Daniel Bikle, MD, PhD
Professor
Medicine
School of Medicine
I am Professor of Medicine and Dermatology emeritus on call back at UCSF and staff Endocrinologist at SFVAMC. I continue both my clinical activities and direct a well funded laboratory investigating hormonal regulation of fracture healing and vitamin D and calcium regulation of both skin cancer and wound response.
Awards
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- Fellowship, ASBMR, ASBMR, 2019
- Louis V Avioli Founders Award, ASBMR, 2016
- Career Award in Vitamin D research, International Workshop for Vitamin D, 2009
- Boy Frame Award for Clinical Excellence in Bone and Mineral Research, ASBMR, 2007
- member Association of American Physicians, Association of American Physicians, 1995
- member American Society of Clinical Investigation, American Society of Clinical Investigation, 1985
- Fellow, American College of Physicians, American College of Physicians, 1982
- Borden Research Award, University of Pennsylvania, 1969
- Horatio C Wood Prize in Pharmacology, University of Pennsylvania, 1969
- Spencer Morris Prize, University of Pennsylvania, 1969
- alpha omega alpha, University of Pennsylvania, 1968
- Baldwin Lucke Memorial Prize, University of Pennsylvania, 1966
- Henderson Memorial Prize in Biochemistry, Harvard, 1965
- Magna Cum Laude, Harvard, 1965
Education & Training
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- PhD Graduate School of Arts and Sciences University of Pennsylvania 1974
- MD School of Medicine University of Pennsylvania 1969
- AB Harvard Harvard 1965
Websites
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- Profile at UCSF Cancer Center (cancer.ucsf.edu)
Grants and Projects
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- BCCMA: Foundational Research to Act Upon and Resist Conditions Unfavorable to bone (FRACTURECURB): Role of abaloparatide for fracture healing, VA, 2022-2026
- Maladaptive Plasticity in Spinal Cord Injury: Cellular Mechanisms, NIH, 2021-2026
- Biomechanical computed tomography facilitates the diagnosis of osteoporosis and fracture prediction in patients with high risk prostate cancer, DOD, 2022-2026
- Vitamin D and Calcium signaling in epidermal stem cell maintenance, activation, and function, NIH, 2018-2021
- Role of IGF-I/integrin signaling in the periosteal response to load, NIH, 2008-2021
- Vitamin D Receptor Coactivators in Keratinocytes, NIH, 2003-2016
- IGF-1 Mediates the Anabolic Effects of PTH on Bone, NIH, 2001-2015
- Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
- Relationship of Keratinocyte Function to Differentiation, NIH, 1988-2010
- Vitamin D and the Differentiation of Keratinocytes, NIH, 1987-2005
- Regulation of Intestinal Calcium Transport by Vitamin D, NIH, 1981-2004
- Estrogen/calcitriol in the Etiology of Breast Cancer, NIH, 1995-1999
- Vitamin D Stimulated Intestinal Calcium Transport, NIH, 1981-1987
Publications (358)
Top publication keywords:
Vitamin DCalcitriolReceptors, Calcium-SensingEpidermisBone and BonesVitaminsReceptors, CalcitriolVitamin D DeficiencyCell DifferentiationBone DevelopmentSkinKeratinocytesParathyroid HormoneInsulin-Like Growth Factor ICalcium
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Vitamin D and Long COVID: Is There a Role in Prevention or Treatment?
The Journal of clinical endocrinology and metabolism 2023 Bikle DD -
Validation of Biomechanical Computed Tomography for Fracture Risk Classification in Metastatic Hormone-sensitive Prostate Cancer.
European urology oncology 2023 Lin JK, Hearn CM, Getzen E, Long Q, Lee DC, Keaveny TM, Jayadevappa R, Robinson KW, Wong YN, Maxwell KN, Narayan V, Haas NB, Takvorian SU, Bikle DD, Chiang JM, Khan AN, Rajapakse CS, Morgans AK, … -
Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics.
Communications biology 2023 Thaler R, Yoshizaki K, Nguyen T, Fukumoto S, Den Besten P, Bikle DD, Oda Y -
Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate.
The Journal of steroid biochemistry and molecular biology 2023 Oda Y, Wong CT, Oh DH, Meyer MB, Pike JW, Bikle DD -
Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship?
Reviews in endocrine & metabolic disorders 2023 Giustina A, di Filippo L, Allora A, Bikle DD, Cavestro GM, Feldman D, Latella G, Minisola S, Napoli N, Trasciatti S, Uygur M, Bilezikian JP
Show all (353 more) Hide
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Highlights from the 24th workshop on vitamin D in Austin, September 2022.
The Journal of steroid biochemistry and molecular biology 2023 Meyer MB, Bernal-Mizrachi C, Bikle DD, Biyani M, Campbell MJ, Chaudhari SN, Christakos S, Ingles SA, Knuth MM, Lee SM, Lisse TS, Liu ES, Piec I, Plum LA, Rao SD, Reynolds CJ, Thacher TD, White JH, … -
Prevalence of osteoporosis in older male veterans receiving hip-containing computed tomography scans: opportunistic use of biomechanical computed tomography analysis (BCT).
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2022 Teng PF, Chiang JM, Schafer AL, Sukerkar PA, Keaveny TM, Bikle D -
Skin and bone crosstalk during aging.
Nature aging 2022 Mauro T, Bikle D -
Role of vitamin D and calcium signaling in epidermal wound healing.
Journal of endocrinological investigation 2022 Bikle DD -
Response to Letters to the Editor RE: Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality.
Journal of general internal medicine 2022 Seal KH, Bertenthal D, Bikle DD -
Vitamin D Regulation of Immune Function.
Current osteoporosis reports 2022 Bikle DD -
Vitamin D regulation of immune function during covid-19.
Reviews in endocrine & metabolic disorders 2022 Bikle DD -
Association of Vitamin D Status and COVID-19-Related Hospitalization and Mortality.
Journal of general internal medicine 2022 Seal KH, Bertenthal D, Carey E, Grunfeld C, Bikle DD, Lu CM -
Ligand-Independent Actions of the Vitamin D Receptor: More Questions Than Answers.
JBMR plus 2021 Bikle DD -
Hypercalcemia in non-Hodgkin's lymphoma due to cosecretion of PTHrP and 1,25-dihydroxyvitamin D.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2021 Gonciulea AR, Wang Y, Bikle DD, Sellmeyer DE -
Vitamin D regulation of and by long non coding RNAs.
Molecular and cellular endocrinology 2021 Bikle DD -
Decreased Calcium-Sensing Receptor Expression Controls Calcium Signaling and Cell-To-Cell Adhesion Defects in Aged Skin.
The Journal of investigative dermatology 2021 Celli A, Tu CL, Lee E, Bikle DD, Mauro TM -
Introduction: Special Issue on Vitamin D Dedicated to the Memory of Anthony W Norman.
JBMR plus 2020 Bouillon R, Haussler M, Bikle D, Christakos S, Welsh J -
Ablation of Ephrin B2 in Col2 Expressing Cells Delays Fracture Repair.
Endocrinology 2020 Wang Y, Ling L, Tian F, Won Kim SH, Ho S, Bikle DD -
Transcriptional Regulation of Dental Epithelial Cell Fate.
International journal of molecular sciences 2020 Yoshizaki K, Fukumoto S, Bikle DD, Oda Y -
The Free Hormone Hypothesis: When, Why, and How to Measure the Free Hormone Levels to Assess Vitamin D, Thyroid, Sex Hormone, and Cortisol Status.
JBMR plus 2020 Bikle DD -
MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19.
European journal of endocrinology 2020 Bilezikian JP, Bikle D, Hewison M, Lazaretti-Castro M, Formenti AM, Gupta A, Madhavan MV, Nair N, Babalyan V, Hutchings N, Napoli N, Accili D, Binkley N, Landry DW, Giustina A -
Deletion of Mediator 1 suppresses TGFβ signaling leading to changes in epidermal lineages and regeneration.
PloS one 2020 Oda Y, Nguyen T, Hata A, Meyer MB, Pike JW, Bikle DD -
Vitamin D and calcium signaling in epidermal stem cells and their regeneration.
World journal of stem cells 2020 Oda Y, Bikle DD -
p120-catenin suppresses proliferation and tumor growth of oral squamous cell carcinoma via inhibiting nuclear phospholipase C-γ1 signaling.
Journal of cellular physiology 2020 Li L, Ji S, Shrestha C, Jiang Y, Liao L, Xu F, Liu Z, Bikle DD, Xie Z -
Editorial: Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions.
Frontiers in endocrinology 2020 Xie Z, Wang X, Bikle DD -
New aspects of vitamin D metabolism and action - addressing the skin as source and target.
Nature reviews. Endocrinology 2020 Bikle D, Christakos S -
Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level.
Journal of the Endocrine Society 2020 Bikle DD -
The Vitamin D Receptor as Tumor Suppressor in Skin.
Advances in experimental medicine and biology 2020 Bikle DD -
Vitamin D Metabolism Revised: Fall of Dogmas.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2019 Bouillon R, Bikle D -
Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport.
Journal of the Endocrine Society 2019 Munson S, Wang Y, Chang W, Bikle DD -
Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.
Endocrine reviews 2019 Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J -
Do sunscreens block vitamin D production? A critical review by an international panel of experts.
The British journal of dermatology 2019 Bikle DD -
New developments in our understanding of vitamin metabolism, action and treatment.
Metabolism: clinical and experimental 2019 Christakos S, Li S, De La Cruz J, Bikle DD -
Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions.
Frontiers in endocrinology 2019 Bikle DD, Schwartz J -
The Fracture Callus Is Formed by Progenitors of Different Skeletal Origins in a Site-Specific Manner.
JBMR plus 2019 Wang Y, Chen L, Kang M, Ling L, Tian F, Won-Kim SH, Ho S, Bikle DD -
Rapid onset of hypercalcemia from high-grade lymphoma in the setting of HIV-related immune reconstitution inflammatory syndrome.
Bone reports 2018 Kim SJ, Peluso MJ, Wang Y, Bikle D, Shoback D, Kim S -
Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations.
The Journal of clinical endocrinology and metabolism 2018 Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta … -
Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D.
British journal of clinical pharmacology 2018 Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N -
Vitamin D and bone and beyond.
Bone reports 2018 Bikle DD, Bouillon R -
p120-catenin is required for regulating epidermal proliferation, differentiation, and barrier function.
Journal of cellular physiology 2018 Xie Z, Tang Y, Man MQ, Shrestha C, Bikle DD -
Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny during Cutaneous Wound Repair.
The Journal of investigative dermatology 2018 Oda Y, Hu L, Nguyen T, Fong C, Zhang J, Guo P, Bikle DD -
Vitamin D Assays.
Frontiers of hormone research 2018 Bikle DD -
Physiologic and pathophysiologic roles of extra renal CYP27b1: Case report and review.
Bone reports 2018 Bikle DD, Patzek S, Wang Y -
Current Controversies: Are Free Vitamin Metabolite Levels a More Accurate Assessment of Vitamin D Status than Total Levels?
Endocrinology and metabolism clinics of North America 2017 Bikle DD, Malmstroem S, Schwartz J -
IGF-1 signaling mediated cell-specific skeletal mechano-transduction.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2017 Tian F, Wang Y, Bikle DD -
Vitamin D Prevents Sunburn: Tips for the Summer?
The Journal of investigative dermatology 2017 Bikle DD -
Vitamin D: Mechanisms of Action and Clinical Applications.
Endocrinology and metabolism clinics of North America 2017 Gallagher JC, Bikle DD -
Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene.
The Journal of biological chemistry 2017 Yoshizaki K, Hu L, Nguyen T, Sakai K, Ishikawa M, Takahashi I, Fukumoto S, DenBesten PK, Bikle DD, Oda Y, Yamada Y -
Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization.
Endocrinology 2017 Oda Y, Hu L, Nguyen T, Fong C, Tu CL, Bikle DD -
Current Assays to Determine Free 25-Hydroxyvitamin D in Serum.
Journal of AOAC International 2017 Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD -
VITAMIN D BINDING PROTEIN AND 25-HYDROXYVITAMIN D LEVELS: EMERGING CLINICAL APPLICATIONS.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2017 Jassil NK, Sharma A, Bikle D, Wang X -
Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status?
The Journal of steroid biochemistry and molecular biology 2017 Bikle D, Bouillon R, Thadhani R, Schoenmakers I -
p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice.
Journal of cellular physiology 2016 Xie Z, Yuan Y, Jiang Y, Shrestha C, Chen Y, Liao L, Ji S, Deng X, Liao E, Bikle DD -
Osteogenic Differentiation of Periosteal Cells During Fracture Healing.
Journal of cellular physiology 2016 Wang T, Zhang X, Bikle DD -
The vitamin D hypothesis: Dead or alive?: Response to Dr. William Grant's "The UVB-vitamin D3-pigment hypothesis is alive and well-AJPA-2016-00237".
American journal of physical anthropology 2016 Elias PM, Williams ML, Bikle DD -
Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer.
Frontiers in physiology 2016 Bikle DD, Jiang Y, Nguyen T, Oda Y, Tu CL -
Extraskeletal actions of vitamin D.
Annals of the New York Academy of Sciences 2016 Bikle DD -
Phosphoprotein Phosphatase 1 Is Required for Extracellular Calcium-Induced Keratinocyte Differentiation.
BioMed research international 2016 Shrestha C, Tang Y, Fan H, Li L, Zeng Q, Pennypacker SD, Bikle DD, Xie Z -
The Endocrine Society Centennial: Extrarenal Production of 1,25 Dihyroxyvitamin D Is Now Proven.
Endocrinology 2016 Bikle DD -
The Transient Role for Calcium and Vitamin D during the Developmental Hair Follicle Cycle.
The Journal of investigative dermatology 2016 Mady LJ, Ajibade DV, Hsaio C, Teichert A, Fong C, Wang Y, Christakos S, Bikle DD -
Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway.
The Journal of biological chemistry 2016 Tahimic CG, Long RK, Kubota T, Sun MY, Elalieh H, Fong C, Menendez AT, Wang Y, Vilardaga JP, Bikle DD -
Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites.
European journal of medicinal chemistry 2016 Teske KA, Bogart JW, Sanchez LM, Yu OB, Preston JV, Cook JM, Silvaggi NR, Bikle DD, Arnold LA -
Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial.
Journal of the American Geriatrics Society 2016 Schwartz JB, Kane L, Bikle D -
Antitumor Activity of 3-Indolylmethanamines 31B and PS121912.
Anticancer research 2015 Guthrie ML, Sidhu PS, Hill EK, Horan TC, Nandhikonda P, Teske KA, Yuan NY, Sidorko M, Rodali R, Cook JM, Han L, Silvaggi NR, Bikle DD, Moore RG, Singh RK, Arnold LA -
Role of IGF-I signaling in muscle bone interactions.
Bone 2015 Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER -
Pregnane X receptor expression in skin: the good and the bad.
Experimental dermatology 2015 Bikle DD -
Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD -
Vitamin D and calcium regulation of epidermal wound healing.
The Journal of steroid biochemistry and molecular biology 2015 Oda Y, Tu CL, Menendez A, Nguyen T, Bikle DD -
A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting.
Calcified tissue international 2015 Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC -
IGF-I Signaling in Osterix-Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 Wang Y, Menendez A, Fong C, ElAlieh HZ, Kubota T, Long R, Bikle DD -
Maternal Hypercalcemia Due to Failure of 1,25-Dihydroxyvitamin-D3 Catabolism in a Patient With CYP24A1 Mutations.
The Journal of clinical endocrinology and metabolism 2015 Shah AD, Hsiao EC, O'Donnell B, Salmeen K, Nussbaum R, Krebs M, Baumgartner-Parzer S, Kaufmann M, Jones G, Bikle DD, Wang Y, Mathew AS, Shoback D, Block-Kurbisch I -
Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 Babey M, Wang Y, Kubota T, Fong C, Menendez A, ElAlieh HZ, Bikle DD -
Selective Hyaluronan-CD44 Signaling Promotes miRNA-21 Expression and Interacts with Vitamin D Function during Cutaneous Squamous Cell Carcinomas Progression Following UV Irradiation.
Frontiers in immunology 2015 Bourguignon LY, Bikle D -
UVB induces epidermal 11β-hydroxysteroid dehydrogenase type 1 activity in vivo.
Experimental dermatology 2015 Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM -
Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction.
Liver international : official journal of the International Association for the Study of the Liver 2015 Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB -
Highlights from the 17th workshop on vitamin D, Chicago, IL, June 17-21, 2014.
The Journal of steroid biochemistry and molecular biology 2015 Welsh J, Bikle DD, Lips P -
Vitamin D receptor, a tumor suppressor in skin.
Canadian journal of physiology and pharmacology 2014 Bikle DD -
Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer.
The Journal of steroid biochemistry and molecular biology 2014 Bikle DD, Oda Y, Tu CL, Jiang Y -
Evidence That Loss-of-Function Filaggrin Gene Mutations Evolved in Northern Europeans to Favor Intracutaneous Vitamin D3 Production.
Evolutionary biology 2014 Thyssen JP, Bikle DD, Elias PM -
Anticancer activity of VDR-coregulator inhibitor PS121912.
Cancer chemotherapy and pharmacology 2014 Sidhu PS, Teske K, Feleke B, Yuan NY, Guthrie ML, Fernstrum GB, Vyas ND, Han L, Preston J, Bogart JW, Silvaggi NR, Cook JM, Singh RK, Bikle DD, Arnold LA -
Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD -
Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair.
PloS one 2014 Yoshizaki K, Hu L, Nguyen T, Sakai K, He B, Fong C, Yamada Y, Bikle DD, Oda Y -
Calcium, Orai1, and epidermal proliferation.
The Journal of investigative dermatology 2014 Bikle DD, Mauro TM -
Highlights from the 16th Vitamin D Workshop, San Francisco, CA, June 11-14, 2013.
The Journal of steroid biochemistry and molecular biology 2014 Bikle D -
LncRNA: a new player in 1α, 25(OH)(2) vitamin D(3) /VDR protection against skin cancer formation.
Experimental dermatology 2014 Jiang YJ, Bikle DD -
Vitamin D-binding protein and vitamin D in blacks and whites.
The New England journal of medicine 2014 Hollis BW, Bikle DD -
Development of novel Vitamin D Receptor-Coactivator Inhibitors.
ACS medicinal chemistry letters 2014 Sidhu PS, Nassif N, McCallum MM, Teske K, Feleke B, Yuan NY, Nandhikonda P, Cook JM, Singh RK, Bikle DD, Arnold LA -
Vitamin D metabolism, mechanism of action, and clinical applications.
Chemistry & biology 2014 Bikle DD -
A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations.
The Journal of clinical endocrinology and metabolism 2014 Schwartz JB, Lai J, Lizaola B, Kane L, Markova S, Weyland P, Terrault NA, Stotland N, Bikle D -
Vitamin D and cancer: the promise not yet fulfilled.
Endocrine 2014 Bikle DD -
IDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENING.
Nuclear receptor research 2014 Teske K, Nandhikonda P, Bogart JW, Feleke B, Sidhu P, Yuan N, Preston J, Goy R, Han L, Silvaggi NR, Singh RK, Bikle DD, Cook JM, Arnold LA -
The vitamin D receptor: a tumor suppressor in skin.
Advances in experimental medicine and biology 2014 Bikle DD -
LncRNA profiling reveals new mechanism for VDR protection against skin cancer formation.
The Journal of steroid biochemistry and molecular biology 2013 Jiang YJ, Bikle DD -
Reprint of: policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich, et al.
Frontiers in neuroendocrinology 2013 Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth … -
Variability in free 25(OH) vitamin D levels in clinical populations.
The Journal of steroid biochemistry and molecular biology 2013 Schwartz JB, Lai J, Lizaola B, Kane L, Weyland P, Terrault NA, Stotland N, Bikle D -
Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation.
The Journal of steroid biochemistry and molecular biology 2013 Hu L, Bikle DD, Oda Y -
The protective role of vitamin d signaling in non-melanoma skin cancer.
Cancers 2013 Bikle DD, Jiang Y -
Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading.
Acta astronautica 2013 Kubota T, Elalieh HZ, Saless N, Fong C, Wang Y, Babey M, Cheng Z, Bikle DD -
Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.
European journal of endocrinology 2013 Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth … -
Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development.
Bone research 2013 Wang Y, Bikle DD, Chang W -
Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al.
Endocrinology 2013 Gore AC, Balthazart J, Bikle D, Carpenter DO, Crews D, Czernichow P, Diamanti-Kandarakis E, Dores RM, Grattan D, Hof PR, Hollenberg AN, Lange C, Lee AV, Levine JE, Millar RP, Nelson RJ, Porta M, Poth … -
Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships.
The Journal of clinical endocrinology and metabolism 2013 Kane L, Moore K, Lütjohann D, Bikle D, Schwartz JB -
Fifteenth vitamin D workshop.
The Journal of steroid biochemistry and molecular biology 2013 Norman AW, Bikle D, Bouillon R -
Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual.
Endocrinology 2013 Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J -
Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor.
Biochemistry 2013 Nandhikonda P, Yasgar A, Baranowski AM, Sidhu PS, McCallum MM, Pawlak AJ, Teske K, Feleke B, Yuan NY, Kevin C, Bikle DD, Ayers SD, Webb P, Rai G, Simeonov A, Jadhav A, Maloney D, Arnold LA -
Vitamin D: beyond bone.
Annals of the New York Academy of Sciences 2013 Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD -
Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W -
Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function.
Best practice & research. Clinical endocrinology & metabolism 2013 Tu CL, Bikle DD -
Anabolic effects of IGF-1 signaling on the skeleton.
Frontiers in endocrinology 2013 Tahimic CG, Wang Y, Bikle DD -
Ceramides stimulate caspase-14 expression in human keratinocytes.
Experimental dermatology 2013 Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR -
Protective actions of vitamin D in UVB induced skin cancer.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2012 Bikle DD -
Vitamin D in cutaneous carcinogenesis: part I.
Journal of the American Academy of Dermatology 2012 Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM -
Vitamin D in cutaneous carcinogenesis: part II.
Journal of the American Academy of Dermatology 2012 Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM -
Simulated spaceflight produces a rapid and sustained loss of osteoprogenitors and an acute but transitory rise of osteoclast precursors in two genetic strains of mice.
American journal of physiology. Endocrinology and metabolism 2012 Shahnazari M, Kurimoto P, Boudignon BM, Orwoll BE, Bikle DD, Halloran BP -
Protective role of vitamin D signaling in skin cancer formation.
The Journal of steroid biochemistry and molecular biology 2012 Bikle DD, Elalieh H, Welsh J, Oh D, Cleaver J, Teichert A -
1α,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway.
The Journal of steroid biochemistry and molecular biology 2012 Jiang YJ, Teichert AE, Fong F, Oda Y, Bikle DD -
Calcium regulation of keratinocyte differentiation.
Expert review of endocrinology & metabolism 2012 Bikle DD, Xie Z, Tu CL -
Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone.
Current molecular pharmacology 2012 Bikle DD, Wang Y -
Vitamin D and bone.
Current osteoporosis reports 2012 Bikle DD -
Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function.
The Journal of investigative dermatology 2012 Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD -
PTH/PTHrP and vitamin D control antimicrobial peptide expression and susceptibility to bacterial skin infection.
Science translational medicine 2012 Muehleisen B, Bikle DD, Aguilera C, Burton DW, Sen GL, Deftos LJ, Gallo RL -
The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.
Endocrine reviews 2012 Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS -
Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators.
Journal of medicinal chemistry 2012 Nandhikonda P, Lynt WZ, McCallum MM, Ara T, Baranowski AM, Yuan NY, Pearson D, Bikle DD, Guy RK, Arnold LA -
Vitamin D receptor mediates DNA repair and is UV inducible in intact epidermis but not in cultured keratinocytes.
The Journal of investigative dermatology 2012 Demetriou SK, Ona-Vu K, Teichert AE, Cleaver JE, Bikle DD, Oh DH -
Vitamin D and the skin: Physiology and pathophysiology.
Reviews in endocrine & metabolic disorders 2012 Bikle DD -
SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease.
The Journal of investigative dermatology 2012 Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle DD, Holleran WM, Uchida Y, Mauro TM -
Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alterations.
The Journal of investigative dermatology 2011 Oda Y, Hu L, Bul V, Elalieh H, Reddy JK, Bikle DD -
Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011 Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM -
Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011 Long RK, Nishida S, Kubota T, Wang Y, Sakata T, Elalieh HZ, Halloran BP, Bikle DD -
Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium.
The Journal of biological chemistry 2011 Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E -
Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice.
The Journal of investigative dermatology 2011 Teichert AE, Elalieh H, Elias PM, Welsh J, Bikle DD -
IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011 Wang Y, Cheng Z, Elalieh HZ, Nakamura E, Nguyen MT, Mackem S, Clemens TL, Bikle DD, Chang W -
Vitamin D metabolism and function in the skin.
Molecular and cellular endocrinology 2011 Bikle DD -
Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas.
Cancer prevention research (Philadelphia, Pa.) 2011 Tang JY, Xiao TZ, Oda Y, Chang KS, Shpall E, Wu A, So PL, Hebert J, Bikle D, Epstein EH -
The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A.
The Journal of investigative dermatology 2011 Tu CL, Chang W, Bikle DD -
The vitamin D receptor: a tumor suppressor in skin.
Discovery medicine 2011 Bikle DD -
Vitamin D regulation of immune function.
Vitamins and hormones 2011 Bikle DD -
Vitamin D: an ancient hormone.
Experimental dermatology 2011 Bikle DD -
Endoplasmic reticulum Ca2+ depletion activates XBP1 and controls terminal differentiation in keratinocytes and epidermis.
The British journal of dermatology 2010 Celli A, Mackenzie DS, Crumrine DS, Tu CL, Hupe M, Bikle DD, Elias PM, Mauro TM -
Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells.
The Journal of biological chemistry 2010 Palmer MT, Lee YK, Maynard CL, Oliver JR, Bikle DD, Jetten AM, Weaver CT -
Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice.
Journal of cellular physiology 2010 Teichert A, Elalieh H, Bikle D -
The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation.
The Journal of investigative dermatology 2010 Oda Y, Chalkley RJ, Burlingame AL, Bikle DD -
Differential regulation of epidermal function by VDR coactivators.
The Journal of steroid biochemistry and molecular biology 2010 Bikle DD, Teichert A, Arnold LA, Uchida Y, Elias PM, Oda Y -
Vitamin D: newly discovered actions require reconsideration of physiologic requirements.
Trends in endocrinology and metabolism: TEM 2010 Bikle DD -
Vitamin D and the skin.
Journal of bone and mineral metabolism 2010 Bikle DD -
Association of prediagnostic serum vitamin D levels with the development of basal cell carcinoma.
The Journal of investigative dermatology 2009 Asgari MM, Tang J, Warton ME, Chren MM, Quesenberry CP, Bikle D, Horst RL, Orentreich N, Vogelman JH, Friedman GD -
Vitamin D and immune function: understanding common pathways.
Current osteoporosis reports 2009 Bikle DD -
Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature review.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009 Pao VY, Chang S, Shoback DM, Bikle DD -
Quantification of the vitamin D receptor-coregulator interaction.
Biochemistry 2009 Teichert A, Arnold LA, Otieno S, Oda Y, Augustinaite I, Geistlinger TR, Kriwacki RW, Guy RK, Bikle DD -
Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation.
Molecular biology of the cell 2009 Xie Z, Chang SM, Pennypacker SD, Liao EY, Bikle DD -
Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation.
The Journal of investigative dermatology 2008 Oda Y, Uchida Y, Moradian S, Crumrine D, Elias PM, Bikle DD -
Nonclassic actions of vitamin D.
The Journal of clinical endocrinology and metabolism 2008 Bikle D -
Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism.
The Journal of investigative dermatology 2008 Bikle DD -
The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development.
Science signaling 2008 Chang W, Tu C, Chen TH, Bikle D, Shoback D -
Vitamin D and the immune system: role in protection against bacterial infection.
Current opinion in nephrology and hypertension 2008 Bikle DD -
Growth hormone/insulin-like growth factor-1/PTH axis in bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008 Bikle DD -
Integrins, insulin like growth factors, and the skeletal response to load.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2008 Bikle DD -
Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes.
The Journal of biological chemistry 2007 Tu CL, Chang W, Xie Z, Bikle DD -
Vitamin D insufficiency/deficiency in gastrointestinal disorders.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007 Bikle DD -
Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3.
The Journal of investigative dermatology 2007 Schauber J, Oda Y, Büchau AS, Yun QC, Steinmeyer A, Zügel U, Bikle DD, Gallo RL -
IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007 Wang Y, Nishida S, Boudignon BM, Burghardt A, Elalieh HZ, Hamilton MM, Majumdar S, Halloran BP, Clemens TL, Bikle DD -
What is new in vitamin D: 2006-2007.
Current opinion in rheumatology 2007 Bikle DD -
Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone.
Endocrinology 2007 Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM -
Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading.
Journal of applied physiology (Bethesda, Md. : 1985) 2007 Boudignon BM, Bikle DD, Kurimoto P, Elalieh H, Nishida S, Wang Y, Burghardt A, Majumdar S, Orwoll BE, Rosen C, Halloran BP -
Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.
The Journal of clinical investigation 2007 Schauber J, Dorschner RA, Coda AB, Büchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, Zügel U, Bikle DD, Modlin RL, Gallo RL -
The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activation and human keratinocyte differentiation.
The Journal of biological chemistry 2007 Xie Z, Bikle DD -
Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation.
The Journal of steroid biochemistry and molecular biology 2007 Oda Y, Ishikawa MH, Hawker NP, Yun QC, Bikle DD -
Sequential regulation of keratinocyte differentiation by 1,25(OH)2D3, VDR, and its coregulators.
The Journal of steroid biochemistry and molecular biology 2007 Bikle D, Teichert A, Hawker N, Xie Z, Oda Y -
The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes.
The Journal of investigative dermatology 2006 Tu CL, Chang W, Bikle DD -
Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3.
The Journal of investigative dermatology 2006 Hawker NP, Pennypacker SD, Chang SM, Bikle DD -
Role of IGF-I signaling in regulating osteoclastogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 Wang Y, Nishida S, Elalieh HZ, Long RK, Halloran BP, Bikle DD -
Evaluation of fetal bone structure and mineralization in IGF-I deficient mice using synchrotron radiation microtomography and Fourier transform infrared spectroscopy.
Bone 2006 Burghardt AJ, Wang Y, Elalieh H, Thibault X, Bikle D, Peyrin F, Majumdar S -
Insulin-like growth factor-I is essential for embryonic bone development.
Endocrinology 2006 Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran BP, Doty SB, Bikle DD -
Development and progression of alopecia in the vitamin D receptor null mouse.
Journal of cellular physiology 2006 Bikle DD, Elalieh H, Chang S, Xie Z, Sundberg JP -
Gender differences in the response of CD-1 mouse bone to parathyroid hormone: potential role of IGF-I.
The Journal of endocrinology 2006 Wang Y, Sakata T, Elalieh HZ, Munson SJ, Burghardt A, Majumdar S, Halloran BP, Bikle DD -
Hairless suppresses vitamin D receptor transactivation in human keratinocytes.
Endocrinology 2005 Xie Z, Chang S, Oda Y, Bikle DD -
Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes.
Endocrinology 2005 Rodriguez L, Tu C, Cheng Z, Chen TH, Bikle D, Shoback D, Chang W -
Vitamin D and skin cancer: a problem in gene regulation.
The Journal of steroid biochemistry and molecular biology 2005 Bikle DD, Oda Y, Xie Z -
Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1.
Molecular biology of the cell 2005 Xie Z, Singleton PA, Bourguignon LY, Bikle DD -
Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes.
The Journal of investigative dermatology 2005 Tu CL, Chang W, Bikle DD -
Vitamin D and skin cancer.
The Journal of nutrition 2004 Bikle DD -
The effect of LXR activators on AP-1 proteins in keratinocytes.
The Journal of investigative dermatology 2004 Schmuth M, Elias PM, Hanley K, Lau P, Moser A, Willson TM, Bikle DD, Feingold KR -
Vitamin D regulated keratinocyte differentiation.
Journal of cellular biochemistry 2004 Bikle DD -
Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiation.
The Journal of steroid biochemistry and molecular biology 2004 Bikle DD, Oda Y, Xie Z -
Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function.
The Journal of steroid biochemistry and molecular biology 2004 Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Dardenne O, Xie Z, Arnaud RS, Feingold K, Elias PM -
Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in VDR transactivation during keratinocyte differentiation.
The Journal of steroid biochemistry and molecular biology 2004 Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD -
25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis.
The Journal of investigative dermatology 2004 Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Choi EH, Dardenne O, Xie Z, Arnaud RS, Feingold K, Elias PM -
The role of the calcium-sensing receptor in epidermal differentiation.
Cell calcium 2004 Tu CL, Oda Y, Komuves L, Bikle DD -
Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003 Sakata T, Wang Y, Halloran BP, Elalieh HZ, Cao J, Bikle DD -
PTH differentially regulates expression of RANKL and OPG.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003 Huang JC, Sakata T, Pfleger LL, Bencsik M, Halloran BP, Bikle DD, Nissenson RA -
Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores.
The Journal of investigative dermatology 2003 Behne MJ, Tu CL, Aronchik I, Epstein E, Bench G, Bikle DD, Pozzan T, Mauro TM -
bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells.
Calcified tissue international 2003 Nauman EA, Sakata T, Keaveny TM, Halloran BP, Bikle DD -
Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation.
Molecular endocrinology (Baltimore, Md.) 2003 Oda Y, Sihlbom C, Chalkley RJ, Huang L, Rachez C, Chang CP, Burlingame AL, Freedman LP, Bikle DD -
Skeletal unloading induces resistance to insulin-like growth factor I on bone formation.
Bone 2003 Sakata T, Halloran BP, Elalieh HZ, Munson SJ, Rudner L, Venton L, Ginzinger D, Rosen CJ, Bikle DD -
The impact of skeletal unloading on bone formation.
Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology 2003 Bikle DD, Sakata T, Halloran BP -
Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma.
Journal of cellular physiology 2003 Yang LC, Ng DC, Bikle DD -
Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate.
Journal of cellular biochemistry 2003 Dolezalova H, Shankar G, Huang MC, Bikle DD, Goetzl EJ -
Vitamin D regulated keratinocyte differentiation: role of coactivators.
Journal of cellular biochemistry 2003 Bikle DD, Tu CL, Xie Z, Oda Y -
Squamous cell carcinomas fail to respond to the prodifferentiating actions of 1,25(OH)2D: why?
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 2003 Bikle DD, Xie Z, Ng D, Tu CL, Oda Y -
Mechanical and chemical characteristics of mineral produced by basic fibroblast growth factor-treated bone marrow stromal cells in vitro.
Tissue engineering 2002 Nauman EA, Ebenstein DM, Hughes KF, Pruitt L, Halloran BP, Bikle DD, Keaveny TM -
The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3.
The Journal of investigative dermatology 2002 Bikle DD, Ng D, Oda Y, Hanley K, Feingold K, Xie Z -
Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002 Bikle DD, Sakata T, Leary C, Elalieh H, Ginzinger D, Rosen CJ, Beamer W, Majumdar S, Halloran BP -
Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation.
Journal of cellular physiology 2002 Komuves L, Oda Y, Tu CL, Chang WH, Ho-Pao CL, Mauro T, Bikle DD -
Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth.
The Journal of investigative dermatology 2002 Xie Z, Komuves L, Yu QC, Elalieh H, Ng DC, Leary C, Chang S, Crumrine D, Yoshizawa T, Kato S, Bikle DD -
The skeletal structure of insulin-like growth factor I-deficient mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001 Bikle D, Majumdar S, Laib A, Powell-Braxton L, Rosen C, Beamer W, Nauman E, Leary C, Halloran B -
Inhibition of 1,25-dihydroxyvitamin-D-induced keratinocyte differentiation by blocking the expression of phospholipase C-gamma1.
The Journal of investigative dermatology 2001 Xie Z, Bikle DD -
The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes.
The Journal of biological chemistry 2001 Tu CL, Chang W, Bikle DD -
Calcium- and vitamin D-regulated keratinocyte differentiation.
Molecular and cellular endocrinology 2001 Bikle DD, Ng D, Tu CL, Oda Y, Xie Z -
Osteoblasts respond to pulsatile fluid flow with short-term increases in PGE(2) but no change in mineralization.
Journal of applied physiology (Bethesda, Md. : 1985) 2001 Nauman EA, Satcher RL, Keaveny TM, Halloran BP, Bikle DD -
Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D.
Journal of lipid research 2001 Hanley K, Wood L, Ng DC, He SS, Lau P, Moser A, Elias PM, Bikle DD, Williams ML, Feingold KR -
Selective inhibition of vitamin D hydroxylases in human keratinocytes.
Steroids 2001 Schuster I, Egger H, Bikle D, Herzig G, Reddy GS, Stuetz A, Stuetz P, Vorisek G -
The role of phospholipase C-gamma1 in 1alpha,25-dihydroxyvitamin D(3) regulated keratinocyte differentiation.
Steroids 2001 Xie Z, Bikle DD -
Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo.
The Journal of investigative dermatology 2000 Kömüves LG, Hanley K, Lefebvre AM, Man MQ, Ng DC, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR -
Requirement of an AP-1 site in the calcium response region of the involucrin promoter.
The Journal of biological chemistry 2000 Ng DC, Shafaee S, Lee D, Bikle DD -
Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha.
The Journal of biological chemistry 2000 Hanley K, Kömüves LG, Ng DC, Schoonjans K, He SS, Lau P, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR -
Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription.
The Journal of investigative dermatology 2000 Hanley K, Ng DC, He SS, Lau P, Min K, Elias PM, Bikle DD, Mangelsdorf DJ, Williams ML, Feingold KR -
The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation.
The Journal of biological chemistry 2000 Oda Y, Tu CL, Chang W, Crumrine D, Kömüves L, Mauro T, Elias PM, Bikle DD -
Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes.
The Journal of investigative dermatology 1999 Tu CL, Oda Y, Bikle DD -
Phospholipase C-gamma1 is required for calcium-induced keratinocyte differentiation.
The Journal of biological chemistry 1999 Xie Z, Bikle DD -
Differences in calcium metabolism between black and white men and women.
Mineral and electrolyte metabolism 1999 Bikle DD, Ettinger B, Sidney S, Tekawa IS, Tolan K -
1,25 dihydroxyvitamin D3 enhances the calcium response of keratinocytes.
Journal of cellular physiology 1999 Ratnam AV, Bikle DD, Cho JK -
Bone and hormonal changes induced by skeletal unloading in the mature male rat.
The American journal of physiology 1999 Dehority W, Halloran BP, Bikle DD, Curren T, Kostenuik PJ, Wronski TJ, Shen Y, Rabkin B, Bouraoui A, Morey-Holton E -
Six putative IQ motifs of the recombinant chicken intestinal brush border myosin I are involved in calmodulin binding.
Archives of biochemistry and biophysics 1999 Khoroshev MI, Munson SJ, Bikle DD -
Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999 Kostenuik PJ, Harris J, Halloran BP, Turner RT, Morey-Holton ER, Bikle DD -
The response of bone to unloading.
Journal of bone and mineral metabolism 1999 Bikle DD, Halloran BP -
The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation.
The Journal of biological chemistry 1998 Oda Y, Tu CL, Pillai S, Bikle DD -
Differential regulation of vitamin D responsive elements in normal and transformed keratinocytes.
The Journal of investigative dermatology 1998 Xie Z, Bikle DD -
Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha.
The Journal of investigative dermatology 1998 Hanley K, Jiang Y, He SS, Friedman M, Elias PM, Bikle DD, Williams ML, Feingold KR -
All-trans retinoic acid blocks the antiproliferative prodifferentiating actions of 1,25-dihydroxyvitamin D3 in normal human keratinocytes.
Journal of cellular physiology 1998 Gibson DF, Bikle DD, Harris J -
Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1.
Molecular endocrinology (Baltimore, Md.) 1997 Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL, Portale AA -
Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells.
The American journal of physiology 1997 Kostenuik PJ, Halloran BP, Morey-Holton ER, Bikle DD -
Biochemical markers in the assessment of bone disease.
The American journal of medicine 1997 Bikle DD -
Vitamin D: a calciotropic hormone regulating calcium-induced keratinocyte differentiation.
Journal of the American Academy of Dermatology 1997 Bikle DD -
Decrease of Ca(2+)-ATPase activity in human keratinocytes during calcium-induced differentiation.
Journal of cellular physiology 1997 Cho JK, Bikle DD -
The expression of the gap junctional protein Cx43 is restricted to proliferating and non differentiated normal and transformed keratinocytes.
Experimental dermatology 1997 Gibson DF, Bikle DD, Harris J, Goldberg GS -
Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997 Halloran BP, Bikle DD, Harris J, Tanner S, Curren T, Morey-Holton E -
Spaceflight and the skeleton: lessons for the earthbound.
Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology 1997 Bikle DD, Halloran BP, Morey-Holton E -
Cloning of the human phospholipase C-gamma1 promoter and identification of a DR6-type vitamin D-responsive element.
The Journal of biological chemistry 1997 Xie Z, Bikle DD -
Racial differences in bone density between young adult black and white subjects persist after adjustment for anthropometric, lifestyle, and biochemical differences.
The Journal of clinical endocrinology and metabolism 1997 Ettinger B, Sidney S, Cummings SR, Libanati C, Bikle DD, Tekawa IS, Tolan K, Steiger P -
Space flight and the skeleton: lessons for the earthbound.
The Endocrinologist 1997 Bikle DD, Halloran BP, Morey-Holton E -
Antiestrogen potentiation of antiproliferative effects of vitamin D3 analogues in breast cancer cells.
Cancer research 1996 Love-Schimenti CD, Gibson DF, Ratnam AV, Bikle DD -
Zipper protein, a B-G protein with the ability to regulate actin/myosin 1 interactions in the intestinal brush border.
The Journal of biological chemistry 1996 Bikle DD, Munson S, Komuves L -
1,25(OH)2D3-modulated calcium induced keratinocyte differentiation.
The journal of investigative dermatology. Symposium proceedings 1996 Bikle DD -
Squamous carcinoma cell lines fail to respond to 1,25-Dihydroxyvitamin D despite normal levels of the vitamin D receptor.
The Journal of investigative dermatology 1996 Ratnam AV, Bikle DD, Su MJ, Pillai S -
Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor.
The Journal of clinical investigation 1996 Bikle DD, Ratnam A, Mauro T, Harris J, Pillai S -
Evidence for separate control mechanisms at the message, protein, and enzyme activation levels for transglutaminase during calcium-induced differentiation of normal and transformed human keratinocytes.
The Journal of investigative dermatology 1996 Gibson DF, Ratnam AV, Bikle DD -
Regulation of involucrin gene expression by calcium in normal human keratinocytes.
Frontiers in bioscience : a journal and virtual library 1996 Ng DC, Su MJ, Kim R, Bikle DD -
22-Oxa calcitriol is a less potent regulator of keratinocyte proliferation and differentiation due to decreased cellular uptake and enhanced catabolism.
The Journal of investigative dermatology 1995 Bikle DD, Abe-Hashimoto J, Su MJ, Felt S, Gibson DF, Pillai S -
Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995 Halloran BP, Bikle DD, Harris J, Autry CP, Currier PA, Tanner S, Patterson-Buckendahl P, Morey-Holton E -
1,25-Dihydroxyvitamin D3 upregulates the phosphatidylinositol signaling pathway in human keratinocytes by increasing phospholipase C levels.
The Journal of clinical investigation 1995 Pillai S, Bikle DD, Su MJ, Ratnam A, Abe J -
1,25(OH)2D3-regulated human keratinocyte proliferation and differentiation: basic studies and their clinical application.
The Journal of nutrition 1995 Bikle DD -
The molecular response of bone to growth hormone during skeletal unloading: regional differences.
Endocrinology 1995 Bikle DD, Harris J, Halloran BP, Currier PA, Tanner S, Morey-Holton E -
Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity.
Annals of internal medicine 1995 Pettifor JM, Bikle DD, Cavaleros M, Zachen D, Kamdar MC, Ross FP -
Altered skeletal pattern of gene expression in response to spaceflight and hindlimb elevation.
The American journal of physiology 1994 Bikle DD, Harris J, Halloran BP, Morey-Holton E -
Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994 Bikle DD, Morey-Holton ER, Doty SB, Currier PA, Tanner SJ, Halloran BP -
Skeletal unloading induces resistance to insulin-like growth factor I.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994 Bikle DD, Harris J, Halloran BP, Morey-Holton ER -
Expression of the genes for insulin-like growth factors and their receptors in bone during skeletal growth.
The American journal of physiology 1994 Bikle DD, Harris J, Halloran BP, Roberts CT, Leroith D, Morey-Holton E -
Role of vitamin D, its metabolites, and analogs in the management of osteoporosis.
Rheumatic diseases clinics of North America 1994 Bikle DD -
Impact of skeletal unloading on bone formation: role of systemic and local factors.
Acta astronautica 1994 Bikle DD, Halloran BP, Morey-Holton E -
1,25-Dihydroxyvitamin D3 potentiates the keratinocyte response to calcium.
The Journal of biological chemistry 1994 Su MJ, Bikle DD, Mancianti ML, Pillai S -
Production of 1,25 dihydroxyvitamin D3 by perfused pig skin.
The Journal of investigative dermatology 1994 Bikle DD, Halloran BP, Riviere JE -
Regulation of calmodulin binding to the ATP extractable 110 kDa protein (myosin I) from chicken duodenal brush border by 1,25-(OH)2D3.
Biochimica et biophysica acta 1994 Kaune R, Munson S, Bikle DD -
Regulation of keratinocyte growth, differentiation, and vitamin D metabolism by analogs of 1,25-dihydroxyvitamin D.
The Journal of investigative dermatology 1993 Bikle DD, Gee E, Pillai S -
Alcohol-induced bone disease: relationship to age and parathyroid hormone levels.
Alcoholism, clinical and experimental research 1993 Bikle DD, Stesin A, Halloran B, Steinbach L, Recker R -
Skeletal unloading decreases production of 1,25-dihydroxyvitamin D.
The American journal of physiology 1993 Halloran BP, Bikle DD, Harris J, Foskett HC, Morey-Holton E -
Elevated 1,25-dihydroxyvitamin D levels in patients with chronic obstructive pulmonary disease treated with prednisone.
The Journal of clinical endocrinology and metabolism 1993 Bikle DD, Halloran B, Fong L, Steinbach L, Shellito J -
Vitamin D, calcium, and epidermal differentiation.
Endocrine reviews 1993 Bikle DD, Pillai S -
Zipper protein, a newly described tropomyosin-like protein of the intestinal brush border.
The Journal of biological chemistry 1993 Bikle DD, Munson S, Morrison N, Eisman J -
Alcohol-induced bone disease.
World review of nutrition and dietetics 1993 Bikle DD -
Localization and quantitation of calcium pools and calcium binding sites in cultured human keratinocytes.
Journal of cellular physiology 1993 Pillai S, Menon GK, Bikle DD, Elias PM -
Metabolic acidosis reverses the increase in serum 1,25(OH)2D in phosphorus-restricted normal men.
The American journal of physiology 1992 Portale AA, Halloran BP, Harris ST, Bikle DD, Morris RC -
Clinical counterpoint: vitamin D: new actions, new analogs, new therapeutic potential.
Endocrine reviews 1992 Bikle DD -
Effects of dietary protein deficiency on mineral metabolism and bone mineral density.
The American journal of clinical nutrition 1992 Orwoll E, Ware M, Stribrska L, Bikle D, Sanchez T, Andon M, Li H -
Progestin antagonism of estrogen stimulated 1,25-dihydroxyvitamin D levels.
The Journal of clinical endocrinology and metabolism 1992 Bikle DD, Halloran BP, Harris ST, Portale AA -
Adenosine triphosphate stimulates phosphoinositide metabolism, mobilizes intracellular calcium, and inhibits terminal differentiation of human epidermal keratinocytes.
The Journal of clinical investigation 1992 Pillai S, Bikle DD -
Lanthanum influx into cultured human keratinocytes: effect on calcium flux and terminal differentiation.
Journal of cellular physiology 1992 Pillai S, Bikle DD -
Squamous carcinoma cell lines produce 1,25 dihydroxyvitamin D, but fail to respond to its prodifferentiating effect.
The Journal of investigative dermatology 1991 Bikle DD, Pillai S, Gee E -
Tumor necrosis factor-alpha regulation of 1,25-dihydroxyvitamin D production by human keratinocytes.
Endocrinology 1991 Bikle DD, Pillai S, Gee E, Hincenbergs M -
Limited tissue distribution of the intestinal brush border myosin I protein.
Gastroenterology 1991 Bikle DD, Munson S, Mancianti ML -
Uncoupling of the calcium-sensing mechanism and differentiation in squamous carcinoma cell lines.
Experimental cell research 1991 Pillai S, Bikle DD, Mancianti ML, Hincenbergs M -
Epidermal vitamin D metabolism, function, and regulation.
Advances in lipid research 1991 Pillai S, Bikle DD -
Role of intracellular-free calcium in the cornified envelope formation of keratinocytes: differences in the mode of action of extracellular calcium and 1,25 dihydroxyvitamin D3.
Journal of cellular physiology 1991 Pillai S, Bikle DD -
Different responses of trabecular and cortical bone to 1,25(OH)2D3 infusion.
The American journal of physiology 1990 Bikle DD, Halloran BP, McGalliard-Cone C, Morey-Holton E -
Calcium regulation of growth and differentiation of normal human keratinocytes: modulation of differentiation competence by stages of growth and extracellular calcium.
Journal of cellular physiology 1990 Pillai S, Bikle DD, Mancianti ML, Cline P, Hincenbergs M -
Serum vitamin D metabolites are not responsible for low turnover osteoporosis in chronic liver disease.
The Journal of clinical endocrinology and metabolism 1989 Diamond T, Stiel D, Mason R, Lissner D, Bikle D, Wilson S, Posen S -
Effects of simulated weightlessness on rat osteocalcin and bone calcium.
The American journal of physiology 1989 Patterson-Buckendahl P, Globus RK, Bikle DD, Cann CE, Morey-Holton E -
Bone response to normal weight bearing after a period of skeletal unloading.
The American journal of physiology 1989 Sessions ND, Halloran BP, Bikle DD, Wronski TJ, Cone CM, Morey-Holton E -
Transpleural gradient of 1,25-dihydroxyvitamin D in tuberculous pleuritis.
The Journal of clinical investigation 1989 Barnes PF, Modlin RL, Bikle DD, Adams JS -
Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes.
The Journal of clinical investigation 1989 Pillai S, Bikle DD, Eessalu TE, Aggarwal BB, Elias PM -
Isotopic labeling affects 1,25-dihydroxyvitamin D metabolism.
Biochemistry 1989 Halloran BP, Bikle DD, Castro ME, Gee E -
Free, and not total, 1,25-dihydroxyvitamin D regulates 25-hydroxyvitamin D metabolism by keratinocytes.
Endocrinology 1989 Bikle DD, Gee E -
Regulation of 1,25-dihydroxyvitamin D production in human keratinocytes by interferon-gamma.
Endocrinology 1989 Bikle DD, Pillai S, Gee E, Hincenbergs M -
Calmodulin binding to the intestinal brush-border membrane: comparison to other calcium-binding proteins.
Biochimica et biophysica acta 1989 Bikle D, Munson S, Christakos S, Kumar R, Buckendahl P -
Glucocorticoids and inhibition of bone formation induced by skeletal unloading.
The American journal of physiology 1988 Halloran BP, Bikle DD, Cone CM, Morey-Holton E -
Serum dihydrotachysterol levels and biological action in normal man.
The Journal of clinical endocrinology and metabolism 1988 Taylor A, Bikle DD, Norman ME -
1,25-Dihydroxyvitamin D production and receptor binding in human keratinocytes varies with differentiation.
The Journal of biological chemistry 1988 Pillai S, Bikle DD, Elias PM -
Biochemical and morphological characterization of growth and differentiation of normal human neonatal keratinocytes in a serum-free medium.
Journal of cellular physiology 1988 Pillai S, Bikle DD, Hincenbergs M, Elias PM -
Effects of alcohol abuse on bone.
Comprehensive therapy 1988 Bikle DD -
Vitamin D and epidermal differentiation: evidence for a role of endogenously produced vitamin D metabolites in keratinocyte differentiation.
Skin pharmacology : the official journal of the Skin Pharmacology Society 1988 Pillai S, Bikle DD, Elias PM -
Vitamin D metabolite production and function in keratinocytes.
Annals of the New York Academy of Sciences 1988 Bikle DD, Pillai S -
The effect of vitamin D status on cutaneous sterologenesis in vivo and in vitro.
Biochimica et biophysica acta 1987 Feingold KR, Williams ML, Pillai S, Menon GK, Halloran BP, Bikle DD, Elias PM -
Effect of dietary acid and calcium on 25-hydroxyvitamin D metabolism by chick kidney.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1987 Cunningham J, Bikle DD, Avioli LV -
The effects of simulated weightlessness on bone maturation.
Endocrinology 1987 Bikle DD, Halloran BP, Cone CM, Globus RK, Morey-Holton E -
Chronic administration of 1,25-dihydroxyvitamin D3: increased bone but impaired mineralization.
Endocrinology 1986 Wronski TJ, Halloran BP, Bikle DD, Globus RK, Morey-Holton ER -
Stimulation by 1,25-dihydroxyvitamin D3 of adenylate cyclase along the villus of chick duodenum.
Endocrinology 1986 Long RG, Bikle DD, Munson SJ -
Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein.
The Journal of clinical endocrinology and metabolism 1986 Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG -
Effect of ethanol on intestinal calcium transport in chicks.
Gastroenterology 1986 Bikle DD, Gee EA, Munson SJ -
Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate.
The Journal of clinical investigation 1986 Halloran BP, Bikle DD, Levens MJ, Castro ME, Globus RK, Holton E -
Free 25-hydroxyvitamin D levels are normal in subjects with liver disease and reduced total 25-hydroxyvitamin D levels.
The Journal of clinical investigation 1986 Bikle DD, Halloran BP, Gee E, Ryzen E, Haddad JG -
1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation.
The Journal of clinical investigation 1986 Bikle DD, Nemanic MK, Gee E, Elias P -
Neonatal human foreskin keratinocytes produce 1,25-dihydroxyvitamin D3.
Biochemistry 1986 Bikle DD, Nemanic MK, Whitney JO, Elias PW -
Skeletal response to dietary calcium in a rat model simulating weightlessness.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1986 Globus RK, Bikle DD, Halloran B, Morey-Holton E -
The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading.
Endocrinology 1986 Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E -
The temporal response of bone to unloading.
Endocrinology 1986 Globus RK, Bikle DD, Morey-Holton E -
The villus gradient of brush border membrane calmodulin and the calcium-independent calmodulin-binding protein parallels that of calcium-accumulating ability.
Endocrinology 1986 Bikle DD, Munson S -
1,25-Dihydroxyvitamin D increases calmodulin binding to specific proteins in the chick duodenal brush border membrane.
The Journal of clinical investigation 1985 Bikle DD, Munson S -
Bone loss during simulated weightlessness: is it glucocorticoid mediated?
The Physiologist 1985 Bikle DD, Halloran BP, Cone CM, Morey-Holton E -
Effect of simulated weightlessness and chronic 1,25-dihydroxyvitamin D administration on bone metabolism.
The Physiologist 1985 Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E -
Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels.
The Journal of clinical endocrinology and metabolism 1985 Bikle DD, Siiteri PK, Ryzen E, Haddad JG -
Bone disease in alcohol abuse.
Annals of internal medicine 1985 Bikle DD, Genant HK, Cann C, Recker RR, Halloran BP, Strewler GJ -
Measurement of 25,26-dihydroxyvitamin D: importance of the configuration of the C-25 hydroxyl group.
Biochemistry 1984 Bikle DD, Halloran BP, Whitney JO, Hollis BW -
Differential response of duodenal epithelial cells to 1,25-dihydroxyvitamin D3 according to position on the villus: a comparison of calcium uptake, calcium-binding protein, and alkaline phosphatase activity.
Endocrinology 1984 Bikle DD, Zolock DT, Munson S -
Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease.
The Journal of clinical investigation 1984 Bikle DD, Gee E, Halloran B, Haddad JG -
Separation of isotopically labeled vitamin D metabolites by high-performance liquid chromatography.
Journal of chromatography 1984 Halloran BP, Bikle DD, Whitney JO -
Calmodulin may mediate 1,25-dihydroxyvitamin D-stimulated intestinal calcium transport.
FEBS letters 1984 Bikle DD, Munson S, Chafouleas J -
Effects of simulated weightlessness on bone mineral metabolism.
Endocrinology 1984 Globus RK, Bikle DD, Morey-Holton E -
Acute, but not chronic, metabolic acidosis disturbs 25-hydroxyvitamin D3 metabolism.
Kidney international 1984 Cunningham J, Bikle DD, Avioli LV -
The relationship of membrane fluidity to calcium flux in chick intestinal brush border membranes.
Endocrinology 1984 Bikle DD, Whitney J, Munson S -
The role of calmodulin in 1,25-dihydroxyvitamin D regulation of calcium transport across the intestinal brush border membrane.
Progress in clinical and biological research 1984 Bikle DD, Munson S, Chafouleas JG -
Calcium flux across chick duodenal brush border membrane vesicles: regulation by 1,25-dihydroxyvitamin D.
Endocrinology 1983 Bikle DD, Munson S, Zolock DT -
Simulating certain aspects of hypogravity: effects on bone maturation in the non-weight bearing skeleton.
Aviation, space, and environmental medicine 1983 Simmons DJ, Grazman B, Russell JE, Walker WV, Bikle DD, Morey ER -
Fluoride treatment of osteoporosis: a new look at an old drug.
Annals of internal medicine 1983 Bikle DD -
Calcium absorption and vitamin D metabolism.
Clinics in gastroenterology 1983 Bikle DD -
Adaptive response of humans to changes in dietary calcium: relationship between vitamin D regulated intestinal function and serum 1,25-dihydroxyvitamin D levels.
Gastroenterology 1983 Bikle DD, Herman RH, Hull S, Hagler L, Harris D, Halloran B -
Calcium potentiates the cyclic nucleotide and phosphaturic response to parathyroid hormone infusion.
The Journal of clinical endocrinology and metabolism 1983 Bikle DD, Herman RH -
Pharmacokinetics and pharmacodynamics of 1,25-dihydroxyvitamin D3 in the chick.
Endocrinology 1982 Bikle DD, Peck CC, Holford NH, Zolock DT, Morrissey RL -
The vitamin D endocrine system.
Advances in internal medicine 1982 Bikle DD -
In vitro stimulation of 25-hydroxycholecalciferol 1 alpha-hydroxylation by parathyroid hormone in chick kidney slices: evidence for a role for adenosine 3',5'-monophosphate.
Endocrinology 1981 Rost CR, Bikle DD, Kaplan RA -
Action of vitamin D on intestinal calcium transport.
Annals of the New York Academy of Sciences 1981 Bikle DD, Zolock DT, Morrissey RL -
The intestinal response to vitamin D.
Reviews of physiology, biochemistry and pharmacology 1981 Bikle DD, Morrissey RL, Zolock DT, Rasmussen H -
Studies of the chick renal mitochondrial 25-hydroxyvitamin D-3 24-hydroxylase.
Biochimica et biophysica acta 1980 Bikle DD -
Prolactin but not growth hormone stimulates 1,25-dihydroxyvitamin D3 production by chick renal preparations in vitro.
Endocrinology 1980 Bikle DD, Spencer EM, Burke WH, Rost CR -
Calcium accumulation by chick intestinal mitochondria. Regulation by vitamin D-3 and 1,25-dihydroxyvitamin D-3.
Biochimica et biophysica acta 1980 Bikle DD, Askew EW, Zolock DT, Morrissey RL, Herman RH -
Effects of 1 alpha-hydroxy vitamin D3 on the rachitic chick intestine: a comparison to the effects of 1,25-dihydroxyvitamin D3.
Calcified tissue international 1980 Bikle DD, Empson RN, Morrissey RL, Zolock DT, Bucci TJ, Herman RH, Pechet MM -
The mechanism of action of vitamin D in the intestine.
The American journal of clinical nutrition 1979 Bikle DD, Morrissey RL, Zolock DT -
Stimulation of chick gut alkaline phosphatase activity by actinomycin D and 1,25-dihydroxyvitamin D3: evidence for independent mechanisms.
The Journal of laboratory and clinical medicine 1979 Bikle DD, Morrissey RL, Zolock DT, Herman RH -
Work-induced muscle hypertrophy in vitamin D-deficient rats.
The American journal of clinical nutrition 1979 Bikle DD, Hagler L, Lollini LO, Hull SF, Herman RH -
Independence of 1,25-dihydroxyvitamin D3-mediated calcium transport from de novo RNA and protein synthesis.
The Journal of biological chemistry 1978 Bikle DD, Zolock DT, Morrissey RL, Herman RH -
Intestinal response to 1 alpha, 25-dihydroxycholecalciferol. I. RNA polymerase, alkaline phosphatase, calcium and phosphorus uptake in vitro, and in vivo calcium transport and accumulation.
Biochimica et biophysica acta 1978 Morrissey RL, Zolock DT, Bikle DD, Empson RN, Bucci TJ -
Intestinal response to 1alpha,25-dihydroxycholecalciferol. II. A timed study of the intracellular localization of calcium binding protein.
Biochimica et biophysica acta 1978 Morrissey RL, Empson RN, Zolock DT, Bikle DD, Bucci TJ -
Ionic control of 1,25-dihydroxy vitamin D-3 production by isolated chick renal mitochondria. Influence of anions and sucrose.
Biochimica et biophysica acta 1978 Bikle DD, Rasmussen H -
The effect of 1,25-dihydroxyvitamin D-3 on the distribution of alkaline phosphatase activity along the chick intestinal villus.
Biochimica et biophysica acta 1977 Bikle DD, Empson RN, Herman RH, Morrissey RL, Zolock DR -
The ionic control of 1,25-dihydroxyvitamin D3 production in isolated chick renal tubules.
The Journal of clinical investigation 1975 Bikle DD, Rasmussen H -
The ionic control of 1,25-dihydroxyvitamin D3 synthesis in isolated chick renal mitochondria. The role of calcium as influenced by inorganic phosphate and hydrogen-ion.
The Journal of clinical investigation 1975 Bikle DD, Murphy EW, Rasmussen H -
A comparison of the metabolism of 25-hydroxyvitamin D3 by chick renal tubules, homogenates and mitochondria.
Biochimica et biophysica acta 1974 Bikle DD, Rasmussen H -
The metabolism of 25-hydroxycholecalciferol by isolated renal tubules in vitro as studied by a new chromatographic technique.
Biochimica et biophysica acta 1974 Bikle DD, Rasmussen H -
Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol.
The Journal of clinical investigation 1972 Rasmussen H, Wong M, Bikle D, Goodman DB