Corey Harwell, PhD
Associate Professor
Neurology
School of Medicine

Grants and Projects

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• Temporal Specification of Basal Forebrain Circuitry, NIH, 2019-2029
• The impact of early life opioid exposure on the molecular and functional trajectories of septal cell types, NIH, 2023-2028
• Sonic Hedgehog Dependent Neuron-Astrocyte Crosstalk During Cortical Circuit Assembly, NIH, 2023-2028
• Epigenetic Regulation of Cortical Neuronal Lineage Progression, NIH, 2017-2022

Publications (25)

Top publication keywords:
TelencephalonThyroid Nuclear Factor 1NeurogliaInterneuronsHedgehog ProteinsCell MovementNeuronsGABAergic NeuronsNeurogenesisAstrocytesCerebral CortexEpendymoglial CellsPreoptic AreaSeptum of BrainNeural Stem Cells

• Conservation, alteration, and redistribution of mammalian striatal interneurons.
  bioRxiv : the preprint server for biology 2024 Corrigan EK, DeBerardine M, Poddar A, Turrero García M, Schmitz MT, Harwell CC, Paredes MF, Krienen FM, Pollen AA
• PRDM16 co-operates with LHX2 to shape the human brain.
  Oxford open neuroscience 2024 Suresh V, Bhattacharya B, Tshuva RY, Danan Gotthold M, Olender T, Bose M, Pradhan SJ, Zeev BB, Smith RS, Tole S, Galande S, Harwell CC, Baizabal JM, Reiner O
• Astrocyte Development in the Rodent.
  Advances in neurobiology 2024 Xie Y, Harwell CC, Garcia ADR
• Developmental origin and local signals cooperate to determine septal astrocyte identity.
  bioRxiv : the preprint server for biology 2023 Xie Y, Reid CM, Granados AA, Garcia MT, Dale-Huang F, Hanson SM, Mancia W, Liu J, Adam M, Mosto O, Pisco AO, Alvarez-Buylla A, Harwell CC
• A developmentally defined population of neurons in the lateral septum controls responses to aversive stimuli.
  bioRxiv : the preprint server for biology 2023 García MT, Tran DN, Peterson RE, Stegmann SK, Hanson SM, Reid CM, Xie Y, Vu S, Harwell CC

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• PRDM16 co-operates with LHX2 to shape the human brain.
  bioRxiv : the preprint server for biology 2023 Suresh V, Bhattacharya B, Tshuva RY, Danan Gotthold M, Olender T, Bose M, Pradhan SJ, Ben Zeev B, Smith RS, Tole S, Galande S, Harwell C, Baizabal JM, Reiner O
• Astrocytes as master modulators of neural networks: Synaptic functions and disease-associated dysfunction of astrocytes.
  Annals of the New York Academy of Sciences 2023 Stogsdill JA, Harwell CC, Goldman SA
• Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis.
  The EMBO journal 2022 Mukhtar T, Breda J, Adam MA, Boareto M, Grobecker P, Karimaddini Z, Grison A, Eschbach K, Chandrasekhar R, Vermeul S, Okoniewski M, Pachkov M, Harwell CC, Atanasoski S, Beisel C, Iber D, van Nimwegen …
• Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development.
  Cell reports 2022 Xie Y, Kuan AT, Wang W, Herbert ZT, Mosto O, Olukoya O, Adam M, Vu S, Kim M, Tran D, Gómez N, Charpentier C, Sorour I, Lacey TE, Tolstorukov MY, Sabatini BL, Lee WA, Harwell CC
• Transcriptional profiling of sequentially generated septal neuron fates.
  eLife 2021 Turrero García M, Stegmann SK, Lacey TE, Reid CM, Hrvatin S, Weinreb C, Adam MA, Nagy MA, Harwell CC
• Attraction and repulsion cooperate during brain-circuit wiring.
  Nature 2021 Xie Y, Harwell C
• The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors.
  Developmental neuroscience 2021 Merk DJ, Zhou P, Cohen SM, Pazyra-Murphy MF, Hwang GH, Rehm KJ, Alfaro J, Reid CM, Zhao X, Park E, Xu PX, Chan JA, Eck MJ, Nazemi KJ, Harwell CC, Segal RA
• Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production.
  Development (Cambridge, England) 2020 Turrero García M, Baizabal JM, Tran DN, Peixoto R, Wang W, Xie Y, Adam MA, English LA, Reid CM, Brito SI, Booker MA, Tolstorukov MY, Harwell CC
• Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner.
  eLife 2020 Granger AJ, Wang W, Robertson K, El-Rifai M, Zanello AF, Bistrong K, Saunders A, Chow BW, Nuñez V, Turrero García M, Harwell CC, Gu C, Sabatini BL
• Epigenetic regulation of cortical neurogenesis; orchestrating fate switches at the right time and place.
  Current opinion in neurobiology 2020 Adam MA, Harwell CC
• Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization.
  eLife 2019 Hill SA, Blaeser AS, Coley AA, Xie Y, Shepard KA, Harwell CC, Gao WJ, Garcia ADR
• The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Garcia ADR, Han YG, Triplett JW, Farmer WT, Harwell CC, Ihrie RA
• The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position.
  Neuron 2018 Baizabal JM, Mistry M, García MT, Gómez N, Olukoya O, Tran D, Johnson MB, Walsh CA, Harwell CC
• The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position.
  Neuron 2018 Baizabal JM, Mistry M, García MT, Gómez N, Olukoya O, Tran D, Johnson MB, Walsh CA, Harwell CC
• Radial glia in the ventral telencephalon.
  FEBS letters 2017 Turrero García M, Harwell CC
• Lineage Relationships Do Not Drive MGE/PoA-Derived Interneuron Clustering in the Brain.
  Neuron 2016 Turrero García M, Mazzola E, Harwell CC
• Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons.
  Neuron 2015 Harwell CC, Fuentealba LC, Gonzalez-Cerrillo A, Parker PR, Gertz CC, Mazzola E, Garcia MT, Alvarez-Buylla A, Cepko CL, Kriegstein AR
• Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation.
  Neuron 2012 Harwell CC, Parker PR, Gee SM, Okada A, McConnell SK, Kreitzer AC, Kriegstein AR
• Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity.
  Neuron 2011 Ihrie RA, Shah JK, Harwell CC, Levine JH, Guinto CD, Lezameta M, Kriegstein AR, Alvarez-Buylla A
• Soluble CPG15 expressed during early development rescues cortical progenitors from apoptosis.
  Nature neuroscience 2005 Putz U, Harwell C, Nedivi E