Daniel Shapiro, MD, MPH
Assistant Professor
Emergency Medicine
School of Medicine

The goal of my research program is to generate evidence to improve health outcomes and prevent harms for children with common acute illnesses. I seek to achieve this by comparing the effectiveness of interventions that are widely used in pediatric emergency medicine but that have not been assessed using rigorous research methods. Specific areas of focus include diagnostic testing and management of acute respiratory illnesses such as bronchiolitis and pneumonia.

Education & Training

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• Fellowship Pediatric Emergency Medicine Boston Children's Hospital
• Residency Pediatrics Boston Combined Residency Program
• MPH Public Health Harvard T.H. Chan School of Public Health
• Fellowship Health Services Research Harvard-wide Pediatric Health Services Research Fellowship
• MD School of Medicine University of California, San Francisco

Publications (75)

Top publication keywords:
Office VisitsConjunctivitis, BacterialStreptococcus pyogenesEmergency Service, HospitalAmbulatory CareDrug PrescriptionsRespiratory Tract InfectionsStreptococcal InfectionsPractice Patterns, Physicians'PneumoniaCommunity-Acquired InfectionsAnti-Bacterial AgentsPharyngitisBronchiolitisDrug Utilization

• Glucocorticoids for Preventing Migraine Recurrence in the Emergency Department.
  JAMA neurology 2026 Gelfand AA, Orr SL, Shapiro DJ
• Tranexamic Acid Use for Posttonsillectomy Hemorrhage Across US Children's Hospitals.
  Pediatric emergency care 2026 Bergmann KR, Hall M, Ramgopal S, Badaki-Makun O, Chaudhari PP, Eltorki M, Geanacopoulos AT, Gonzalez F, Keating EM, Phamduy TT, Rees CA, Shapiro DJ, Chinnadurai S, Neuman MI
• Variations in Corticosteroids Used for Asthma Exacerbations in the Pediatric Emergency Department: A Pediatric Emergency Care Applied Research Network Registry Study.
  The journal of allergy and clinical immunology. In practice 2026 Andoh AA, Tanverdi MS, Shapiro DJ, Lipshaw MJ, Cushing AM, Olsen CS, Meeks HD, Morris K, Leonard JC, Zorc JJ, Pediatric Emergency Care Applied Research Network
• Overview of 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Group A Streptococcal (GAS) Pharyngitis: Risk assessment using clinical scoring systems in children and adults.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2026 Barshak MB, Linder JA, Watson ME, Wessels MR, Carter DM, Cohen AL, Bard JD, Erdem G, Gregory CJ, Kourtis AP, Martin JM, Mochon AB, Shapiro DJ, Stevens RW, Kaur D
• Differences in antibiotic treatment for children hospitalized with pneumonia.
  Journal of hospital medicine 2026 Cotter JM, Hall M, Hersh AL, Shapiro DJ, Lipsett SC, Gerber JS, Cogen JD, Brogan TV, Blaschke AJ, Ambroggio L, Neuman MI

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• Dexamethasone Treatment Regimen and Clinical Outcomes in Children With Asthma Exacerbations.
  Annals of emergency medicine 2026 Dave S, Green-Hopkins I, Bardach NS, Grupp-Phelan J, Shapiro DJ
• 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Group A Streptococcal (GAS) Pharyngitis: Risk assessment using clinical scoring systems in children and adults.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2025 Linder JA, Watson ME, Wessels MR, Carter DM, Cohen AL, Dien Bard J, Erdem G, Gregory CJ, Kourtis AP, Martin JM, Mochon AB, Shapiro D, Stevens RW, Kaur D, Barshak MB
• Urinalysis with Reflex to Culture: Is 10 the Magic Number?
  Journal of the Pediatric Infectious Diseases Society 2025 Sick-Samuels AC, Shapiro DJ
• Variations in Medical Clearance Testing for Mental Health Emergency Department Visits.
  Pediatrics 2025 Rees CA, Hall M, Ramgopal S, Badaki-Makun O, Eltorki M, Chaudhari PP, Gonzalez F, Phamduy TT, Shapiro DJ, Bergmann KR, Neuman MI
• Clinically Significant Neuroimaging Findings Among Pediatric Patients Presenting to the Emergency Department With Symptoms of Psychosis: A Multicenter Retrospective Study.
  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2025 Hoffmann JA, Parikh TK, Lorenz D, Goldman MP, Powers EM, Patel SJ, Lavina IS, Heyming TW, England JT, Saidinejad M, Claudius I, Ghosh P, Shapiro DJ, Swan TB, Bouvay KL, Kurowski EM, Smith NM, Davis JR…
• Association between wildfire smoke exposure and pediatric emergency department visits for headache.
  Headache 2025 Shapiro HFJ, Gelfand AA, Shapiro DJ, Elser H, Chen C, Casey JA
• Pediatric Intravenous Fluid Use in the Emergency Department During Hurricane Helene.
  JAMA pediatrics 2025 Diasso-Adamou A, Gonzalez F, Geanacopoulos AT, Neuman MI, Rees CA, Phamduy TT, Chaudhari PP, Bergmann KR, Badaki-Makun O, Shapiro DJ, Eltorki M, Keating EM, Noorbakhsh KA, Ramgopal S
• State-Level Policies and Antibiotic Use for Pediatric Conjunctivitis.
  JAMA pediatrics 2025 Oke I, Geanacopoulos AT, Subramanian SV, Wu AC, Bardach NS, Shapiro DJ
• Urine Testing in Children with Viral Symptoms: A Nationwide Analysis of Ambulatory Visits, 2014-2019.
  The Journal of pediatrics 2025 Wattier RL, Shapiro DJ, Copp HL, Kaiser SV, Hersh AL
• Outpatient Follow-Up and Future Care-Seeking for Pediatric Ambulatory Care-Sensitive Conditions.
  Academic pediatrics 2024 Shapiro DJ, Hall M, Ramgopal S, Chaudhari PP, Eltorki M, Badaki-Makun O, Bergmann KR, Macy ML, Foster CC, Neuman MI
• Trends in Respiratory Viral Testing in Pediatric Emergency Departments Following the COVID-19 Pandemic.
  Annals of emergency medicine 2024 Ramgopal S, Badaki-Makun O, Eltorki M, Chaudhari P, Phamduy TT, Shapiro D, Rees CA, Bergmann KR, Neuman MI, Lorenz D, Michelson KA
• Trends and hospital practice variation for analgesia for children with sickle cell disease with vaso-occlusive pain episodes: An 11-year analysis.
  The American journal of emergency medicine 2024 Eltorki M, Hall M, Ramgopal S, Chaudhari PP, Badaki-Makun O, Rees CA, Bergmann KR, Shapiro DJ, Gonzalez F, Phamduy T, Neuman MI
• Outpatient Antibiotic Use and Treatment Failure Among Children With Pneumonia.
  JAMA network open 2024 Shapiro DJ, Hall M, Neuman MI, Hersh AL, Cotter JM, Cogen JD, Brogan TV, Ambroggio L, Blaschke AJ, Lipsett SC, Gerber JS, Florin TA
• Trends in dexamethasone treatment for asthma in U.S. emergency departments.
  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2024 Shapiro DJ, Coon ER, Kaiser SV, Grupp-Phelan J, Hersh AL, Bardach NS
• Antibiotic Treatment and Health Care Use in Children and Adolescents With Conjunctivitis.
  JAMA ophthalmology 2024 Shapiro DJ, Geanacopoulos AT, Subramanian SV, Wu AC, Bardach NS, Oke I
• Antibiotic route and outcomes for children hospitalized with pneumonia.
  Journal of hospital medicine 2024 Cotter JM, Hall M, Neuman MI, Blaschke AJ, Brogan TV, Cogen JD, Gerber JS, Hersh AL, Lipsett SC, Shapiro DJ, Ambroggio L
• Harnessing the Power of Generative AI for Clinical Summaries: Perspectives From Emergency Physicians.
  Annals of emergency medicine 2024 Barak-Corren Y, Wolf R, Rozenblum R, Creedon JK, Lipsett SC, Lyons TW, Michelson KA, Miller KA, Shapiro DJ, Reis BY, Fine AM
• Acute care utilization for ambulatory care-sensitive conditions among publicly insured children.
  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2024 Shapiro DJ, Hall M, Ramgopal S, Alpern ER, Chaudhari PP, Eltorki M, Badaki-Makun O, Bergmann KR, Macy ML, Foster CC, Neuman MI
• Management of Pediatric Pneumonia: A Decade After the Pediatric Infectious Diseases Society and Infectious Diseases Society of America Guideline.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2023 Ambroggio L, Cotter J, Hall M, Shapiro DJ, Lipsett SC, Hersh AL, Shah SS, Brogan TV, Gerber JS, Williams DJ, Blaschke AJ, Cogen JD, Neuman MI
• National Patterns of Outpatient Follow-Up Visits After Emergency Care for Acute Bronchiolitis.
  JAMA network open 2023 Shapiro DJ, Bourgeois FT, Fine AM, Hersh AL, Coon ER, Neuman MI, Wu AC
• Association between clinician specialty and prescription of preventive medication for young adults with migraine: A retrospective cohort study.
  Headache 2023 Shapiro HFJ, Loder E, Shapiro DJ
• Patterns of Outpatient Follow-up Visits After Hospitalizations for Acute Bronchiolitis.
  JAMA pediatrics 2023 Shapiro DJ, Wu AC, Hersh AL, Coon ER
• Comparison of antibiotic prescribing between physicians and advanced practice clinicians.
  Infection control and hospital epidemiology 2023 Hersh AL, Shapiro DJ, Sanchez GV, Hicks LA
• Ambulatory follow-up among publicly insured children discharged from the emergency department.
  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2023 Ramgopal S, Rodean J, Alpern ER, Hall M, Chaudhari PP, Marin JR, Shah SS, Freedman SB, Eltorki M, Badaki-Makun O, Shapiro DJ, Rhine T, Morse RB, Neuman MI
• Intermittent Tiotropium for Episodic Wheezing.
  Pediatrics 2022 Shapiro DJ, Wu AC
• Antibiotics and outcomes of CF pulmonary exacerbations in children infected with MRSA and Pseudomonas aeruginosa.
  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2022 Cogen JD, Hall M, Faino AV, Ambroggio L, Blaschke AJ, Brogan TV, Cotter JM, Gibson RL, Grijalva CG, Hersh AL, Lipsett SC, Shah SS, Shapiro DJ, Neuman MI, Gerber JS
• Respiratory virus testing and clinical outcomes among children hospitalized with pneumonia.
  Journal of hospital medicine 2022 Shapiro DJ, Thurm CW, Hall M, Lipsett SC, Hersh AL, Ambroggio L, Shah SS, Brogan TV, Gerber JS, Grijalva CG, Blaschke AJ, Cogen JD, Neuman MI
• Association Between Molecular Streptococcal Testing and Antibiotic Use for Pharyngitis in Children.
  Journal of the Pediatric Infectious Diseases Society 2022 Shapiro DJ, Fine AM, Hersh AL, Bourgeois FT
• Rapid streptococcal pharyngitis testing and antibiotic prescribing before and during the coronavirus disease 2019 (COVID-19) pandemic.
  Antimicrobial stewardship & healthcare epidemiology : ASHE 2022 Seibert AM, Stenehjem E, Wallin A, Willis P, Brunisholz K, Kumar N, Stanfield V, Fino N, Shapiro DJ, Hersh A
• Factors Associated With Corticosteroid Treatment for Pediatric Acute Respiratory Tract Infections.
  Journal of the Pediatric Infectious Diseases Society 2021 Shapiro DJ, Palmer NP, Bourgeois FT
• Patient Ethnicity and Pediatric Visits to the Emergency Department for Fever.
  Pediatric emergency care 2021 Shapiro DJ, Fine AM
• Association between antibiotic prescribing and visit duration among patients with respiratory tract infections.
  Infection control and hospital epidemiology 2021 Shapiro DJ, King LM, Tsay SV, Hicks LA, Hersh AL
• Short- Versus Prolonged-Duration Antibiotics for Outpatient Pneumonia in Children.
  The Journal of pediatrics 2021 Shapiro DJ, Hall M, Lipsett SC, Hersh AL, Ambroggio L, Shah SS, Brogan TV, Gerber JS, Williams DJ, Grijalva CG, Blaschke AJ, Neuman MI
• A Young Boy with Fever and Grunting.
  Clinical practice and cases in emergency medicine 2021 Shapiro DJ, Neal JT
• Unnecessary Antibiotic Prescribing in US Ambulatory Care Settings, 2010-2015.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021 Hersh AL, King LM, Shapiro DJ, Hicks LA, Fleming-Dutra KE
• Contribution of Penicillin Allergy Labels to Second-Line Broad-Spectrum Antibiotic Prescribing for Pediatric Respiratory Tract Infections.
  Infectious diseases and therapy 2020 Hersh AL, Shapiro DJ, Zhang M, Madaras-Kelly K
• National Trends in Incidence of Purulent Skin and Soft Tissue Infections in Patients Presenting to Ambulatory and Emergency Department Settings, 2000-2015.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2020 Fritz SA, Shapiro DJ, Hersh AL
• Association between use of diagnostic tests and antibiotic prescribing for pharyngitis in the United States.
  Infection control and hospital epidemiology 2020 Shapiro DJ, King LM, Fleming-Dutra KE, Hicks LA, Hersh AL
• Identifying Patients at Lowest Risk for Streptococcal Pharyngitis: A National Validation Study.
  The Journal of pediatrics 2020 Shapiro DJ, Barak-Corren Y, Neuman MI, Mandl KD, Harper MB, Fine AM
• Ambulatory Antibiotic Prescribing for Children with Pneumonia After Publication of National Guidelines: A Cross-Sectional Retrospective Study.
  Infectious diseases and therapy 2019 Poole NM, Shapiro DJ, Kronman MP, Hersh AL
• Antibiotic Prescribing for Children in United States Emergency Departments: 2009-2014.
  Pediatrics 2019 Poole NM, Shapiro DJ, Fleming-Dutra KE, Hicks LA, Hersh AL, Kronman MP
• Antibiotic Prescriptions Associated With Dental-Related Emergency Department Visits.
  Annals of emergency medicine 2018 Roberts RM, Hersh AL, Shapiro DJ, Fleming-Dutra KE, Hicks LA
• Reply to Mercuro et al.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018 Kabbani S, Hersh AL, Shapiro DJ, Fleming-Dutra KE, Pavia AT, Hicks LA
• Uropathogen Resistance and Antibiotic Prophylaxis: A Meta-analysis.
  Pediatrics 2018 Selekman RE, Shapiro DJ, Boscardin J, Williams G, Craig JC, Brandström P, Pennesi M, Roussey-Kesler G, Hari P, Copp HL
• Opportunities to Improve Fluoroquinolone Prescribing in the United States for Adult Ambulatory Care Visits.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018 Kabbani S, Hersh AL, Shapiro DJ, Fleming-Dutra KE, Pavia AT, Hicks LA
• Geographic Variability in Diagnosis and Antibiotic Prescribing for Acute Respiratory Tract Infections.
  Infectious diseases and therapy 2017 Hersh AL, Shapiro DJ, Pavia AT, Fleming-Dutra KE, Hicks LA
• Outpatient Macrolide Antibiotic Prescribing in the United States, 2008-2011.
  Open forum infectious diseases 2017 Sanchez GV, Shapiro DJ, Hersh AL, Hicks LA, Fleming-Dutra KE
• Viral Features and Testing for Streptococcal Pharyngitis.
  Pediatrics 2017 Shapiro DJ, Lindgren CE, Neuman MI, Fine AM
• Frequency of First-line Antibiotic Selection Among US Ambulatory Care Visits for Otitis Media, Sinusitis, and Pharyngitis.
  JAMA internal medicine 2016 Hersh AL, Fleming-Dutra KE, Shapiro DJ, Hyun DY, Hicks LA, Outpatient Antibiotic Use Target-Setting Workgroup
• Outpatient Antibiotic Prescribing Among United States Nurse Practitioners and Physician Assistants.
  Open forum infectious diseases 2016 Sanchez GV, Hersh AL, Shapiro DJ, Cawley JF, Hicks LA
• Outpatient Antibiotic Prescribing Practices for Uncomplicated Urinary Tract Infection in Women in the United States, 2002-2011.
  Open forum infectious diseases 2016 Kobayashi M, Shapiro DJ, Hersh AL, Sanchez GV, Hicks LA
• Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011.
  JAMA 2016 Fleming-Dutra KE, Hersh AL, Shapiro DJ, Bartoces M, Enns EA, File TM, Finkelstein JA, Gerber JS, Hyun DY, Linder JA, Lynfield R, Margolis DJ, May LS, Merenstein D, Metlay JP, Newland JG, Piccirillo JF…
• Race, otitis media, and antibiotic selection.
  Pediatrics 2014 Fleming-Dutra KE, Shapiro DJ, Hicks LA, Gerber JS, Hersh AL
• Overprescribing and inappropriate antibiotic selection for children with pharyngitis in the United States, 1997-2010.
  JAMA pediatrics 2014 Dooling KL, Shapiro DJ, Van Beneden C, Hersh AL, Hicks LA
• Burden of ambulatory visits and antibiotic prescribing patterns for adults with community-acquired pneumonia in the United States, 1998 through 2009.
  JAMA internal medicine 2014 Wortham JM, Shapiro DJ, Hersh AL, Hicks LA
• Clinical management of skin and soft tissue infections in the U.S. Emergency Departments.
  The western journal of emergency medicine 2014 Mistry RD, Shapiro DJ, Goyal MK, Zaoutis TE, Gerber JS, Liu C, Hersh AL
• A comparison of inpatient versus outpatient resistance patterns of pediatric urinary tract infection.
  The Journal of urology 2014 Saperston KN, Shapiro DJ, Hersh AL, Copp HL
• A National Study of the Impact of Rapid Influenza Testing on Clinical Care in the Emergency Department.
  Journal of the Pediatric Infectious Diseases Society 2013 Blaschke AJ, Shapiro DJ, Pavia AT, Byington CL, Ampofo K, Stockmann C, Hersh AL
• Antibiotic prescribing for adults in ambulatory care in the USA, 2007-09.
  The Journal of antimicrobial chemotherapy 2013 Shapiro DJ, Hicks LA, Pavia AT, Hersh AL
• Sociodemographic characteristics and beverage intake of children who drink tap water.
  American journal of preventive medicine 2013 Patel AI, Shapiro DJ, Wang YC, Cabana MD
• Emergency department management of childhood pneumonia in the United States prior to publication of national guidelines.
  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2013 Neuman MI, Shah SS, Shapiro DJ, Hersh AL
• Antibiotic resistance patterns of outpatient pediatric urinary tract infections.
  The Journal of urology 2013 Edlin RS, Shapiro DJ, Hersh AL, Copp HL
• Trends in adverse reactions to trimethoprim-sulfamethoxazole.
  Pediatrics 2012 Goldman JL, Jackson MA, Herigon JC, Hersh AL, Shapiro DJ, Leeder JS
• National trends in visit rates and antibiotic prescribing for adults with acute sinusitis.
  Archives of internal medicine 2012 Fairlie T, Shapiro DJ, Hersh AL, Hicks LA
• Hypertension screening during ambulatory pediatric visits in the United States, 2000-2009.
  Pediatrics 2012 Shapiro DJ, Hersh AL, Cabana MD, Sutherland SM, Patel AI
• A national depiction of children with return visits to the emergency department within 72 hours, 2001-2007.
  Pediatric emergency care 2012 Cho CS, Shapiro DJ, Cabana MD, Maselli JH, Hersh AL
• Antibiotic prescribing in ambulatory pediatrics in the United States.
  Pediatrics 2011 Hersh AL, Shapiro DJ, Pavia AT, Shah SS
• Variability in pediatric infectious disease consultants' recommendations for management of community-acquired pneumonia.
  PloS one 2011 Hersh AL, Shapiro DJ, Newland JG, Polgreen PM, Beekmann SE, Shah SS
• National ambulatory antibiotic prescribing patterns for pediatric urinary tract infection, 1998-2007.
  Pediatrics 2011 Copp HL, Shapiro DJ, Hersh AL
• National trends in visit rates and antibiotic prescribing for children with acute sinusitis.
  Pediatrics 2010 Shapiro DJ, Gonzales R, Cabana MD, Hersh AL