Danielle Schlosser, PhD
Assistant Professor
Psychiatry
School of Medicine

The goal of her research program is to design, develop, and investigate neuroscience-informed digital health solutions to improve the lives of people with schizophrenia and depression. She has a broad background in clinical psychology, with specific training in behavioral neuroscience, early detection and intervention of psychosis, and digital health research. Dr. Schlosser's research is focused on translating the latest findings in the area of reward processing and psychological determinants of motivation into new interventions to treat individuals with schizophrenia and depression. Her focus in on targeting domains that transcend diagnostic labels, such as motivational states and enhancing outcomes, such as quality of life. More recently, with funding from NIMH, her research was focused on developing a mobile app called PRIME, which was designed to target the motivational system and thereby enhance the drive to improve one's quality of life and health outcomes. Her lab is testing the feasibility and impact of PRIME in two ongoing clinical trials in schizophrenia and they recently completed a pilot trial in depression. Two of the three trials were conducted entirely remotely, one with individuals with depression and the other with individuals recently diagnosed with schizophrenia.

• Development and testing of a web-based battery to remotely assess cognitive health in individuals with schizophrenia.
  Schizophrenia research 2019 Biagianti B, Fisher M, Brandrett B, Schlosser D, Loewy R, Nahum M, Vinogradov S
• Efficacy of PRIME, a Mobile App Intervention Designed to Improve Motivation in Young People With Schizophrenia.
  Schizophrenia bulletin 2018 Schlosser DA, Campellone TR, Truong B, Etter K, Vergani S, Komaiko K, Vinogradov S
• Childhood trauma and clinical high risk for psychosis.
  Schizophrenia research 2018 Loewy RL, Corey S, Amirfathi F, Dabit S, Fulford D, Pearson R, Hua JPY, Schlosser D, Stuart BK, Mathalon DH, Vinogradov S
• Summary of Key Issues Raised in the Technology for Early Awareness of Addiction and Mental Illness (TEAAM-I) Meeting.
  Psychiatric services (Washington, D.C.) 2018 Baumel A, Baker J, Birnbaum ML, Christensen H, De Choudhury M, Mohr DC, Muench F, Schlosser D, Titov N, Kane JM
• Social motivation in people with recent-onset schizophrenia spectrum disorders.
  Journal of psychiatric research 2018 Campellone TR, Truong B, Gard D, Schlosser DA
• Potential Benefits of Incorporating Peer-to-Peer Interactions Into Digital Interventions for Psychotic Disorders: A Systematic Review.
  Psychiatric services (Washington, D.C.) 2017 Biagianti B, Quraishi SH, Schlosser DA
• The feasibility, acceptability, and outcomes of PRIME-D: A novel mobile intervention treatment for depression.
  Depression and anxiety 2017 Schlosser DA, Campellone TR, Truong B, Anguera JA, Vergani S, Vinogradov S, Arean P
• 189. Trauma, Stress Mechanisms, and Risk for Psychosis.
  Schizophrenia Bulletin 2017 Rachel Loewy, Sarah Corey, Seghel Yohannes, Felix Amirfathi, Rahel Pearson, Sawsan Dabit, Daniel Fulford, Barbara Stuart, Danielle Schlosser, Daniel Mathalon, Elissa Epel, Owen Wolkowitz, Sophia …
• SU133. CLIMB: A Mobile Intervention to Enhance Social Functioning in People With Psychotic Disorders: Results From a Feasibility Study.
  Schizophrenia Bulletin 2017 Bruno Biagianti, Danielle Schlosser, Mor Nahum, Josh Woolley, Sophia Vinogradov
• Creating Live Interactions to Mitigate Barriers (CLIMB): A Mobile Intervention to Improve Social Functioning in People With Chronic Psychotic Disorders.
  JMIR mental health 2016 Biagianti B, Schlosser D, Nahum M, Woolley J, Vinogradov S
• Feasibility of PRIME: A Cognitive Neuroscience-Informed Mobile App Intervention to Enhance Motivated Behavior and Improve Quality of Life in Recent Onset Schizophrenia.
  JMIR research protocols 2016 Schlosser D, Campellone T, Kim D, Truong B, Vergani S, Ward C, Vinogradov S
• Intensive Auditory Cognitive Training Improves Verbal Memory in Adolescents and Young Adults at Clinical High Risk for Psychosis.
  Schizophrenia bulletin 2016 Loewy R, Fisher M, Schlosser DA, Biagianti B, Stuart B, Mathalon DH, Vinogradov S
• Modeling the role of negative symptoms in determining social functioning in individuals at clinical high risk of psychosis.
  Schizophrenia research 2015 Schlosser DA, Campellone TR, Biagianti B, Delucchi KL, Gard DE, Fulford D, Stuart BK, Fisher M, Loewy RL, Vinogradov S
• Motivational deficits in individuals at-risk for psychosis and across the course of schizophrenia.
  Schizophrenia research 2014 Schlosser DA, Fisher M, Gard D, Fulford D, Loewy RL, Vinogradov S
• Family-Focused Treatment for Adolescents and Young Adults at High Risk for Psychosis: Results of a Randomized Trial
  Journal of the American Academy of Child & Adolescent Psychiatry 2014 David J. Miklowitz, Mary P. O’Brien, Danielle A. Schlosser, Jean Addington, Kristin A. Candan, Catherine Marshall, Isabel Domingues, Barbara C. Walsh, Jamie L. Zinberg, Sandra D. De Silva, Michelle …
• Family-focused treatment for adolescents and young adults at high risk for psychosis: results of a randomized trial.
  Journal of the American Academy of Child and Adolescent Psychiatry 2014 Miklowitz DJ, O'Brien MP, Schlosser DA, Addington J, Candan KA, Marshall C, Domingues I, Walsh BC, Zinberg JL, De Silva SD, Friedman-Yakoobian M, Cannon TD
• Poster #T207 A NOVEL DIGITAL HEALTH APPROACH TO TREATING NEGATIVE SYMPTOMS USING A PERSONALIZED REAL-TIME INTERVENTION FOR MOTIVATIONAL ENHANCEMENT (PRIME).
  Schizophrenia Research 2014 Danielle Schlosser, Silvia Vergani, Daniel Kim, Tim Campellone, Charlie Ward, Sophia Vinogradov
• In people with ultra high risk symptoms, risk of transition to psychotic disorders is highest in the first 2 years.
  Evidence-based mental health 2014 Schlosser DA
• Neuroplasticity-based auditory training via laptop computer improves cognition in young individuals with recent onset schizophrenia.
  Schizophrenia bulletin 2014 Fisher M, Loewy R, Carter C, Lee A, Ragland JD, Niendam T, Schlosser D, Pham L, Miskovich T, Vinogradov S
• Cognitive interventions targeting brain plasticity in the prodromal and early phases of schizophrenia.
  Annual review of clinical psychology 2013 Fisher M, Loewy R, Hardy K, Schlosser D, Vinogradov S
• Environmental Risk and Protective Factors and Their Influence on the Emergence of Psychosis.
  Adolescent psychiatry (Hilversum, Netherlands) 2012 Schlosser DA, Pearson R, Perez VB, Loewy RL
• A randomized trial of family focused treatment for adolescents and young adults at risk for psychosis: study rationale, design and methods.
  Early intervention in psychiatry 2011 Schlosser DA, Miklowitz DJ, O'Brien MP, De Silva SD, Zinberg JL, Cannon TD
• Recovery from an at-risk state: clinical and functional outcomes of putatively prodromal youth who do not develop psychosis.
  Schizophrenia bulletin 2011 Schlosser DA, Jacobson S, Chen Q, Sugar CA, Niendam TA, Li G, Bearden CE, Cannon TD
• Predicting the longitudinal effects of the family environment on prodromal symptoms and functioning in patients at-risk for psychosis.
  Schizophrenia research 2010 Schlosser DA, Zinberg JL, Loewy RL, Casey-Cannon S, O'Brien MP, Bearden CE, Vinogradov S, Cannon TD
• Multifamily group treatment for schizophrenia.
  International journal of group psychotherapy 2009 Stuart BK, Schlosser DA