Chukwuka Didigu, MD, PhD
Clinical Fellow
Medicine
School of Medicine

Publications (10)

Top publication keywords:
Receptors, CXCR4Genetic TherapyHIV InfectionsCyclohexanesVirus InternalizationHIVHost-Pathogen InteractionsHIV-1EndodeoxyribonucleasesReceptors, CCR5TriazolesZinc FingersCD4-Positive T-LymphocytesCCR5 Receptor AntagonistsHantavirus Infections

• Gene therapy targeting HIV entry.
  Viruses 2014 Didigu C, Doms R
• The major cellular sterol regulatory pathway is required for Andes virus infection.
  PLoS pathogens 2014 Petersen J, Drake MJ, Bruce EA, Riblett AM, Didigu CA, Wilen CB, Malani N, Male F, Lee FH, Bushman FD, Cherry S, Doms RW, Bates P, Briley K
• Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.
  Blood 2013 Didigu CA, Wilen CB, Wang J, Duong J, Secreto AJ, Danet-Desnoyers GA, Riley JL, Gregory PD, June CH, Holmes MC, Doms RW
• IL-31 is produced by the malignant T-cell population in cutaneous T-Cell lymphoma and correlates with CTCL pruritus.
  The Journal of investigative dermatology 2013 Singer EM, Shin DB, Nattkemper LA, Benoit BM, Klein RS, Didigu CA, Loren AW, Dentchev T, Wysocka M, Yosipovitch G, Rook AH
• Quantitative phosphoproteomics reveals extensive cellular reprogramming during HIV-1 entry.
  Cell host & microbe 2013 Wojcechowskyj JA, Didigu CA, Lee JY, Parrish NF, Sinha R, Hahn BH, Bushman FD, Jensen ST, Seeholzer SH, Doms RW

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• Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5.
  Journal of virology 2012 Parker ZF, Iyer SS, Wilen CB, Parrish NF, Chikere KC, Lee FH, Didigu CA, Berro R, Klasse PJ, Lee B, Moore JP, Shaw GM, Hahn BH, Doms RW
• Kruppel-like factor 2 modulates CCR5 expression and susceptibility to HIV-1 infection.
  Journal of immunology (Baltimore, Md. : 1950) 2012 Richardson MW, Jadlowsky J, Didigu CA, Doms RW, Riley JL
• Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth.
  Developmental cell 2012 Zheng X, Xu C, Smith AO, Stratman AN, Zou Z, Kleaveland B, Yuan L, Didiku C, Sen A, Liu X, Skuli N, Zaslavsky A, Chen M, Cheng L, Davis GE, Kahn ML
• Novel approaches to inhibit HIV entry.
  Viruses 2012 Didigu CA, Doms RW
• A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5.
  Journal of virology 2010 Tilton JC, Wilen CB, Didigu CA, Sinha R, Harrison JE, Agrawal-Gamse C, Henning EA, Bushman FD, Martin JN, Deeks SG, Doms RW