Clifford Lowell, MD, PhD
Professor
Laboratory Medicine
School of Medicine

Many of these studies also involve use of mice lacking these kinases in specific hematopoietic lineages, such as neutrophils, macrophages or DCs, generated through Cre/Lox technology. We have also used this approach to study other tyrosine kinases (Pyk2/Fak) and intracellular signaling molecules (WASp, STIM1, STIM2) in innate immune cells. Our major findings have illuminated the function of Src-family and Syk kinases in leukocyte integrin signaling – loss of these kinases results in significant defects in inflammatory and host defense functions mediated by integrins. We have found that leukocyte integrin signaling utilizes the same intracellular pathways initiated by classical immunoreceptors (such as FcγRs) by co-opting ITAM-containing adapter proteins. We have also demonstrated the important ways these kinases regulate innate immune cells in the setting of autoimmune and inflammatory diseases, using the Lyn kinase-deficient model. Ongoing studies also involve examination of cytoplasmic tyrosine phosphatases (mainly SHP1) in the counter regulation tyrosine kinases, especially in the setting of hematopoietic malignancy and inflammatory disease. Recent publications highlight the role of SHP1, as a negative regulator of anti-tumor immunity, as well as the role of integrin signaling adapter protein SKAP2 in human autoimmune disease, in particular type 1 diabetes. Publications total = 228; h-index 97.

• NEF-Induced HIV-Associated Nephropathy Through HCK/LYN Tyrosine Kinases.
  The American journal of pathology 2023 Hu C, Priceputu E, Cool M, Chrobak P, Bouchard N, Forestier C, Lowell CA, Bénichou S, Hanna Z, Royal V, Jolicoeur P
• Neutrophils inhibit γδ T cell functions in the imiquimod-induced mouse model of psoriasis.
  Frontiers in immunology 2022 Costa S, Bevilacqua D, Caveggion E, Gasperini S, Zenaro E, Pettinella F, Donini M, Dusi S, Constantin G, Lonardi S, Vermi W, De Sanctis F, Ugel S, Cestari T, Abram CL, Lowell CA, Rodegher P, Tagliaro …
• Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells.
  JCI insight 2022 Thomas K, Zondler L, Ludwig N, Kardell M, Lüneburg C, Henke K, Mersmann S, Margraf A, Spieker T, Tekath T, Velic A, Holtmeier R, Hermann J, Jankowski V, Meersch M, Vestweber D, Westphal M, Roth J, …
• Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis.
  Cell reports 2022 Poh AR, O'Brien M, Chisanga D, He H, Baloyan D, Traichel J, Dijkstra C, Chopin M, Nutt S, Whitehead L, Boon L, Parkin A, Lowell C, Pajic M, Shi W, Nikfarjam M, Ernst M
• Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.
  Science advances 2022 Poh AR, Love CG, Chisanga D, Steer JH, Baloyan D, Chopin M, Nutt S, Rautela J, Huntington ND, Etemadi N, O'Brien M, O'Keefe R, Ellies LG, Macri C, Mintern JD, Whitehead L, Gangadhara G, Boon L, Chand …
• Hyperuricemia reduces neutrophil function.
  Blood 2022 Lowell CA
• Autoantigen specific T-cell receptor induces organ-specific autoimmunity by escaping T cell negative selection.
  The Journal of Immunology 2022 Mianmian Yin, Jennifer A Smith, Marissa Chou, Jackie Chan, Yongmei Hu, Clifford A Lowell, Douglas B Gould, Mark S Anderson, Anthony L DeFranco
• Development of uveitis in a mouse model of spontaneous autoimmunity correlates with frequency of autoantigen-specific regulatory T cells.
  The Journal of Immunology 2022 Mianmian Yin, Kamir J Hiam, Irina Proekt, Jackie Chan, Yongmei Hu, Clifford A Lowell, Douglas B Gould, Matthew Spitzer, Mark S Anderson, Anthony L DeFranco
• A dominant function of LynB kinase in preventing autoimmunity.
  Science advances 2022 Brian BF, Sauer ML, Greene JT, Senevirathne SE, Lindstedt AJ, Funk OL, Ruis BL, Ramirez LA, Auger JL, Swanson WL, Nunez MG, Moriarity BS, Lowell CA, Binstadt BA, Freedman TS
• Neutrophils in acute inflammation: current concepts and translational implications.
  Blood 2022 Margraf A, Lowell CA, Zarbock A
• Spleen tyrosine kinase facilitates neutrophil activation and worsens long-term neurologic deficits after spinal cord injury.
  Journal of neuroinflammation 2021 McCreedy DA, Abram CL, Hu Y, Min SW, Platt ME, Kirchhoff MA, Reid SK, Jalufka FL, Lowell CA
• Regulation of CNS Lymphoma Progression By the Myeloid Microenvironment.
  Blood 2021 Hua-Xin Gao, Eleanor Fraser, Mario Merlini, Huimin Geng, Lingjing Chen, Ming Lu, Yasmin Moshfegh, Joseph Cleveland, Jae Ryu, Jigyasa Sharma, David A. Solomon, Katerina Akassoglou, Clifford Lowell, …
• Signal Integration by Translocation and Phosphorylation of PKCδ in the B Cell Alternate Pathway.
  Journal of immunology (Baltimore, Md. : 1950) 2021 Khan N, Hu Y, Lowell CA, Rothstein TL
• HIV-1 Nef Induces Hck/Lyn-Dependent Expansion of Myeloid-Derived Suppressor Cells Associated with Elevated Interleukin-17/G-CSF Levels.
  Journal of virology 2021 Priceputu E, Cool M, Bouchard N, Caceres-Cortes JR, Lowell CA, Hanna Z, Jolicoeur P
• Diabetes With Multiple Autoimmune and Inflammatory Conditions Linked to an Activating SKAP2 Mutation.
  Diabetes care 2021 Rutsch N, Chamberlain CE, Dixon W, Spector L, Letourneau-Freiberg LR, Lwin WW, Philipson LH, Zarbock A, Saintus K, Wang J, German MS, Anderson MS, Lowell CA
• 1126-P: Activating SKAP2 Mutation Linked to Diabetes with Multiple Autoimmune and Inflammatory Conditions.
  Diabetes 2021 CHESTER CHAMBERLAIN, NIKLAS RUTSCH, WESLEY DIXON, LISA R. LETOURNEAU-FREIBERG, LOUIS H. PHILIPSON, MICHAEL GERMAN, MARK S. ANDERSON, CLIFFORD A. LOWELL
• Neutrophil-specific deletion of Syk results in recruitment-independent stabilization of the barrier and a long-term improvement in cognitive function after traumatic injury to the developing brain.
  Neurobiology of disease 2021 Trivedi A, Tercovich KG, Casbon AJ, Raber J, Lowell C, Noble-Haeusslein LJ
• Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling.
  Cell reports 2021 Okubo K, Brenner MD, Cullere X, Saggu G, Patchen ML, Bose N, Mihori S, Yuan Z, Lowell CA, Zhu C, Mayadas TN
• A CD22-Shp1 phosphatase axis controls integrin ß 7 display and B cell function in mucosal immunity.
  The FASEB Journal 2021 Romain Ballet, Martin Brennan, Carolin Brandl, Ningguo Feng, Jeremy Berri, Julian Cheng, Borja Ocón, Amin Alborzian Deh Sheikh, Alex Marki, Yuhan Bi, Clare Abram, Clifford Lowell, Takeshi Tsubata, …
• Activation of Lyn kinase and translocation of its PKCd target regulate phosphorylation in the IL-4-induced alternate pathway for BCR signaling.
  The Journal of Immunology 2021 Naeem Khan, Yongmei Hu, Clifford A Lowell, Thomas L Rothstein
• Correlation of autoantigen-specific Treg frequency with development of spontaneous organ-specific autoimmunity in a mouse model of uveitis.
  The Journal of Immunology 2021 Mianmian Yin, Kamir Hiam, Irina Proekt, Jackie Chan, Yongmei Hu, Clifford A Lowell, Douglas B Gould, Mark S Anderson, Anthony L DeFranco
• T-cell receptor repertoire of mice with organ-specific autoimmunity resulting from a partial defect in T cell negative selection and dendritic cell enhancement.
  The Journal of Immunology 2021 Mianmian Yin, Jennifer A Smith, Marissa Chou, Jackie Chan, Yongmei Hu, Clifford A Lowell, Douglas B Gould, Mark S Anderson, Anthony L DeFranco
• A CD22-Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity.
  Nature immunology 2021 Ballet R, Brennan M, Brandl C, Feng N, Berri J, Cheng J, Ocón B, Alborzian Deh Sheikh A, Marki A, Bi Y, Abram CL, Lowell CA, Tsubata T, Greenberg HB, Macauley MS, Ley K, Nitschke L, Butcher EC
• A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.
  American journal of physiology. Lung cellular and molecular physiology 2020 Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell C, Matthay MA
• Complement activation on endothelium initiates antibody-mediated acute lung injury.
  The Journal of clinical investigation 2020 Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR
• Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
  Frontiers in immunology 2020 Myers DR, Abram CL, Wildes D, Belwafa A, Welsh AMN, Schulze CJ, Choy TJ, Nguyen T, Omaque N, Hu Y, Singh M, Hansen R, Goldsmith MA, Quintana E, Smith JAM, Lowell CA
• ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Grimes D, Johnson R, Pashos M, Cummings C, Kang C, Sampedro GR, Tycksen E, McBride HJ, Sah R, Lowell CA, Clemens RA
• The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection.
  Infection and immunity 2020 Liang J, Zhang JJ, Huang HI, Kanayama M, Youssef N, Jin YJ, Reyes EY, Abram CL, Yang S, Lowell CA, Wang D, Shao L, Shinohara ML, Zhang JY, Hammer GE
• Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice.
  Cancer immunology research 2020 Poh AR, Dwyer AR, Eissmann MF, Chand AL, Baloyan D, Boon L, Murrey MW, Whitehead L, O'Brien M, Lowell CA, Putoczki TL, Pixley FJ, O'Donoghue RJJ, Ernst M
• Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils.
  The Journal of clinical investigation 2020 Mahiddine K, Blaisdell A, Ma S, Créquer-Grandhomme A, Lowell CA, Erlebacher A
• Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration.
  Haematologica 2019 Rohwedder I, Kurz ARM, Pruenster M, Immler R, Pick R, Eggersmann T, Klapproth S, Johnson JL, Alsina SM, Lowell CA, Mócsai A, Catz SD, Sperandio M
• L-selectin shedding affects bacterial clearance in the lung: a new regulatory pathway for integrin outside-in signaling.
  Blood 2019 Cappenberg A, Margraf A, Thomas K, Bardel B, McCreedy DA, Van Marck V, Mellmann A, Lowell CA, Zarbock A
• CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases.
  Science signaling 2019 Ma J, Abram CL, Hu Y, Lowell CA
• CRAC channel regulation of innate immune cells in health and disease.
  Cell calcium 2019 Clemens RA, Lowell CA
• Early Targeting of L-Selectin on Leukocytes Promotes Recovery after Spinal Cord Injury, Implicating Novel Mechanisms of Pathogenesis.
  eNeuro 2018 McCreedy DA, Lee S, Sontag CJ, Weinstein P, Olivas AD, Martinez AF, Fandel TM, Trivedi A, Lowell CA, Rosen SD, Noble-Haeusslein LJ
• Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma.
  Blood advances 2018 Rubenstein JL, Geng H, Fraser EJ, Formaker P, Chen L, Sharma J, Killea P, Choi K, Ventura J, Kurhanewicz J, Lowell C, Hwang J, Treseler P, Sneed PK, Li J, Wang X, Chen N, Gangoiti J, Munster PN, …
• PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling.
  British journal of pharmacology 2017 Herter JM, Margraf A, Volmering S, Correia BE, Bradshaw JM, Bisconte A, Hill RJ, Langrish CL, Lowell CA, Zarbock A
• Neutrophils: Their Role in Innate and Adaptive Immunity 2017.
  Journal of immunology research 2017 Rosales C, Lowell CA, Schnoor M, Uribe-Querol E
• B cell autoimmunity at the extremes.
  Nature immunology 2017 Zikherman J, Lowell CA
• Efficiency and Specificity of Gene Deletion in Lung Epithelial Doxycycline-Inducible Cre Mice.
  American journal of respiratory cell and molecular biology 2017 Sinha M, Lowell CA
• STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production.
  Blood 2017 Clemens RA, Chong J, Grimes D, Hu Y, Lowell CA
• Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells.
  Journal of leukocyte biology 2017 Costa S, Marini O, Bevilacqua D, DeFranco AL, Hou B, Lonardi S, Vermi W, Rodegher P, Panato A, Tagliaro F, Lowell CA, Cassatella MA, Girolomoni G, Scapini P
• Shp1 function in myeloid cells.
  Journal of leukocyte biology 2017 Abram CL, Lowell CA
• Differentiating pulmonary transfusion reactions using recipient and transfusion factors.
  Transfusion 2017 Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL, TRALI Study Group
• SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.
  Nature 2017 Chen J, Zhong MC, Guo H, Davidson D, Mishel S, Lu Y, Rhee I, Pérez-Quintero LA, Zhang S, Cruz-Munoz ME, Wu N, Vinh DC, Sinha M, Calderon V, Lowell CA, Danska JS, Veillette A
• Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.
  Cancer cell 2017 Poh AR, Love CG, Masson F, Preaudet A, Tsui C, Whitehead L, Monard S, Khakham Y, Burstroem L, Lessene G, Sieber O, Lowell C, Putoczki TL, O'Donoghue RJJ, Ernst M
• Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions.
  The Journal of experimental medicine 2017 Boras M, Volmering S, Bokemeyer A, Rossaint J, Block H, Bardel B, Van Marck V, Heitplatz B, Kliche S, Reinhold A, Lowell C, Zarbock A
• Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9.
  PloS one 2016 Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL
• Targeting NF-KB Activation in Novel Intracranial Models of CNS Lymphoma.
  Blood 2016 Huimin Geng, Huaxin Gao, Cigall Kadoch, Ming Lu, Lingjing Chen, Rana Anjum, Lisa Drew, Sebastien Degorce, Keith Dillman, Michele Mayo, Shawn Anderson, Colin Collins, Clifford A. Lowell, James L. …
• Isolation of Highly Pure Primary Mouse Alveolar Epithelial Type II Cells by Flow Cytometric Cell Sorting.
  Bio-protocol 2016 Sinha M, Lowell CA
• Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection.
  Immunity 2016 Iborra S, Martínez-López M, Cueto FJ, Conde-Garrosa R, Del Fresno C, Izquierdo HM, Abram CL, Mori D, Campos-Martín Y, Reguera RM, Kemp B, Yamasaki S, Robinson MJ, Soto M, Lowell CA, Sancho D
• LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.
  The Journal of clinical investigation 2016 Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL
• Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis.
  Journal of immunology (Baltimore, Md. : 1950) 2016 Hang L, Blum AM, Kumar S, Urban JF, Mitreva M, Geary TG, Jardim A, Stevenson MM, Lowell CA, Weinstock JV
• MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.
  PLoS pathogens 2016 Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M
• Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells.
  American journal of respiratory cell and molecular biology 2016 Sinha M, Lowell CA
• Triggering of organ-specific autoimmunity through synergy of defects in key tolerance checkpoints.
  The Journal of Immunology 2016 Irina Proekt, Corey Miller, Marion Jeanne, Kayla Fasano, Clifford A Lowell, Douglas Gould, Mark S Anderson, Anthony L DeFranco
• FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection.
  PLoS pathogens 2016 Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV
• Neutrophils in animal models of autoimmune disease.
  Seminars in immunology 2016 Németh T, Mócsai A, Lowell CA
• Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
  Nature 2016 Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW,…
• Abstract PR11: Targeted engagement of B cell autoimmunity checkpoints to overcome drug resistance in pediatric Ph-like ALL.
  Targeted Therapeutics and Resistance 2016 Zhengshan Chen, Huimin Geng, Clifford A. Lowell, Stephen P. Hunger, Markus Müschen
• Neutrophils: Their Role in Innate and Adaptive Immunity.
  Journal of immunology research 2016 Rosales C, Demaurex N, Lowell CA, Uribe-Querol E
• The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation.
  Immunity 2016 Volmering S, Block H, Boras M, Lowell CA, Zarbock A
• Integrins: Regulation of Adhesion and Downstream Signaling.
  Encyclopedia of Immunobiology 2016 Clifford A. Lowell
• Targeted Activation of B Cell Autoimmunity Checkpoints in Acute Lymphoblastic Leukemia.
  Blood 2015 Zhengshan Chen, Huimin Geng, Clifford A. Lowell, Arthur Weiss, Stephen P. Hunger, Ari Melnick, Markus Muschen
• LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.
  eLife 2015 Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A
• Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.
  Immunity 2015 Yi T, Li J, Chen H, Wu J, An J, Xu Y, Hu Y, Lowell CA, Cyster JG
• Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice.
  Shock (Augusta, Ga.) 2015 Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J
• The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Mazzi P, Caveggion E, Lapinet-Vera JA, Lowell CA, Berton G
• Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Stadtmann A, Block H, Volmering S, Abram C, Sohlbach C, Boras M, Lowell CA, Zarbock A
• Intracellular signalling during neutrophil recruitment.
  Cardiovascular research 2015 Mócsai A, Walzog B, Lowell CA
• Regulation of neutrophil cytokine production during inflammation (INC6P.319).
  The Journal of Immunology 2015 Jacques Deguine, Meenal Sinha, Clifford Lowell, Gregory Barton
• Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
  Nature 2015 Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW,…
• A2.21 The role of HCK, FGR and LYN in in vivo inflammation in mice.
  Annals of the Rheumatic Diseases 2015 M Kovács, T Németh, Z Jakus, C Sitaru, E Simon, K Futosi, B Botz, Z Helyes, CA Lowell, A Mócsai
• Store-operated calcium signaling in neutrophils.
  Journal of leukocyte biology 2015 Clemens RA, Lowell CA
• Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.
  Transfusion 2015 Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL, TRALI Study Group
• Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.
  Transfusion 2014 Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, …
• Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia.
  Blood 2014 Zhengshan Chen, Seyedmehdi Shojaee, Huimin Geng, Jae-Woong Lee, Maike Buchner, Lars Klemm, Clifford A. Lowell, Elisabeth Paietta, Cheryl L. Willman, William L. Carroll, Ari Melnick, Jae U. Jung, …
• The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
  The Journal of experimental medicine 2014 Kovács M, Németh T, Jakus Z, Sitaru C, Simon E, Futosi K, Botz B, Helyes Z, Lowell CA, Mócsai A
• Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.
  Critical care medicine 2014 Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, …
• Actin cytoskeleton reorganization by Syk regulates Fcγ receptor responsiveness by increasing its lateral mobility and clustering.
  Developmental cell 2014 Jaumouillé V, Farkash Y, Jaqaman K, Das R, Lowell CA, Grinstein S
• Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice.
  Journal of immunological methods 2014 Abram CL, Roberge GL, Hu Y, Lowell CA
• ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use.
  Cell metabolism 2014 Acín-Pérez R, Carrascoso I, Baixauli F, Roche-Molina M, Latorre-Pellicer A, Fernández-Silva P, Mittelbrunn M, Sanchez-Madrid F, Pérez-Martos A, Lowell CA, Manfredi G, Enríquez JA
• Molecular editing of cellular responses by the high-affinity receptor for IgE.
  Science (New York, N.Y.) 2014 Suzuki R, Leach S, Liu W, Ralston E, Scheffel J, Zhang W, Lowell CA, Rivera J
• STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense.
  Blood 2014 Zhang H, Clemens RA, Liu F, Hu Y, Baba Y, Theodore P, Kurosaki T, Lowell CA
• Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL
• B cell-specific loss of Lyn kinase leads to autoimmunity.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Lamagna C, Hu Y, DeFranco AL, Lowell CA
• Inhibitory Receptors and Phosphatases Enable Oncogenic Tyrosine Kinase Signaling In B Cell Lineage Leukemia.
  Blood 2013 Zhengshan Chen, Seyedmehdi Shojaee, Huimin Geng, Jaewoong Lee, Maike Buchner, Lars Klemm, Clifford A. Lowell, Elisabeth Paietta, Cheryl L. Willman, William L. Carroll, Ari M. Melnick, Jae U. Jung, …
• Novel Intracranial Xenografts Of CNS Lymphoma Implicate a Role For Cereblon As a Mediator Of Lenalidomide Efficacy.
  Blood 2013 Hua-Xin Gao, Shawn Anderson, Cigall Kadoch, Mekhala Maiti, Lingjing Chen, Dong-Han Yao, Gerd Melkus, Maria Wang, Yan Ren, Michael Breider, Carla Heise, Clifford A. Lowell, Colin Collins, James L. …
• Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL
• A critical role for Lyn kinase in strengthening endothelial integrity and barrier function.
  Blood 2013 Han J, Zhang G, Welch EJ, Liang Y, Fu J, Vogel SM, Lowell CA, Du X, Cheresh DA, Malik AB, Li Z
• Expression of the TEL-Syk fusion protein in hematopoietic stem cells leads to rapidly fatal myelofibrosis in mice.
  PloS one 2013 Graham MT, Abram CL, Hu Y, Lowell CA
• The multifaceted functions of neutrophils.
  Annual review of pathology 2013 Mayadas TN, Cullere X, Lowell CA
• Neutrophils mediate antibody-induced antitumor effects in mice.
  Blood 2013 Albanesi M, Mancardi DA, Jönsson F, Iannascoli B, Fiette L, Di Santo JP, Lowell CA, Bruhns P
• Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA
• Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Vérollet C, Gallois A, Dacquin R, Lastrucci C, Pandruvada SN, Ortega N, Poincloux R, Behar A, Cougoule C, Lowell C, Al Saati T, Jurdic P, Maridonneau-Parini I
• The roles of tumor associated macrophages and interferon gamma in immune surveillance in CNS lymphoma (P2211).
  The Journal of Immunology 2013 Hua-Xin Gao, Valerie Wong, Lingjing Chen, Richard Locksley, Clifford Lowell, James Rubenstein
• CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma.
  Blood 2013 Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C
• Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice.
  Immunity 2013 Abram CL, Roberge GL, Pao LI, Neel BG, Lowell CA
• Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Fumagalli L, Campa CC, Germena G, Lowell CA, Hirsch E, Berton G
• Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization.
  Developmental cell 2013 Heit B, Kim H, Cosío G, Castaño D, Collins R, Lowell CA, Kain KC, Trimble WS, Grinstein S
• Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma.
  Blood 2012 Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE
• Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung.
  Cell reports 2012 Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TM
• Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.
  Journal of cell science 2012 Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD
• Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens.
  The Journal of biological chemistry 2012 Ma J, Becker C, Lowell CA, Underhill DM
• Distinct and overlapping functional roles of Src family kinases in mouse platelets.
  Journal of thrombosis and haemostasis : JTH 2012 Séverin S, Nash CA, Mori J, Zhao Y, Abram C, Lowell CA, Senis YA, Watson SP
• Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.
  The Journal of experimental medicine 2012 Block H, Herter JM, Rossaint J, Stadtmann A, Kliche S, Lowell CA, Zarbock A
• Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans.
  Anesthesia and analgesia 2012 Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA
• Establishment of a Novel System for Studying the Syk Function in B Cells.
  Chembiomolecular Science 2012 Tomohiro Kurosaki, Clifford A. Lowell
• Overview: studying integrins in vivo.
  Methods in molecular biology (Clifton, N.J.) 2012 Lowell CA, Mayadas TN
• B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Ni M, MacFarlane AW, Toft M, Lowell CA, Campbell KS, Hamerman JA
• Transfusion-related acute lung injury: incidence and risk factors.
  Blood 2011 Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, …
• Dynamic Changes in Macrophage Polarization Correlate with Progression and Response in CNS Lymphoma: Insights Into the Transcriptome of Lymphoma-Associated M2 Macrophages,.
  Blood 2011 Cigall Kadoch, Valerie Wong, Lingjing Chen, Anna Bet-Lachin, Ritu Roy, William Hyun, Caroline Behler, Clifford Lowell, James L. Rubenstein
• Genomic and Molecular Properties of Relapsed CNS Lymphoma Using Novel Primary Meningeal Lymphoma Cell Lines and Intracranial Xenografts,.
  Blood 2011 Hua-Xin Gao, Shawn Anderson, Lingjing Chen, Cigall Kadoch, Byron C Hann, Clifford Lowell, Colin Collins, James L. Rubenstein
• Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus.
  Immunity 2011 Zhu JW, Doan K, Park J, Chau AH, Zhang H, Lowell CA, Weiss A
• Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa.
  Journal of leukocyte biology 2011 Xu X, Zhang H, Song Y, Lynch SV, Lowell CA, Wiener-Kronish JP, Caughey GH
• Deletion of Syk in neutrophils prevents immune complex arthritis.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA
• B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA
• Critical role for Syk in responses to vascular injury.
  Blood 2011 Andre P, Morooka T, Sim D, Abe K, Lowell C, Nanda N, Delaney S, Siu G, Yan Y, Hollenbach S, Pandey A, Gao H, Wang Y, Nakajima K, Parikh SA, Shi C, Phillips D, Owen W, Sinha U, Simon DI
• The process of macrophage migration promotes matrix metalloproteinase-independent invasion by tumor cells.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Guiet R, Van Goethem E, Cougoule C, Balor S, Valette A, Al Saati T, Lowell CA, Le Cabec V, Maridonneau-Parini I
• Differential transformation capacity of Src family kinases during the initiation of prostate cancer.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Cai H, Smith DA, Memarzadeh S, Lowell CA, Cooper JA, Witte ON
• BCAP negatively regulates TLR signaling in macrophages (116.13).
  The Journal of Immunology 2011 Minjian Ni, Alexander MacFarlane, Kerry Campbell, Clifford Lowell, Jessica Hamerman
• Neutrophils give us a shock.
  The Journal of clinical investigation 2011 Lowell CA
• Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells.
  Immunity 2011 Ma G, Pan PY, Eisenstein S, Divino CM, Lowell CA, Takai T, Chen SH
• Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk.
  Cold Spring Harbor perspectives in biology 2011 Lowell CA
• IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Nelson MP, Christmann BS, Werner JL, Metz AE, Trevor JL, Lowell CA, Steele C
• Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Kamen LA, Schlessinger J, Lowell CA
• Interferon-γ production by neutrophils during bacterial pneumonia in mice.
  American journal of respiratory and critical care medicine 2010 Yamada M, Gomez JC, Chugh PE, Lowell CA, Dinauer MC, Dittmer DP, Doerschuk CM
• Mechanisms of Pre-B Cell Receptor-Inactivation In Acute Lymphoblastic Leukemia.
  Blood 2010 Cihangir Duy, Daniel Nowak, Lars Klemm, Rahul Nahar, Carina Ng, Emily Elliott, Wolf-Karsten Hofmann, Nora Heisterkamp, Clifford A. Lowell, Phillip Koeffler, Markus Muschen
• SYK Is a Tumor Suppressor In Pre-B Cell Acute Lymphoblastic Leukemia and Not a Therapeutic Target.
  Blood 2010 Carina Ng, Rahul Nahar, Emily Elliott, Clifford A. Lowell, Markus Muschen
• The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.
  Immunity 2010 Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A
• Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.
  The Journal of experimental medicine 2010 Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA
• Interim results of a phase I trial of intraventricular rituximab plus methotrexate in recurrent CNS lymphoma: Macrophage polarization and acquired resistance to therapy.
  Journal of Clinical Oncology 2010 J. L. Rubenstein, C. Kadoch, V. S. Wong, W. Hyun, C. Lowell
• Abstract 2728: Multivariate analysis of cerebrospinal fluid protein biomarkers in central nervous system lymphoma patients and controls.
  Clinical Research 2010 Valerie S. Wong, Lingjing Chen, Cigall Kadoch, Anly Tsang, Lisa Siu, Clifford Lowell, James L. Rubenstein
• Abstract 5580: Macrophage polarization and acquired resistance to rituximab in CNS lymphoma.
  Clinical Research 2010 Cigall Kadoch, Valerie S. Wong, Tara C. Rambaldo, William C. Hyun, Hua Xin Gao, Clifford A. Lowell, James L. Rubenstein
• An important role of the SRC family kinase Lyn in stimulating platelet granule secretion.
  The Journal of biological chemistry 2010 Li Z, Zhang G, Liu J, Stojanovic A, Ruan C, Lowell CA, Du X
• Management practices and phytoremediation by native grasses.
  International journal of phytoremediation 2010 Nedunuri KV, Lowell C, Meade W, Vonderheide AP, Shann JR
• c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.
  FEBS letters 2010 Baruzzi A, Iacobucci I, Soverini S, Lowell CA, Martinelli G, Berton G
• Macrophage Polarization and Acquired Resistance to Rituximab in CNS Lymphoma.
  Blood 2009 Cigall Kadoch, Valerie D. Wong, Tara Rambaldo, William Hyun, Clifford Lowell, James Rubenstein
• Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis.
  Blood 2009 Cougoule C, Le Cabec V, Poincloux R, Al Saati T, Mège JL, Tabouret G, Lowell CA, Laviolette-Malirat N, Maridonneau-Parini I
• The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells.
  Immunological reviews 2009 Hamerman JA, Ni M, Killebrew JR, Chu CL, Lowell CA
• Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.
  The Journal of clinical investigation 2009 Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA
• Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection.
  Blood 2009 Van Ziffle JA, Lowell CA
• Microarray kit analysis of cytokines in blood product units and segments.
  Transfusion 2009 Weiskopf RB, Yau R, Sanchez R, Lowell C, Toy P
• Leukocyte adhesion deficiency syndrome: a controversy solved.
  Immunology and cell biology 2009 Abram CL, Lowell CA
• CalDAG-GEF-I is required for E-selectin-dependent slow leukocyte rolling (94.2).
  The Journal of Immunology 2009 Alexander Zarbock, Helena Mueller, Wolfgang Bergmeier, Clifford A. Lowell, Hugo Van Aken, Denisa D. Wagner, Klaus Ley
• Receptor-independent, lipid dependent mechanism of Syk kinase activation in dendritic cells (134.71).
  The Journal of Immunology 2009 Gilbert Ng, Karan Sharma, Sandra M Ward, Melanie D Desrosiers, Leslie A Stephens, Michael Schoel, Tonglei Li, Clifford A Lowell, Chang-Chun Ling, Matthias W Amrein, Yan Shi
• Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL
• The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina.
  Infection and immunity 2009 Nelson MP, Metz AE, Li S, Lowell CA, Steele C
• Multiple roles of Lyn kinase in myeloid cell signaling and function.
  Immunological reviews 2009 Scapini P, Pereira S, Zhang H, Lowell CA
• TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria.
  Journal of Experimental Medicine 2009 Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, William E. Seaman
• Erratum: Corrigendum: Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.
  Nature Immunology 2009 Jessica A Hamerman, Nadia K Tchao, Clifford A Lowell, Lewis L Lanier
• TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria.
  The Journal of cell biology 2009 N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE
• Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Miller AL, Zhang C, Shokat KM, Lowell CA
• The ins and outs of leukocyte integrin signaling.
  Annual review of immunology 2009 Abram CL, Lowell CA
• Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase.
  Journal of immunology (Baltimore, Md. : 1950) 2008 Sarantos MR, Zhang H, Schaff UY, Dixit N, Hayenga HN, Lowell CA, Simon SI
• Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells.
  Immunity 2008 Ng G, Sharma K, Ward SM, Desrosiers MD, Stephens LA, Schoel WM, Li T, Lowell CA, Ling CC, Amrein MW, Shi Y
• PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.
  The Journal of experimental medicine 2008 Zarbock A, Abram CL, Hundt M, Altman A, Lowell CA, Ley K
• Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling.
  Journal of thrombosis and haemostasis : JTH 2008 Liu J, Joglekar M, Ware J, Fitzgerald ME, Lowell CA, Berndt MC, Gartner TK
• Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase.
  Journal of leukocyte biology 2008 Paul R, Obermaier B, Van Ziffle J, Angele B, Pfister HW, Lowell CA, Koedel U
• Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.
  Blood 2008 Yin H, Liu J, Li Z, Berndt MC, Lowell CA, Du X
• The diverse functions of Src family kinases in macrophages.
  Frontiers in bioscience : a journal and virtual library 2008 Abram CL, Lowell CA
• Immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters DAP12 and FcR? required for E-selectin mediated slow rolling.
  The FASEB Journal 2008 Alexander Zarbock, Clifford A. Lowell, Klaus Ley
• Increased TLR Responses in Dendritic Cells Lacking the Itam-Containing Adapters Dap12 and FcR?.
  The FASEB Journal 2008 Jessica A Hamerman, Yen-Ling Yu, Kuan-Yin Shen, Clifford A Lowell, Lewis L Lanier, Ching-Liang Chu
• Regulation of myeloproliferation and M2 macrophage programming by Lyn/Hck, SHIP and Stat5.
  The FASEB Journal 2008 Wenbin Xiao, Hong Hong, Yuko Kawakami, Clifford A. Lowell, Toshiaki Kawakami
• Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5.
  The Journal of clinical investigation 2008 Xiao W, Hong H, Kawakami Y, Lowell CA, Kawakami T
• Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma.
  European journal of immunology 2008 Chu CL, Yu YL, Shen KY, Lowell CA, Lanier LL, Hamerman JA
• Immunoreceptor-like signaling by beta 2 and beta 3 integrins.
  Trends in cell biology 2007 Jakus Z, Fodor S, Abram CL, Lowell CA, Mócsai A
• Convergence of immunoreceptor and integrin signaling.
  Immunological reviews 2007 Abram CL, Lowell CA
• TRALI--definition, mechanisms, incidence and clinical relevance.
  Best practice & research. Clinical anaesthesiology 2007 Toy P, Lowell C
• Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.
  Immunity 2007 Zarbock A, Lowell CA, Ley K
• The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.
  Blood 2007 Hong H, Kitaura J, Xiao W, Horejsi V, Ra C, Lowell CA, Kawakami Y, Kawakami T
• Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Guo B, Blair D, Chiles TC, Lowell CA, Rothstein TL
• B Cell Receptor Crosstalk: The IL-4-induced Alternate Pathway for BCR Signaling Operates in Parallel with the Classical Pathway, Is Sensitive to Rottlerin, and Depends on Lyn (86.14).
  The Journal of Immunology 2007 Benchang Guo, Derek Blair, Thomas Chiles, Clifford Lowell, Thomas Rothstein
• Inhibition of Toll-like receptor and Fc receptor responses in macrophages by TREM-2 and DAP12 (44.7).
  The Journal of Immunology 2007 Jessica A Hamerman, Jessica R Jarjoura, Nadia K Tchao, Mary Beth Humphrey, Mary C Nakamura, Clifford A Lowell, William E Seaman, Lewis L Lanier
• The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Fumagalli L, Zhang H, Baruzzi A, Lowell CA, Berton G
• The expanding role for ITAM-based signaling pathways in immune cells.
  Science's STKE : signal transduction knowledge environment 2007 Abram CL, Lowell CA
• Microarray analysis of a mouse model of transfusion-related acute lung injury (TRALI) reveals prominent increased expression of neutrophil-derived chemokines.
  The FASEB Journal 2007 Mark R Looney, Rebecca Barbeau, Andrea Barczak, Yuanyuan Xiao, Clifford A Lowell, David J Erle, Michael A Matthay
• Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.
  The Journal of experimental medicine 2006 Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH
• Src family kinases mediate neutrophil adhesion to adherent platelets.
  Blood 2006 Evangelista V, Pamuklar Z, Piccoli A, Manarini S, Dell'elba G, Pecce R, Martelli N, Federico L, Rojas M, Berton G, Lowell CA, Totani L, Smyth SS
• Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs.
  Nature immunology 2006 Mócsai A, Abram CL, Jakus Z, Hu Y, Lanier LL, Lowell CA
• Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils.
  Immunity 2006 Zhang H, Schaff UY, Green CE, Chen H, Sarantos MR, Hu Y, Wara D, Simon SI, Lowell CA
• Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.
  Immunity 2006 Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN
• The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in sustained adhesion.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Giagulli C, Ottoboni L, Caveggion E, Rossi B, Lowell C, Constantin G, Laudanna C, Berton G
• Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis.
  Blood 2006 Mermel CH, McLemore ML, Liu F, Pereira S, Woloszynek J, Lowell CA, Link DC
• Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury.
  The Journal of clinical investigation 2006 Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA
• Lyn kinase promotes erythroblast expansion and late-stage development.
  Blood 2006 Karur VG, Lowell CA, Besmer P, Agosti V, Wojchowski DM
• Src-family kinases mediate an outside-in signal necessary for beta2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin.
  The Biochemical journal 2006 Totani L, Piccoli A, Manarini S, Federico L, Pecce R, Martelli N, Cerletti C, Piccardoni P, Lowell CA, Smyth SS, Berton G, Evangelista V
• A role for PKCtheta in outside-in alpha(IIb)beta3 signaling.
  Journal of thrombosis and haemostasis : JTH 2006 Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ
• Rewiring phagocytic signal transduction.
  Immunity 2006 Lowell CA
• Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Yu M, Lowell CA, Neel BG, Gu H
• Beautiful blistering.
  Blood 2006 Clifford A. Lowell
• Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr.
  Blood 2006 Sasanuma H, Tatsuno A, Hidano S, Ohshima K, Matsuzaki Y, Hayashi K, Lowell CA, Kitamura D, Goitsuka R
• Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Hernandez-Hansen V, Bard JD, Tarleton CA, Wilder JA, Lowell CA, Wilson BS, Oliver JM
• Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Xiao W, Nishimoto H, Hong H, Kitaura J, Nunomura S, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Ra C, Kawakami T
• Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes.
  Pflugers Archiv : European journal of physiology 2005 De Franceschi L, Villa-Moruzzi E, Biondani A, Siciliano A, Brugnara C, Alper SL, Lowell CA, Berton G
• G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth.
  Blood 2005 Zhu QS, Xia L, Mills GB, Lowell CA, Touw IP, Corey SJ
• The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4.
  Biochemical pharmacology 2005 Lee JY, Lowell CA, Lemay DG, Youn HS, Rhee SH, Sohn KH, Jang B, Ye J, Chung JH, Hwang DH
• The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Chu CL, Lowell CA
• Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.
  Blood 2005 Underhill DM, Rossnagle E, Lowell CA, Simmons RM
• Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.
  Nature immunology 2005 Hamerman JA, Tchao NK, Lowell CA, Lanier LL
• Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Kitaura J, Eto K, Kinoshita T, Kawakami Y, Leitges M, Lowell CA, Kawakami T
• Src and Syk kinases: key regulators of phagocytic cell activation.
  Trends in immunology 2005 Berton G, Mócsai A, Lowell CA
• Minimum conditions of major histocompatibility complex compatibility and recipient immune compromise required to establish donor white blood cell persistence in a murine transfusion model.
  Transfusion 2005 Lee TH, Wen L, Montalvo L, Esho O, Lowell C, Reed W, Busch M
• The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.
  Immunity 2005 Zhang H, Meng F, Chu CL, Takai T, Lowell CA
• The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.
  Experimental cell research 2005 Continolo S, Baruzzi A, Majeed M, Caveggion E, Fumagalli L, Lowell CA, Berton G
• IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion.
  Blood 2005 Kitaura J, Kinoshita T, Matsumoto M, Chung S, Kawakami Y, Leitges M, Wu D, Lowell CA, Kawakami T
• Lyn Kinase Supports Primary Erythroid Progenitor Cell Development.
  Blood 2004 Vinit Karur, Bethany Vincent, Clifford Lowell, Don M. Wojchowski
• The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Pereira S, Zhang H, Takai T, Lowell CA
• Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors.
  Nature immunology 2004 Tassiulas I, Hu X, Ho H, Kashyap Y, Paik P, Hu Y, Lowell CA, Ivashkiv LB
• Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Kitaura J, Xiao W, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Kawakami T
• Responses of neutrophils to anti-integrin antibodies depends on costimulation through low affinity Fc gamma Rs: full activation requires both integrin and nonintegrin signals.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Jakus Z, Berton G, Ligeti E, Lowell CA, Mócsai A
• Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Hernandez-Hansen V, Smith AJ, Surviladze Z, Chigaev A, Mazel T, Kalesnikoff J, Lowell CA, Krystal G, Sklar LA, Wilson BS, Oliver JM
• Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury.
  The Journal of clinical investigation 2004 Chou WH, Choi DS, Zhang H, Mu D, McMahon T, Kharazia VN, Lowell CA, Ferriero DM, Messing RO
• Src-family kinases: rheostats of immune cell signaling.
  Molecular immunology 2004 Lowell CA
• CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Scapini P, Morini M, Tecchio C, Minghelli S, Di Carlo E, Tanghetti E, Albini A, Lowell C, Berton G, Noonan DM, Cassatella MA
• The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC
• SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils.
  Immunity 2003 Newbrough SA, Mocsai A, Clemens RA, Wu JN, Silverman MA, Singer AL, Lowell CA, Koretzky GA
• Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Kitaura J, Song J, Tsai M, Asai K, Maeda-Yamamoto M, Mocsai A, Kawakami Y, Liu FT, Lowell CA, Barisas BG, Galli SJ, Kawakami T
• The Src kinase Lyn is a negative regulator of mast cell proliferation.
  Journal of leukocyte biology 2003 Hernandez-Hansen V, Mackay GA, Lowell CA, Wilson BS, Oliver JM
• Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice.
  Journal of immunology (Baltimore, Md. : 1950) 2003 Whyburn LR, Halcomb KE, Contreras CM, Lowell CA, Witte ON, Satterthwaite AB
• The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
  Journal of immunology (Baltimore, Md. : 1950) 2003 Pereira S, Lowell C
• Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading.
  Immunity 2003 Chen H, Mocsai A, Zhang H, Ding RX, Morisaki JH, White M, Rothfork JM, Heiser P, Colucci-Guyon E, Lowell CA, Gresham HD, Allen PM, Brown EJ
• Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement.
  Journal of cellular physiology 2003 Caveggion E, Continolo S, Pixley FJ, Stanley ER, Bowtell DD, Lowell CA, Berton G
• Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development.
  Nature immunology 2003 Saijo K, Schmedt C, Su IH, Karasuyama H, Lowell CA, Reth M, Adachi T, Patke A, Santana A, Tarakhovsky A
• G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells.
  Blood 2003 Mócsai A, Zhang H, Jakus Z, Kitaura J, Kawakami T, Lowell CA
• Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.
  Science (New York, N.Y.) 2003 Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsai A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, Kahn ML
• Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
  The Journal of cell biology 2002 Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ
• Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin.
  Blood 2002 Cho MJ, Pestina TI, Steward SA, Lowell CA, Jackson CW, Gartner TK
• Non-immunogenic murine hepatocellular carcinoma Hepa1-6 cells expressing the membrane form of macrophage colony stimulating factor are rejected in vivo and lead to CD8+ T-cell immunity against the parental tumor.
  Molecular therapy : the journal of the American Society of Gene Therapy 2001 Dan Q, Sanchez R, Delgado C, Wepsic HT, Morgan K, Chen Y, Jeffes EW, Lowell CA, Morgan TR, Jadus MR
• Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion.
  Journal of leukocyte biology 2001 Majeed M, Caveggion E, Lowell CA, Berton G
• The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.
  Journal of virology 2001 Hanna Z, Weng X, Kay DG, Poudrier J, Lowell C, Jolicoeur P
• Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.
  Blood 2001 O'Laughlin-Bunner B, Radosevic N, Taylor ML, DeBerry C, Metcalfe DD, Zhou M, Lowell C, Linnekin D
• Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases.
  Journal of immunology (Baltimore, Md. : 1950) 2001 Pereira S, Zhou M, Mócsai A, Lowell C
• Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn.
  Current biology : CB 2001 Yu CC, Yen TS, Lowell CA, DeFranco AL
• Fyn and Lyn phosphorylate the Fc receptor ? chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway.
  Blood 2000 Lynn S. Quek, Jean-Max Pasquet, Ingeborg Hers, Richard Cornall, Graham Knight, Michael Barnes, Margaret L. Hibbs, Ashley R. Dunn, Clifford A. Lowell, Steve P. Watson
• Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway.
  Blood 2000 Quek LS, Pasquet JM, Hers I, Cornall R, Knight G, Barnes M, Hibbs ML, Dunn AR, Lowell CA, Watson SP
• Evidence of a role for SHP-1 in platelet activation by the collagen receptor glycoprotein VI.
  The Journal of biological chemistry 2000 Pasquet JM, Quek L, Pasquet S, Poole A, Matthews JR, Lowell C, Watson SP
• Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.
  Journal of immunology (Baltimore, Md. : 1950) 2000 Kawakami Y, Kitaura J, Satterthwaite AB, Kato RM, Asai K, Hartman SE, Maeda-Yamamoto M, Lowell CA, Rawlings DJ, Witte ON, Kawakami T
• CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification.
  Immunity 2000 Fujimoto M, Fujimoto Y, Poe JC, Jansen PJ, Lowell CA, DeFranco AL, Tedder TF
• Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Kawakami Y, Kitaura J, Hartman SE, Lowell CA, Siraganian RP, Kawakami T
• A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Satterthwaite AB, Willis F, Kanchanastit P, Fruman D, Cantley LC, Helgason CD, Humphries RK, Lowell CA, Simon M, Leitges M, Tarakhovsky A, Tedder TF, Lesche R, Wu H, Witte ON
• Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases.
  Journal of immunology (Baltimore, Md. : 1950) 2000 Mócsai A, Jakus Z, Vántus T, Berton G, Lowell CA, Ligeti E
• Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta.
  Journal of leukocyte biology 2000 Weinstein SL, Finn AJ, Davé SH, Meng F, Lowell CA, Sanghera JS, DeFranco AL
• Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.
  The Journal of experimental medicine 2000 Fitzer-Attas CJ, Lowry M, Crowley MT, Finn AJ, Meng F, DeFranco AL, Lowell CA
• Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr.
  The Journal of experimental medicine 2000 Gresham HD, Dale BM, Potter JW, Chang PW, Vines CM, Lowell CA, Lagenaur CF, Willman CL
• Flow cytometric detection of CD10 (cALLA) on peripheral blood B lymphocytes of neonates.
  British journal of haematology 1999 Brady KA, Atwater SK, Lowell CA
• Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages.
  Journal of cell science 1999 Suen PW, Ilic D, Caveggion E, Berton G, Damsky CH, Lowell CA
• Integrin signalling in neutrophils and macrophages.
  Cellular signalling 1999 Berton G, Lowell CA
• Integrin signal transduction in myeloid leukocytes.
  Journal of leukocyte biology 1999 Lowell CA, Berton G
• Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck.
  Journal of immunology (Baltimore, Md. : 1950) 1999 Mócsai A, Ligeti E, Lowell CA, Berton G
• Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
  The Journal of experimental medicine 1998 Satterthwaite AB, Lowell CA, Khan WN, Sideras P, Alt FW, Witte ON
• A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.
  The EMBO journal 1998 Meng F, Lowell CA
• Positive and negative roles of the tyrosine kinase Lyn in B cell function.
  Seminars in immunology 1998 DeFranco AL, Chan VW, Lowell CA
• The molecular mechanism of B cell activation by toll-like receptor protein RP-105.
  The Journal of experimental medicine 1998 Chan VW, Mecklenbräuker I, Su I, Texido G, Leitges M, Carsetti R, Lowell CA, Rajewsky K, Miyake K, Tarakhovsky A
• Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Lowell CA, Berton G
• Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes.
  Current biology : CB 1998 Chan VW, Lowell CA, DeFranco AL
• Macrophages kill T9 glioma tumor cells bearing the membrane isoform of macrophage colony stimulating factor through a phagocytosis-dependent pathway.
  Journal of immunology (Baltimore, Md. : 1950) 1998 Jadus MR, Williams CC, Avina MD, Ly M, Kim S, Liu Y, Narasaki R, Lowell CA, Wepsic HT
• Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.
  Genes & development 1997 Schwartzberg PL, Xing L, Hoffmann O, Lowell CA, Garrett L, Boyce BF, Varmus HE
• A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages.
  The Journal of experimental medicine 1997 Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, Tybulewicz VL, DeFranco AL
• Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.
  Immunity 1997 Chan VW, Meng F, Soriano P, DeFranco AL, Lowell CA
• Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn.
  The Journal of experimental medicine 1997 Meng F, Lowell CA
• Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport.
  The Journal of clinical investigation 1997 De Franceschi L, Fumagalli L, Olivieri O, Corrocher R, Lowell CA, Berton G
• Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.
  Genes & development 1996 Lowell CA, Soriano P
• Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.
  The Journal of cell biology 1996 Lowell CA, Fumagalli L, Berton G
• Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis.
  Blood 1996 CA Lowell, M Niwa, P Soriano, HE Varmus
• Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis.
  Blood 1996 Lowell CA, Niwa M, Soriano P, Varmus HE
• Neutrophil activation by adhesion: mechanisms and pathophysiological implications.
  International journal of clinical & laboratory research 1996 Berton G, Yan SR, Fumagalli L, Lowell CA
• Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity.
  Genes & development 1994 Lowell CA, Soriano P, Varmus HE
• Cancer genes and hematopoiesis.
  Blood 1994 Varmus HE, Lowell CA
• Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2.
  The Journal of experimental medicine 1989 Lowell CA, Klickstein LB, Carter RH, Mitchell JA, Fearon DT, Ahearn JM
• Sucrose-metabolizing enzymes in transport tissues and adjacent sink structures in developing citrus fruit.
  Plant physiology 1989 Lowell CA, Tomlinson PT, Koch KE
• Fenoprofen-induced immune hemolysis. Difficulties in diagnosis and complications in compatibility testing.
  American journal of clinical pathology 1988 Shirey RS, Morton SJ, Lawton KB, Lowell C, Kickler TS, Ness PM
• Structure of the murine serum amyloid A gene family. Gene conversion.
  The Journal of biological chemistry 1986 Lowell CA, Potter DA, Stearman RS, Morrow JF
• Transcriptional regulation of serum amyloid A gene expression.
  The Journal of biological chemistry 1986 Lowell CA, Stearman RS, Morrow JF
• The sequence and structure of a new serum amyloid A gene.
  Nucleic acids research 1986 Stearman RS, Lowell CA, Peltzman CG, Morrow JF
• Regulation of synthesis of amyloid A-related protein.
  Annals of the New York Academy of Sciences 1982 Stearman RS, Lowell CA, Pearson WR, Morrow JF
• Mechanism of mitochondrial DNA replication in mouse L-cells. Replication of unicircular dimer molecules.
  Journal of molecular biology 1981 Bogenhagen D, Lowell C, Clayton DA
• S1 nuclease-specific nicking of mitochondrial DNA containing displacement loops.
  Analytical biochemistry 1978 Lowell C, Bogenhagen D, Clayton DA
• Topical anesthetic effectiveness. An old and new product evaluated.
  The New York journal of dentistry 1972 Howitt JW, Lowell C
• Topical anesthetic effectiveness. An old and new product evaluated.
  The New York state dental journal 1972 Howitt JW, Lowell C