Christine Hong, DMD, MS
Professor
Orofacial Sciences
School of Dentistry

Education & Training

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• MS Oral Biology UCLA 06/2011
• Certificate Orthodontics UCLA 06/2011
• DMD Dentistry Harvard University 06/2008
• BA Chemistry Cornell University 05/2001

Grants and Projects

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• Molecular Regulation of MSC fate Decision and Bone Formation by PGC-1a, NIH, 2017-2022
• Promoting DMSC-mediated craniofacial regeneration by estrogen, NIH, 2014-2021
• The molecular regulation of NGF-mediated differentiation of dental pulp stem cells, NIH, 2016-2020

Publications (36)

Top publication keywords:
TonsillectomyCleft PalateOrthodontic Anchorage ProceduresOsteogenesisReceptors, Nerve Growth FactorDental ImplantsDiphosphonatesAdenoidsOrthodontic WiresSOX9 Transcription FactorChondrogenesisOrthodontic Appliance DesignNanodiamondsJumonji Domain-Containing Histone DemethylasesPalatal Expansion Technique

• Epigenetic Regulation of NGF-Mediated Osteogenic Differentiation in Human Dental Mesenchymal Stem Cells.
  Stem cells (Dayton, Ohio) 2022 Liu Z, Suh JS, Deng P, Bezouglaia O, Do M, Mirnia M, Cui ZK, Lee M, Aghaloo T, Wang CY, Hong C
• Indigenous microbiota protects development of medication-related osteonecrosis induced by periapical disease in mice.
  International journal of oral science 2022 Du W, Yang M, Kim T, Kim S, Williams DW, Esmaeili M, Hong C, Shin KH, Kang MK, Park NH, Kim RH
• Impact of rapid palatal expansion on the size of adenoids and tonsils in children.
  Sleep medicine 2022 Yoon A, Abdelwahab M, Bockow R, Vakili A, Lovell K, Chang I, Ganguly R, Liu SY, Kushida C, Hong C
• The ERα/KDM6B regulatory axis modulates osteogenic differentiation in human mesenchymal stem cells.
  Bone research 2022 Liu Z, Lee HL, Suh JS, Deng P, Lee CR, Bezouglaia O, Mirnia M, Chen V, Zhou M, Cui ZK, Kim RH, Lee M, Aghaloo T, Hong C, Wang CY
• Growth differentiation factor 6, a repressive target of EZH2, promotes the commitment of human embryonic stem cells to mesenchymal stem cells.
  Bone research 2020 Deng P, Yu Y, Hong C, Wang CY

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• Correcting severe scissor bite in an adult.
  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2019 Baik UB, Kim Y, Sugawara J, Hong C, Park JH
• Inhibition of IKK/NF-κB Signaling Enhances Differentiation of Mesenchymal Stromal Cells from Human Embryonic Stem Cells.
  Stem cell reports 2019 Deng P, Zhou C, Alvarez R, Hong C, Wang CY
• Author Correction: Single CD271 marker isolates mesenchymal stem cells from human dental pulp.
  International journal of oral science 2019 Alvarez R, Lee HL, Hong C, Wang CY
• Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3.
  Stem cell reports 2018 Yu Y, Deng P, Yu B, Szymanski JM, Aghaloo T, Hong C, Wang CY
• PGC-1α Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ.
  Cell stem cell 2018 Yu B, Huo L, Liu Y, Deng P, Szymanski J, Li J, Luo X, Hong C, Lin J, Wang CY
• PGC-1α Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ.
  Cell stem cell 2018 Yu B, Huo L, Liu Y, Deng P, Szymanski J, Li J, Luo X, Hong C, Lin J, Wang CY
• KDM4B protects against obesity and metabolic dysfunction.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Cheng Y, Yuan Q, Vergnes L, Rong X, Youn JY, Li J, Yu Y, Liu W, Cai H, Lin JD, Tontonoz P, Hong C, Reue K, Wang CY
• Local vs. systemic administration of bisphosphonates in rat cleft bone graft: A comparative study.
  PloS one 2018 Hong C, Quach A, Lin L, Olson J, Kwon T, Bezouglaia O, Tran J, Hoang M, Bui K, Kim RH, Tetradis S
• Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3.
  Stem cell reports 2017 Yu Y, Deng P, Yu B, Szymanski JM, Aghaloo T, Hong C, Wang CY
• Reducing posttreatment relapse in cleft lip palatal expansion using an injectable estrogen-nanodiamond hydrogel.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Hong C, Song D, Lee DK, Lin L, Pan HC, Lee D, Deng P, Liu Z, Hadaya D, Lee HL, Mohammad A, Zhang X, Lee M, Wang CY, Ho D
• Effects of monocortical and bicortical mini-implant anchorage on bone-borne palatal expansion using finite element analysis.
  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2017 Lee RJ, Moon W, Hong C
• Effects of Bisphosphonate Administration on Cleft Bone Graft in a Rat Model.
  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2017 Cheng N, Park J, Olson J, Kwon T, Lee D, Lim R, Ha S, Kim R, Zhang X, Ting K, Tetradis S, Hong C
• Ability of mini-implant-facilitated micro-osteoperforations to accelerate tooth movement in rats.
  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2016 Cheung T, Park J, Lee D, Kim C, Olson J, Javadi S, Lawson G, McCabe J, Moon W, Ting K, Hong C
• Biomechanical effects of maxillary expansion on a patient with cleft palate: A finite element analysis.
  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2016 Lee H, Nguyen A, Hong C, Hoang P, Pham J, Ting K
• Alcohol-induced suppression of KDM6B dysregulates the mineralization potential in dental pulp stem cells.
  Stem cell research 2016 Hoang M, Kim JJ, Kim Y, Tong E, Trammell B, Liu Y, Shi S, Lee CR, Hong C, Wang CY, Kim Y
• Inhibition of IKK/NF-κB Signaling Enhances Differentiation of Mesenchymal Stromal Cells from Human Embryonic Stem Cells.
  Stem cell reports 2016 Deng P, Zhou C, Alvarez R, Hong C, Wang CY
• Characterization of the osteogenic potential of mesenchymal stem cells from human periodontal ligament based on cell surface markers.
  International journal of oral science 2015 Alvarez R, Lee HL, Wang CY, Hong C
• Histone methyltransferases and demethylases: regulators in balancing osteogenic and adipogenic differentiation of mesenchymal stem cells.
  International journal of oral science 2015 Deng P, Chen QM, Hong C, Wang CY
• Single CD271 marker isolates mesenchymal stem cells from human dental pulp.
  International journal of oral science 2015 Alvarez R, Lee HL, Hong C, Wang CY
• Transforming Growth Factor-β-Induced KDM4B Promotes Chondrogenic Differentiation of Human Mesenchymal Stem Cells.
  Stem cells (Dayton, Ohio) 2015 Lee HL, Yu B, Deng P, Wang CY, Hong C
• Nanodiamond-Gutta Percha Composite Biomaterials for Root Canal Therapy.
  ACS nano 2015 Lee DK, Kim SV, Limansubroto AN, Yen A, Soundia A, Wang CY, Shi W, Hong C, Tetradis S, Kim Y, Park NH, Kang MK, Ho D
• Regulation of p53 during senescence in normal human keratinocytes.
  Aging cell 2015 Kim RH, Kang MK, Kim T, Yang P, Bae S, Williams DW, Phung S, Shin KH, Hong C, Park NH
• Volumetric assessment of cleft lip and palate defects using cone beam computed tomography.
  Journal of the California Dental Association 2013 Lee D, Atti E, Blackburn J, Yen S, Lee D, Tetradis S, Hong C
• KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells.
  International journal of oral science 2013 Xu J, Yu B, Hong C, Wang CY
• Mechanical stability and clinical applicability assessment of novel orthodontic mini-implant design.
  The Angle orthodontist 2013 Song HN, Hong C, Banh R, Ohebsion T, Asatrian G, Leung HY, Wu BM, Moon W
• Mechanical stability assessment of novel orthodontic mini-implant designs: Part 2.
  The Angle orthodontist 2011 Hong C, Truong P, Song HN, Wu BM, Moon W
• Stability comparison between commercially available mini-implants and a novel design: part 1.
  The Angle orthodontist 2011 Hong C, Lee H, Webster R, Kwak J, Wu BM, Moon W
• A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling.
  Cell 2009 Ramirez-Carrozzi VR, Braas D, Bhatt DM, Cheng CS, Hong C, Doty KR, Black JC, Hoffmann A, Carey M, Smale ST
• Distalization of the entire maxillary arch in an adult.
  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2009 Kyung SH, Lee JY, Shin JW, Hong C, Dietz V, Gianelly AA
• Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
  The Journal of clinical investigation 2004 Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG
• Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Bergo MO, Gavino B, Ross J, Schmidt WK, Hong C, Kendall LV, Mohr A, Meta M, Genant H, Jiang Y, Wisner ER, Van Bruggen N, Carano RA, Michaelis S, Griffey SM, Young SG