Cristina Alvira, MD
Professor
Pediatrics
School of Medicine

Publications (53)

Top publication keywords:
NF-kappa B p50 SubunitInfant, PrematurePulmonary ArteryHyperoxiaPulmonary AlveoliEndothelial CellsI-kappa B KinaseNeovascularization, PhysiologicHypoxia-Inducible Factor 1, alpha SubunitBronchopulmonary DysplasiaLungNF-kappa BTransforming Growth Factor betaOrganogenesisMyocytes, Smooth Muscle

• miR-203 modulates pregnant myometrium contractility via transient receptor potential vanilloid 4 channel expression.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Ying L, Fornes DD, Dobberfuhl AD, Ansari JR, Alvira CM, Cornfield DN
• Pediatric subspecialty workforce: what is needed to secure its vitality and survival?
  Pediatric research 2024 Dammann CE, Alvira CM, Devaskar SU, St Geme JW, Golden WC, Gordon CM, Hoffmann B, Lakshminrusimha S, Leslie LK, Trent M, Winer KK, Fromme HB
• Studying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report.
  American journal of respiratory cell and molecular biology 2024 Hough RF, Alvira CM, Bastarache JA, Erzurum SC, Kuebler WM, Schmidt EP, Shimoda LA, Abman SH, Alvarez DF, Belvitch P, Bhattacharya J, Birukov KG, Chan SY, Cornfield DN, Dudek SM, Garcia JGN, …
• Seeing pulmonary hypertension through a paediatric lens: a viewpoint.
  The European respiratory journal 2024 Agarwal S, Fineman J, Cornfield DN, Alvira CM, Zamanian RT, Goss K, Yuan K, Bonnet S, Boucherat O, Pullamsetti S, Alcázar MA, Goncharova E, Kudryashova TV, Nicolls MR, de Jesús Pérez V
• Hyperoxia prevents the dynamic neonatal increases in lung mesenchymal cell diversity.
  Scientific reports 2024 Zanini F, Che X, Suresh NE, Knutsen C, Klavina P, Xie Y, Domingo-Gonzalez R, Liu M, Kum A, Jones RC, Quake SR, Alvira CM, Cornfield DN

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• Integrative analysis of noncoding mutations identifies the druggable genome in preterm birth.
  Science advances 2024 Wang C, Wang YJ, Ying L, Wong RJ, Quaintance CC, Hong X, Neff N, Wang X, Biggio JR, Mesiano S, Quake SR, Alvira CM, Cornfield DN, Stevenson DK, Shaw GM, Li J
• CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia.
  Inflammation and regeneration 2023 Hirani DV, Thielen F, Mansouri S, Danopoulos S, Vohlen C, Haznedar-Karakaya P, Mohr J, Wilke R, Selle J, Grosch T, Mizik I, Odenthal M, Alvira CM, Kuiper-Makris C, Pryhuber GS, Pallasch C, van …
• Loss of prolyl hydroxylase 1 and 2 in SM22α-expressing cells prevents Hypoxia-Induced pulmonary hypertension.
  American journal of physiology. Lung cellular and molecular physiology 2023 Barnes EA, Ito R, Che X, Alvira CM, Cornfield DN
• Hypoxia-Inducible Factor-1α in SM22α-Expressing Cells Modulates Alveolarization.
  American journal of respiratory cell and molecular biology 2023 Barnes EA, Knutsen C, Kindt A, Che X, Ying L, Adams E, Gonzalez E, Oak P, Hilgendorff A, Alvira CM, Cornfield DN
• Endothelial-specific loss of IKKβ disrupts pulmonary endothelial angiogenesis and impairs postnatal lung growth.
  American journal of physiology. Lung cellular and molecular physiology 2023 Rao S, Liu M, Iosef C, Knutsen C, Alvira CM
• Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension.
  The European respiratory journal 2023 Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou EA, Auer N, Mitra A, Guardado ES, Swaminathan G, Condon DF, Yu J, McCarra M, Juul NH, Mallory A, Guzman-Hernandez RA, Yuan K, Rojas V, …
• Developmental diversity and unique sensitivity to injury of lung endothelial subtypes during postnatal growth.
  iScience 2023 Zanini F, Che X, Knutsen C, Liu M, Suresh NE, Domingo-Gonzalez R, Dou SH, Zhang D, Pryhuber GS, Jones RC, Quake SR, Cornfield DN, Alvira CM
• SM22α cell-specific HIF stabilization mitigates hyperoxia-induced neonatal lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2022 Ito R, Barnes EA, Che X, Alvira CM, Cornfield DN
• Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia.
  The European respiratory journal 2022 Hirani D, Alvira CM, Danopoulos S, Milla C, Donato M, Tian L, Mohr J, Dinger K, Vohlen C, Selle J, V Koningsbruggen-Rietschel S, Barbarino V, Pallasch C, Rose-John S, Odenthal M, Pryhuber GS, Mansouri…
• Dynamism of the Human Lung Proteome during Alveolarization: Moving beyond the Transcriptome.
  American journal of respiratory and critical care medicine 2022 Alvira CM
• Transforming Growth Factor-induced Protein Promotes NF-κB-mediated Angiogenesis during Postnatal Lung Development.
  American journal of respiratory cell and molecular biology 2021 Liu M, Iosef C, Rao S, Domingo-Gonzalez R, Fu S, Snider P, Conway SJ, Umbach GS, Heilshorn SC, Dewi RE, Dahl MJ, Null DM, Albertine KH, Alvira CM
• Nanoparticle Delivery of Angiogenic Gene Therapy. Save the Vessels, Save the Lung!
  American journal of respiratory and critical care medicine 2020 Zepp JA, Alvira CM
• Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution.
  eLife 2020 Domingo-Gonzalez R, Zanini F, Che X, Liu M, Jones RC, Swift MA, Quake SR, Cornfield DN, Alvira CM
• NF-κB/NKILA signaling modulates the anti-cancerous effects of EZH2 inhibition.
  Journal of cellular and molecular medicine 2019 Duan S, Chan WK, Oman A, Basile DP, Alvira CM, Buxton ILO, Iosef C
• Enhancing the Development and Retention of Physician-Scientists in Academic Pediatrics: Strategies for Success.
  The Journal of pediatrics 2018 Alvira CM, Steinhorn RH, Balistreri WF, Fineman JR, Oishi PE, Padbury JF, Kinsella JP, Abman SH
• Distinct roles for IκB kinases alpha and beta in regulating pulmonary endothelial angiogenic function during late lung development.
  Journal of cellular and molecular medicine 2018 Iosef C, Liu M, Ying L, Rao SP, Concepcion KR, Chan WK, Oman A, Alvira CM
• Pulmonary artery smooth muscle cell HIF-1α regulates endothelin expression via microRNA-543.
  American journal of physiology. Lung cellular and molecular physiology 2018 Wang CC, Ying L, Barnes EA, Adams ES, Kim FY, Engel KW, Alvira CM, Cornfield DN
• Intrauterine growth restriction decreases NF-κB signaling in fetal pulmonary artery endothelial cells of fetal sheep.
  American journal of physiology. Lung cellular and molecular physiology 2018 Dodson RB, Powers KN, Gien J, Rozance PJ, Seedorf G, Astling D, Jones K, Crombleholme TM, Abman SH, Alvira CM
• β1-Subunit of the calcium-sensitive potassium channel modulates the pulmonary vascular smooth muscle cell response to hypoxia.
  American journal of physiology. Lung cellular and molecular physiology 2018 Barnes EA, Lee L, Barnes SL, Brenner R, Alvira CM, Cornfield DN
• Developmental differences in focal adhesion kinase expression modulate pulmonary endothelial barrier function in response to inflammation.
  American journal of physiology. Lung cellular and molecular physiology 2018 Ying L, Alvira CM, Cornfield DN
• Can We Understand the Pathobiology of Bronchopulmonary Dysplasia?
  The Journal of pediatrics 2017 Alvira CM, Morty RE
• Long-term miR-29b suppression reduces aneurysm formation in a Marfan mouse model.
  Physiological reports 2017 Okamura H, Emrich F, Trojan J, Chiu P, Dalal AR, Arakawa M, Sato T, Penov K, Koyano T, Pedroza A, Connolly AJ, Rabinovitch M, Alvira C, Fischbein MP
• Aberrant Pulmonary Vascular Growth and Remodeling in Bronchopulmonary Dysplasia.
  Frontiers in medicine 2016 Alvira CM
• Absence of TNF-α enhances inflammatory response in the newborn lung undergoing mechanical ventilation.
  American journal of physiology. Lung cellular and molecular physiology 2016 Ehrhardt H, Pritzke T, Oak P, Kossert M, Biebach L, Förster K, Koschlig M, Alvira CM, Hilgendorff A
• Loss of PPARγ in endothelial cells leads to impaired angiogenesis.
  Journal of cell science 2016 Vattulainen-Collanus S, Akinrinade O, Li M, Koskenvuo M, Li CG, Rao SP, de Jesus Perez V, Yuan K, Sawada H, Koskenvuo JW, Alvira C, Rabinovitch M, Alastalo TP
• The transient receptor potential vanilloid 4 channel modulates uterine tone during pregnancy.
  Science translational medicine 2015 Ying L, Becard M, Lyell D, Han X, Shortliffe L, Husted CI, Alvira CM, Cornfield DN
• Activation of the nuclear factor-κB pathway during postnatal lung inflammation preserves alveolarization by suppressing macrophage inflammatory protein-2.
  American journal of physiology. Lung cellular and molecular physiology 2015 Hou Y, Liu M, Husted C, Chen C, Thiagarajan K, Johns JL, Rao SP, Alvira CM
• Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia.
  American journal of physiology. Lung cellular and molecular physiology 2014 Kim FY, Barnes EA, Ying L, Chen C, Lee L, Alvira CM, Cornfield DN
• Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of Marfan syndrome.
  Arteriosclerosis, thrombosis, and vascular biology 2014 Emrich FC, Okamura H, Dalal AR, Penov K, Merk DR, Raaz U, Hennigs JK, Chin JT, Miller MO, Pedroza AJ, Craig JK, Koyano TK, Blankenberg FG, Connolly AJ, Mohr FW, Alvira CM, Rabinovitch M, Fischbein MP
• Haemophagocytic lymphohistiocytosis associated with coccidiomycosis.
  BMJ case reports 2014 Ramsi M, Alvira C, Purohit P, Cornfield D
• Disrupted lung development and bronchopulmonary dysplasia: opportunities for lung repair and regeneration.
  Current opinion in pediatrics 2014 Baker CD, Alvira CM
• Nuclear factor-kappa-B signaling in lung development and disease: one pathway, numerous functions.
  Birth defects research. Part A, Clinical and molecular teratology 2014 Alvira CM
• Chronic lung disease in the preterm infant. Lessons learned from animal models.
  American journal of respiratory cell and molecular biology 2014 Hilgendorff A, Reiss I, Ehrhardt H, Eickelberg O, Alvira CM
• Hypoxia-inducible factor-1α in pulmonary artery smooth muscle cells lowers vascular tone by decreasing myosin light chain phosphorylation.
  Circulation research 2013 Kim YM, Barnes EA, Alvira CM, Ying L, Reddy S, Cornfield DN
• Voltage-dependent anion channel-2 interaction with nitric oxide synthase enhances pulmonary artery endothelial cell nitric oxide production.
  American journal of respiratory cell and molecular biology 2012 Alvira CM, Umesh A, Husted C, Ying L, Hou Y, Lyu SC, Nowak J, Cornfield DN
• Inhibiting NF-κB in the developing lung disrupts angiogenesis and alveolarization.
  American journal of physiology. Lung cellular and molecular physiology 2012 Iosef C, Alastalo TP, Hou Y, Chen C, Adams ES, Lyu SC, Cornfield DN, Alvira CM
• Hypoxia-inducible factor-1α regulates KCNMB1 expression in human pulmonary artery smooth muscle cells.
  American journal of physiology. Lung cellular and molecular physiology 2011 Ahn YT, Kim YM, Adams E, Lyu SC, Alvira CM, Cornfield DN
• miR-29b participates in early aneurysm development in Marfan syndrome.
  Circulation research 2011 Merk DR, Chin JT, Dake BA, Maegdefessel L, Miller MO, Kimura N, Tsao PS, Iosef C, Berry GJ, Mohr FW, Spin JM, Alvira CM, Robbins RC, Fischbein MP
• Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions.
  The American journal of pathology 2011 Kim YM, Haghighat L, Spiekerkoetter E, Sawada H, Alvira CM, Wang L, Acharya S, Rodriguez-Colon G, Orton A, Zhao M, Rabinovitch M
• Inhibition of transforming growth factor β worsens elastin degradation in a murine model of Kawasaki disease.
  The American journal of pathology 2011 Alvira CM, Guignabert C, Kim YM, Chen C, Wang L, Duong TT, Yeung RS, Li DY, Rabinovitch M
• Rho kinase modulates postnatal adaptation of the pulmonary circulation through separate effects on pulmonary artery endothelial and smooth muscle cells.
  American journal of physiology. Lung cellular and molecular physiology 2010 Alvira CM, Sukovich DJ, Lyu SC, Cornfield DN
• Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice.
  American journal of physiology. Lung cellular and molecular physiology 2009 Mokres LM, Parai K, Hilgendorff A, Ertsey R, Alvira CM, Rabinovitch M, Bland RD
• Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.
  American journal of physiology. Lung cellular and molecular physiology 2009 Guignabert C, Alvira CM, Alastalo TP, Sawada H, Hansmann G, Zhao M, Wang L, El-Bizri N, Rabinovitch M
• LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor.
  Journal of cell science 2009 Ying L, Lau A, Alvira CM, West R, Cann GM, Zhou B, Kinnear C, Jan E, Sarnow P, Van de Rijn M, Rabinovitch M
• An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.
  The Journal of clinical investigation 2008 Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekker JM, Schellong S, Urashima T, Wang L, Morrell NW, Rabinovitch M
• Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin.
  American journal of physiology. Lung cellular and molecular physiology 2007 Spiekerkoetter E, Alvira CM, Kim YM, Bruneau A, Pricola KL, Wang L, Ambartsumian N, Rabinovitch M
• Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice. Prelude to defective alveolar septation during lung development?
  American journal of physiology. Lung cellular and molecular physiology 2007 Bland RD, Ertsey R, Mokres LM, Xu L, Jacobson BE, Jiang S, Alvira CM, Rabinovitch M, Shinwell ES, Dixit A
• Nuclear factor-kappaB activation in neonatal mouse lung protects against lipopolysaccharide-induced inflammation.
  American journal of respiratory and critical care medicine 2007 Alvira CM, Abate A, Yang G, Dennery PA, Rabinovitch M