Daniel Sirkis, PhD
Specialist
Neurology
School of Medicine

Grants and Projects

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• Biochemical dissection of amyloid precursor protein transport from the Golgi, NIH, 2015-2018
• Biogenesis of the Regulated Secretory Pathway, NIH, 2009-2013

Publications (31)

Top publication keywords:
Receptors, ImmunologicMonocytesFrontotemporal Lobar DegenerationGolgi ApparatusMembrane GlycoproteinsTauopathiesAlzheimer DiseaseEndoplasmic ReticulumCytosolPlaque, AmyloidAdaptor Protein Complex 3Peptide HormonesInterferonsAdaptor Protein Complex beta SubunitsExocytosis

• DNA methylation age from peripheral blood predicts progression to Alzheimer's disease, white matter disease burden, and cortical atrophy.
  Research square 2024 Bonham L, Sirkis D, Pang A, Sugrue L, Santamaría-García H, Ibanez A, Miller B, Yokoyama J, Corley M
• The role of interferon signaling in neurodegeneration and neuropsychiatric disorders.
  Frontiers in psychiatry 2024 Sirkis DW, Oddi AP, Jonson C, Bonham LW, Hoang PT, Yokoyama JS
• Frontotemporal lobar degeneration targets brain regions linked to expression of recently evolved genes.
  Brain : a journal of neurology 2024 Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, …
• Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Sirkis DW, Warly Solsberg C, Johnson TP, Bonham LW, Oddi AP, Geier EG, Miller BL, Rabinovici GD, Yokoyama JS
• C9orf72 gene networks in the human brain correlate with cortical thickness in C9-FTD and implicate vulnerable cell types.
  Frontiers in neuroscience 2024 Broce IJ, Sirkis DW, Nillo RM, Bonham LW, Lee SE, Miller BL, Castruita PA, Sturm VE, Sugrue LS, Desikan RS, Yokoyama JS

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• Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease.
  bioRxiv : the preprint server for biology 2024 Sirkis DW, Solsberg CW, Johnson TP, Bonham LW, Oddi AP, Geier EG, Miller BL, Rabinovici GD, Yokoyama JS
• FTLD targets brain regions expressing recently evolved genes.
  medRxiv : the preprint server for health sciences 2023 Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, …
• Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease?
  Alzheimer's & dementia (Amsterdam, Netherlands) 2023 Mantyh WG, Cochran JN, Taylor JW, Broce IJ, Geier EG, Bonham LW, Anderson AG, Sirkis DW, Joie R, Iaccarino L, Chaudhary K, Edwards L, Strom A, Grant H, Allen IE, Miller ZA, Gorno-Tempini ML, Kramer JH…
• Role for cell death pathway in Alzheimer's disease.
  Science (New York, N.Y.) 2023 Sirkis DW, Yokoyama JS
• C9orf72 gene networks in the human brain correlate with cortical thickness in C9-FTD and implicate vulnerable cell types.
  bioRxiv : the preprint server for biology 2023 Broce IJ, Sirkis DW, Nillo RM, Bonham LW, Lee SE, Miller B, Castruita P, Sturm VE, Sugrue LS, Desikan RS, Yokoyama JS
• Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy.
  Genome medicine 2023 Sirkis DW, Warly Solsberg C, Johnson TP, Bonham LW, Sturm VE, Lee SE, Rankin KP, Rosen HJ, Boxer AL, Seeley WW, Miller BL, Geier EG, Yokoyama JS
• Frontotemporal dementia presentation in patients with heterozygous p.H157Y variant of TREM2.
  Journal of medical genetics 2023 Ogonowski N, Santamaria-Garcia H, Baez S, Lopez A, Laserna A, Garcia-Cifuentes E, Ayala-Ramirez P, Zarante I, Suarez-Obando F, Reyes P, Kauffman M, Cochran N, Schulte M, Sirkis DW, Spina S, Yokoyama …
• Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers.
  eLife 2023 Wu S, Hernandez Villegas NC, Sirkis DW, Thomas-Wright I, Wade-Martins R, Schekman R
• Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Bonham LW, Geier EG, Sirkis DW, Leong JK, Ramos EM, Wang Q, Karydas A, Lee SE, Sturm VE, Sawyer RP, Friedberg A, Ichida JK, Gitler AD, Sugrue L, Cordingley M, Bee W, Weber E, Kramer JH, Rankin KP, …
• Dissecting the clinical heterogeneity of early-onset Alzheimer's disease.
  Molecular psychiatry 2022 Sirkis DW, Bonham LW, Johnson TP, La Joie R, Yokoyama JS
• The Role of Microglia in Inherited White-Matter Disorders and Connections to Frontotemporal Dementia.
  The application of clinical genetics 2021 Sirkis DW, Bonham LW, Yokoyama JS
• The Radiogenomics of Late-onset Alzheimer Disease.
  Topics in magnetic resonance imaging : TMRI 2019 Bonham LW, Sirkis DW, Hess CP, Sugrue LP, Yokoyama JS
• The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease.
  Frontiers in immunology 2019 Bonham LW, Sirkis DW, Yokoyama JS
• Immunological signatures in frontotemporal lobar degeneration.
  Current opinion in neurology 2019 Sirkis DW, Bonham LW, Karch CM, Yokoyama JS
• Recent advances in the genetics of frontotemporal dementia.
  Current genetic medicine reports 2019 Sirkis DW, Geier EG, Bonham LW, Karch CM, Yokoyama JS
• Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia.
  Acta neuropathologica 2018 Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW…
• Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment.
  Molecular biology of the cell 2017 Sirkis DW, Aparicio RE, Schekman R
• Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease.
  Neurocase 2017 Bonham LW, Sirkis DW, Fan J, Aparicio RE, Tse M, Ramos EM, Wang Q, Coppola G, Rosen HJ, Miller BL, Yokoyama JS
• Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression.
  Acta neuropathologica communications 2016 Sirkis DW, Bonham LW, Aparicio RE, Geier EG, Ramos EM, Wang Q, Karydas A, Miller ZA, Miller BL, Coppola G, Yokoyama JS
• Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma.
  Molecular cancer therapeutics 2014 Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI
• Protein sorting at the trans-Golgi network.
  Annual review of cell and developmental biology 2014 Guo Y, Sirkis DW, Schekman R
• C9ORF72 hexanucleotide repeats in behavioral and motor neuron disease: clinical heterogeneity and pathological diversity.
  American journal of neurodegenerative disease 2014 Yokoyama JS, Sirkis DW, Miller BL
• Self-assembly of VPS41 promotes sorting required for biogenesis of the regulated secretory pathway.
  Developmental cell 2013 Asensio CS, Sirkis DW, Maas JW, Egami K, To TL, Brodsky FM, Shu X, Cheng Y, Edwards RH
• Widespread dysregulation of peptide hormone release in mice lacking adaptor protein AP-3.
  PLoS genetics 2013 Sirkis DW, Edwards RH, Asensio CS
• RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway.
  The Journal of cell biology 2010 Asensio CS, Sirkis DW, Edwards RH
• Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Vargas MR, Johnson DA, Sirkis DW, Messing A, Johnson JA