Leanne Jones, PhD
Professor
Anatomy
School of Medicine

Education & Training

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• PhD Microbiology and Molecular Genetics Harvard University
• BS Biology Washington and Lee University

Interests

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• mitochondrial and lipid metabolism
• geroscience
• conserved mechanisms regulating stem cell behavior

Websites

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• Lab Website (joneslabucsf.com)

Grants and Projects

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• UCLA-Caltech Medical Scientist Training Program, NIH, 1983-2024
• Lipid mediated regulation of stem cell behavior and tissue homeostasis, NIH, 2020-2024
• Molecular mechanisms of a multi-tissue innate immune response, NIH, 2019-2023
• Regulation of intestinal stem cell behavior by occluding junctions, NIH, 2017-2021
• Characterization of Age-Related Changes in Stem Cell Behavior, NIH, 2006-2020
• Metabolic regulation of stem cell behavior and longevity, NIH, 2012-2019
• New tools for investigating mitochondrial dynamics in stem cells during aging, NIH, 2016-2018

Publications (27)

Top publication keywords:
Germ CellsAdult Stem CellsMitochondrial DynamicsStem Cell NicheCell Adhesion Molecules, NeuronalDrosophilaErbB ReceptorsTestisRejuvenationDrosophila ProteinsIntestinesStem CellsCellular SenescenceDrosophila melanogasterReceptors, Invertebrate Peptide

• Regeneration, Rejuvenation, and Replacement: Turning Back the Clock on Tissue Aging.
  Cold Spring Harbor perspectives in biology 2021 Rando TA, Jones DL
• Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor.
  Stem cell reports 2021 Resnik-Docampo M, Cunningham KM, Ruvalcaba SM, Choi C, Sauer V, Jones DL
• Lipid Mediated Regulation of Adult Stem Cell Behavior.
  Frontiers in cell and developmental biology 2020 Clémot M, Sênos Demarco R, Jones DL
• EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis.
  Cell reports 2020 Sênos Demarco R, Uyemura BS, Jones DL
• Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila larval testis.
  Scientific reports 2019 Sênos Demarco R, Jones DL

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• DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging.
  Cellular and molecular gastroenterology and hepatology 2019 Lewis SK, Nachun D, Martin MG, Horvath S, Coppola G, Jones DL
• Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis.
  Nature cell biology 2019 Sênos Demarco R, Uyemura BS, D'Alterio C, Jones DL
• Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging.
  The Journal of cell biology 2017 Koehler CL, Perkins GA, Ellisman MH, Jones DL
• Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis.
  Nature cell biology 2016 Resnik-Docampo M, Koehler CL, Clark RI, Schinaman JM, Sauer V, Wong DM, Lewis S, D'Alterio C, Walker DW, Jones DL
• Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot.
  The EMBO journal 2014 Loza-Coll MA, Southall TD, Sandall SL, Brand AH, Jones DL
• Escargot restricts niche cell to stem cell conversion in the Drosophila testis.
  Cell reports 2014 Voog J, Sandall SL, Hime GR, Resende LP, Loza-Coll M, Aslanian A, Yates JR, Hunter T, Fuller MT, Jones DL
• Persistent replicative stress alters polycomb phenotypes and tissue homeostasis in Drosophila melanogaster.
  Cell reports 2014 Landais S, D'Alterio C, Jones DL
• Headcase promotes cell survival and niche maintenance in the Drosophila testis.
  PloS one 2013 Resende LP, Boyle M, Tran D, Fellner T, Jones DL
• The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche.
  Nature 2012 Toledano H, D'Alterio C, Czech B, Levine E, Jones DL
• Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog.
  Cell metabolism 2011 Rera M, Bahadorani S, Cho J, Koehler CL, Ulgherait M, Hur JH, Ansari WS, Lo T, Jones DL, Walker DW
• Regulation of adult stem cell behavior by nutrient signaling.
  Cell cycle (Georgetown, Tex.) 2011 Wang L, McLeod CJ, Jones DL
• Emerging models and paradigms for stem cell ageing.
  Nature cell biology 2011 Jones DL, Rando TA
• Metabolic regulation of stem cell behavior and implications for aging.
  Cell metabolism 2010 Jasper H, Jones DL
• Stem cell dynamics in response to nutrient availability.
  Current biology : CB 2010 McLeod CJ, Wang L, Wong C, Jones DL
• Dietary restriction enhances germline stem cell maintenance.
  Aging cell 2010 Mair W, McLeod CJ, Wang L, Jones DL
• Stem cells and the niche: a dynamic duo.
  Cell stem cell 2010 Voog J, Jones DL
• Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis.
  Nature 2008 Voog J, D'Alterio C, Jones DL
• No place like home: anatomy and function of the stem cell niche.
  Nature reviews. Molecular cell biology 2008 Jones DL, Wagers AJ
• Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis.
  Cell stem cell 2007 Boyle M, Wong C, Rocha M, Jones DL
• Aging and the germ line: where mortality and immortality meet.
  Stem cell reviews 2007 Jones DL
• Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome.
  Science (New York, N.Y.) 2003 Yamashita YM, Jones DL, Fuller MT
• Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue.
  Science (New York, N.Y.) 2001 Kiger AA, Jones DL, Schulz C, Rogers MB, Fuller MT