Connie John, PhD
Professor
Laboratory Medicine
School of Medicine

Awards

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• SRF-Reproduction prize, Reproduction - The official journal of the Society for Reproduction and Fertility, 2018

Education & Training

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• Ph.D. Graduate Division (Pharmaceutical Chemistry) University of California, San Francisco 1990

Publications (46)

Top publication keywords:
Galectin 3Sertoli CellsNeisseria meningitidis, Serogroup CNeisseria meningitidisNeisseria gonorrhoeaeMeningitis, MeningococcalAmidohydrolasesCell-Penetrating PeptidesMonocytesLeydig CellsNeisseria meningitidis, Serogroup BMeningococcal InfectionsLipid ALipopolysaccharidesNeisseria

• Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation.
  mBio 2024 Cardenas AJ, Thomas KS, Broden MW, Ferraro NJ, Pires MM, John CM, Jarvis GA, Criss AK
• Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation.
  bioRxiv : the preprint server for biology 2024 Cardenas AJ, Thomas KS, Broden MW, Ferraro NJ, John CM, Pires MM, Jarvis GA, Criss AK
• Inhibition of galectin-3 post-infarction impedes progressive fibrosis by regulating inflammatory profibrotic cascades.
  Cardiovascular research 2023 Wang X, Gaur M, Mounzih K, Rodriguez HJ, Qiu H, Chen M, Yan L, Cooper BA, Narayan S, Derakhshandeh R, Rao P, Han DD, Nabavizadeh P, Springer ML, John CM
• Comparison of lipooligosaccharides from human challenge strains of Neisseria gonorrhoeae.
  Frontiers in microbiology 2023 John CM, Phillips NJ, Cardenas AJ, Criss AK, Jarvis GA
• Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase.
  The Journal of antimicrobial chemotherapy 2022 Mullally C, Stubbs KA, Thai VC, Anandan A, Bartley S, Scanlon MJ, Jarvis GA, John CM, Lim KYL, Sullivan CM, Sarkar-Tyson M, Vrielink A, Kahler CM

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• Roles of Spermatogonial Stem Cells in Spermatogenesis and Fertility Restoration.
  Frontiers in endocrinology 2022 Diao L, Turek PJ, John CM, Fang F, Reijo Pera RA
• Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS.
  Journal of lipid research 2020 John CM, Phillips NJ, Jarvis GA
• The chimera-type galectin-3 is a positive modulator of trophoblast functions with dysregulated expression in gestational diabetes mellitus.
  American journal of reproductive immunology (New York, N.Y. : 1989) 2020 Freitag N, Tirado-González I, Barrientos G, Cohen M, Daher S, Goldman-Wohl D, Mincheva-Nilsson L, John CM, Jeschke U, Blois SM
• Cationic cell-penetrating peptide is bactericidal against Neisseria gonorrhoeae.
  The Journal of antimicrobial chemotherapy 2019 John CM, Li M, Feng D, Jarvis GA
• Spiral steroids as potential markers for pre-eclampsia: A pilot study.
  Steroids 2019 Chasalow F, John CM, Bochner R
• Treatment of human challenge and MDR strains of Neisseria gonorrhoeae with LpxC inhibitors.
  The Journal of antimicrobial chemotherapy 2018 John CM, Feng D, Jarvis GA
• Novel Campylobacter concisus lipooligosaccharide is a determinant of inflammatory potential and virulence.
  Journal of lipid research 2018 Brunner K, John CM, Phillips NJ, Alber DG, Gemmell MR, Hansen R, Nielsen HL, Hold GL, Bajaj-Elliott M, Jarvis GA
• Isolation of human testicular cells and co-culture with embryonic stem cells.
  Reproduction (Cambridge, England) 2018 Gaur M, Ramathal C, Reijo Pera RA, Turek PJ, John CM
• Rescue of PFOS-induced human Sertoli cell injury by overexpressing a p-FAK-Y407E phosphomimetic mutant.
  Scientific reports 2017 Chen H, Gao Y, Mruk DD, Xiao X, John CM, Turek PJ, Lui WY, Lee WM, Silvestrini B, Cheng CY
• Innate immune response to lipooligosaccharide: pivotal regulator of the pathobiology of invasive Neisseria meningitidis infections.
  Pathogens and disease 2017 John CM, Phillips NJ, Stein DC, Jarvis GA
• Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Anandan A, Evans GL, Condic-Jurkic K, O'Mara ML, John CM, Phillips NJ, Jarvis GA, Wills SS, Stubbs KA, Moraes I, Kahler CM, Vrielink A
• Analysis of Bacterial Lipooligosaccharides by MALDI-TOF MS with Traveling Wave Ion Mobility.
  Journal of the American Society for Mass Spectrometry 2016 Phillips NJ, John CM, Jarvis GA
• Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage.
  The Journal of biological chemistry 2015 John CM, Phillips NJ, Din R, Liu M, Rosenqvist E, Høiby EA, Stein DC, Jarvis GA
• Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins.
  Human reproduction (Oxford, England) 2014 Xiao X, Mruk DD, Tang EI, Wong CK, Lee WM, John CM, Turek PJ, Silvestrini B, Cheng CY
• Induction of endotoxin tolerance by pathogenic Neisseria is correlated with the inflammatory potential of lipooligosaccharides and regulated by microRNA-146a.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Liu M, John CM, Jarvis GA
• Campylobacter jejuni lipooligosaccharide sialylation, phosphorylation, and amide/ester linkage modifications fine-tune human Toll-like receptor 4 activation.
  The Journal of biological chemistry 2013 Stephenson HN, John CM, Naz N, Gundogdu O, Dorrell N, Wren BW, Jarvis GA, Bajaj-Elliott M
• Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells.
  Molecular pharmacology 2013 Dovizio M, Maier TJ, Alberti S, Di Francesco L, Marcantoni E, Münch G, John CM, Suess B, Sgambato A, Steinhilber D, Patrignani P
• Post-injury conditioning with lipopolysaccharide or lipooligosaccharide reduces inflammation in the brain.
  Journal of neuroimmunology 2013 Bingham D, John CM, Levin J, Panter SS, Jarvis GA
• Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals.
  Infection and immunity 2012 John CM, Liu M, Phillips NJ, Yang Z, Funk CR, Zimmerman LI, Griffiss JM, Stein DC, Jarvis GA
• Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure.
  The Journal of biological chemistry 2011 Cheng H, Yang Z, Estabrook MM, John CM, Jarvis GA, McLaughlin S, Griffiss JM
• Tracking human multiple myeloma xenografts in NOD-Rag-1/IL-2 receptor gamma chain-null mice with the novel biomarker AKAP-4.
  BMC cancer 2011 Mirandola L, Yu Y, Jenkins MR, Chiaramonte R, Cobos E, John CM, Chiriva-Internati M
• Galectin-3C inhibits tumor growth and increases the anticancer activity of bortezomib in a murine model of human multiple myeloma.
  PloS one 2011 Mirandola L, Yu Y, Chui K, Jenkins MR, Cobos E, John CM, Chiriva-Internati M
• Post-injury treatment with lipopolysaccharide or lipooligosaccharide protects rat neuronal and glial cell cultures.
  Brain research bulletin 2011 Bingham D, John CM, Panter SS, Jarvis GA
• Characterization and functionality of proliferative human Sertoli cells.
  Cell transplantation 2010 Chui K, Trivedi A, Cheng CY, Cherbavaz DB, Dazin PF, Huynh AL, Mitchell JB, Rabinovich GA, Noble-Haeusslein LJ, John CM
• Phosphoryl moieties of lipid A from Neisseria meningitidis and N. gonorrhoeae lipooligosaccharides play an important role in activation of both MyD88- and TRIF-dependent TLR4-MD-2 signaling pathways.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Liu M, John CM, Jarvis GA
• Human galectin-3 interacts with two anticancer drugs.
  Proteomics 2010 Bogoeva VP, Varriale A, John CM, D'Auria S
• Tumor-specific protein human galectin-1 interacts with anticancer agents.
  Molecular bioSystems 2009 D'Auria S, Petrova L, John C, Russev G, Varriale A, Bogoeva V
• Natural phosphoryl and acyl variants of lipid A from Neisseria meningitidis strain 89I differentially induce tumor necrosis factor-alpha in human monocytes.
  The Journal of biological chemistry 2009 John CM, Liu M, Jarvis GA
• Profiles of structural heterogeneity in native lipooligosaccharides of Neisseria and cytokine induction.
  Journal of lipid research 2008 John CM, Liu M, Jarvis GA
• Deviations in gait pattern in experimental models of hindlimb paresis shown by a novel pressure mapping system.
  Journal of neuroscience research 2007 Boyd BS, Puttlitz C, Noble-Haeusslein LJ, John CM, Trivedi A, Topp KS
• Suitability of allogeneic sertoli cells for ex vivo gene delivery in the injured spinal cord.
  Experimental neurology 2006 Trivedi AA, Igarashi T, Compagnone N, Fan X, Hsu JY, Hall DE, John CM, Noble-Haeusslein LJ
• Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains.
  Infection and immunity 2003 Pridmore AC, Jarvis GA, John CM, Jack DL, Dower SK, Read RC
• Truncated galectin-3 inhibits tumor growth and metastasis in orthotopic nude mouse model of human breast cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2003 John CM, Leffler H, Kahl-Knutsson B, Svensson I, Jarvis GA
• Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected.
  Cellular microbiology 2002 John CM, Jarvis GA, Swanson KV, Leffler H, Cooper MD, Huflejt ME, Griffiss JM
• Neisseria gonorrhoeae that infect men have lipooligosaccharides with terminal N-acetyllactosamine repeats.
  The Journal of biological chemistry 1999 John CM, Schneider H, Griffiss JM
• Characterization of a sialyltransferase-deficient mutant of Neisseria gonorrhoeae strain F62: instability of transposon Tn1545 delta3 in gonococci and evidence that multiple genetic loci are essential for lipooligosaccharide sialylation.
  Microbial pathogenesis 1998 Crooke H, Griffiss JM, John CM, Lissenden S, Bramley J, Regan T, Smith H, Cole J
• XPS and TOF-SIMS microanalysis of a peptide/polymer drug delivery device.
  Analytical chemistry 1995 John CM, Odom RW, Salvati L, Annapragada A, Fu Lu MY
• The structural basis for pyocin resistance in Neisseria gonorrhoeae lipooligosaccharides.
  The Journal of biological chemistry 1991 John CM, Griffiss JM, Apicella MA, Mandrell RE, Gibson BW
• Endogenous sialylation of the lipooligosaccharides of Neisseria meningitidis.
  Journal of bacteriology 1991 Mandrell RE, Kim JJ, John CM, Gibson BW, Sugai JV, Apicella MA, Griffiss JM, Yamasaki R
• Structural models for the cell surface lipooligosaccharides of Neisseria gonorrhoeae and Haemophilus influenzae.
  Biomedical & environmental mass spectrometry 1990 Phillips NJ, John CM, Reinders LG, Gibson BW, Apicella MA, Griffiss JM
• Amino and hydrazino alkyl benzoates as derivatizing agents for the separation and mass spectrometric analysis of oligosaccharides from bacterial lipooligosaccharides.
  Analytical biochemistry 1990 John CM, Gibson BW