Claire Brett, MD
Professor
Anesthesia
School of Medicine

Education & Training

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• Residency School of Medicine University of California, San Francisco

Websites

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• Clinical Profile at UCSF Benioff Children's Hospital (ucsfbenioffchildrens.org)

Publications (39)

Top publication keywords:
Organic Anion Transporters, Sodium-IndependentSodiumOrganic Cation Transport ProteinsSheepKidneyHypoglycemic AgentsHEK293 CellsOrganic Cation Transporter 1DigoxinChoroid PlexusTaurineMetforminVerapamilNucleosidesPharmacogenetics

• Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat.
  Journal of veterinary pharmacology and therapeutics 2023 Azimi M, Yee SW, Riselli A, Silva DB, Giacomini CP, Giacomini KM, Brett CM
• The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.
  Clinical pharmacokinetics 2016 Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM
• The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers.
  Clinical pharmacokinetics 2016 Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM
• Outcomes for extremely premature infants.
  Anesthesia and analgesia 2015 Glass HC, Costarino AT, Stayer SA, Brett CM, Cladis F, Davis PJ
• Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.
  Clinical pharmacology and therapeutics 2014 Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM

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• Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8).
  Journal of pharmaceutical sciences 2013 Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM
• The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.
  Clinical pharmacology and therapeutics 2012 Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini KM
• Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.
  Pharmacogenetics and genomics 2009 Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM
• Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.
  Clinical pharmacology and therapeutics 2007 Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM
• Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin.
  Clinical pharmacology and therapeutics 2007 Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Burchard EG, Giacomini KM
• Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
  The Journal of clinical investigation 2007 Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG, Brett CM, Giacomini KM
• The pharmacogenetics research network: from SNP discovery to clinical drug response.
  Clinical pharmacology and therapeutics 2007 Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA,…
• Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5).
  Molecular pharmacology 2006 Urban TJ, Gallagher RC, Brown C, Castro RA, Lagpacan LL, Brett CM, Taylor TR, Carlson EJ, Ferrin TE, Burchard EG, Packman S, Giacomini KM
• Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants.
  The Journal of pharmacology and experimental therapeutics 2006 Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM
• PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters.
  Pharmacological reviews 2006 Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, Carlson EJ, Ferrin TE, Brett CM, Burchard …
• The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.
  American journal of physiology. Renal physiology 2005 Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM
• Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).
  Pharmacogenetics and genomics 2005 Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, Huang CC, Leabman MK, Giacomini KM
• Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3).
  The pharmacogenomics journal 2005 Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM
• No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects.
  Clinical pharmacology and therapeutics 2003 Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL
• Nucleoside transport in isolated human and rhesus choroid plexus tissue slices.
  Pharmaceutical research 1998 Washington CB, Giacomini KM, Brett CM
• Role of organic cation transporters in drug absorption and elimination.
  Annual review of pharmacology and toxicology 1998 Zhang L, Brett CM, Giacomini KM
• Na+-dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit.
  Biochimica et biophysica acta 1997 Ramanathan VK, Brett CM, Giacomini KM
• Taurine transport in cultured choroid plexus.
  Pharmaceutical research 1997 Ramanathan VK, Chung SJ, Giacomini KM, Brett CM
• Primary cell culture of the rabbit choroid plexus: an experimental system to investigate membrane transport.
  Pharmaceutical research 1996 Ramanathan VK, Hui AC, Brett CM, Giacomini KM
• Saturable disposition of taurine in the rat cerebrospinal fluid.
  The Journal of pharmacology and experimental therapeutics 1996 Chung SJ, Ramanathan VK, Brett CM, Giacomini KM
• Isolated renal brush border and basolateral membrane vesicles and cultured renal cells.
  Pharmaceutical biotechnology 1996 Gutierrez MM, Brett CM, Giacomini KM
• Methods of study drug transport in isolated choroid plexus tissue and cultured cells.
  Pharmaceutical biotechnology 1996 Washington CB, Giacomini KM, Brett CM
• The effect of N-ethylmaleimide on the Na(+)-dependent nucleoside transporter (N3) in rabbit choroid plexus.
  The Journal of pharmacology and experimental therapeutics 1995 Washington CB, Brett CM, Wu X, Giacomini KM
• Characterization of a sodium-dependent taurine transporter in rabbit choroid plexus.
  Biochimica et biophysica acta 1994 Chung SJ, Ramanathan V, Giacomini KM, Brett CM
• Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine.
  Drug metabolism and disposition: the biological fate of chemicals 1993 Cashman JR, Park SB, Yang ZC, Washington CB, Gomez DY, Giacomini KM, Brett CM
• Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney.
  Pharmaceutical research 1993 Brett CM, Washington CB, Ott RJ, Gutierrez MM, Giacomini KM
• Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides.
  The Journal of biological chemistry 1992 Wu X, Yuan G, Brett CM, Hui AC, Giacomini KM
• Nucleoside transport in brush border membrane vesicles from human kidney.
  Biochimica et biophysica acta 1992 Gutierrez MM, Brett CM, Ott RJ, Hui AC, Giacomini KM
• The young lamb can increase cardiovascular performance during isoflurane anesthesia.
  Anesthesiology 1989 Brett CM, Teitel DF, Heymann MA, Rudolph AM
• Pre-induction of anesthesia in pediatric patients with nasally administered sufentanil.
  Anesthesiology 1988 Henderson JM, Brodsky DA, Fisher DM, Brett CM, Hertzka RE
• Short-term hemodynamic effects of captopril in infants with congestive heart failure.
  American journal of diseases of children (1960) 1988 Shaddy RE, Teitel DF, Brett C
• Thiopental dose-response relations in unpremedicated infants, children, and adults.
  Anesthesia and analgesia 1987 Brett CM, Fisher DM
• The cardiovascular effects of isoflurane in lambs.
  Anesthesiology 1987 Brett CM, Teitel DF, Heymann MA, Rudolph AM
• Comparison of enflurane, halothane, and isoflurane for diagnostic and therapeutic procedures in children with malignancies.
  Anesthesiology 1985 Fisher DM, Robinson S, Brett CM, Perin G, Gregory GA