Corey Miller, PhD, MD
Assistant Professor
Diabetes Center
School of Medicine

The Miller Lab is working to develop our understanding of stromal-immune crosstalk, T cell development, and T cell mediated immunity. We use methods in experimental and systems immunology to dissect how the thymus supports thymoctye development while maintaining central immune tolerance.

Education & Training

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• Postdoctoral Scholar University of California, San Francisco 07/2020
• MD Medicine University of California, San Francisco 09/2014
• PhD Biomedical Sciences University of California, San Francisco 08/2011
• BS Biochemistry University of Michigan, Ann Arbor 12/2003

Grants and Projects

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• Mechanisms of thymic stromal-immune crosstalk for homeostasis and naïve T cell licensing across life, NIH, 2021-2026

Publications (16)

Top publication keywords:
Immune ToleranceLymphoid Progenitor CellsTRPM Cation ChannelsLymphatic SystemEndothelial CellsSuccinic AcidThymus GlandCentral ToleranceTranscription FactorsLymphopeniaGenetic HeterogeneityEpithelial CellsThymocytesInterleukin-4Interleukin-7

• Aire in Autoimmunity.
  Annual review of immunology 2024 Miller CN, Waterfield MR, Gardner JM, Anderson MS
• Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.
  Science immunology 2023 Sin JH, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, Parent AV, Gupta A, Kastner P, Chan S, Gardner JM, Ntranos V, Miller CN, Anderson MS, Schjerven H, Waterfield MR
• Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla.
  Nature communications 2021 Bautista JL, Cramer NT, Miller CN, Chavez J, Berrios DI, Byrnes LE, Germino J, Ntranos V, Sneddon JB, Burt TD, Gardner JM, Ye CJ, Anderson MS, Parent AV
• Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells.
  eLife 2020 Wells KL, Miller CN, Gschwind AR, Wei W, Phipps JD, Anderson MS, Steinmetz LM
• Thymic regulatory T cells arise via two distinct developmental programs.
  Nature immunology 2019 Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson …

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• Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
  Nature 2018 Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, …
• Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.
  Immunity 2018 Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J
• Insights into immune tolerance from AIRE deficiency.
  Current opinion in immunology 2017 Proekt I, Miller CN, Lionakis MS, Anderson MS
• Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Michel C, Miller CN, Küchler R, Brors B, Anderson MS, Kyewski B, Pinto S
• Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS
• LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.
  The Journal of clinical investigation 2016 Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL
• Identification of a novel cis-regulatory element essential for immune tolerance.
  The Journal of experimental medicine 2015 LaFlam TN, Seumois G, Miller CN, Lwin W, Fasano KJ, Waterfield M, Proekt I, Vijayanand P, Anderson MS
• Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Ladell K, Hazenberg MD, Fitch M, Emson C, McEvoy-Hein Asgarian BK, Mold JE, Miller C, Busch R, Price DA, Hellerstein MK, McCune JM
• IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.
  International immunology 2013 Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM
• Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins.
  PLoS biology 2006 Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Sadighi Akha AA, Raden D, Kaufman RJ
• The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis.
  The Journal of clinical investigation 2005 Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ