Danielle Williamson, MD, PhD
Assistant Professor
Anesthesia
School of Medicine

Danielle is a proud native of the Pacific Northwest. She completed her MD-PhD at Oregon Health & Science University, before joining the Department of Anesthesia at UCSF as an anesthesia resident and has since completed a fellowship in Critical Care Medicine, and a post-doctoral fellowship in the Sall Lab.

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Her current research interests include understanding how adaptive and maladaptive responses to physiologic stressors such as hypoxia can help us better understand and treat critical illness. In her free time, Danielle enjoys running dirt trails, climbing snow-covered mountains, and exploring the wilderness.

Education & Training

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• Critical Care University of California, San Francisco 2022
• Anesthesia University of California, San Francisco 2021
• MD Oregon Health & Science University 2017
• PhD Biochemistry Oregon Health & Science University 2015
• Internship Providence St Vincent Medical Center

Grants and Projects

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• Determinants of organelle-specific activation of Proprotein Convertase 1, NIH, 2013-2017

Publications (8)

Top publication keywords:
HistidineLung TransplantationFurinAnesthesiologistsOrganellesPeptidesCircular DichroismProprotein Convertase 1Secretory PathwayProprotein ConvertasesCOS CellsHydrogen-Ion ConcentrationEnzyme ActivationGlycerolCystic Fibrosis

• Cystic fibrosis in children: A pediatric anesthesiologist's perspective.
  Paediatric anaesthesia 2022 Williamson DM, Sharma A
• Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3.
  The Journal of biological chemistry 2015 Williamson DM, Elferich J, Shinde U
• Determination of Histidine pKa Values in the Propeptides of Furin and Proprotein Convertase 1/3 Using Histidine Hydrogen-Deuterium Exchange Mass Spectrometry.
  Analytical chemistry 2015 Elferich J, Williamson DM, David LL, Shinde U
• The mechanism by which a propeptide-encoded pH sensor regulates spatiotemporal activation of furin.
  The Journal of biological chemistry 2013 Williamson DM, Elferich J, Ramakrishnan P, Thomas G, Shinde U
• Propeptides of eukaryotic proteases encode histidines to exploit organelle pH for regulation.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Elferich J, Williamson DM, Krishnamoorthy B, Shinde U
• Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3.
  Journal of molecular biology 2012 Dillon SL, Williamson DM, Elferich J, Radler D, Joshi R, Thomas G, Shinde U
• Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action.
  Molecular biology of the cell 2010 Dikeakos JD, Atkins KM, Thomas L, Emert-Sedlak L, Byeon IJ, Jung J, Ahn J, Wortman MD, Kukull B, Saito M, Koizumi H, Williamson DM, Hiyoshi M, Barklis E, Takiguchi M, Suzu S, Gronenborn AM, Smithgall …
• Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis.
  Molecular cell 2009 Aslan JE, You H, Williamson DM, Endig J, Youker RT, Thomas L, Shu H, Du Y, Milewski RL, Brush MH, Possemato A, Sprott K, Fu H, Greis KD, Runckel DN, Vogel A, Thomas G