Daniel Lim, MD, PhD
Professor
Neurological Surgery
School of Medicine

Awards

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• Kavli Fellow, U.S. National Academy of Sciences, 2010
• NIH Director's New Innovator Award, National Institutes of Health, 2009-2014
• Distinguished Researcher Award, Sontag Foundation, 2009-2013

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 2021
• Residency Neurological Surgery University of California, San Francisco 2008
• M.D. Cornell Medical School 2002
• Ph.D. Rockefeller University 2001
• B.A. MCB University of California, Berkeley 1994

Websites

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• Dan Lim Lab Website (danlimlab.ucsf.edu)
• Neurosurgery Dept. Bio (neurosurgery.ucsf.edu)

Grants and Projects

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• Functional long noncoding RNAs in neural development, NIH, 2022-2027
• Chromatin-based regulation of neural stem cells, VA, 2009-2026
• Understanding the neurodevelopmental role and mechanism of histone demethylase JMJD3, NIH, 2020-2025
• A new model for understanding a brain tumor epigenetic driver, NIH, 2022-2024

Publications (108)

Top publication keywords:
Adult Stem CellsStem CellsNeurogenesisProsencephalonRNA, Long NoncodingMyeloid-Lymphoid Leukemia ProteinEssential TremorGene Knockdown TechniquesBrainNeural Stem CellsHistone-Lysine N-MethyltransferaseNeuronsAstrocytesCell TransplantationThyroid Nuclear Factor 1

• CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.
  Science (New York, N.Y.) 2016 Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA
• Single-cell analysis of long non-coding RNAs in the developing human neocortex.
  Genome biology 2016 Liu SJ, Nowakowski TJ, Pollen AA, Lui JH, Horlbeck MA, Attenello FJ, He D, Weissman JS, Kriegstein AR, Diaz AA, Lim DA
• The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells.
  Cell stem cell 2015 Ramos AD, Andersen RE, Liu SJ, Nowakowski TJ, Hong SJ, Gertz C, Salinas RD, Zarabi H, Kriegstein AR, Lim DA
• Activation of neuronal gene expression by the JMJD3 demethylase is required for postnatal and adult brain neurogenesis.
  Cell reports 2014 Park DH, Hong SJ, Salinas RD, Liu SJ, Sun SW, Sgualdino J, Testa G, Matzuk MM, Iwamori N, Lim DA
• Distinct and separable roles for EZH2 in neurogenic astroglia.
  eLife 2014 Hwang WW, Salinas RD, Siu JJ, Kelley KW, Delgado RN, Paredes MF, Alvarez-Buylla A, Oldham MC, Lim DA
• Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo.
  Cell stem cell 2013 Ramos AD, Diaz A, Nellore A, Delgado RN, Park KY, Gonzales-Roybal G, Oldham MC, Song JS, Lim DA

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• Deconstructing intratumoral heterogeneity through multiomic and multiscale analysis of serial sections.
  bioRxiv : the preprint server for biology 2024 Schupp PG, Shelton SJ, Brody DJ, Eliscu R, Johnson BE, Mazor T, Kelley KW, Potts MB, McDermott MW, Huang EJ, Lim DA, Pieper RO, Berger MS, Costello JF, Phillips JJ, Oldham MC
• Epigenetic reprogramming shapes the cellular landscape of schwannoma.
  Nature communications 2024 Liu SJ, Casey-Clyde T, Cho NW, Swinderman J, Pekmezci M, Dougherty MC, Foster K, Chen WC, Villanueva-Meyer JE, Swaney DL, Vasudevan HN, Choudhury A, Pak J, Breshears JD, Lang UE, Eaton CD, Hiam-Galvez…
• Sex-specific role for the long noncoding RNA Pnky in mouse behavior.
  bioRxiv : the preprint server for biology 2023 Saha P, Andersen RE, Hong SJ, Gil E, Simms J, Lim DA
• A road map for the treatment of pediatric diffuse midline glioma.
  Cancer cell 2023 Koschmann C, Al-Holou WN, Alonso MM, Anastas J, Bandopadhayay P, Barron T, Becher O, Cartaxo R, Castro MG, Chung C, Clausen M, Dang D, Doherty R, Duchatel R, Dun M, Filbin M, Franson A, Galban S, …
• EPCO-12. IN VIVO PERTURB-SEQ DEFINES BIOLOGICAL DRIVERS AND THERAPEUTIC VULNERABILITIES UNDERLYING RADIOTHERAPY RESISTANCE IN GLIOBLASTOMA.
  Neuro-Oncology 2023 John Liu, Joanna Pak, Christopher Zou, Sixuan Pan, Emily Payne, Kyla Foster, Katie Lin, Tim Casey-Clyde, Kyounghee Seo, Thomas O'Loughlin, David Wu, Daniel Lim, Harish Vasudevan, Aaron Diaz, Tomoko …
• EPCO-39. CLARIFYING THE MOLECULAR CONSEQUENCES OF ONCOGENIC MUTATIONS THROUGH MULTISCALE AND MULTIOMIC ANALYSIS OF INDIVIDUAL TUMORS.
  Neuro-Oncology 2023 Patrick Schupp, Samuel Shelton, Daniel Brody, Rebecca Eliscu, Brett Johnson, Tali Mazor, Kevin Kelley, Matthew Potts, Michael McDermott, Eric Huang, Daniel Lim, Russell Pieper, Mitchel Berger, Joseph …
• Identifying Gene-Treatment Interactions and Targetable Radiation Vulnerabilities in Glioblastoma through Coupling of In Vivo CRISPR Perturbation and Single Cell Transcriptomics.
  International Journal of Radiation Oncology • Biology • Physics 2023 S.J. Liu, J. Pak, C. Zou, E. Payne, K. Foster, H. Vasudevan, T. Casey-Clyde, K. Seo, T. O'Loughlin, D. Wu, D. Lim, T. Ozawa, J. de Groot, M.S. Berger, W. Weiss, L.A. Gilbert, D. Raleigh
• 385 A Cell Resolution Atlas of the Human Cerebrovasculature Reveals Angiogenic and Inflammatory Cell Programs in Arteriovenous Malformations.
  Neurosurgery 2023 Ethan A. Winkler, Chang Kim, Jayden Ross, Joseph Garcia, Eugene Gil, Irene Oh, Lindsay Chen, David Wu, Joshua Catapano, Kunal P. Raygor, Kazim Narsinh, Helen Kim, Shantel Weinsheimer, Daniel Cooke, …
• TMIC-43. HEDGEHOG LIGANDS FROM GLIOBLASTOMA CELLS INDUCE ASTROCYTES INHIBITION OF CANCER STEM CELLS.
  Neuro-Oncology 2022 Kyounghee Seo, S John Liu, Vikas Daggubati, Joanna J Phillips, Jennifer Clarke, Michael Prados, Aparna Bhaduri, Daniel Lim, Erik Ullian, David Raleigh
• Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Dong C, Zhao C, Chen X, Berry K, Wang J, Zhang F, Liao Y, Han R, Ogurek S, Xu L, Zhang L, Lin Y, Zhou W, Xin M, Lim DA, Campbell K, Nakafuku M, Waclaw RR, Lu QR
• Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells.
  Cell genomics 2022 Wu D, Poddar A, Ninou E, Hwang E, Cole MA, Liu SJ, Horlbeck MA, Chen J, Replogle JM, Carosso GA, Eng NWL, Chang J, Shen Y, Weissman JS, Lim DA
• A single-cell atlas of the normal and malformed human brain vasculature.
  Science (New York, N.Y.) 2022 Winkler EA, Kim CN, Ross JM, Garcia JH, Gil E, Oh I, Chen LQ, Wu D, Catapano JS, Raygor K, Narsinh K, Kim H, Weinsheimer S, Cooke DL, Walcott BP, Lawton MT, Gupta N, Zlokovic BV, Chang EF, Abla AA, …
• Endoluminal Biopsy for Molecular Profiling of Human Brain Vascular Malformations.
  Neurology 2022 Winkler E, Wu D, Gil E, McCoy D, Narsinh K, Sun Z, Mueller K, Ross J, Kim H, Weinsheimer S, Berger M, Nowakowski T, Lim D, Abla A, Cooke D
• Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis.
  eLife 2021 Cebrian-Silla A, Nascimento MA, Redmond SA, Mansky B, Wu D, Obernier K, Romero Rodriguez R, Gonzalez-Granero S, García-Verdugo JM, Lim DA, Álvarez-Buylla A
• Distinct nuclear compartment-associated genome architecture in the developing mammalian brain.
  Nature neuroscience 2021 Ahanger SH, Delgado RN, Gil E, Cole MA, Zhao J, Hong SJ, Kriegstein AR, Nowakowski TJ, Pollen AA, Lim DA
• Long noncoding RNAs in cancer metastasis.
  Nature reviews. Cancer 2021 Liu SJ, Dang HX, Lim DA, Feng FY, Maher CA
• miRNA-independent function of long noncoding pri-miRNA loci.
  Proceedings of the National Academy of Sciences of the United States of America 2021 He D, Wu D, Muller S, Wang L, Saha P, Ahanger SH, Liu SJ, Cui M, Hong SJ, Jain M, Olson HE, Akeson M, Costello JF, Diaz A, Lim DA
• CT and MRI Image Fusion Error: An Analysis of Co-Registration Error Using Commercially Available Deep Brain Stimulation Surgical Planning Software.
  Stereotactic and functional neurosurgery 2021 Burke JF, Tanzillo D, Starr PA, Lim DA, Larson PS
• Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference.
  Methods in molecular biology (Clifton, N.J.) 2021 Liu SJ, Horlbeck MA, Weissman JS, Lim DA
• Endoluminal Biopsy for Molecular Classification of Human Brain Arteriovenous Malformations.
  Neurosurgery 2020 Ethan Winkler, David Wu, Daniel A Lim, Daniel Cooke, Adib A Abla
• Multiplatform Genomic Profiling and Magnetic Resonance Imaging Identify Molecular and Radiologic Determinants of Intratumor Heterogeneity Underlying Aggressive Behavior in Meningioma.
  International Journal of Radiation Oncology • Biology • Physics 2020 H. Vasudevan, S. Magill, K. Seo, J. Villanueva-Meyer, A. Choudhury, S.J. Liu, M. Pekmezci, S. Findakly, S. Hilz, S. LaStella, S.E. Braunstein, N.A. Oberheim, M.K. Aghi, P.V. Theodosopoulos, P.K. Sneed…
• Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.
  Nature communications 2020 Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, …
• Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1.
  Science (New York, N.Y.) 2020 Delgado RN, Mansky B, Ahanger SH, Lu C, Andersen RE, Dou Y, Alvarez-Buylla A, Lim DA
• CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.
  Genome biology 2020 Liu SJ, Malatesta M, Lien BV, Saha P, Thombare SS, Hong SJ, Pedraza L, Koontz M, Seo K, Horlbeck MA, He D, Birk HS, Jain M, Olsen HE, Akeson M, Weissman JS, Monje M, Gupta N, Raleigh DR, Ullian EM, …
• Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans.
  Neuron 2020 Chen W, de Hemptinne C, Miller AM, Leibbrand M, Little SJ, Lim DA, Larson PS, Starr PA
• Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes.
  Nature biotechnology 2020 Horlbeck MA, Liu SJ, Chang HY, Lim DA, Weissman JS
• Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.
  Cell stem cell 2020 Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, …
• Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease.
  Stem cell reports 2019 Gupta N, Henry RG, Kang SM, Strober J, Lim DA, Ryan T, Perry R, Farrell J, Ulman M, Rajalingam R, Gage A, Huhn SL, Barkovich AJ, Rowitch DH
• The Long Noncoding RNA Pnky Is a Trans-acting Regulator of Cortical Development In Vivo.
  Developmental cell 2019 Andersen RE, Hong SJ, Lim JJ, Cui M, Harpur BA, Hwang E, Delgado RN, Ramos AD, Liu SJ, Blencowe BJ, Lim DA
• Chapter 17 Stem Cell Transplantation for Neurological Disease: Technical Considerations and Delivery Devices.
  Nervous System Drug Delivery 2019 Ethan A. Winkler, Daniel A. Lim
• Modulating the expression of long non-coding RNAs for functional studies.
  EMBO reports 2018 Liu SJ, Lim DA
• CONICS integrates scRNA-seq with DNA sequencing to map gene expression to tumor sub-clones.
  Bioinformatics (Oxford, England) 2018 Müller S, Cho A, Liu SJ, Lim DA, Diaz A
• Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.
  Cell 2018 Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY
• Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment.
  Genome biology 2017 Müller S, Kohanbash G, Liu SJ, Alvarado B, Carrera D, Bhaduri A, Watchmaker PB, Yagnik G, Di Lullo E, Malatesta M, Amankulor NM, Kriegstein AR, Lim DA, Aghi M, Okada H, Diaz A
• Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex.
  Science (New York, N.Y.) 2017 Nowakowski TJ, Bhaduri A, Pollen AA, Alvarado B, Mostajo-Radji MA, Di Lullo E, Haeussler M, Sandoval-Espinosa C, Liu SJ, Velmeshev D, Ounadjela JR, Shuga J, Wang X, Lim DA, West JA, Leyrat AA, Kent WJ…
• Maintenance of Positional Identity of Neural Progenitors in the Embryonic and Postnatal Telencephalon.
  Frontiers in molecular neuroscience 2017 Delgado RN, Lim DA
• GENE-33. THE 3D EVOLUTION AND IN VIVO GROWTH PATTERNS OF GLIOMA CELL POPULATIONS.
  Neuro-Oncology 2017 Stephanie Hilz, Samuel J Shelton, Llewellyn Jalbert, Hang K Wong, Tali Mazor, Chibo Hong, Josie Hayes, Tracy Luks, Henrik Bengtsson, Annette Molinaro, Michael McDermott, Mitchel S Berger, Daniel Lim, …
• Forging our understanding of lncRNAs in the brain.
  Cell and tissue research 2017 Andersen RE, Lim DA
• Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells.
  Stem cell reports 2017 Cebrián-Silla A, Alfaro-Cervelló C, Herranz-Pérez V, Kaneko N, Park DH, Sawamoto K, Alvarez-Buylla A, Lim DA, García-Verdugo JM
• In Reply: Thalamotomy-Like Effects from Partial Removal of a Ventral Intermediate Nucleus Deep Brain Stimulator Lead in a Patient With Essential Tremor.
  Neurosurgery 2017 Rolston JD, Lim DA
• Expert Opinion on the Management of Intracerebroventricular (ICV) Drug Delivery.
  Neuropediatrics 2017 I. Slavc, J. Cohen-Pfeffer, S. Gururangan, E. Jurecki, J. Krauser, T. Lester, D. Lim, M. Maldaun, C. Schwering, A. Shaywitz, M. Westphal
• Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas.
  Molecular systems biology 2016 Müller S, Liu SJ, Di Lullo E, Malatesta M, Pollen AA, Nowakowski TJ, Kohanbash G, Aghi M, Kriegstein AR, Lim DA, Diaz A
• Maintenance of neural stem cell regional identity in culture.
  Neurogenesis (Austin, Tex.) 2016 Delgado RN, Lu C, Lim DA
• The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis.
  Cold Spring Harbor perspectives in biology 2016 Lim DA, Alvarez-Buylla A
• SCell: integrated analysis of single-cell RNA-seq data.
  Bioinformatics (Oxford, England) 2016 Diaz A, Liu SJ, Sandoval C, Pollen A, Nowakowski TJ, Lim DA, Kriegstein A
• Merging DBS with viral vector or stem cell implantation: "hybrid" stereotactic surgery as an evolution in the surgical treatment of Parkinson's disease.
  Molecular therapy. Methods & clinical development 2016 Rowland NC, Kalia SK, Kalia LV, Larson PS, Lim DA, Bankiewicz KS
• Uncovering the roles of long noncoding RNAs in neural development and glioma progression.
  Neuroscience letters 2015 Ramos AD, Attenello FJ, Lim DA
• Thalamotomy-Like Effects From Partial Removal of a Ventral Intermediate Nucleus Deep Brain Stimulator Lead in a Patient With Essential Tremor: Case Report.
  Neurosurgery 2015 Rolston JD, Ramos AD, Heath S, Englot DJ, Lim DA
• Embryonic Nkx2.1-expressing neural precursor cells contribute to the regional heterogeneity of adult V-SVZ neural stem cells.
  Developmental biology 2015 Delgado RN, Lim DA
• Molecular identity of human outer radial glia during cortical development.
  Cell 2015 Pollen AA, Nowakowski TJ, Chen J, Retallack H, Sandoval-Espinosa C, Nicholas CR, Shuga J, Liu SJ, Oldham MC, Diaz A, Lim DA, Leyrat AA, West JA, Kriegstein AR
• Transcriptional and epigenetic insights from stem cells and developing tissues.
  Development (Cambridge, England) 2015 Lim DA
• Combining cell transplants or gene therapy with deep brain stimulation for Parkinson's disease.
  Movement disorders : official journal of the Movement Disorder Society 2014 Rowland NC, Starr PA, Larson PS, Ostrem JL, Marks WJ, Lim DA
• Analysis of Mll1 deficiency identifies neurogenic transcriptional modules and Brn4 as a factor for direct astrocyte-to-neuron reprogramming.
  Neurosurgery 2014 Potts MB, Siu JJ, Price JD, Salinas RD, Cho MJ, Ramos AD, Hahn J, Margeta M, Oldham MC, Lim DA
• Adult neural stem cells stake their ground.
  Trends in neurosciences 2014 Lim DA, Alvarez-Buylla A
• The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiation.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Price JD, Park KY, Chen J, Salinas RD, Cho MJ, Kriegstein AR, Lim DA
• Interventional magnetic resonance imaging-guided cell transplantation into the brain with radially branched deployment.
  Molecular therapy : the journal of the American Society of Gene Therapy 2014 Silvestrini MT, Yin D, Martin AJ, Coppes VG, Mann P, Larson PS, Starr PA, Zeng X, Gupta N, Panter SS, Desai TA, Lim DA
• An ingredient for the elixir of youth.
  Cell research 2014 Andersen RE, Lim DA
• Stem cell epigenetics: looking forward.
  Cell stem cell 2014 Benitah SA, Bracken A, Dou Y, Huangfu D, Ivanova N, Koseki H, Laurent L, Lim DA, Meshorer E, Pombo A, Sander M, Xu GL
• A review of percutaneous treatments for trigeminal neuralgia.
  Neurosurgery 2014 Cheng JS, Lim DA, Chang EF, Barbaro NM
• Chromatin-based epigenetics of adult subventricular zone neural stem cells.
  Frontiers in genetics 2013 Gonzales-Roybal G, Lim DA
• A Review of Percutaneous Treatments for Trigeminal Neuralgia.
  Neurosurgery 2013 Cheng JS, Lim DA, Chang EF, Barbaro NM
• Devices for cell transplantation into the central nervous system: Design considerations and emerging technologies.
  Surgical neurology international 2013 Potts MB, Silvestrini MT, Lim DA
• Radially branched deployment for more efficient cell transplantation at the scale of the human brain.
  Stereotactic and functional neurosurgery 2013 Silvestrini MT, Yin D, Coppes VG, Mann P, Martin AJ, Larson PS, Starr PA, Gupta N, Panter SS, Desai TA, Lim DA
• Surrogate consent for critical care research: exploratory study on public perception and influences on recruitment.
  Critical care (London, England) 2013 Lim DA, Chan MF, Childs C
• Neural stem cell engraftment and myelination in the human brain.
  Science translational medicine 2012 Gupta N, Henry RG, Strober J, Kang SM, Lim DA, Bucci M, Caverzasi E, Gaetano L, Mandelli ML, Ryan T, Perry R, Farrell J, Jeremy RJ, Ulman M, Huhn SL, Barkovich AJ, Rowitch DH
• An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation.
  Cell stem cell 2012 Potts MB, Lim DA
• Normalization, bias correction, and peak calling for ChIP-seq.
  Statistical applications in genetics and molecular biology 2012 Diaz A, Park K, Lim DA, Song JS
• Oscillations in sensorimotor cortex in movement disorders: an electrocorticography study.
  Brain : a journal of neurology 2012 Crowell AL, Ryapolova-Webb ES, Ostrem JL, Galifianakis NB, Shimamoto S, Lim DA, Starr PA
• Glial Nature of Adult Neural Stem Cells: Neurogenic Competence in Adult Astrocytes.
  Neural Development and Stem Cells 2012 William W. Hwang, Arturo Alvarez-Buylla, Daniel A. Lim
• Malignant Gliomas: Treatment Using Genetically-Modified Neural Stem Cells.
  2011 Michael C. Oh, Mitchel S. Berger, Daniel A. Lim
• Asymmetry-defective oligodendrocyte progenitors are glioma precursors.
  Cancer cell 2011 Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C
• Keeping them quiet: BMPs maintain adult neural stem cell quiescence.
  Cell stem cell 2010 Johnston MA, Lim DA
• Novel treatment strategies for malignant gliomas using neural stem cells.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2009 Oh MC, Lim DA
• Future directions: use of interventional MRI for cell-based therapy of Parkinson disease.
  Neurosurgery clinics of North America 2009 Roskom J, Swistowski A, Zeng X, Lim DA
• Intraoperative MRI in functional neurosurgery. Preface.
  Neurosurgery clinics of North America 2009 Lim DA, Larson PS
• Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells.
  Nature 2009 Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A
• Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study.
  Journal of neuro-oncology 2009 Lim DA, Tarapore P, Chang E, Burt M, Chakalian L, Barbaro N, Chang S, Lamborn KR, McDermott MW
• miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells.
  BMC medicine 2008 Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG
• Chapter 1 Structure and Function of the Brain and Spinal Cord.
  Essentials of Neuroanesthesia and Neurointensive Care 2008 Daniel A. Lim, Michael Sughrue, Michael W. McDermott
• Lumbar Spine Coccidioidomycosis Osteomyelitis Requiring Lumbo-Pelvic Reconstruction.
  Neurosurgery Quarterly 2007 Daniel C. Lu, Daniel A. Lim, Dean Chou
• Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype.
  Neuro-oncology 2007 Lim DA, Cha S, Mayo MC, Chen MH, Keles E, VandenBerg S, Berger MS
• Multiple target deep brain stimulation for multiple sclerosis related and poststroke Holmes' tremor.
  Stereotactic and functional neurosurgery 2007 Lim DA, Khandhar SM, Heath S, Ostrem JL, Ringel N, Starr P
• The adult neural stem cell niche: lessons for future neural cell replacement strategies.
  Neurosurgery clinics of North America 2007 Lim DA, Huang YC, Alvarez-Buylla A
• In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesis.
  Molecular and cellular neurosciences 2005 Lim DA, Suárez-Fariñas M, Naef F, Hacker CR, Menn B, Takebayashi H, Magnasco M, Patil N, Alvarez-Buylla A
• Sonic hedgehog controls stem cell behavior in the postnatal and adult brain.
  Development (Cambridge, England) 2004 Palma V, Lim DA, Dahmane N, Sánchez P, Brionne TC, Herzberg CD, Gitton Y, Carleton A, Alvarez-Buylla A, Ruiz i Altaba A
• For the long run: maintaining germinal niches in the adult brain.
  Neuron 2004 Alvarez-Buylla A, Lim DA
• Telomerase activity in the subventricular zone of adult mice.
  Molecular and cellular neurosciences 2003 Caporaso GL, Lim DA, Alvarez-Buylla A, Chao MV
• Postnatal development of radial glia and the ventricular zone (VZ): a continuum of the neural stem cell compartment.
  Cerebral cortex (New York, N.Y. : 1991) 2003 Tramontin AD, García-Verdugo JM, Lim DA, Alvarez-Buylla A
• DNA hybridization to mismatched templates: a chip study.
  Physical review. E, Statistical, nonlinear, and soft matter physics 2002 Naef F, Lim DA, Patil N, Magnasco M
• Investigating the use of primary adult subventricular zone neural precursor cells for neuronal replacement therapies.
  Brain research bulletin 2002 Lim DA, Flames N, Collado L, Herrera DG
• A Ca(2+) switch aligns the active site of calpain.
  Cell 2002 Moldoveanu T, Hosfield CM, Lim D, Elce JS, Jia Z, Davies PL
• Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 Gritti A, Bonfanti L, Doetsch F, Caille I, Alvarez-Buylla A, Lim DA, Galli R, Verdugo JM, Herrera DG, Vescovi AL
• Noggin antagonizes BMP signaling to create a niche for adult neurogenesis.
  Neuron 2000 Lim DA, Tramontin AD, Trevejo JM, Herrera DG, García-Verdugo JM, Alvarez-Buylla A
• A relationship between behavior, neurotrophin expression, and new neuron survival.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Li XC, Jarvis ED, Alvarez-Borda B, Lim DA, Nottebohm F
• Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Lim DA, Alvarez-Buylla A
• Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.
  Cell 1999 Doetsch F, Caillé I, Lim DA, García-Verdugo JM, Alvarez-Buylla A
• Condensation-free X-ray diffraction data collection with capillaries at 277 K.
  Journal of Applied Crystallography 1999 D. Lim, Q. Ye, Z. Jia
• Architecture and cell types of the adult subventricular zone: in search of the stem cells.
  Journal of neurobiology 1998 García-Verdugo JM, Doetsch F, Wichterle H, Lim DA, Alvarez-Buylla A
• Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control.
  Journal of virology 1998 Lim DA, Gossen M, Lehman CW, Botchan MR
• Postnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis.
  Proceedings of the National Academy of Sciences of the United States of America 1997 Lim DA, Fishell GJ, Alvarez-Buylla A
• DNA-binding domain of bovine papillomavirus type 1 E1 helicase: structural and functional aspects.
  Journal of virology 1993 Thorner LK, Lim DA, Botchan MR
• The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase.
  Proceedings of the National Academy of Sciences of the United States of America 1993 Yang L, Mohr I, Fouts E, Lim DA, Nohaile M, Botchan M