Daniel Santi, MD, PhD
Professor Emeritus
Pharmaceutical Chemistry
School of Pharmacy
Dr. Santi received a Ph.D. in Medicinal Chemistry from SUNY in 1967 and a M.D. from UCSF in 1981. He was Assistant Professor of Chemistry at UCSB from 1968 to 1974. He joined the UCSF faculty in 1974 and was Professor of Biochemistry and Biophysics, and of Pharmaceutical Chemistry at UCSF until 2000 when he became CEO of Kosan Biosciences.
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He returned to UCSF in 2007 where he served as interim Director of the UCSF CTSI and then Director of Translational Research at QB3. He became an Associate Dean of External Relationships in the School of Pharmacy in 2009, and manages an Industry Outreach Program. Dr. Santi has published over 300 scientific papers and is co-inventor on over 40 US patents.
Santi was a member of the original Scientific Advisory Board of Chiron Corp. and has co-founded five biotechnology companies. In 1988, he founded and was Chairman of the peptide-combinatorial chemistry company Protos Corp., which merged with Chiron in 1992. He was also a co-founder of Parnassus Pharmaceuticals, and of Prospect Genomics which merged with Structural Genomix in 2001. In 1996, he co-founded Kosan Biosciences where he served as CEO and Chairman until 2006 when Kosan was acquired by Bristol Myers Squibb. He co-founded the platform technology company ProLynx LLC in 2010, where he currently serves as President.
Education & Training
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- M.D. Medicine University of California, San Francisco 1980
Grants and Projects
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- Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
- RNA Modification Enzymes: Methyltransferase/PSI-synthase, NIH, 1996-2013
- Combinatorial Biosynthesis of Polyketides, NIH, 2005-2006
- THYMIDYLATE SYNTHASE, NIH, 1978-2002
- Enzyme Targets of Opportunistic Pathogens in Aids, NIH, 1991-2000
- THYMIDYLATE SYNTHASE, NIH, 1978-1998
- Protein Sequencer and Dna Sequencer, NIH, 1996-1997
- Enzymes of Folate Metabolism in Protozoa, NIH, 1982-1997
- Drug Targets of Opportunistic Pathogens in Aids, NIH, 1990-1994
- Dna Synthesizer and Zymark Robotic System, NIH, 1990-1991
- Amino Acid Analyzer/hplc/dna Synthesizer, NIH, 1988-1991
- Aids Retrovirus Reverse Transcriptase, NIH, 1987-1990
Publications (157)
Top publication keywords:
ProdrugsHypogonadismFollicle Stimulating HormoneTestosteronePolyethylene GlycolsInfertilityCamptothecinSemenSperm MotilitySemen AnalysisInfertility, MaleErectile DysfunctionChorionic GonadotropinVardenafil DihydrochlorideSpermatozoa
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Long-Acting Poly(ADP-ribose) Polymerase Inhibitor Prodrug for Humans.
Bioconjugate chemistry 2024 Carreras CW, Fontaine SD, Reid RR, Ashley GW, Santi DV -
Are they functional hypogonadal men? Testosterone serum levels unravel male idiopathic infertility subgroups.
Endocrine 2024 Spaggiari G, Costantino F, Dalla Valentina L, Romeo M, Furini C, Roli L, De Santis MC, Canu G, Trenti T, Granata ARM, Simoni M, Santi D -
Could a Long-Acting Prodrug of SN-38 be Efficacious in Sacituzumab Govitecan-Resistant Tumors?
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2024 Santi DV, Ashley GW, Cabel L, Bidard FC -
Randomized double-blind placebo-controlled trial on levothyroxine and liothyronine combination therapy in totally thyroidectomized subjects: the LEVOLIO study.
European journal of endocrinology 2024 Brigante G, Santi D, Boselli G, Margiotta G, Corleto R, Monzani ML, Craparo A, Locaso M, Sperduti S, Roy N, Casarini L, Trenti T, Tagliavini S, De Santis MC, Roli L, Rochira V, Simoni M -
Gonadotropins in the Management of Couple Infertility: Toward the Rational Use of an Empirical Therapy.
Seminars in reproductive medicine 2023 Romeo M, Donno V, Spaggiari G, Granata ARM, Simoni M, La Marca A, Santi D
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Is weight loss a therapeutic tool in the management of male infertility?
Maturitas 2023 Santi D, Corona G -
Microbiota Composition and Probiotics Supplementations on Sleep Quality-A Systematic Review and Meta-Analysis.
Clocks & sleep 2023 Santi D, Debbi V, Costantino F, Spaggiari G, Simoni M, Greco C, Casarini L -
APHRODITE criteria: addressing male patients with hypogonadism and/or infertility owing to altered idiopathic testicular function.
Reproductive biomedicine online 2023 Esteves SC, Humaidan P, Ubaldi FM, Alviggi C, Antonio L, Barratt CLR, Behre HM, Jørgensen N, Pacey AA, Simoni M, Santi D -
The chronic alcohol consumption influences the gonadal axis in men: Results from a meta-analysis.
Andrology 2023 Santi D, Cignarelli A, Baldi M, Sansone A, Spaggiari G, Simoni M, Corona G -
Sperm Concentration Improvement May Be a Parameter Predicting Efficacy of FSH Therapy of Male Idiopathic Infertility.
Cells 2023 Santi D, Spaggiari G, Dalla Valentina L, Romeo M, Nuzzo F, Serlenga L, Roli L, De Santis MC, Trenti T, Granata ARM, Simoni M -
Alterations in the Menstrual Cycle as a Peculiar Sign of Type 1 Diabetes Mellitus: A Meta-analytic Approach.
Canadian journal of diabetes 2023 Greco C, Cacciani M, Corleto R, Simoni M, Spaggiari G, Santi D -
Genetic Variants of Gonadotropins and Their Receptors Could Influence Controlled Ovarian Stimulation: IVF Data from a Prospective Multicenter Study.
Genes 2023 Alviggi C, Longobardi S, Papaleo E, Santi D, Alfano S, Vanni VS, Campitiello MR, De Rosa P, Strina I, Huhtaniemi I, Pursiheimo JP, D'Hooghe T, Humaidan P, Conforti A -
Does an increase in adipose tissue 'weight' affect male fertility? A systematic review and meta-analysis based on semen analysis performed using the WHO 2010 criteria.
Andrology 2023 Santi D, Lotti F, Sparano C, Rastrelli G, Isidori AM, Pivonello R, Barbonetti A, Salonia A, Minhas S, Krausz C, Vignozzi L, Maggi M, Corona G -
Semen Analysis in "Urology-Naïve" Patients: A Chance of Uroandrological Screening in Young Males.
Journal of clinical medicine 2023 Puliatti S, Toso S, Ticonosco M, Rabito S, Sighinolfi MC, Ferrari R, Rochira V, Santi D, Trenti T, Navarra M, Ferretti S, Montano L, Micali S -
A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors.
Cancer research communications 2023 Fontaine SD, Carreras CW, Reid RR, Ashley GW, Santi DV -
Talking about sex: erectile dysfunction in the oncology patient.
Endocrine-related cancer 2023 Romeo M, Spaggiari G, Furini C, Granata ARM, Toss A, Simoni M, Santi D -
Prolactin and spermatogenesis: new lights on the interplay between prolactin and sperm parameters.
Endocrine 2023 Spaggiari G, Costantino F, Granata ARM, Tagliavini S, Canu G, Varani M, De Santis MC, Roli L, Trenti T, Simoni M, Santi D -
Glycemic control predicts SARS-CoV-2 prognosis in diabetic subjects.
Acta diabetologica 2023 Greco C, Pirotti T, Brigante G, Filippini T, Pacchioni C, Trenti T, Simoni M, Santi D -
Exploring the human chorionic gonadotropin induced steroid secretion profile of mouse Leydig tumor cell line 1 by a 20 steroid LC-MS/MS panel.
The Journal of steroid biochemistry and molecular biology 2023 Fanelli F, Magagnoli M, Mezzullo M, Lispi M, Limoncella S, Tommasini A, Pelusi C, Santi D, Simoni M, Pagotto U, Casarini L -
Systematic review and meta-analysis of long-term reintervention following thoracic endovascular repair for blunt traumatic aortic injury.
Journal of vascular surgery 2023 Gennai S, Leone N, Mezzetto L, Veraldi GF, Santi D, Spaggiari G, Resch T, Silingardi R -
Not only a matter of glucose: The andrological consequences of diabetes mellitus.
Andrology 2023 Rastrelli G, Santi D -
Determinants of sexual function in men living with HIV younger than 50 years old: Focus on organic, relational, and psychological issues.
Andrology 2023 De Vincentis S, Decaroli MC, Milic J, Fanelli F, Tartaro G, Diazzi C, Mezzullo M, De Santis MC, Roli L, Trenti T, Santi D, Pagotto U, Guaraldi G, Rochira V -
Male infertility and gonadotropin treatment: What can we learn from real-world data?
Best practice & research. Clinical obstetrics & gynaecology 2022 Esteves SC, Achermann APP, Simoni M, Santi D, Casarini L -
Very low-calorie ketogenic diet rapidly augments testosterone levels in non-diabetic obese subjects.
Andrology 2022 Cignarelli A, Santi D, Genchi VA, Conte E, Giordano F, Di Leo S, Natalicchio A, Laviola L, Giorgino F, Perrini S -
Follicle-stimulating hormone effectiveness in male idiopathic infertility: What happens in daily practice?
Andrology 2022 Romeo M, Spaggiari G, Nuzzo F, Granata ARM, Simoni M, Santi D -
PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors.
Molecular cancer therapeutics 2022 Thomas A, Fontaine SD, Diolaiti ME, Desai P, Kumar R, Takahashi N, Sciuto L, Nichols S, Ashworth A, Feng FY, Ashley GW, Nguyen M, Pommier Y, Santi DV -
Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers.
ACS applied materials & interfaces 2022 Meher N, Ashley GW, Bidkar AP, Dhrona S, Fong C, Fontaine SD, Beckford Vera DR, Wilson DM, Seo Y, Santi DV, VanBrocklin HF, Flavell RR -
Which sperm parameter limits could really guide the clinical decision in assisted reproduction?
Andrology 2022 Santi D, Spaggiari G, Morini D, Melli B, Dalla Valentina L, Aguzzoli L, Simoni M, Villani MT -
Testosterone Serum Levels Are Related to Sperm DNA Fragmentation Index Reduction after FSH Administration in Males with Idiopathic Infertility.
Biomedicines 2022 Lispi M, Drakopoulos P, Spaggiari G, Caprio F, Colacurci N, Simoni M, Santi D -
Ketogenic state improves testosterone serum levels-results from a systematic review and meta-analysis.
Endocrine 2022 Furini C, Spaggiari G, Simoni M, Greco C, Santi D -
Editorial: Follicle-stimulating hormone: Fertility and beyond-volume II.
Frontiers in endocrinology 2022 Simoni M, Huhtaniemi I, Casarini L, Santi D -
Neither rationale nor scientific evidence exist to support that double stimulation is potentially unsafe.
Human reproduction (Oxford, England) 2022 Casarini L, Vaiarelli A, Cimadomo D, Santi D, Simoni M, Garcìa-Velasco JA, Alviggi C, La Marca A, Rienzi L, Ubaldi FM -
A long-acting C-natriuretic peptide for achondroplasia.
Proceedings of the National Academy of Sciences of the United States of America 2022 Schneider EL, Carreras CW, Reid R, Ashley GW, Santi DV -
Qualitative and quantitative analysis of doctor-patient interactions during andrological consultations.
Andrology 2022 Santi D, Spaggiari G, Romeo M, Ebert R, Corradini F, Baraldi C, Granata ARM, Rochira V, Simoni M, Gavioli L, Niemants NSA -
Human fertility and sleep disturbances: A narrative review.
Sleep medicine 2022 Spaggiari G, Romeo M, Casarini L, Granata ARM, Simoni M, Santi D -
Diabetic Neuropathic Cachexia: A Clinical Case and Review of Literature.
Life (Basel, Switzerland) 2022 Bellelli A, Santi D, Simoni M, Greco C -
Real-world evidence analysis of the follicle-stimulating hormone use in male idiopathic infertility.
Best practice & research. Clinical obstetrics & gynaecology 2022 Santi D, Spaggiari G, Granata ARM, Simoni M -
Effect of the Glucagon-Like Peptide-1 Receptor Agonists on Autonomic Function in Subjects with Diabetes: A Systematic Review and Meta-Analysis.
Diabetes & metabolism journal 2022 Greco C, Santi D, Brigante G, Pacchioni C, Simoni M -
Accurate and time-saving, two-step intracavernosal injection procedure to diagnose psychological erectile dysfunction.
Andrology 2022 Santi D, Spaggiari G, Simoni M, Granata ARM -
First Year Metabolic and Hormonal Behavior Define two Different Populations of SGA Newborn for Weight or Height.
Journal of the Endocrine Society 2022 Guazzarotti L, Mauri S, Santi D, Pogliani L, Zuccotti G -
Semen cryopreservation in men undergoing cancer treatment: a ten-year study.
Minerva obstetrics and gynecology 2022 Melli B, Morini D, Daolio J, Nicoli A, Valli B, Capodanno F, Spaggiari G, Aguzzoli L, Villani MT, Santi D, Sileo FG -
The (decision) tree of fertility: an innovative decision-making algorithm in assisted reproduction technique.
Journal of assisted reproduction and genetics 2022 Villani MT, Morini D, Spaggiari G, Furini C, Melli B, Nicoli A, Iannotti F, La Sala GB, Simoni M, Aguzzoli L, Santi D -
Seasonal reproduction and gonadal function: a focus on humans starting from animal studies.
Biology of reproduction 2022 Beltran-Frutos E, Casarini L, Santi D, Brigante G -
A very long-acting IL-15: implications for the immunotherapy of cancer.
Journal for immunotherapy of cancer 2022 Hangasky JA, Chen W, Dubois SP, Daenthanasanmak A, Müller JR, Reid R, Waldmann TA, Santi DV -
From subjective to objective: A pilot study on testicular radiomics analysis as a measure of gonadal function.
Andrology 2021 De Santi B, Spaggiari G, Granata AR, Romeo M, Molinari F, Simoni M, Santi D -
Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line.
Molecular and cellular endocrinology 2021 Limoncella S, Lazzaretti C, Paradiso E, D'Alessandro S, Barbagallo F, Pacifico S, Guerrini R, Tagliavini S, Trenti T, Santi D, Simoni M, Sola M, Di Rocco G, Casarini L -
Are sperm parameters able to predict the success of assisted reproductive technology? A retrospective analysis of over 22,000 assisted reproductive technology cycles.
Andrology 2021 Villani MT, Morini D, Spaggiari G, Falbo AI, Melli B, La Sala GB, Romeo M, Simoni M, Aguzzoli L, Santi D -
Association of Nonalcoholic Fatty Liver Disease (NAFLD) with Peripheral Diabetic Polyneuropathy: A Systematic Review and Meta-Analysis.
Journal of clinical medicine 2021 Greco C, Nascimbeni F, Carubbi F, Andreone P, Simoni M, Santi D -
The Prevalence of Hypogonadism and the Effectiveness of Androgen Administration on Body Composition in HIV-Infected Men: A Meta-Analysis.
Cells 2021 Santi D, Spaggiari G, Vena W, Pizzocaro A, Maggi M, Rochira V, Corona G -
Does sacituzumab-govitecan act as a conventional antibody drug conjugate (ADC), a prodrug of SN-38 or both?
Annals of translational medicine 2021 Santi DV, Cabel L, Bidard FC -
Improvement of sperm morphology after surgical varicocele repair.
Andrology 2021 Morini D, Spaggiari G, Daolio J, Melli B, Nicoli A, De Feo G, Valli B, Viola D, Garganigo S, Magnani E, Pilia A, Polese A, Colla R, Simoni M, Aguzzoli L, Villani MT, Santi D -
Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles.
Bioconjugate chemistry 2021 Hearn BR, Fontaine SD, Schneider EL, Kraemer Y, Ashley GW, Santi DV -
A prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males.
Scientific reports 2021 Brigante G, Spaggiari G, Rossi B, Granata A, Simoni M, Santi D -
Psychotropic Drugs Levels in Seminal Fluid: A New Therapeutic Drug Monitoring Analysis?
Frontiers in endocrinology 2021 Mazzilli R, Curto M, De Bernardini D, Olana S, Capi M, Salerno G, Cipolla F, Zamponi V, Santi D, Mazzilli F, Simmaco M, Lionetto L -
HIV and Sexual Dysfunction in Men.
Journal of clinical medicine 2021 De Vincentis S, Tartaro G, Rochira V, Santi D -
The "Hitchhiker's Guide to the Galaxy" of Endothelial Dysfunction Markers in Human Fertility.
International journal of molecular sciences 2021 Santi D, Spaggiari G, Greco C, Lazzaretti C, Paradiso E, Casarini L, Potì F, Brigante G, Simoni M -
Spontaneous pregnancies among infertile couples during assisted reproduction lockdown for COVID-19 pandemic.
Andrology 2021 Villani MT, Morini D, Spaggiari G, Simoni M, Aguzzoli L, Santi D -
Gynecological malignancy mimicking a thyroid lymph node metastasis.
Endocrinology, diabetes & metabolism case reports 2021 Pederzoli S, Spaggiari G, Bernardelli G, Mattioli F, Baldessari C, Maiorana A, Rochira V, Santi D -
Health status is related to testosterone, estrone and body fat: moving to functional hypogonadism in adult men with HIV.
European journal of endocrinology 2021 De Vincentis S, Decaroli MC, Fanelli F, Diazzi C, Mezzullo M, Morini F, Bertani D, Milic J, Carli F, Cuomo G, Santi D, Tartaro G, Tagliavini S, De Santis MC, Roli L, Trenti T, Pagotto U, Guaraldi G, … -
A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models.
Cancer research 2020 Fontaine SD, Ashley GW, Houghton PJ, Kurmasheva RT, Diolaiti M, Ashworth A, Peer CJ, Nguyen R, Figg WD, Beckford-Vera DR, Santi DV -
Elevated levels of nitrous dioxide are associated with lower AMH levels: a real-world analysis.
Human reproduction (Oxford, England) 2020 La Marca A, Spaggiari G, Domenici D, Grassi R, Casonati A, Baraldi E, Trenti T, Simoni M, Santi D -
Eating Behavior after Bariatric Surgery (EBBS) Questionnaire: a New Validated Tool to Quantify the Patients' Compliance to Post-Bariatric Dietary and Lifestyle Suggestions.
Obesity surgery 2020 Spaggiari G, Santi D, Budriesi G, Dondi P, Cavedoni S, Leonardi L, Delvecchio C, Valentini L, Bondi M, Miloro C, Toschi PF -
Interleukin 15 Pharmacokinetics and Consumption by a Dynamic Cytokine Sink.
Frontiers in immunology 2020 Hangasky JA, Waldmann TA, Santi DV -
Effects of acute hCG stimulation on serum INSL3 and 25-OH vitamin D in Klinefelter syndrome.
Andrology 2020 Santi D, Ivell R, Anand-Ivell R, De Toni L, Fanelli F, Mezzullo M, Pelusi C, Pagotto U, Belli S, Granata ARM, Roli L, Rochira V, Trenti T, Ferlin A, Simoni M -
Prospects for FSH Treatment of Male Infertility.
The Journal of clinical endocrinology and metabolism 2020 Simoni M, Brigante G, Rochira V, Santi D, Casarini L -
Multilevel approach to male fertility by machine learning highlights a hidden link between haematological and spermatogenetic cells.
Andrology 2020 Santi D, Spaggiari G, Casonati A, Casarini L, Grassi R, Vecchi B, Roli L, De Santis MC, Orlando G, Gravotta E, Baraldi E, Setti M, Trenti T, Simoni M -
To beer or not to beer: A meta-analysis of the effects of beer consumption on cardiovascular health.
PloS one 2020 Spaggiari G, Cignarelli A, Sansone A, Baldi M, Santi D -
Testicular ultrasound inhomogeneity is an informative parameter for fertility evaluation.
Asian journal of andrology 2020 Spaggiari G, M Granata AR, Santi D -
Follicle-stimulating Hormone (FSH) Action on Spermatogenesis: A Focus on Physiological and Therapeutic Roles.
Journal of clinical medicine 2020 Santi D, Crépieux P, Reiter E, Spaggiari G, Brigante G, Casarini L, Rochira V, Simoni M -
FSH for the Treatment of Male Infertility.
International journal of molecular sciences 2020 Casarini L, Crépieux P, Reiter E, Lazzaretti C, Paradiso E, Rochira V, Brigante G, Santi D, Simoni M -
The physician's gender influences the results of the diagnostic workup for erectile dysfunction.
Andrology 2020 Rastrelli G, Cipriani S, Craparo A, De Vincentis S, Granata ARM, Spaggiari G, Simoni M, Maggi M, Santi D -
Prospective use of the single-mouse experimental design for the evaluation of PLX038A.
Cancer chemotherapy and pharmacology 2020 Ghilu S, Li Q, Fontaine SD, Santi DV, Kurmasheva RT, Zheng S, Houghton PJ -
Seasonal Changes of Serum Gonadotropins and Testosterone in Men Revealed by a Large Data Set of Real-World Observations Over Nine Years.
Frontiers in endocrinology 2020 Santi D, Spaggiari G, Granata ARM, Setti M, Tagliavini S, Trenti T, Simoni M -
FSH treatment of male idiopathic infertility: Time for a paradigm change.
Andrology 2020 Simoni M, Santi D -
Use of follicle-stimulating hormone for the male partner of idiopathic infertile couples in Italy: Results from a multicentre, observational, clinical practice survey.
Andrology 2020 Santi D, De Vincentis S, Alfano P, Balercia G, Calogero AE, Cargnelutti F, Coccia ME, Condorelli RA, Dal Lago A, de Angelis C, Gallo M, Iannantuoni N, Lombardo F, Marino A, Mazzella M, Pallotti F, … -
An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men.
Andrology 2019 Esteves SC, Santi D, Simoni M -
PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89.
Molecular cancer therapeutics 2019 Beckford Vera DR, Fontaine SD, VanBrocklin HF, Hearn BR, Reid R, Ashley GW, Santi DV -
PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity.
Cancer chemotherapy and pharmacology 2019 Fontaine SD, Santi AD, Reid R, Smith PC, Ashley GW, Santi DV -
Editorial: Follicle-Stimulating Hormone: Fertility and Beyond.
Frontiers in endocrinology 2019 Simoni M, Huhtaniemi I, Santi D, Casarini L -
Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study.
Endocrine connections 2019 Melcangi RC, Casarini L, Marino M, Santi D, Sperduti S, Giatti S, Diviccaro S, Grimoldi M, Caruso D, Cavaletti G, Simoni M -
Semi-annual seasonal pattern of serum thyrotropin in adults.
Scientific reports 2019 Santi D, Spaggiari G, Brigante G, Setti M, Tagliavini S, Trenti T, Simoni M -
Species-specific optimization of PEG~SN-38 prodrug pharmacokinetics and antitumor effects in a triple-negative BRCA1-deficient xenograft.
Cancer chemotherapy and pharmacology 2019 Fontaine SD, Hann B, Reid R, Ashley GW, Santi DV -
Effect of treatment with testosterone on endothelial function in hypogonadal men: a systematic review and meta-analysis.
International journal of impotence research 2019 Sansone A, Rastrelli G, Cignarelli A, de Rocco Ponce M, Condorelli RA, Giannetta E, Maseroli E, Pinto S, Salzano C, Santi D -
An Observational Retrospective Cohort Trial on 4,828 IVF Cycles Evaluating Different Low Prognosis Patients Following the POSEIDON Criteria.
Frontiers in endocrinology 2019 Levi-Setti PE, Zerbetto I, Baggiani A, Zannoni E, Sacchi L, Smeraldi A, Morenghi E, De Cesare R, Drovanti A, Santi D -
Expression and clinicopathological role of miR146a in thyroid follicular carcinoma.
Endocrine 2019 Pignatti E, Vighi E, Magnani E, Kara E, Roncati L, Maiorana A, Santi D, Madeo B, Cioni K, Carani C, Rochira V, Simoni M, Brigante G -
Relative hyperestrogenism in Klinefelter Syndrome: results from a meta-analysis.
Endocrine 2019 Santi D, De Vincentis S, Scaltriti S, Rochira V -
Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis.
International journal of molecular sciences 2019 Potì F, Santi D, Spaggiari G, Zimetti F, Zanotti I -
Two Hormones for One Receptor: Evolution, Biochemistry, Actions, and Pathophysiology of LH and hCG.
Endocrine reviews 2018 Casarini L, Santi D, Brigante G, Simoni M -
Clinical relevance of genetic variants of gonadotrophins and their receptors in controlled ovarian stimulation: a systematic review and meta-analysis.
Human reproduction update 2018 Alviggi C, Conforti A, Santi D, Esteves SC, Andersen CY, Humaidan P, Chiodini P, De Placido G, Simoni M -
A Controlled Release System for Long-Acting Intravitreal Delivery of Small Molecules.
Translational vision science & technology 2018 Machinaga N, Ashley GW, Reid R, Yamasaki A, Tanaka K, Nakamura K, Yabe Y, Yoshigae Y, Santi DV -
Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management - meta-analyses.
Reproductive biomedicine online 2018 Santi D, Spaggiari G, Simoni M -
Could chronic Vardenafil administration influence the cardiovascular risk in men with type 2 diabetes mellitus?
PloS one 2018 Santi D, Locaso M, Granata AR, Trenti T, Roli L, Pacchioni C, Rochira V, Carani C, Simoni M -
AN ITALIAN SURVEY OF COMPLIANCE WITH MAJOR GUIDELINES FOR L-THYROXINE OF PRIMARY HYPOTHYROIDISM.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2018 Vezzani S, Giannetta E, Altieri B, Barbonetti A, Bellastella G, Certo R, Cignarelli A, Cinti F, D'Andrea S, Di Dalmazi G, Frara S, Garelli S, Giuffrida G, Maiorino MI, Mele C, Mezza T, Pani MG, Samà … -
Response: Commentary: Efficacy of Follicle-Stimulating Hormone (FSH) Alone, FSH + Luteinizing Hormone, Human Menopausal Gonadotropin or FSH + Human Chorionic Gonadotropin on Assisted Reproductive Technology Outcomes in the "Personalized" Medicine Era: A Meta-analysis.
Frontiers in endocrinology 2018 Santi D, Casarini L, Alviggi C, Simoni M -
Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system.
Journal of controlled release : official journal of the Controlled Release Society 2018 Hearn BR, Fontaine SD, Pfaff SJ, Schneider EL, Henise J, Ashley GW, Santi DV -
Seasonal variation of semen parameters correlates with environmental temperature and air pollution: A big data analysis over 6 years.
Environmental pollution (Barking, Essex : 1987) 2018 Santi D, Magnani E, Michelangeli M, Grassi R, Vecchi B, Pedroni G, Roli L, De Santis MC, Baraldi E, Setti M, Trenti T, Simoni M -
'Spare' Luteinizing Hormone Receptors: Facts and Fiction.
Trends in endocrinology and metabolism: TEM 2018 Casarini L, Santi D, Simoni M, Potì F -
Pharmacogenetics of G-protein-coupled receptors variants: FSH receptor and infertility treatment.
Best practice & research. Clinical endocrinology & metabolism 2018 Santi D, Potì F, Simoni M, Casarini L -
Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment.
Frontiers in endocrinology 2017 Spaggiari G, Brigante G, De Vincentis S, Cattini U, Roli L, De Santis MC, Baraldi E, Tagliavini S, Varani M, Trenti T, Rochira V, Simoni M, Santi D -
Serum Calcium to Phosphorous (Ca/P) Ratio Is a Simple, Inexpensive, and Accurate Tool in the Diagnosis of Primary Hyperparathyroidism.
JBMR plus 2017 Madeo B, Kara E, Cioni K, Vezzani S, Trenti T, Santi D, Simoni M, Rochira V -
Gene Expression and Apoptosis Levels in Cumulus Cells of Patients with Polymorphisms of FSHR and LHB Undergoing in Vitro Fertilization Program.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017 Bosco L, Ruvolo G, Luparello C, Ferrari S, Valerio D, Santi D, Piomboni P, Sarcina E, Lispi M, Roccheri MC -
Molecular basis of androgen action on human sexual desire.
Molecular and cellular endocrinology 2017 Santi D, Spaggiari G, Gilioli L, Potì F, Simoni M, Casarini L -
A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP-1 Receptor Agonist.
ACS chemical biology 2017 Schneider EL, Hearn BR, Pfaff SJ, Reid R, Parkes DG, Vrang N, Ashley GW, Santi DV -
Advances in Robotic Transaxillary Thyroidectomy in Europe.
Current surgery reports 2017 Piccoli M, Mullineris B, Santi D, Gozzo D -
Efficacy of Follicle-Stimulating Hormone (FSH) Alone, FSH + Luteinizing Hormone, Human Menopausal Gonadotropin or FSH + Human Chorionic Gonadotropin on Assisted Reproductive Technology Outcomes in the "Personalized" Medicine Era: A Meta-analysis.
Frontiers in endocrinology 2017 Santi D, Casarini L, Alviggi C, Simoni M -
Genetics of gonadotropins and their receptors as markers of ovarian reserve and response in controlled ovarian stimulation.
Best practice & research. Clinical obstetrics & gynaecology 2017 Riccetti L, De Pascali F, Gilioli L, Santi D, Brigante G, Simoni M, Casarini L -
Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients.
The Journal of steroid biochemistry and molecular biology 2017 Melcangi RC, Santi D, Spezzano R, Grimoldi M, Tabacchi T, Fusco ML, Diviccaro S, Giatti S, Carrà G, Caruso D, Simoni M, Cavaletti G -
Central hypogonadism due to a giant, "silent" FSH-secreting, atypical pituitary adenoma: effects of adenoma dissection and short-term Leydig cell stimulation by luteinizing hormone (LH) and human chorionic gonadotropin (hCG).
The aging male : the official journal of the International Society for the Study of the Aging Male 2017 Santi D, Spaggiari G, Casarini L, Fanelli F, Mezzullo M, Pagotto U, Granata ARM, Carani C, Simoni M -
Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake.
Bioconjugate chemistry 2016 Schneider EL, Hearn BR, Pfaff SJ, Fontaine SD, Reid R, Ashley GW, Grabulovski S, Strassberger V, Vogt L, Jung T, Santi DV -
Effects of chronic administration of the phosphodiesterase inhibitor vardenafil on serum levels of adrenal and testicular steroids in men with type 2 diabetes mellitus.
Endocrine 2016 Santi D, Granata AR, Pignatti E, Trenti T, Roli L, Bozic R, Zaza S, Pacchioni C, Rochira V, Carani C, Simoni M -
Subcutaneously Administered Self-Cleaving Hydrogel-Octreotide Conjugates Provide Very Long-Acting Octreotide.
Bioconjugate chemistry 2016 Schneider EL, Henise J, Reid R, Ashley GW, Santi DV -
Treatment with human, recombinant FSH improves sperm DNA fragmentation in idiopathic infertile men depending on the FSH receptor polymorphism p.N680S: a pharmacogenetic study.
Human reproduction (Oxford, England) 2016 Simoni M, Santi D, Negri L, Hoffmann I, Muratori M, Baldi E, Cambi M, Marcou M, Greither T, Baraldi E, Tagliavini S, Carra D, Lombardo F, Gandini L, Pallotti F, Krausz C, Rastrelli G, Ferlin A, … -
Sperm quality and environment: A retrospective, cohort study in a Northern province of Italy.
Environmental research 2016 Santi D, Vezzani S, Granata AR, Roli L, De Santis MC, Ongaro C, Donati F, Baraldi E, Trenti T, Setti M, Simoni M -
Surgical sealants with tunable swelling, burst pressures, and biodegradation rates.
Journal of biomedical materials research. Part B, Applied biomaterials 2016 Henise J, Hearn BR, Santi DV, Kamata H, Sakai T, Ashley GW -
Hydrogel Drug Delivery System Using Self-Cleaving Covalent Linkers for Once-a-Week Administration of Exenatide.
Bioconjugate chemistry 2016 Schneider EL, Henise J, Reid R, Ashley GW, Santi DV -
Six months of daily treatment with vardenafil improves parameters of endothelial inflammation and of hypogonadism in male patients with type 2 diabetes and erectile dysfunction: a randomized, double-blind, prospective trial.
European journal of endocrinology 2016 Santi D, Granata AR, Guidi A, Pignatti E, Trenti T, Roli L, Bozic R, Zaza S, Pacchioni C, Romano S, Nofer JR, Rochira V, Carani C, Simoni M -
Impact of gene polymorphisms of gonadotropins and their receptors on human reproductive success.
Reproduction (Cambridge, England) 2015 Casarini L, Santi D, Marino M -
High-Resolution Melting Is a Sensitive, Cost-Effective, Time-Saving Technique for BRAF V600E Detection in Thyroid FNAB Washing Liquid: A Prospective Cohort Study.
European thyroid journal 2015 Marino M, Monzani ML, Brigante G, Cioni K, Madeo B, Santi D, Maiorana A, Bettelli S, Moriondo V, Pignatti E, Bonacini L, Carani C, Rochira V, Simoni M -
Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2015 Schneider EL, Ashley GW, Dillen L, Stoops B, Austin NE, Malcolm BA, Santi DV -
Erectile Dysfunction is Common among Men with Acromegaly and is Associated with Morbidities Related to the Disease.
The journal of sexual medicine 2015 Lotti F, Rochira V, Pivonello R, Santi D, Galdiero M, Maseroli E, Balestrieri A, Faustini-Fustini M, Peri A, Sforza A, Colao A, Maggi M, Corona G -
Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system.
Bioconjugate chemistry 2015 Henise J, Hearn BR, Ashley GW, Santi DV -
Long-term stabilization of maleimide-thiol conjugates.
Bioconjugate chemistry 2014 Fontaine SD, Reid R, Robinson L, Ashley GW, Santi DV -
Therapy of endocrine disease. Effects of chronic use of phosphodiesterase inhibitors on endothelial markers in type 2 diabetes mellitus: a meta-analysis.
European journal of endocrinology 2014 Santi D, Giannetta E, Isidori AM, Vitale C, Aversa A, Simoni M -
The TRHR Gene Is Associated with Hypothalamo-Pituitary Sensitivity to Levothyroxine.
European thyroid journal 2014 Brigante G, Spaggiari G, Santi D, Cioni K, Gnarini V, Diazzi C, Pignatti E, Casarini L, Marino M, Tüttelmann F, Carani C, Simoni M -
Biosimilar recombinant follicle stimulating hormones in infertility treatment.
Expert opinion on biological therapy 2014 Santi D, Simoni M -
Macromolecular prodrug that provides the irinotecan (CPT-11) active-metabolite SN-38 with ultralong half-life, low C(max), and low glucuronide formation.
Journal of medicinal chemistry 2014 Santi DV, Schneider EL, Ashley GW -
Male sexual dysfunction and HIV--a clinical perspective.
Nature reviews. Urology 2014 Santi D, Brigante G, Zona S, Guaraldi G, Rochira V -
β-Eliminative releasable linkers adapted for bioconjugation of macromolecules to phenols.
Bioconjugate chemistry 2013 Schneider EL, Robinson L, Reid R, Ashley GW, Santi DV -
The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
Nucleic acids research 2013 Czudnochowski N, Ashley GW, Santi DV, Alian A, Finer-Moore J, Stroud RM -
Hydrogel drug delivery system with predictable and tunable drug release and degradation rates.
Proceedings of the National Academy of Sciences of the United States of America 2013 Ashley GW, Henise J, Reid R, Santi DV -
Erectile dysfunction is more common in young to middle-aged HIV-infected men than in HIV-uninfected men.
The journal of sexual medicine 2012 Zona S, Guaraldi G, Luzi K, Beggi M, Santi D, Stentarelli C, Madeo B, Rochira V -
Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates.
Proceedings of the National Academy of Sciences of the United States of America 2012 Santi DV, Schneider EL, Reid R, Robinson L, Ashley GW -
Premature decline of serum total testosterone in HIV-infected men in the HAART-era.
PloS one 2011 Rochira V, Zirilli L, Orlando G, Santi D, Brigante G, Diazzi C, Carli F, Carani C, Guaraldi G -
Using chemobiosynthesis and synthetic mini-polyketide synthases to produce pharmaceutical intermediates in Escherichia coli.
Applied and environmental microbiology 2010 Menzella HG, Carney JR, Li Y, Santi DV -
Synthesis of methyl halides from biomass using engineered microbes.
Journal of the American Chemical Society 2009 Bayer TS, Widmaier DM, Temme K, Mirsky EA, Santi DV, Voigt CA -
Molecular modeling and crystal structure of ERK2-hypothemycin complexes.
Journal of structural biology 2008 Rastelli G, Rosenfeld R, Reid R, Santi DV -
Semisynthesis and cytotoxicity of hypothemycin analogues.
ChemMedChem 2007 Hearn BR, Sundermann K, Cannoy J, Santi DV -
Rational design and assembly of synthetic trimodular polyketide synthases.
Chemistry & biology 2007 Menzella HG, Carney JR, Santi DV -
The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261.
Biochemistry 2006 Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM -
Activating hybrid modular interfaces in synthetic polyketide synthases by cassette replacement of ketosynthase domains.
Chemistry & biology 2006 Chandran SS, Menzella HG, Carney JR, Santi DV -
Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides.
Proceedings of the National Academy of Sciences of the United States of America 2006 Schirmer A, Kennedy J, Murli S, Reid R, Santi DV -
Total synthesis of multi-kilobase DNA sequences from oligonucleotides.
Nature protocols 2006 Reisinger SJ, Patel KG, Santi DV -
Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster.
Journal of industrial microbiology & biotechnology 2005 Menzella HG, Reisinger SJ, Welch M, Kealey JT, Kennedy J, Reid R, Tran CQ, Santi DV -
Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.
Nature biotechnology 2005 Menzella HG, Reid R, Carney JR, Chandran SS, Reisinger SJ, Patel KG, Hopwood DA, Santi DV -
GeMS: an advanced software package for designing synthetic genes.
Nucleic acids research 2005 Jayaraj S, Reid R, Santi DV -
Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster.
Proceedings of the National Academy of Sciences of the United States of America 2004 Kodumal SJ, Patel KG, Reid R, Menzella HG, Welch M, Santi DV -
Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.
Bioorganic & medicinal chemistry 2004 Tian ZQ, Liu Y, Zhang D, Wang Z, Dong SD, Carreras CW, Zhou Y, Rastelli G, Santi DV, Myles DC -
DNA ligation by selection.
BioTechniques 2004 Kodumal SJ, Santi DV -
A sensitive and robust method for quantification of intracellular short-chain coenzyme A esters.
Analytical biochemistry 2004 Shimazu M, Vetcher L, Galazzo JL, Licari P, Santi DV -
The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase.
Protein engineering 2003 Gonzalez-Pacanowska D, Ruiz-Perez LM, Carreras-Gómez MA, Costi MP, Stroud RM, Finer-Moore J, Santi DV -
Filter binding assay for the geldanamycin-heat shock protein 90 interaction.
Analytical biochemistry 2003 Carreras CW, Schirmer A, Zhong Z, Santi DV -
Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90.
Chemistry & biology 2003 Jez JM, Chen JC, Rastelli G, Stroud RM, Santi DV -
Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure.
Biochemistry 2003 Finer-Moore JS, Santi DV, Stroud RM -
A model of structure and catalysis for ketoreductase domains in modular polyketide synthases.
Biochemistry 2003 Reid R, Piagentini M, Rodriguez E, Ashley G, Viswanathan N, Carney J, Santi DV, Hutchinson CR, McDaniel R -
Stable expression of a synthetic gene for the human motilin receptor: use in an aequorin-based receptor activation assay.
Analytical biochemistry 2002 Carreras CW, Siani MA, Santi DV, Dillon SB -
Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli.
The Journal of biological chemistry 2002 Agarwalla S, Kealey JT, Santi DV, Stroud RM -
Order of substrate binding to tyrosyl-tRNA synthetase of Escherichia coli B.
FEBS letters 1971 Santi DV, Peña VA