Daniel Calabrese, MD
Assistant Professor
Medicine
School of Medicine

He serves as an attending physician in the intensive care unit, pulmonary consult service and outpatient pulmonary clinic at the SF VAMC. He is also an attending physician for the Advanced Lung Disease Service at UCSF Parnassus where he evaluates patients in the lung transplant clinics. He is active in the International Society for Heart and Lung Transplantation.

His research focuses on the mechanisms for innate immune inflammation in lung transplant outcomes. This research uses mouse models of human lung disease and human tissue samples to understand primary graft dysfunction, antibody-mediated rejection and chronic lung allograft dysfunction. The goal of this work is to improve outcomes following lung transplantation.

• The Emperor Has Some Clothes: Emerging Molecular Diagnostics in Post-Lung Transplant Decision Making.
  American journal of respiratory and critical care medicine 2024 Calabrese DR, Shaver CM
• Macrophage and CD8 T cell discordance are associated with acute lung allograft dysfunction progression.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2024 Calabrese DR, Ekstrand CA, Yellamilli S, Singer JP, Hays SR, Leard LE, Shah RJ, Venado A, Kolaitis NA, Perez A, Combes A, Greenland JR
• Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction.
  medRxiv : the preprint server for health sciences 2024 Prather AA, Gao Y, Betancourt L, Kordahl RC, Sriram A, Huang CY, Hays SR, Kukreja J, Calabrese DR, Venado A, Kapse B, Greenland JR, Singer JP
• MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death.
  American journal of respiratory and critical care medicine 2024 Aguilar OA, Qualls AE, Gonzalez-Hinojosa MDR, Obeidalla S, Kerchberger VE, Tsao T, Singer JP, Looney MR, Raymond W, Hays SR, Golden JA, Kukreja J, Shaver CM, Ware LB, Christie J, Diamond JM, Lanier LL…
• Short airway telomeres are associated with primary graft dysfunction and chronic lung allograft dysfunction.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023 Greenland JR, Guo R, Lee S, Tran L, Kapse B, Kukreja J, Hays SR, Golden JA, Calabrese DR, Singer JP, Wolters PJ
• Decreased Lymphocytic Bronchitis Severity in the Era of Azithromycin Prophylaxis.
  Transplantation direct 2023 Santos J, Hays SR, Golden JA, Calabrese DR, Kolaitis N, Kleinhenz ME, Shah R, Estrada AV, Leard LE, Kukreja J, Singer JP, Greenland JR
• Theseus and the search for an antibody-mediated rejection molecular state in lung transplant biopsies.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Calabrese DR, Greenland JR
• The Association Between Frailty and Chronic Lung Allograft Dysfunction After Lung Transplantation.
  Transplantation 2023 Singer JP, Gao Y, Huang CY, Kordahl RC, Sriram A, Hays SR, Kukreja J, Venado A, Calabrese DR, Greenland JR
• Regadenoson Is All the RAGE: Targeting the Inflammatory Cascade in Primary Graft Dysfunction.
  The Annals of thoracic surgery 2023 Bromberger B, Calabrese DR, Brzezinski M, Kukreja J
• Paradox of Power: Dynamic Tools to Predict Respiratory Failure in Spontaneously Breathing Patients.
  Anesthesiology 2023 Calabrese DR, London MJ
• Development of the Lung Transplant Frailty Scale (LT-FS).
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023 Singer JP, Christie JD, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Arcasoy SM, Lederer DJ, Calabrese D, Wang P, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J,…
• Subphenotypes of frailty in lung transplant candidates.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Singer JP, Calfee CS, Delucchi K, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Wang P, Arcasoy SM, Lederer DJ, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, …
• Design and implementation of a digital health home spirometry intervention for remote monitoring of lung transplant function.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023 Odisho AY, Liu AW, Maiorano AR, Bigazzi MOA, Medina E, Leard LE, Shah R, Venado A, Perez A, Golden J, Kleinhenz ME, Kolaitis NA, Maheshwari J, Trinh BN, Kukreja J, Greenland J, Calabrese D, Neinstein …
• Design and Implementation of a Digital Health Home Spirometry Intervention for Remote Monitoring of Lung Transplant Function.
  The Journal of Heart and Lung Transplantation 2023 Anobel Y. Odisho, Andrew W. Liu, Ali R. Maiorano, M. Olivia A. Bigazzi, Eli Medina, Lorriana E. Leard, Rupal Shah, Aida Venado, Alyssa Perez, Jeffrey Golden, Mary Ellen Kleinhenz, Nicholas A. Kolaitis…
• The Lung Allocation Score Remains Inequitable for Patients with Pulmonary Arterial Hypertension, Even after the 2015 Revision.
  American journal of respiratory and critical care medicine 2023 Kolaitis NA, Chen H, Calabrese DR, Kumar K, Obata J, Bach C, Golden JA, Simon MA, Kukreja J, Hays SR, Leard LE, Singer JP, De Marco T
• Frailty and genetic risk predict fracture after lung transplantation.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Macrae TA, Lazo J, Viduya J, Florez R, Dewey K, Gao Y, Singer JP, Hays SR, Golden JA, Kukreja J, Greenland JR, Calabrese DR
• Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression.
  The Journal of experimental medicine 2022 Shemesh A, Su Y, Calabrese DR, Chen D, Arakawa-Hoyt J, Roybal KT, Heath JR, Greenland JR, Lanier LL
• Lymphocytic Airway Inflammation in Lung Allografts.
  Frontiers in immunology 2022 Santos J, Calabrese DR, Greenland JR
• Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression.
  The Journal of clinical investigation 2022 Valet C, Magnen M, Qiu L, Cleary SJ, Wang KM, Ranucci S, Grockowiak E, Boudra R, Conrad C, Seo Y, Calabrese DR, Greenland JR, Leavitt AD, Passegué E, Méndez-Ferrer S, Swirski FK, Looney MR
• Inflammation on bronchoalveolar lavage cytology is associated with decreased chronic lung allograft dysfunction-free survival.
  Clinical transplantation 2022 Greenland NY, Deiter F, Calabrese DR, Hays SR, Kukreja J, Leard LE, Kolaitis NA, Golden JA, Singer JP, Greenland JR
• Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2021 Wang P, Leung J, Lam A, Lee S, Calabrese DR, Hays SR, Golden JA, Kukreja J, Singer JP, Wolters PJ, Tang Q, Greenland JR
• Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction.
  Frontiers in immunology 2021 Dugger DT, Calabrese DR, Gao Y, Deiter F, Tsao T, Maheshwari J, Hays SR, Leard L, Kleinhenz ME, Shah R, Golden J, Kukreja J, Gordon ED, Singer JP, Greenland JR
• Ribavirin to the Rescue: Natural Killer-Cell Function After Hepatitis C Virus Treatment in Liver Transplant Recipients.
  Transplantation 2021 Calabrese DR
• Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates.
  Annals of the American Thoracic Society 2021 Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, …
• Implementation of a Chatbot Mobile Health Intervention with Home Spirometry to Monitor Lung Transplant Recipients Remotely.
  The Journal of Heart and Lung Transplantation 2021 A. Odisho, J.P. Singer, A. Perez, L.E. Leard, R. Shah, J.A. Golden, M. Kleinhenz, N. Kolaitis, J. Maheshwari, A. Liu, B. Trinh, J. Kukreja, J. Greenland, D. Calabrese, S.R. Hays
• Measuring Quality in Lung Transplant Care: The QUILT Initiative.
  The Journal of Heart and Lung Transplantation 2021 A. Venado, J.P. Singer, L.E. Leard, R. Shah, M.E. Kleinhenz, J. Golden, A. Perez, N. Kolaitis, D. Calabrese, J. Maheshwari, B. Trinh, J. Kukreja, S. Hays
• The association of post-operative delirium with patient-reported outcomes and mortality after lung transplantation.
  Clinical transplantation 2021 DeBolt CL, Gao Y, Sutter N, Soong A, Leard L, Jeffrey G, Kleinhenz ME, Calabrese D, Greenland J, Venado A, Hays SR, Shah R, Kukreja J, Trinh B, Kolaitis NA, Douglas V, Diamond JM, Smith P, Singer J
• Rapid molecular detection of airway pathogens in lung transplant recipients.
  Transplant infectious disease : an official journal of the Transplantation Society 2021 Hoover J, Mintz MA, Deiter F, Aminian E, Chen J, Hays SR, Singer JP, Calabrese DR, Kukreja J, Greenland JR
• Ribavirin to the Rescue: Natural Killer Cell Function After Hepatitis C Virus Treatment in Liver Transplant Recipients
  Transplantation 2020 Daniel R. Calabrese
• Complement activation on endothelium initiates antibody-mediated acute lung injury.
  The Journal of clinical investigation 2020 Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR
• Frailty after lung transplantation is associated with impaired health-related quality of life and mortality.
  Thorax 2020 Venado A, Kolaitis NA, Huang CY, Gao Y, Glidden DV, Soong A, Sutter N, Katz PP, Greenland JR, Calabrese DR, Hays SR, Golden JA, Shah RJ, Leard LE, Kukreja J, Deuse T, Wolters PJ, Covinsky K, Blanc PD,…
• Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients.
  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2019 Kolaitis NA, Calabrese DR, Ahearn P, Venado A, Florez R, Lei HL, Isaak K, Henricksen E, Martinez E, Chong T, Shah RJ, Leard LE, Kleinhenz ME, Golden J, De Marco T, Greenland JR, Kukreja J, Hays SR, …
• Dectin-1 genetic deficiency predicts chronic lung allograft dysfunction and death.
  JCI insight 2019 Calabrese DR, Wang P, Chong T, Hoover J, Singer JP, Torgerson D, Hays SR, Golden JA, Kukreja J, Dugger D, Christie JD, LTOG investigators, Greenland JR
• At the Bottom of Thomas Bayes' Tea Cup: Practical Applications of Lung Transplant Immunophenotyping.
  Transplantation 2019 Calabrese DR
• Natural killer cells in lung transplantation.
  Thorax 2018 Calabrese DR, Lanier LL, Greenland JR
• Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients.
  Clinical transplantation 2018 Calabrese DR, Florez R, Dewey K, Hui C, Torgerson D, Chong T, Faust H, Rajalingam R, Hays SR, Golden JA, Kukreja J, Singer JP, Greenland JR
• HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017 Greenland JR, Sun H, Calabrese D, Chong T, Singer JP, Kukreja J, Hays SR, Golden JA, Caughey GH, Venstrom JM, Rajalingam R
• Cingulate gyrus neuroanatomy in schizophrenia subjects and their non-psychotic siblings.
  Schizophrenia research 2008 Calabrese DR, Wang L, Harms MP, Ratnanather JT, Barch DM, Cloninger CR, Thompson PA, Miller MI, Csernansky JG
• Planar relationships of the semicircular canals in two strains of mice.
  Journal of the Association for Research in Otolaryngology : JARO 2006 Calabrese DR, Hullar TE