Dante Capaldi, PhD
Assistant Professor
Radiation Oncology
School of Medicine

He completed his PhD in Medical Biophysics at Western University, Canada, where he developed and evaluated imaging biomarkers of pulmonary structure and function using MRI and CT without the use of exogenous contrast agents or specialized equipment for characterization of asthma, chronic obstructive pulmonary disease, and non-small cell lung cancer. Subsequently, he completed his Medical Physics Residency and NSERC Postdoctoral Fellowship at Stanford University, where his clinical research focused on SRS treatments of cranial lesions and advanced imaging methods in assessing treatment response.

• Quantification of pulmonary functional MRI: state-of-the-art and emerging image processing methods and measurements.
  Physics in medicine and biology 2022 Sharma M, Wyszkiewicz PV, Desaigoudar V, Guo F, Capaldi DP, Parraga G
• A geometry-informed deep learning framework for ultra-sparse 3D tomographic image reconstruction.
  Computers in biology and medicine 2022 Shen L, Zhao W, Capaldi D, Pauly J, Xing L
• Treatment planning system commissioning of the first clinical biology-guided radiotherapy machine.
  Journal of applied clinical medical physics 2022 Simiele E, Capaldi D, Breitkreutz D, Han B, Yeung T, White J, Zaks D, Owens M, Maganti S, Xing L, Surucu M, Kovalchuk N
• Functional Lung Avoidance for Individualized Radiation Therapy: Results of a Double-Masked, Randomized Controlled Trial.
  International journal of radiation oncology, biology, physics 2022 Yaremko BP, Capaldi DPI, Sheikh K, Palma DA, Warner A, Dar AR, Yu E, Rodrigues GB, Louie AV, Landis M, Sanatani M, Vincent MD, Younus J, Kuruvilla S, Chen JZ, Erickson A, Gaede S, Parraga G, Hoover DA
• Beam commissioning of the first clinical biology-guided radiotherapy system.
  Journal of applied clinical medical physics 2022 Han B, Capaldi D, Kovalchuk N, Simiele E, White J, Zaks D, Xing L, Surucu M
• IMRT and SBRT Treatment Planning Study for the First Clinical Biology-Guided Radiotherapy System.
  Technology in cancer research & treatment 2022 Pham D, Simiele E, Breitkreutz D, Capaldi D, Han B, Surucu M, Oderinde S, Vitzthum L, Gensheimer M, Bagshaw H, Chin A, Xing L, Chang DT, Kovalchuk N
• Acute and Late Esophageal Toxicity After SABR to Thoracic Tumors Near or Abutting the Esophagus.
  International journal of radiation oncology, biology, physics 2021 Sodji QH, Ko R, von Eyben R, Owen SG, Capaldi DPI, Bush K, Binkley MS, Alrowais F, Pickthorn B, Maxim PG, Gensheimer MF, Diehn M, Loo BW
• Ultra-short echo-time magnetic resonance imaging lung segmentation with under-Annotations and domain shift.
  Medical image analysis 2021 Guo F, Capaldi DP, McCormack DG, Fenster A, Parraga G
• A robotically assisted 3D printed quality assurance lung phantom for Calypso.
  Physics in medicine and biology 2021 Capaldi DPI, Skinner LB, Dubrowski P, Zhang H, Xing L, Chuang CF, Loo BW, Bush KK, Fahimian BP, Yu AS
• Prior-image-based CT reconstruction using attenuation-mismatched priors.
  Physics in medicine and biology 2021 Zhang H, Capaldi D, Zeng D, Ma J, Xing L
• Prior-image-based CT reconstruction using attenuation mismatched prior.
  Physics in medicine and biology 2021 Zhang H, Capaldi DPI, Zeng D, Ma J, Xing L
• Pulmonary Ventilation Maps Generated with Free-breathing Proton MRI and a Deep Convolutional Neural Network.
  Radiology 2020 Capaldi DPI, Guo F, Xing L, Parraga G
• Precision radiotherapy using monochromatic inverse Compton x-ray sources.
  Medical physics 2020 Simiele EA, Breitkreutz DY, Capaldi DPI, Liu W, Bush KK, Skinner LB
• Technical Note: Performance of CyberKnife® tracking using low-dose CT and kV imaging.
  Medical physics 2020 Nano TF, Capaldi DPI, Yeung T, Chuang CF, Wang L, Descovich M
• Technical Note: Evaluation of audiovisual biofeedback smartphone application for respiratory monitoring in radiation oncology.
  Medical physics 2020 Capaldi DPI, Nano TF, Zhang H, Skinner LB, Xing L
• An integrated quality assurance phantom for frameless single-isocenter multitarget stereotactic radiosurgery.
  Physics in medicine and biology 2020 Capaldi DPI, Skinner LB, Dubrowski P, Yu AS
• Parametric Response Mapping of Coregistered Positron Emission Tomography and Dynamic Contrast Enhanced Computed Tomography to Identify Radioresistant Subvolumes in Locally Advanced Cervical Cancer.
  International journal of radiation oncology, biology, physics 2020 Capaldi DPI, Hristov DH, Kidd EA
• Pulmonary Imaging Phenotypes of Chronic Obstructive Pulmonary Disease Using Multiparametric Response Maps.
  Radiology 2020 MacNeil JL, Capaldi DPI, Westcott AR, Eddy RL, Barker AL, McCormack DG, Kirby M, Parraga G
• Chronic Obstructive Pulmonary Disease: Thoracic CT Texture Analysis and Machine Learning to Predict Pulmonary Ventilation.
  Radiology 2019 Westcott A, Capaldi DPI, McCormack DG, Ward AD, Fenster A, Parraga G
• CT and Functional MRI to Evaluate Airway Mucus in Severe Asthma.
  Chest 2019 Svenningsen S, Haider E, Boylan C, Mukherjee M, Eddy RL, Capaldi DPI, Parraga G, Nair P
• Incorporating prior knowledge via volumetric deep residual network to optimize the reconstruction of sparsely sampled MRI.
  Magnetic resonance imaging 2019 Wu Y, Ma Y, Capaldi DP, Liu J, Zhao W, Du J, Xing L
• A framework for Fourier-decomposition free-breathing pulmonary 1 H MRI ventilation measurements.
  Magnetic resonance in medicine 2018 Guo F, Capaldi DPI, McCormack DG, Fenster A, Parraga G
• Hyperpolarized 3 He MRI ventilatory apparent diffusion coefficient of alpha-1 antitrypsin deficiency.
  Journal of magnetic resonance imaging : JMRI 2018 Westcott A, Capaldi DPI, Ouriadov A, McCormack DG, Parraga G
• Development of a pulmonary imaging biomarker pipeline for phenotyping of chronic lung disease.
  Journal of medical imaging (Bellingham, Wash.) 2018 Guo F, Capaldi D, Kirby M, Sheikh K, Svenningsen S, McCormack DG, Fenster A, Parraga G, Canadian Respiratory Research Network
• Free-breathing Pulmonary MR Imaging to Quantify Regional Ventilation.
  Radiology 2018 Capaldi DPI, Eddy RL, Svenningsen S, Guo F, Baxter JSH, McLeod AJ, Nair P, McCormack DG, Parraga G, Canadian Respiratory Research Network
• Through the Looking Glass and What Was Found There: Imaging Biomarkers of Chronic Obstructive Pulmonary Disease.
  American journal of respiratory and critical care medicine 2017 Capaldi DPI, Parraga G
• On the Potential Role of MRI Biomarkers of COPD to Guide Bronchoscopic Lung Volume Reduction.
  Academic radiology 2017 Adams CJ, Capaldi DPI, Di Cesare R, McCormack DG, Parraga G, Canadian Respiratory Research Network
• Free-breathing Functional Pulmonary MRI: Response to Bronchodilator and Bronchoprovocation in Severe Asthma.
  Academic radiology 2017 Capaldi DPI, Sheikh K, Eddy RL, Guo F, Svenningsen S, Nair P, McCormack DG, Parraga G, Canadian Respiratory Research Network
• Thoracic CT-MRI coregistration for regional pulmonary structure-function measurements of obstructive lung disease.
  Medical physics 2017 Guo F, Svenningsen S, Kirby M, Capaldi DP, Sheikh K, Fenster A, Parraga G
• A pilot randomised clinical trial of mepolizumab in COPD with eosinophilic bronchitis.
  The European respiratory journal 2017 Dasgupta A, Kjarsgaard M, Capaldi D, Radford K, Aleman F, Boylan C, Altman LC, Wight TN, Parraga G, O'Byrne PM, Nair P
• Ultrashort echo time MRI biomarkers of asthma.
  Journal of magnetic resonance imaging : JMRI 2016 Sheikh K, Guo F, Capaldi DP, Ouriadov A, Eddy RL, Svenningsen S, Parraga G, Canadian Respiratory Research Network
• Anatomical pulmonary magnetic resonance imaging segmentation for regional structure-function measurements of asthma.
  Medical physics 2016 Guo F, Svenningsen S, Eddy RL, Capaldi DPI, Sheikh K, Fenster A, Parraga G
• Imaging how and where we breathe oxygen: another Big Short?
  Journal of thoracic disease 2016 Capaldi DP, Guo F, Parraga G
• Regional Heterogeneity of Chronic Obstructive Pulmonary Disease Phenotypes: Pulmonary (3)He Magnetic Resonance Imaging and Computed Tomography.
  COPD 2016 Pike D, Kirby M, Eddy RL, Guo F, Capaldi DP, Ouriadov A, McCormack DG, Parraga G
• Pulmonary Imaging Biomarkers of Gas Trapping and Emphysema in COPD: (3)He MR Imaging and CT Parametric Response Maps.
  Radiology 2016 Capaldi DP, Zha N, Guo F, Pike D, McCormack DG, Kirby M, Parraga G
• Second-order Texture Measurements of (3)He Ventilation MRI: Proof-of-concept Evaluation of Asthma Bronchodilator Response.
  Academic radiology 2015 Zha N, Pike D, Svenningsen S, Capaldi DP, McCormack DG, Parraga G
• Magnetic resonance imaging biomarkers of chronic obstructive pulmonary disease prior to radiation therapy for non-small cell lung cancer.
  European journal of radiology open 2015 Sheikh K, Capaldi DP, Hoover DA, Palma DA, Yaremko BP, Parraga G
• Globally optimal co-segmentation of three-dimensional pulmonary ¹H and hyperpolarized ³He MRI with spatial consistence prior.
  Medical image analysis 2015 Guo F, Yuan J, Rajchl M, Svenningsen S, Capaldi DP, Sheikh K, Fenster A, Parraga G
• Functional lung avoidance for individualized radiotherapy (FLAIR): study protocol for a randomized, double-blind clinical trial.
  BMC cancer 2014 Hoover DA, Capaldi DP, Sheikh K, Palma DA, Rodrigues GB, Dar AR, Yu E, Dingle B, Landis M, Kocha W, Sanatani M, Vincent M, Younus J, Kuruvilla S, Gaede S, Parraga G, Yaremko BP
• Free-breathing pulmonary 1H and Hyperpolarized 3He MRI: comparison in COPD and bronchiectasis.
  Academic radiology 2014 Capaldi DP, Sheikh K, Guo F, Svenningsen S, Etemad-Rezai R, Coxson HO, Leipsic JA, McCormack DG, Parraga G