Clay Gustafson, MD, PhD
Associate Clinical Professor
Pediatrics
School of Medicine

Awards

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• ALSF "A" Award, Alex's Lemonade Stand, 2012-2014

Education & Training

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• Hematology/Oncology Fellowship Pediatric Hematology/Oncology University of California San Francisco 2012
• Pediatrics Residency Pediatrics University of Texas Southwestern 2008
• MD, PhD Medicine/Biochemistry and Genetics University of Texas Medical Branch 2005
• BA Biochemistry/English Literature Rice University, Houston, Texas 1996

Interests

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• I131-MIBG
• Novel Therapeutics for Childhood Cancer
• Pediatric Solid Tumors
• MYC and MYCN signaling in cancer
• Neuroblastoma

Websites

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• Gustafson Lab Site (gustafsonlab.ucsf.edu)

Publications (39)

Top publication keywords:
Phenylurea CompoundsProto-Oncogene Proteins c-mycGenes, mycTumor Suppressor Protein p53Gene AmplificationProtein Kinase CProtein Kinase InhibitorsIsoenzymesNeuroblastoma3-IodobenzylguanidineNuclear ProteinsOncogene ProteinsAurora Kinase AN-Myc Proto-Oncogene ProteinGene Expression Regulation, Neoplastic

• Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer.
  Frontiers in oncology 2015 Cage TA, Chanthery Y, Chesler L, Grimmer M, Knight Z, Shokat K, Weiss WA, Gustafson WC
• Drugging MYCN through an allosteric transition in Aurora kinase A.
  Cancer cell 2014 Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA
• Targeting MYCN in neuroblastoma by BET bromodomain inhibition.
  Cancer discovery 2013 Puissant A, Frumm SM, Alexe G, Bassil CF, Qi J, Chanthery YH, Nekritz EA, Zeid R, Gustafson WC, Greninger P, Garnett MJ, McDermott U, Benes CH, Kung AL, Weiss WA, Bradner JE, Stegmaier K
• Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma.
  Science translational medicine 2012 Chanthery YH, Gustafson WC, Itsara M, Persson A, Hackett CS, Grimmer M, Charron E, Yakovenko S, Kim G, Matthay KK, Weiss WA
• The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53.
  Neoplasia (New York, N.Y.) 2021 Yi JS, Sias-Garcia O, Nasholm N, Hu X, Iniguez AB, Hall MD, Davis M, Guha R, Moreno-Smith M, Barbieri E, Duong K, Koach J, Qi J, Bradner JE, Stegmaier K, Weiss WA, Gustafson WC

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• Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.
  Cancer research 2021 Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GH, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, …
• 124I-MIBG PET/CT to Monitor Metastatic Disease in Children with Relapsed Neuroblastoma.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2020 Aboian MS, Huang SY, Hernandez-Pampaloni M, Hawkins RA, VanBrocklin HF, Huh Y, Vo KT, Gustafson WC, Matthay KK, Seo Y
• Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface.
  Cancer research 2019 Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, …
• Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.
  Cancer cell 2019 Zhang L, He X, Liu X, Zhang F, Huang LF, Potter AS, Xu L, Zhou W, Zheng T, Luo Z, Berry KP, Pribnow A, Smith SM, Fuller C, Jones BV, Fouladi M, Drissi R, Yang ZJ, Gustafson WC, Remke M, Pomeroy SL, …
• Technical Note: Simplified and practical pretherapy tumor dosimetry - A feasibility study for 131 I-MIBG therapy of neuroblastoma using 124 I-MIBG PET/CT.
  Medical physics 2019 Seo Y, Huh Y, Huang SY, Hernandez-Pampaloni JM, Hawkins RA, Gustafson WC, Vo KT, Matthay KK
• CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.
  The Journal of clinical investigation 2017 Chen L, Alexe G, Dharia NV, Ross L, Iniguez AB, Conway AS, Wang EJ, Veschi V, Lam N, Qi J, Gustafson WC, Nasholm N, Vazquez F, Weir BA, Cowley GS, Ali LD, Pantel S, Jiang G, Harrington WF, Lee Y, …
• Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors.
  Oncotarget 2017 Vo KT, Karski EE, Nasholm NM, Allen S, Hollinger F, Gustafson WC, Long-Boyle JR, Shiboski S, Matthay KK, DuBois SG
• A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.
  Cancer cell 2017 Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA
• Erratum to: Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group.
  European journal of nuclear medicine and molecular imaging 2016 Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Parisi MT, Shulkin BL, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG
• N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.
  Cancer cell 2016 Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, Witte ON
• Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo.
  Protein science : a publication of the Protein Society 2015 Yu D, Dong Z, Gustafson WC, Ruiz-González R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X
• Extended Sedation With Continuous Midazolam or Dexmedetomidine Infusion for Young Children Receiving 131 I-MIBG Radiopharmaceutical Therapy for Advanced Neuroblastoma.
  Pediatric blood & cancer 2015 Lee JS, Wu R, Wong T, DuBois SG, Matthay K, Gustafson C, Hawkins R, Roy-Burman A
• Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group.
  European journal of nuclear medicine and molecular imaging 2015 Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG
• A new "angle" on kinase inhibitor design: Prioritizing amphosteric activity above kinase inhibition.
  Molecular & cellular oncology 2015 Meyerowitz JG, Weiss WA, Gustafson WC
• The genetics of splicing in neuroblastoma.
  Cancer discovery 2015 Chen J, Hackett CS, Zhang S, Song YK, Bell RJ, Molinaro AM, Quigley DA, Balmain A, Song JS, Costello JF, Gustafson WC, Van Dyke T, Kwok PY, Khan J, Weiss WA
• Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.
  Cell reports 2014 Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T, Kwok PY, …
• An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging.
  Nature communications 2014 Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X
• Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma.
  Science (New York, N.Y.) 2013 Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY, Fouse SD, Yamamoto S, Ueda H, Tatsuno K, Asthana S, Jalbert LE, Nelson SJ, Bollen AW, Gustafson WC, Charron E, Weiss WA, Smirnov IV, Song JS…
• EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
  Cancer cell 2013 Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA
• Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model.
  Molecular imaging and biology 2012 Seo Y, Gustafson WC, Dannoon SF, Nekritz EA, Lee CL, Murphy ST, VanBrocklin HF, Hernandez-Pampaloni M, Haas-Kogan DA, Weiss WA, Matthay KK
• Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW
• Progress towards personalized therapeutics: biologic- and risk-directed therapy for neuroblastoma.
  Expert review of neurotherapeutics 2011 Gustafson WC, Matthay KK
• Addiction to B-MYB.
  Oncotarget 2010 Gustafson WC, Weiss WA
• Myc proteins as therapeutic targets.
  Oncogene 2010 Gustafson WC, Weiss WA
• Role of gastrointestinal hormones in neuroblastoma.
  World journal of surgery 2005 Gustafson WC, De Berry BB, Evers BM, Chung DH
• Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis.
  The Journal of biological chemistry 2004 Ray S, Lu Y, Kaufmann SH, Gustafson WC, Karp JE, Boldogh I, Fields AP, Brasier AR
• Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter.
  The Journal of biological chemistry 2003 Gustafson WC, Ray S, Jamieson L, Thompson EA, Brasier AR, Fields AP
• Characterization of the role of protein kinase C isozymes in colon carcinogenesis using transgenic mouse models.
  Methods in molecular biology (Clifton, N.J.) 2003 Fields AP, Murray NR, Gustafson WC
• Genomic analysis of glucocorticoid-regulated promoters in murine T-lymphoma cells.
  Recent progress in hormone research 2003 Chen L, Finnerty C, Gustafson WC, Bush CR, Chi P, Guo H, Luxon B, Fields AP, Thompson EA
• Protein kinase C in disease: cancer.
  Methods in molecular biology (Clifton, N.J.) 2003 Fields AP, Gustafson WC
• Comparison of GLUT1, GLUT3, and GLUT4 mRNA and the subcellular distribution of their proteins in normal human muscle.
  Metabolism: clinical and experimental 2000 Stuart CA, Wen G, Gustafson WC, Thompson EA
• Nucleolar protein p120 contains an arginine-rich domain that binds to ribosomal RNA.
  The Biochemical journal 1998 Gustafson WC, Taylor CW, Valdez BC, Henning D, Phippard A, Ren Y, Busch H, Durban E
• Overexpression of human nucleolar proteins in insect cells: characterization of nucleolar protein p120.
  Protein expression and purification 1996 Ren Y, Busch R, Durban E, Taylor C, Gustafson WC, Valdez B, Li YP, Smetana K, Busch H
• Functional domains of nucleolar phosphoprotein p120.
  Physiological chemistry and physics and medical NMR 1995 Durban E, Valdez BC, Gustafson WC, Taylor CW, Cardellini E, Busch H