Courtney Lane-Donovan, MD, PhD
Assistant Professor
Neurology
School of Medicine

Education & Training

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• Neurology Residency UCSF 06/2021
• MD University of Texas Southwestern Medical Center 06/2017
• PhD Neuroscience University of Texas Southwestern Medical Center 06/2017
• SB Biological Engineering Massachusetts Institute of Technology 06/2009
• SB Biology Massachusetts Institute of Technology 06/2009

Grants and Projects

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• The Role of Reelin in Adult Neuronal Function and Alzheimer's Disease, NIH, 2014-2016
• A Novel Lysosomal pH Reporter to Identify Effects of Aging and Disease on Lysosome Function Significance, NIH

Publications (23)

Top publication keywords:
Extracellular Matrix ProteinsTauopathiesPeptide HydrolasesNeurodegenerative DiseasesSupranuclear Palsy, Progressivetau ProteinsApolipoprotein E3Apolipoproteins ECell Adhesion Molecules, NeuronalReceptors, LDLLow Density Lipoprotein Receptor-Related Protein-1Serine EndopeptidasesLysosomesCentral Nervous SystemAlzheimer Disease

• Lysosomal Protease-Mediated APP Degradation is pH-Dependent, Mutation-Sensitive, and Facilitates Tau Proteolysis.
  Research square 2025 Ackley C, Liau Z, Arya S, Antee T, Knudsen GM, Lane-Donovan C, Sampognaro PJ, Kao AW
• Changes of a Cerebral Cavernous Malformation Associated With Lecanemab Therapy in a Patient With Alzheimer Disease.
  Neurology. Clinical practice 2025 Schwartz NU, Dietz CD, Prufer Araújo I, Villanueva-Meyer JE, Chiong W, Lane-Donovan C, Vandevrede L, Ljubenkov PA, Wang Y, Soleimani-Meigooni DN, La Joie R, Rojas JC
• Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Lane-Donovan C, Smith AW, Saloner R, Miller BL, Casaletto KB, Kao AW
• Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias.
  Neurology 2024 Asken BM, Tanner JA, Vandevrede L, Apple A, Chapleau M, Gaynor LS, Lane-Donovan C, Lenio S, Yadollahikhales G, Lee S, Gontrum E, Knudtson M, Iaccarino L, La Joie R, Cobigo Y, Staffaroni AM, Casaletto …
• Disentangling tau: One protein, many therapeutic approaches.
  Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Lane-Donovan C, Boxer AL

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• Tau pathology in neurodegenerative disease: disease mechanisms and therapeutic avenues.
  The Journal of clinical investigation 2023 Samudra N, Lane-Donovan C, VandeVrede L, Boxer AL
• Mycobacterium avium Complex Infection as a Rare Cause of Cerebral Mass Lesion and IRIS in a Patient With AIDS: Case Report and Review of the Literature.
  Open forum infectious diseases 2021 Lane-Donovan C, Bainbridge E, Szumowski J, Kerkhoff AD, Peluso MJ
• Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Durakoglugil MS, Wasser CR, Wong CH, Pohlkamp T, Xian X, Lane-Donovan C, Fritschle K, Naestle L, Herz J
• Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer's disease.
  eLife 2018 Xian X, Pohlkamp T, Durakoglugil MS, Wong CH, Beck JK, Lane-Donovan C, Plattner F, Herz J
• Building a better blood-brain barrier.
  eLife 2017 Lane-Donovan C, Herz J
• The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease.
  Journal of lipid research 2017 Lane-Donovan C, Herz J
• ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
  Trends in endocrinology and metabolism: TEM 2017 Lane-Donovan C, Herz J
• NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents.
  Alzheimer's & dementia (New York, N. Y.) 2017 Kounnas MZ, Lane-Donovan C, Nowakowski DW, Herz J, Comer WT
• Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Lane-Donovan C, Wong WM, Durakoglugil MS, Wasser CR, Jiang S, Xian X, Herz J
• Physiologic Reelin does not play a strong role in protection against acute stroke.
  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016 Lane-Donovan C, Desai C, Pohlkamp T, Plautz EJ, Herz J, Stowe AM
• High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice.
  PloS one 2016 Lane-Donovan C, Herz J
• Reelin protects against amyloid β toxicity in vivo.
  Science signaling 2015 Lane-Donovan C, Philips GT, Wasser CR, Durakoglugil MS, Masiulis I, Upadhaya A, Pohlkamp T, Coskun C, Kotti T, Steller L, Hammer RE, Frotscher M, Bock HH, Herz J
• Science Signaling Podcast: 7 July 2015.
  Science Signaling 2015 Courtney Lane-Donovan, Joachim Herz, Annalisa M. VanHook
• Lrp4 domains differentially regulate limb/brain development and synaptic plasticity.
  PloS one 2015 Pohlkamp T, Durakoglugil M, Lane-Donovan C, Xian X, Johnson EB, Hammer RE, Herz J
• Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning.
  Science signaling 2014 Wasser CR, Masiulis I, Durakoglugil MS, Lane-Donovan C, Xian X, Beffert U, Agarwala A, Hammer RE, Herz J
• Is apolipoprotein e required for cognitive function in humans?: implications for Alzheimer drug development.
  JAMA neurology 2014 Lane-Donovan C, Herz J
• More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration.
  Neuron 2014 Lane-Donovan C, Philips GT, Herz J
• Intermittent practice facilitates stable motor memories.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Overduin SA, Richardson AG, Lane CE, Bizzi E, Press DZ