Christopher Tinkle, MD, PhD
Assistant Member
Neurology
School of Medicine

Publications (53)

Top publication keywords:
Radiotherapy, Image-GuidedMedulloblastomaRadiotherapy, ConformalMeningeal CarcinomatosisBrachytherapyRhabdomyosarcomaNeoplasm Recurrence, LocalCerebellar NeoplasmsSarcomaGliomaBone NeoplasmsBrain NeoplasmsCranial IrradiationBrain Stem NeoplasmsCraniospinal Irradiation

• PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma.
  The Journal of clinical investigation 2024 Duchatel RJ, Jackson ER, Parackal SG, Kiltschewskij D, Findlay IJ, Mannan A, Staudt DE, Thomas BC, Germon ZP, Laternser S, Kearney PS, Jamaluddin MFB, Douglas AM, Beitaki T, McEwen HP, Persson ML, …
• ATM inhibition enhances the efficacy of radiation across distinct molecular subgroups of pediatric high-grade glioma.
  Neuro-oncology 2023 Xie J, Kuriakose T, Bianski B, Twarog N, Savage E, Xu K, Zhu X, He C, Hansen B, Wang H, High A, Li Y, Rehg JE, Tillman HS, Freeman BB, Rankovic Z, Onar-Thomas A, Fan Y, Wu G, Peng J, Miller S, Baker …
• Correlation between Multiparametric MR Imaging and Molecular Genetics in Pontine Pediatric High-Grade Glioma.
  AJNR. American journal of neuroradiology 2023 Rameh V, Vajapeyam S, Ziaei A, Kao P, London WB, Baker SJ, Chiang J, Lucas J, Tinkle CL, Wright KD, Poussaint TY
• Response assessment in pediatric craniopharyngioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) Working Group.
  Neuro-oncology 2023 Hoffman LM, Jaimes C, Mankad K, Mirsky DM, Tamrazi B, Tinkle CL, Kline C, Ramasubramanian A, Malbari F, Mangum R, Lindsay H, Horne V, Daniels DJ, Keole S, Grosshans DR, Young Poussaint T, Packer R, …
• Efficacy and Safety of Stereotactic Body Radiation Therapy for Pediatric Malignancies: The LITE-SABR Systematic Review and Meta-Analysis.
  Advances in radiation oncology 2023 Singh R, Valluri A, Didwania P, Lehrer EJ, Baliga S, Hiniker S, Braunstein SE, Murphy ES, Lazarev S, Tinkle C, Terezakis S, Palmer JD

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• Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children's Research Hospital including the multi-center SJYC07 and SJMB03 clinical trials.
  Acta neuropathologica 2022 Liu APY, Dhanda SK, Lin T, Sioson E, Vasilyeva A, Gudenas B, Tatevossian RG, Jia S, Neale G, Bowers DC, Hassall T, Partap S, Crawford JR, Chintagumpala M, Bouffet E, McCowage G, Broniscer A, Qaddoumi …
• Revised clinical and molecular risk strata define the incidence and pattern of failure in medulloblastoma following risk-adapted radiotherapy and dose-intensive chemotherapy: results from a phase III multi-institutional study.
  Neuro-oncology 2022 Lucas JT, Tinkle CL, Huang J, Onar-Thomas A, Srinivasan S, Tumlin P, Becksfort JB, Klimo P, Boop FA, Robinson GW, Orr BA, Harreld JH, Krasin MJ, Northcott PA, Ellison DW, Gajjar A, Merchant TE
• Convergent evolution and multi-wave clonal invasion in H3 K27-altered diffuse midline gliomas treated with a PDGFR inhibitor.
  Acta neuropathologica communications 2022 Arunachalam S, Szlachta K, Brady SW, Ma X, Ju B, Shaner B, Mulder HL, Easton J, Raphael BJ, Myers M, Tinkle C, Allen SJ, Orr BA, Wetmore CJ, Baker SJ, Zhang J
• Accuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry.
  Neuro-oncology 2022 Lazow MA, Fuller C, DeWire M, Lane A, Bandopadhayay P, Bartels U, Bouffet E, Cheng S, Cohen KJ, Cooney TM, Coven SL, Dholaria H, Diez B, Dorris K, El-Ayadi M, El-Sheikh A, Fisher PG, Fonseca A, Garcia…
• Population pharmacokinetics of crenolanib in children and young adults with brain tumors.
  Cancer chemotherapy and pharmacology 2022 Bisbee C, Campagne O, Gajjar A, Tinkle CL, Stewart CF
• Phase I study using crenolanib to target PDGFR kinase in children and young adults with newly diagnosed DIPG or recurrent high-grade glioma, including DIPG.
  Neuro-oncology advances 2021 Tinkle CL, Broniscer A, Chiang J, Campagne O, Huang J, Orr BA, Li X, Patay Z, Zhang J, Baker SJ, Merchant TE, Jain V, Onar-Thomas A, Stewart CF, Wetmore C, Gajjar A
• Data vignettes for the application of response surface models in drug combination analysis.
  Data in brief 2021 Twarog NR, Martinez NE, Gartrell J, Xie J, Tinkle CL, Shelat AA
• SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents.
  Molecular cancer therapeutics 2021 Gartrell J, Mellado-Largarde M, Clay MR, Bahrami A, Sahr NA, Sykes A, Blankenship K, Hoffmann L, Xie J, Cho HP, Twarog N, Connelly M, Yan KK, Yu J, Porter SN, Pruett-Miller SM, Neale G, Tinkle CL, …
• Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.
  Nature communications 2021 He C, Xu K, Zhu X, Dunphy PS, Gudenas B, Lin W, Twarog N, Hover LD, Kwon CH, Kasper LH, Zhang J, Li X, Dalton J, Jonchere B, Mercer KS, Currier DG, Caufield W, Wang Y, Xie J, Broniscer A, Wetmore C, …
• Multi-institutional analysis of treatment modalities in basal ganglia and thalamic germinoma.
  Pediatric blood & cancer 2021 Graham RT, Abu-Arja MH, Stanek JR, Cappellano A, Coleman C, Chi S, Cooney T, Dhall G, Ellen JG, Finlay JL, Fisher MJ, Friedman GK, Gajjar A, Gauvain K, Hoffman LM, Hukin J, Lucas JT, Mueller S, …
• Using response surface models to analyze drug combinations.
  Drug discovery today 2021 Twarog NR, Martinez NE, Gartrell J, Xie J, Tinkle CL, Shelat AA
• Model-based evaluation of image-guided fractionated whole-brain radiation therapy in pediatric diffuse intrinsic pontine glioma xenografts.
  CPT: pharmacometrics & systems pharmacology 2021 Husband HR, Campagne O, He C, Zhu X, Bianski BM, Baker SJ, Shelat AA, Tinkle CL, Stewart CF
• Late effects of radiation therapy in pediatric patients and survivorship.
  Pediatric blood & cancer 2021 Palmer JD, Tsang DS, Tinkle CL, Olch AJ, Kremer LCM, Ronckers CM, Gibbs IC, Constine LS
• NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas.
  Journal of neuropathology and experimental neurology 2021 Dahl NA, Donson AM, Sanford B, Wang D, Walker FM, Gilani A, Foreman NK, Tinkle CL, Baker SJ, Hoffman LM, Venkataraman S, Vibhakar R
• Stereotactic Body Radiation Therapy for Metastatic and Recurrent Solid Tumors in Children and Young Adults.
  International journal of radiation oncology, biology, physics 2020 Tinkle CL, Singh C, Lloyd S, Guo Y, Li Y, Pappo AS, DuBois SG, Lucas JT, Haas-Kogan DA, Terezakis SA, Braunstein SE, Krasin MJ
• Assessment and Treatment Outcomes of Persistent Radiation-Induced Alopecia in Patients With Cancer.
  JAMA dermatology 2020 Phillips GS, Freret ME, Friedman DN, Trelles S, Kukoyi O, Freites-Martinez A, Unger RH, Disa JJ, Wexler LH, Tinkle CL, Mechalakos JG, Dusza SW, Beal K, Wolden SL, Lacouture ME
• Safety and efficacy of brainstem biopsy in children and young adults.
  Journal of neurosurgery. Pediatrics 2020 Hersh DS, Kumar R, Moore KA, Smith LGF, Tinkle CL, Chiang J, Patay Z, Gajjar A, Choudhri AF, Lee-Diaz JA, Vaughn B, Klimo P
• Clinical, imaging, and molecular analysis of pediatric pontine tumors lacking characteristic imaging features of DIPG.
  Acta neuropathologica communications 2020 Chiang J, Diaz AK, Makepeace L, Li X, Han Y, Li Y, Klimo P, Boop FA, Baker SJ, Gajjar A, Merchant TE, Ellison DW, Broniscer A, Patay Z, Tinkle CL
• Radiation dose response of neurologic symptoms during conformal radiotherapy for diffuse intrinsic pontine glioma.
  Journal of neuro-oncology 2020 Tinkle CL, Campbell K, Han Y, Li Y, Bianski B, Broniscer A, Khan RB, Merchant TE
• Efficacy and Safety of Limited-Margin Conformal Radiation Therapy for Pediatric Rhabdomyosarcoma: Long-Term Results of a Phase 2 Study.
  International journal of radiation oncology, biology, physics 2020 Tinkle CL, Pappo A, Wu J, Mao S, Hua CH, Shulkin BL, McCarville MB, Kaste SC, Davidoff AM, Bahrami A, Green DM, Ness KK, Merchant TE, Spunt SL, Krasin MJ
• MRI Patterns of Extrapontine Lesion Extension in Diffuse Intrinsic Pontine Gliomas.
  AJNR. American journal of neuroradiology 2020 Makepeace L, Scoggins M, Mitrea B, Li Y, Edwards A, Tinkle CL, Hwang S, Gajjar A, Patay Z
• Preclinical Models of Craniospinal Irradiation for Medulloblastoma.
  Cancers 2020 Stripay JL, Merchant TE, Roussel MF, Tinkle CL
• Defining Optimal Target Volumes of Conformal Radiation Therapy for Diffuse Intrinsic Pontine Glioma.
  International journal of radiation oncology, biology, physics 2019 Tinkle CL, Simone B, Chiang J, Li X, Campbell K, Han Y, Li Y, Hover LD, Molitoris JK, Becksfort J, Lucas JT, Patay Z, Baker SJ, Broniscer A, Merchant TE
• An LC/ESI-MS/MS method to quantify the PI3K inhibitor GDC-0084 in human plasma and cerebrospinal fluid: Validation and clinical application.
  Biomedical chromatography : BMC 2019 Zhong B, Campagne O, Tinkle CL, Stewart CF
• Molecular grouping and outcomes of young children with newly diagnosed ependymoma treated on the multi-institutional SJYC07 trial.
  Neuro-oncology 2019 Upadhyaya SA, Robinson GW, Onar-Thomas A, Orr BA, Billups CA, Bowers DC, Bendel AE, Hassall T, Crawford JR, Partap S, Fisher PG, Tatevossian RG, Seah T, Qaddoumi IA, Vinitsky A, Armstrong GT, Sabin ND…
• A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration.
  Acta neuropathologica 2019 Chiang J, Harreld JH, Tinkle CL, Moreira DC, Li X, Acharya S, Qaddoumi I, Ellison DW
• Association between hippocampal dose and memory in survivors of childhood or adolescent low-grade glioma: a 10-year neurocognitive longitudinal study.
  Neuro-oncology 2019 Acharya S, Wu S, Ashford JM, Tinkle CL, Lucas JT, Qaddoumi I, Gajjar A, Krasin MJ, Conklin HM, Merchant TE
• Curative-intent radiotherapy for pediatric osteosarcoma: The St. Jude experience.
  Pediatric blood & cancer 2019 Tinkle CL, Lu J, Han Y, Li Y, McCarville BM, Neel MD, Bishop MW, Krasin MJ
• Treatment patterns and disease outcomes for pediatric patients with refractory or recurrent Hodgkin lymphoma treated with curative-intent salvage radiotherapy.
  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2019 Tinkle CL, Williams NL, Wu H, Wu J, Kaste SC, Shulkin BL, Talleur AC, Flerlage JE, Hudson MM, Metzger ML, Krasin MJ
• Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression.
  Cancer cell 2018 Larson JD, Kasper LH, Paugh BS, Jin H, Wu G, Kwon CH, Fan Y, Shaw TI, Silveira AB, Qu C, Xu R, Zhu X, Zhang J, Russell HR, Peters JL, Finkelstein D, Xu B, Lin T, Tinkle CL, Patay Z, Onar-Thomas A, …
• Preclinical Modeling of Image-Guided Craniospinal Irradiation for Very-High-Risk Medulloblastoma.
  International journal of radiation oncology, biology, physics 2018 Smith SMC, Bianski BM, Orr BA, Harknett G, Onar-Thomas A, Gilbertson RJ, Merchant TE, Roussel MF, Tinkle CL
• Long-Term Risk of Venous Thromboembolism in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018 Madenci AL, Weil BR, Liu Q, Murphy AJ, Gibson TM, Yasui Y, Leisenring WM, Howell RM, Tinkle CL, Nekhlyudov L, Diller LR, Armstrong GT, Oeffinger KC, Weldon CB
• Evaluation of 11C-Methionine PET and Anatomic MRI Associations in Diffuse Intrinsic Pontine Glioma.
  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2018 Tinkle CL, Duncan EC, Doubrovin M, Han Y, Li Y, Kim H, Broniscer A, Snyder SE, Merchant TE, Shulkin BL
• Late Infection-Related Mortality in Asplenic Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018 Weil BR, Madenci AL, Liu Q, Howell RM, Gibson TM, Yasui Y, Neglia JP, Leisenring WM, Smith SA, Tonorezos ES, Friedman DN, Constine LS, Tinkle CL, Diller LR, Armstrong GT, Oeffinger KC, Weldon CB
• Clinical Implementation of Magnetic Resonance Imaging Systems for Simulation and Planning of Pediatric Radiation Therapy.
  Journal of medical imaging and radiation sciences 2018 Hua CH, Uh J, Krasin MJ, Lucas JT, Tinkle CL, Acharya S, Smith HL, Kadbi M, Merchant TE
• Radiomics Features Differentiate Between Normal and Tumoral High-Fdg Uptake.
  Scientific reports 2018 Hsu CY, Doubrovin M, Hua CH, Mohammed O, Shulkin BL, Kaste S, Federico S, Metzger M, Krasin M, Tinkle C, Merchant TE, Lucas JT
• Nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) in pediatric and young adult patients: Results from a prospective study using limited-margin radiotherapy.
  Cancer 2017 Tinkle CL, Fernandez-Pineda I, Sykes A, Lu Z, Hua CH, Neel MD, Bahrami A, Shulkin BL, Kaste SC, Pappo A, Spunt SL, Krasin MJ
• Craniospinal irradiation for treatment of metastatic pediatric low-grade glioma.
  Journal of neuro-oncology 2017 Tsang DS, Murphy ES, Ezell SE, Lucas JT, Tinkle C, Merchant TE
• Quantification of Pediatric Abdominal Organ Motion With a 4-Dimensional Magnetic Resonance Imaging Method.
  International journal of radiation oncology, biology, physics 2017 Uh J, Krasin MJ, Li Y, Li X, Tinkle C, Lucas JT, Merchant TE, Hua C
• Prognostic Relevance of Treatment Failure Patterns in Pediatric High-Grade Glioma: Is There a Role for a Revised Failure Classification System?
  International journal of radiation oncology, biology, physics 2017 Lucas JT, Cooper DA, Hwang S, Tinkle C, Li X, Li Y, Orr B, Merchant TE, Broniscer A
• Late toxicity and outcomes following radiation therapy for chest wall sarcomas in pediatric patients.
  Practical radiation oncology 2017 Lucas JT, Fernandez-Pineda I, Tinkle CL, Bishop MW, Kaste SC, Heda R, Davidoff AM, Krasin MJ
• Rapid and fulminant leptomeningeal spread following radiotherapy in diffuse intrinsic pontine glioma.
  Pediatric blood & cancer 2017 Tinkle CL, Orr BA, Lucas JT, Klimo P, Patay Z, Baker SJ, Broniscer A, Qaddoumi I
• Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma.
  Sarcoma 2015 Tinkle CL, Weinberg V, Braunstein SE, Wustrack R, Horvai A, Jahan T, O'Donnell RJ, Gottschalk AR
• Inverse Planned High-Dose-Rate Brachytherapy for Locoregionally Advanced Cervical Cancer: 4-Year Outcomes.
  International journal of radiation oncology, biology, physics 2015 Tinkle CL, Weinberg V, Chen LM, Littell R, Cunha JAM, Sethi RA, Chan JK, Hsu IC
• Hepatocellular carcinoma: natural history, current management, and emerging tools.
  Biologics : targets & therapy 2012 Tinkle CL, Haas-Kogan D
• New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Tinkle CL, Pasolli HA, Stokes N, Fuchs E
• Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Tinkle CL, Lechler T, Pasolli HA, Fuchs E
• MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis.
  Cell 2000 Coussens LM, Tinkle CL, Hanahan D, Werb Z