Daniel Mordes, MD, PhD
Assistant Professor
Institute for Neurodegenerative Diseases
School of Medicine

His research group integrates human stem cell-derived neuronal models and patient brain samples to study neurodegeneration at the Mission Bay campus. Currently, his research support includes the NINDS, Target ALS, The Frick Foundation for ALS Research, The Association for Frontotemporal Degeneration, and the Weill Neurohub Alliance for Therapies in Neuroscience. Dr. Mordes completed clinical training in neuropathology at Massachusetts General Hospital and post-doctoral training in stem cell biology and neuroscience with Kevin Eggan at Harvard University and the Broad Institute, and served as a neuropathologist for the Harvard Brain Tissue Resource Center (Brain Bank).

• Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS.
  Nature aging 2024 Limone F, Mordes DA, Couto A, Joseph BJ, Mitchell JM, Therrien M, Ghosh SD, Meyer D, Zhang Y, Goldman M, Bortolin L, Cobos I, Stevens B, McCarroll SA, Kadiu I, Burberry A, Pietiläinen O, Eggan K
• Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP.
  bioRxiv : the preprint server for biology 2023 Nadel CM, Wucherer K, Oehler A, Thwin AC, Basu K, Callahan MD, Southworth DR, Mordes DA, Craik CS, Gestwicki JE
• Running up that pill for amyotrophic lateral sclerosis.
  Brain : a journal of neurology 2023 Smeyers J, Mordes DA
• The E46K mutation modulates α-synuclein prion replication in transgenic mice.
  PLoS pathogens 2022 Holec SAM, Lee J, Oehler A, Batia L, Wiggins-Gamble A, Lau J, Ooi FK, Merz GE, Wang M, Mordes DA, Olson SH, Woerman AL
• Pluripotent stem cell strategies for rebuilding the human brain.
  Frontiers in aging neuroscience 2022 Limone F, Klim JR, Mordes DA
• Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human α-synuclein.
  Acta neuropathologica 2022 Holec SAM, Lee J, Oehler A, Ooi FK, Mordes DA, Olson SH, Prusiner SB, Woerman AL
• Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.
  PLoS pathogens 2020 Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, Prusiner SB
• Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein.
  Nature neuroscience 2020 Farhan SMK, Howrigan DP, Abbott LE, Klim JR, Topp SD, Byrnes AE, Churchhouse C, Phatnani H, Smith BN, Rampersaud E, Wu G, Wuu J, Shatunov A, Iacoangeli A, Khleifat AA, Mordes DA, Ghosh S, ALSGENS …
• Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein.
  Nature neuroscience 2019 Farhan SMK, Howrigan DP, Abbott LE, Klim JR, Topp SD, Byrnes AE, Churchhouse C, Phatnani H, Smith BN, Rampersaud E, Wu G, Wuu J, Shatunov A, Iacoangeli A, Al Khleifat A, Mordes DA, Ghosh S, ALSGENS …
• Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.
  Acta neuropathologica 2019 Woerman AL, Oehler A, Kazmi SA, Lee J, Halliday GM, Middleton LT, Gentleman SM, Mordes DA, Spina S, Grinberg LT, Olson SH, Prusiner SB
• ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.
  Nature neuroscience 2019 Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, Eggan K
• Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients.
  Acta neuropathologica communications 2018 Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K
• The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis.
  Genes & development 2018 Zhang Y, Burberry A, Wang JY, Sandoe J, Ghosh S, Udeshi ND, Svinkina T, Mordes DA, Mok J, Charlton M, Li QZ, Carr SA, Eggan K
• Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, Prusiner SB
• MSA prions exhibit remarkable stability and resistance to inactivation.
  Acta neuropathologica 2017 Woerman AL, Kazmi SA, Patel S, Freyman Y, Oehler A, Aoyagi A, Mordes DA, Halliday GM, Middleton LT, Gentleman SM, Olson SH, Prusiner SB
• Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Hill SJ, Mordes DA, Cameron LA, Neuberg DS, Landini S, Eggan K, Livingston DM
• Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging.
  Nature communications 2016 Tian F, Yang W, Mordes DA, Wang JY, Salameh JS, Mok J, Chew J, Sharma A, Leno-Duran E, Suzuki-Uematsu S, Suzuki N, Han SS, Lu FK, Ji M, Zhang R, Liu Y, Strominger J, Shneider NA, Petrucelli L, Xie XS,…
• Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.
  Science translational medicine 2016 Burberry A, Suzuki N, Wang JY, Moccia R, Mordes DA, Stewart MH, Suzuki-Uematsu S, Ghosh S, Singh A, Merkle FT, Koszka K, Li QZ, Zon L, Rossi DJ, Trowbridge JJ, Notarangelo LD, Eggan K
• A 34-Year-Old Male with An Intracranial Mass.
  Brain pathology (Zurich, Switzerland) 2016 LaBuzetta JN, Mordes D, Arrillaga I, Chi A, Dietrich J
• Pigmented Lesions of the Nervous System and the Neural Crest: Lessons From Embryology.
  Neurosurgery 2016 Agarwalla PK, Koch MJ, Mordes DA, Codd PJ, Coumans JV
• Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.
  Scientific reports 2015 Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM
• Case Records of the Massachusetts General Hospital. Case 30-2015: A 50-Year-Old Man with Cardiogenic Shock.
  The New England journal of medicine 2015 Wheeler TM, Baker JN, Chad DA, Zilinski JL, Verzosa S, Mordes DA
• Propagation of prions causing synucleinopathies in cultured cells.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K…
• Case records of the Massachusetts General Hospital. Case 12-2015. A newborn boy with respiratory distress, lethargy, and hypernatremia.
  The New England journal of medicine 2015 Lin TY, Ebb DH, Boepple PA, Thiele EA, Rincon SP, Mordes DA
• VE1 antibody immunoreactivity in normal anterior pituitary and adrenal cortex without detectable BRAF V600E mutations.
  American journal of clinical pathology 2014 Mordes DA, Lynch K, Campbell S, Dias-Santagata D, Nose V, Louis DN, Hoang MP
• Intracranial organizing hematoma with papillary endothelial hyperplasia features after resection and involved field radiotherapy for cerebellar juvenile pilocytic astrocytoma.
  Clinical imaging 2013 Ginat DT, Walcott BP, Mordes D, Schaefer PW, Nahed B
• Glioblastoma mimicking an arteriovenous malformation.
  Frontiers in neurology 2013 Khanna A, Venteicher AS, Walcott BP, Kahle KT, Mordes DA, William CM, Ghogawala Z, Ogilvy CS
• Cytopathology of subacute thyroiditis.
  Diagnostic cytopathology 2011 Mordes DA, Brachtel EF
• A workshop on leadership for MD/PhD students.
  Medical education online 2011 Ciampa EJ, Hunt AA, Arneson KO, Mordes DA, Oldham WM, Vin Woo K, Owens DA, Cannon MD, Dermody TS
• In vitro fluid dynamics of the Ahmed glaucoma valve modified with expanded polytetrafluoroethylene.
  Current eye research 2011 DeCroos FC, Kondo Y, Mordes D, Lee MR, Ahmad S, Asrani S, Allingham RR, Olbrich KC, Klitzman B
• Expanded polytetrafluoroethylene membrane alters tissue response to implanted Ahmed glaucoma valve.
  Current eye research 2009 DeCroos FC, Ahmad S, Kondo Y, Chow J, Mordes D, Lee MR, Asrani S, Allingham RR, Olbrich KC, Klitzman B
• Dpb11 activates the Mec1-Ddc2 complex.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Mordes DA, Nam EA, Cortez D
• The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.
  Molecular and cellular biology 2008 Xu X, Vaithiyalingam S, Glick GG, Mordes DA, Chazin WJ, Cortez D
• Activation of ATR and related PIKKs.
  Cell cycle (Georgetown, Tex.) 2008 Mordes DA, Cortez D
• TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.
  Genes & development 2008 Mordes DA, Glick GG, Zhao R, Cortez D
• Identification of photoreceptor genes affected by PRPF31 mutations associated with autosomal dominant retinitis pigmentosa.
  Neurobiology of disease 2007 Mordes D, Yuan L, Xu L, Kawada M, Molday RS, Wu JY
• Function of a conserved checkpoint recruitment domain in ATRIP proteins.
  Molecular and cellular biology 2007 Ball HL, Ehrhardt MR, Mordes DA, Glick GG, Chazin WJ, Cortez D
• Pre-mRNA splicing and retinitis pigmentosa.
  Molecular vision 2006 Mordes D, Luo X, Kar A, Kuo D, Xu L, Fushimi K, Yu G, Sternberg P, Wu JY