Connor O'Brien, MD
Assistant Professor
Medicine
School of Medicine

Clinical interests: Cardiologist with expertise in echocardiography and critical care medicine. Focus on care for adults with severe cardiac dysfunction or systemic shock who need prompt treatment in intensive care. Research interests: Translating basic science discoveries to clinical applications that improve understanding of underlying disease processes and effective treatments.

Awards

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• Timothy F Beckett Award, Stanford University, 2020
• Gerald Reaven Award in Basic Science, Stanford University, 2018
• Ruth L Kirschstein National Research Service Award, National Institutes of Health, 2017-2019
• Best Clinical Fellow Award, Stanford University, 2017
• Timothy F Beckett Award, Stanford University, 2016
• Johnson and Johnson Fellowship in Global Health, Stanford University, 2013-2015
• Benjamin Kean Fellowship, American Society of Tropical Medicine and Hygiene, 2012
• Conrad George Lattes Fellowship, Columbia University, 2012
• Alpha Omega Alpha, Columbia University, 2011
• Gold Humanism Society Award, Columbia University, 2011
• Elliot Stellar Chance Award, University of Pennsylvania, 2005

Education & Training

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• Critical Care Medicine Stanford University 06/2019
• Cardiovascular Medicine Fellowship Stanford University 06/2018
• Internal Medicine Residency Stanford University 06/2015
• MD Columbia University College of Physicians and Surgeons 05/2012
• BA Biology and Biological Basis of Behavior University of Pennsylvania 05/2005

Interests

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• cardiogenic shock
• critical care
• regenerative medicine
• mitochondria
• Critical care cardiology

Publications (34)

Top publication keywords:
Drug ResistanceCritical CareCurriculumClinical CompetenceHospital MortalityHeart FailurePeptide FragmentsPlasmodium falciparumEducation, Medical, GraduateArtemisininsMalaria, FalciparumNatriuretic Peptide, BrainShock, CardiogenicCardiologyAntimalarials

• Interhospital Variation in Admissions Managed With Critical Care Therapies or Invasive Hemodynamic Monitoring in Tertiary Cardiac Intensive Care Units: An Analysis From the Critical Care Cardiology Trials Network Registry.
  Circulation. Cardiovascular quality and outcomes 2024 Donnelly S, Barnett CF, Bohula EA, Chaudhry SP, Chonde MD, Cooper HA, Daniels LB, Dodson MW, Gerber D, Goldfarb MJ, Guo J, Kontos MC, Liu S, Luk AC, Menon V, O'Brien CG, Papolos AI, Pisani BA, Potter …
• Prognostic significance of haemodynamic parameters in patients with cardiogenic shock.
  European heart journal. Acute cardiovascular care 2023 Berg DD, Kaur G, Bohula EA, Baird-Zars VM, Alviar CL, Barnett CF, Barsness GW, Burke JA, Chaudhry SP, Chonde M, Cooper HA, Daniels LB, Dodson MW, Gerber DA, Ghafghazi S, Gidwani UK, Goldfarb MJ, Guo J…
• Pulmonary Artery Catheter Use and Mortality in the Cardiac Intensive Care Unit.
  JACC. Heart failure 2023 Kadosh BS, Berg DD, Bohula EA, Park JG, Baird-Zars VM, Alviar C, Alzate J, Barnett CF, Barsness GW, Burke J, Chaudhry SP, Daniels LB, DeFilippis A, Delicce A, Fordyce CB, Ghafghazi S, Gidwani U, …
• Presentation and Outcomes of Patients With Preoperative Critical Illness Undergoing Cardiac Surgery
  JACC Advances 2023 Metkus T, Alviar C, Baird-Zars V, et al.
• Critical Care Cardiology Trials Network (CCCTN): a cohort profile.
  European heart journal. Quality of care & clinical outcomes 2022 Metkus TS, Baird-Zars VM, Alfonso CE, Alviar CL, Barnett CF, Barsness GW, Berg DD, Bertic M, Bohula EA, Burke J, Burstein B, Chaudhry SP, Cooper HA, Daniels LB, Fordyce CB, Ghafghazi S, Goldfarb M, …

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• Association between Obesity and Length of COVID-19 Hospitalization: Unexpected Insights from the American Heart Association National COVID-19 Registry.
  Journal of obesity & metabolic syndrome 2022 Collins WJ, Chang AY, Weng Y, Dahlen A, O'Brien CG, Hom J, Ahuja N, Rodriguez F, Rohatgi N
• Impact of Bradyarrhythmias Requiring Pacing on Outcomes in Patients With COVID-19
  Impact of Bradyarrhythmias Requiring Pacing on Outcomes in Patients With COVID-19 2022 Vasti EC MD, MPH; Ashland MD MS, O'Donnell C MD; Rodriguez F MD, MPH; Wang P MD; O'Brien CG MD
• The shock team: a multidisciplinary approach to early patient phenotyping and appropriate care escalation in cardiogenic shock.
  Current opinion in cardiology 2022 Brusca SB, Caughron H, Njoroge JN, Cheng R, O'Brien CG, Barnett CF
• Training in Critical Care Cardiology Within Critical Care Medicine Fellowship: A Novel Pathway.
  Journal of the American College of Cardiology 2022 O'Brien CG, Barnett CF, Dudzinski DM, Sanchez PA, Katz JN, Harold JG, Hennessey EK, Mohabir PK
• Critical care management of the patient with pulmonary hypertension.
  European heart journal. Acute cardiovascular care 2022 Barnett CF, O'Brien C, De Marco T
• N-Terminal Pro-B-Type Natriuretic Peptide as a Biomarker for the Severity and Outcomes With COVID-19 in a Nationwide Hospitalized Cohort.
  Journal of the American Heart Association 2021 O'Donnell C, Ashland MD, Vasti EC, Lu Y, Chang AY, Wang P, Daniels LB, de Lemos JA, Morrow DA, Rodriguez F, O'Brien CG
• Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury: Insights Into the SENECA Trial.
  JACC. CardioOncology 2021 O'Brien CG, Ozen MO, Ikeda G, Vaskova E, Jung JH, Bayardo N, Santoso MR, Shi L, Wahlquist C, Jiang Z, Jung Y, Zeng Y, Egan E, Sinclair R, Gee A, Witteles R, Mercola M, Svensson KJ, Demirci U, Yang PC
• The Use of Factor Eight Inhibitor Bypass Activity (FEIBA) for the Treatment of Perioperative Hemorrhage in Left Ventricular Assist Device Implantation.
  Journal of cardiothoracic and vascular anesthesia 2021 O'Donnell C, Rodriguez AJ, Madhok J, Sharifi H, Wang H, O'Brien CG, Boyd J, Hiesinger W, Hsu J, Hill CC
• A Phase II study of autologous mesenchymal stromal cells and c-kit positive cardiac cells, alone or in combination, in patients with ischaemic heart failure: the CCTRN CONCERT-HF trial.
  European journal of heart failure 2021 Bolli R, Mitrani RD, Hare JM, Pepine CJ, Perin EC, Willerson JT, Traverse JH, Henry TD, Yang PC, Murphy MP, March KL, Schulman IH, Ikram S, Lee DP, O'Brien C, Lima JA, Ostovaneh MR, Ambale-Venkatesh B…
• miR-106a-363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury.
  Basic research in cardiology 2021 Jung JH, Ikeda G, Tada Y, von Bornstädt D, Santoso MR, Wahlquist C, Rhee S, Jeon YJ, Yu AC, O'brien CG, Red-Horse K, Appel EA, Mercola M, Woo J, Yang PC
• Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium.
  Journal of the American College of Cardiology 2021 Ikeda G, Santoso MR, Tada Y, Li AM, Vaskova E, Jung JH, O'Brien C, Egan E, Ye J, Yang PC
• Worldwide Survey of COVID-19-Associated Arrhythmias.
  Circulation. Arrhythmia and electrophysiology 2021 Coromilas EJ, Kochav S, Goldenthal I, Biviano A, Garan H, Goldbarg S, Kim JH, Yeo I, Tracy C, Ayanian S, Akar J, Singh A, Jain S, Zimerman L, Pimentel M, Osswald S, Twerenbold R, Schaerli N, Crotti L,…
• Allogeneic Mesenchymal Cell Therapy in Anthracycline-Induced Cardiomyopathy Heart Failure Patients: The CCTRN SENECA Trial.
  JACC. CardioOncology 2020 Bolli R, Perin EC, Willerson JT, Yang PC, Traverse JH, Henry TD, Pepine CJ, Mitrani RD, Hare JM, Murphy MP, March KL, Ikram S, Lee DP, O'Brien C, Durand JB, Miller K, Lima JA, Ostovaneh MR, Ambale-…
• Electrical Storm in COVID-19.
  JACC. Case reports 2020 O'Brien C, Ning N, McAvoy J, Mitchell JE, Kalwani N, Wang P, Nguyen D, Reejhsinghani R, Rogers A, Lorenzo J
• COVID-19 and Disruptive Modifications to Cardiac Critical Care Delivery: JACC Review Topic of the Week.
  Journal of the American College of Cardiology 2020 Katz JN, Sinha SS, Alviar CL, Dudzinski DM, Gage A, Brusca SB, Flanagan MC, Welch T, Geller BJ, Miller PE, Leonardi S, Bohula EA, Price S, Chaudhry SP, Metkus TS, O'Brien CG, Sionis A, Barnett CF, …
• Cardiogenic Shock: Reflections at the Crossroad Between Perfusion, Tissue Hypoxia, and Mitochondrial Function.
  The Canadian journal of cardiology 2019 O'Brien C, Beaubien-Souligny W, Amsallem M, Denault A, Haddad F
• Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation.
  The New England journal of medicine 2019 Perez MV, Mahaffey KW, Hedlin H, Rumsfeld JS, Garcia A, Ferris T, Balasubramanian V, Russo AM, Rajmane A, Cheung L, Hung G, Lee J, Kowey P, Talati N, Nag D, Gummidipundi SE, Beatty A, Hills MT, Desai …
• Meta-analysis of short- and long-term efficacy of mononuclear cell transplantation in patients with myocardial infarction.
  American heart journal 2019 Yang D, O'Brien CG, Ikeda G, Traverse JH, Taylor DA, Henry TD, Bolli R, Yang PC
• Routine Indwelling Urethral Catheterization in Acute Heart Failure Patients Is Associated With Increased Urinary Tract Complications Without Improved Heart Failure Outcomes.
  Circulation journal : official journal of the Japanese Circulation Society 2018 Jang AY, O'Brien C, Chung WJ, Oh PC, Yu J, Lee K, Kang WC, Moon J
• Alternative Therapies for Chronic Hepatitis B Patients With Partial Virological Response to Standard Entecavir Monotherapy.
  Journal of clinical gastroenterology 2016 Chaung KT, O'Brien C, Ha NB, Nguyen NH, Trinh HN, Nguyen MH
• Hurdles to clinical translation of human induced pluripotent stem cells.
  The Journal of clinical investigation 2015 Neofytou E, O'Brien CG, Couture LA, Wu JC
• Current treatment guidelines for chronic hepatitis B and their applications.
  Journal of clinical gastroenterology 2014 Uribe LA, O'Brien CG, Wong RJ, Gish RR, Tsai N, Nguyen MH
• Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model.
  Antimicrobial agents and chemotherapy 2013 Henrich PP, O'Brien C, Sáenz FE, Cremers S, Kyle DE, Fidock DA
• Tuberculosis associated with transient hemolytic anemia responsive to tuberculosis chemotherapy: a case report.
  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2013 Safe IP, O'brien C, Ferreira FR, Souza ML, Ramasawmy R
• Risk factors and characterization of Plasmodium vivax-associated admissions to pediatric intensive care units in the Brazilian Amazon.
  PloS one 2012 Lança EF, Magalhães BM, Vitor-Silva S, Siqueira AM, Benzecry SG, Alexandre MA, O'Brien C, Bassat Q, Lacerda MV
• Pfatp6 molecular profile of Plasmodium falciparum isolates in the western Brazilian Amazon.
  Malaria journal 2012 Brasil LW, Areas AL, Melo GC, Oliveira CM, Alecrim MG, Lacerda MV, O'Brien C, Oelemann WM, Zalis MG
• Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum.
  Current opinion in infectious diseases 2011 O'Brien C, Henrich PP, Passi N, Fidock DA
• In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei.
  The Journal of antibiotics 2011 Fitzgerald JT, Henrich PP, O'Brien C, Krause M, Ekland EH, Mattheis C, Sá JM, Fidock D, Khosla C
• In vivo and in vitro antimalarial properties of azithromycin-chloroquine combinations that include the resistance reversal agent amlodipine.
  Antimicrobial agents and chemotherapy 2011 Pereira MR, Henrich PP, Sidhu AB, Johnson D, Hardink J, Van Deusen J, Lin J, Gore K, O'Brien C, Wele M, Djimde A, Chandra R, Fidock DA