicotine of high-affinity nicotinic receptors in rat brain demonstrated by receptor autoradiography.
  The Journal of pharmacology and experimental therapeutics 2003 Nguyen HN, Rasmussen BA, Perry DC
• Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography.
  Journal of neurochemistry 2002 Perry DC, Xiao Y, Nguyen HN, Musachio JL, Dávila-García MI, Kellar KJ
• Depletion of intracellular calcium stores is toxic to SH-SY5Y neuronal cells.
  Brain research 2002 Nguyen HN, Wang C, Perry DC