Christian Vaisse, MD, PhD
Professor
Diabetes Center
School of Medicine

Websites

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• Profile at endocrine.medicine.ucsf.edu (endocrine.medicine.ucsf.edu)

Grants and Projects

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• Obesity in Ciliopathies: How Neuronal Primary Cilia Control Appetite, NIH, 2016-2026
• The Melanocortin-4 Receptor in Human Obesity, NIH, 2002-2025
• UCSF Nutrition Obesity Research Center, NIH, 2015-2025
• From Obesity GWAS to therapeutic targets, NIH, 2020-2025
• Diabetes Research Center, NIH, 2002-2021
• The Melanocortin-4 Receptor in Human Obesity, NIH, 2002-2020
• Identification & functional characterization of SIM1 obesity-associated variants, NIH, 2012-2016
• Role of Pro-opiomelanocortin mutations in human obesity, NIH, 2005-2010
• General Clinical Research Center, NIH, 1974-2009
• General Clinical Research Center, NIH, 1974-2007
• Pediatric Clinical Research Center, NIH, 1981-2007

Publications (75)

Top publication keywords:
Body WeightReceptor, Melanocortin, Type 4EatingHypothalamusPro-OpiomelanocortinObesityObesity, MorbidAdenylyl CyclasesMelanocortinsMutationCiliaAlstrom SyndromeBardet-Biedl SyndromeLeptinReceptors, Corticotropin

• Author Correction: Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation.
  Nature metabolism 2024 Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N
• Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain.
  Cells 2024 Brewer KK, Brewer KM, Terry TT, Caspary T, Vaisse C, Berbari NF
• Identification of AgRP cells in the murine hindbrain that drive feeding.
  Molecular metabolism 2024 Bachor TP, Hwang E, Yulyaningsih E, Attal K, Mifsud F, Pham V, Vagena E, Huarcaya R, Valdearcos M, Vaisse C, Williams KW, Emmerson PJ, Xu AW
• Ciliary ARL13B prevents obesity in mice.
  bioRxiv : the preprint server for biology 2023 Terry TT, Gigante ED, Alexandre CM, Brewer KM, Engle SE, Yue X, Berbari NF, Vaisse C, Caspary T
• 1522-P: Identification of AgRP Cells in the Murine Hindbrain That Drive Feeding.
  Diabetes 2023 TOMAS P. BACHOR, KUSH ATTAL, EIRINI VAGENA, FRANCOIS MIFSUD, VIANA PHAM, MARTIN VALDEARCOS-CONTRERAS, CHRISTIAN VAISSE, ALLISON XU

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• Physiological Condition-Dependent Changes in Ciliary GPCR Localization in the Brain.
  eNeuro 2023 Brewer KM, Engle SE, Bansal R, Brewer KK, Jasso KR, McIntyre JC, Vaisse C, Reiter JF, Berbari NF
• MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R.
  JCI insight 2023 Bernard A, Ojeda Naharros I, Yue X, Mifsud F, Blake A, Bourgain-Guglielmetti F, Ciprin J, Zhang S, McDaid E, Kim K, Nachury MV, Reiter JF, Vaisse C
• KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation.
  Science advances 2022 Jiang Z, Elsarrag SZ, Duan Q, LaGory EL, Wang Z, Alexanian M, McMahon S, Rulifson IC, Winchester S, Wang Y, Vaisse C, Brown JD, Quattrocelli M, Lin CY, Haldar SM
• Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight.
  The Journal of clinical investigation 2021 Wang Y, Bernard A, Comblain F, Yue X, Paillart C, Zhang S, Reiter JF, Vaisse C
• OR04-01 MRAP2 Regulates Energy Homeostasis by Promoting Primary Cilia Localization of MC4R.
  Journal of the Endocrine Society 2020 Adelaide A Bernard, Irene Ojeda Naharros, Florence Bourgain Guglielmetti, Xinyu Yue, Christian Vaisse
• Detailed 3-dimensional body shape features predict body composition, blood metabolites, and functional strength: the Shape Up! studies.
  The American journal of clinical nutrition 2019 Ng BK, Sommer MJ, Wong MC, Pagano I, Nie Y, Fan B, Kennedy S, Bourgeois B, Kelly N, Liu YE, Hwaung P, Garber AK, Chow D, Vaisse C, Curless B, Heymsfield SB, Shepherd JA
• CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.
  2019 Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N
• Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation.
  Nature metabolism 2019 Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N
• CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency.
  Science (New York, N.Y.) 2018 Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N
• Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.
  Nature genetics 2018 Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C
• Cilia and Obesity.
  Cold Spring Harbor perspectives in biology 2017 Vaisse C, Reiter JF, Berbari NF
• Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.
  Cell reports 2017 Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW
• The Association of Serum Leptin with Mortality in Older Adults.
  PloS one 2015 Mishra S, Harris TB, Hsueh WC, Hue T, Leak TS, Li R, Mehta M, Vaisse C, Sahyoun NR
• Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions.
  PloS one 2014 Evans DS, Calton MA, Kim MJ, Kwok PY, Miljkovic I, Harris T, Koster A, Liu Y, Tranah GJ, Ahituv N, Hsueh WC, Vaisse C
• Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.
  Obesity (Silver Spring, Md.) 2014 Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, …
• Functional characterization of SIM1-associated enhancers.
  Human molecular genetics 2013 Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N
• The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus.
  International journal of obesity (2005) 2013 Aslan IR, Ranadive SA, Valle I, Kollipara S, Noble JA, Vaisse C
• Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR.
  Nature chemical biology 2012 Ersoy BA, Pardo L, Zhang S, Thompson DA, Millhauser G, Govaerts C, Vaisse C
• Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations.
  Obesity surgery 2011 Aslan IR, Campos GM, Calton MA, Evans DS, Merriman RB, Vaisse C
• Replication and extension of association between common genetic variants in SIM1 and human adiposity.
  Obesity (Silver Spring, Md.) 2011 Swarbrick MM, Evans DS, Valle MI, Favre H, Wu SH, Njajou OT, Li R, Zmuda JM, Miljkovic I, Harris TB, Kwok PY, Vaisse C, Hsueh WC
• Monogenic Disorders Within the Energy Balance Pathway.
  Obesity Before Birth 2011 Ivy R. Aslan, Sayali A. Ranadive, Christian Vaisse
• Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice.
  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2010 Ionova-Martin SS, Wade JM, Tang S, Shahnazari M, Ager JW, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO
• Systematic examination of the SIM1 gene region: Replication and extension of association between common genetic variants and adiposity.
  Obesity Research & Clinical Practice 2010 M.M. Swarbrick, D.S. Evans, M.I.V. Ascencio, H. Favre, S.-H. Wu, O.T. Njajou, R. Li, J.M. Zmuda, I. Miljkovic, T.B. Harris, P.-Y. Kwok, C. Vaisse, W.-C. Hsueh
• Bariatric surgery in a patient with complete MC4R deficiency.
  International journal of obesity (2005) 2010 Aslan IR, Ranadive SA, Ersoy BA, Rogers SJ, Lustig RH, Vaisse C
• Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity.
  Bone 2009 Ionova-Martin SS, Do SH, Barth HD, Szadkowska M, Porter AE, Ager JW, Ager JW, Alliston T, Vaisse C, Ritchie RO
• In silico mutagenesis: a case study of the melanocortin 4 receptor.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Bromberg Y, Overton J, Vaisse C, Leibel RL, Rost B
• Narrowing down the role of common variants in the genetic predisposition to obesity.
  Genome medicine 2009 Calton MA, Vaisse C
• Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus.
  Clinical endocrinology 2008 Ranadive SA, Ersoy B, Favre H, Cheung CC, Rosenthal SM, Miller WL, Vaisse C
• Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study.
  Human molecular genetics 2008 Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C
• Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene.
  The Journal of clinical endocrinology and metabolism 2008 Clément K, Dubern B, Mencarelli M, Czernichow P, Ito S, Wakamatsu K, Barsh GS, Vaisse C, Leger J
• Lessons from extreme human obesity: monogenic disorders.
  Endocrinology and metabolism clinics of North America 2008 Ranadive SA, Vaisse C
• Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain.
  Pediatric research 2008 Dubern B, Lubrano-Berthelier C, Mencarelli M, Ersoy B, Frelut ML, Bouglé D, Costes B, Simon C, Tounian P, Vaisse C, Clement K
• Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes.
  Diabetes, obesity & metabolism 2007 Louet JF, Smith SB, Gautier JF, Molokhia M, Virally ML, Kevorkian JP, Guillausseau PJ, Vexiau P, Charpentier G, German MS, Vaisse C, Urbanek M, Mauvais-Jarvis F
• Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo.
  PloS one 2007 Srinivasan S, Santiago P, Lubrano C, Vaisse C, Conklin BR
• Medical sequencing at the extremes of human body mass.
  American journal of human genetics 2007 Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, Yosef N, Ruppin E, Sharan R, Vaisse C, Sunyaev S, Dent R, Cohen J, McPherson R, …
• MUTATIONAL ANALYSIS OF THE PROOPIOMELANOCORTIN GENE IN OBESE CHILDREN.
  Journal of Pediatric Gastroenterology and Nutrition 2006 B Dubern, C Lubrano-berthelier, D Bouglé, ML Frelut, C Simon, C Vaisse, K Clément, P Tounian
• Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating.
  The Journal of clinical endocrinology and metabolism 2006 Lubrano-Berthelier C, Dubern B, Lacorte JM, Picard F, Shapiro A, Zhang S, Bertrais S, Hercberg S, Basdevant A, Clement K, Vaisse C
• Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function.
  Peptides 2005 Govaerts C, Srinivasan S, Shapiro A, Zhang S, Picard F, Clement K, Lubrano-Berthelier C, Vaisse C
• Lack of support for the association between GAD2 polymorphisms and severe human obesity.
  PLoS biology 2005 Swarbrick MM, Waldenmaier B, Pennacchio LA, Lind DL, Cavazos MM, Geller F, Merriman R, Ustaszewska A, Malloy M, Scherag A, Hsueh WC, Rief W, Mauvais-Jarvis F, Pullinger CR, Kane JP, Dent R, McPherson …
• High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes.
  The Journal of clinical endocrinology and metabolism 2005 Sobngwi E, Gautier JF, Kevorkian JP, Villette JM, Riveline JP, Zhang S, Vexiau P, Leal SM, Vaisse C, Mauvais-Jarvis F
• Leptin regulation of bone resorption by the sympathetic nervous system and CART.
  Nature 2005 Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G
• A statistical approach for array CGH data analysis.
  BMC bioinformatics 2005 Picard F, Robin S, Lavielle M, Vaisse C, Daudin JJ
• PAX4 gene variations predispose to ketosis-prone diabetes.
  Human molecular genetics 2004 Mauvais-Jarvis F, Smith SB, Le May C, Leal SM, Gautier JF, Molokhia M, Riveline JP, Rajan AS, Kevorkian JP, Zhang S, Vexiau P, German MS, Vaisse C
• Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.
  The Journal of clinical investigation 2004 Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C
• A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans.
  The Journal of clinical endocrinology and metabolism 2004 Lubrano-Berthelier C, Le Stunff C, Bougnères P, Vaisse C
• Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance.
  Diabetes 2004 Mauvais-Jarvis F, Sobngwi E, Porcher R, Riveline JP, Kevorkian JP, Vaisse C, Charpentier G, Guillausseau PJ, Vexiau P, Gautier JF
• The human MC4R promoter: characterization and role in obesity.
  Diabetes 2003 Lubrano-Berthelier C, Cavazos M, Le Stunff C, Haas K, Shapiro A, Zhang S, Bougneres P, Vaisse C
• Emerging trends in the search for genetic variants predisposing to human obesity.
  Current opinion in clinical nutrition and metabolic care 2003 Swarbrick MM, Vaisse C
• Engineering the melanocortin-4 receptor to control G(s) signaling in vivo.
  Annals of the New York Academy of Sciences 2003 Srinivasan S, Vaisse C, Conklin BR
• Molecular genetics of human obesity-associated MC4R mutations.
  Annals of the New York Academy of Sciences 2003 Lubrano-Berthelier C, Cavazos M, Dubern B, Shapiro A, Stunff CL, Zhang S, Picart F, Govaerts C, Froguel P, Bougneres P, Clement K, Vaisse C
• Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations.
  Human molecular genetics 2003 Lubrano-Berthelier C, Durand E, Dubern B, Shapiro A, Dazin P, Weill J, Ferron C, Froguel P, Vaisse C
• Elevated plasma ghrelin levels in Prader Willi syndrome.
  Nature medicine 2002 Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS
• The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.
  Human heredity 2000 Navas MA, Vaisse C, Boger S, Heimesaat M, Kollee LA, Stoffel M
• Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass.
  Diabetes 2000 Lahlou N, Clement K, Carel JC, Vaisse C, Lotton C, Le Bihan Y, Basdevant A, Lebouc Y, Froguel P, Roger M, Guy-Grand B
• Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity.
  The Journal of clinical investigation 2000 Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P
• The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes.
  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000 Clement K, Hercberg S, Passinge B, Galan P, Varroud-Vial M, Shuldiner AR, Beamer BA, Charpentier G, Guy-Grand B, Froguel P, Vaisse C
• Glycodelin: a pane in the implantation window.
  Seminars in reproductive medicine 2000 Mueller MD, Vigne JL, Vaisse C, Taylor RN
• Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells.
  The Journal of clinical endocrinology and metabolism 1998 Taylor RN, Savouret JF, Vaisse C, Vigne JL, Ryan I, Hornung D, Seppälä M, Milgrom E
• A frameshift mutation in human MC4R is associated with a dominant form of obesity.
  Nature genetics 1998 Vaisse C, Clement K, Guy-Grand B, Froguel P
• A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.
  Nature 1998 Clément K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougnères P, Lebouc Y, Froguel P, Guy-Grand B
• La mutation du gène du récepteur de la leptine entraîne chez l'homme une obésité massive associée à des anomalies hypothalamo-hypophysaires.
  Médecine/sciences 1998 K Clément, C Vaisse, A Basdevant, B Guy-Grand, P Froguel
• Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6.
  Diabetes 1997 Vaisse C, Kim J, Espinosa R, Le Beau MM, Stoffel M
• Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.
  Nature genetics 1996 Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M, Friedman JM
• Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes.
  Lancet (London, England) 1995 Ruiz J, Blanché H, James RW, Garin MC, Vaisse C, Charpentier G, Cohen N, Morabia A, Passa P, Froguel P
• Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.
  The New England journal of medicine 1995 Clément K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD
• A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus.
  Nature genetics 1995 Hager J, Hansen L, Vaisse C, Vionnet N, Philippi A, Poller W, Velho G, Carcassi C, Contu L, Julier C
• Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues.
  DNA and cell biology 1991 Mellon SH, Kushner JA, Vaisse C
• The human placental protein 14 (PP14) gene is localized on chromosome 9q34.
  Human genetics 1991 Van Cong N, Vaisse C, Gross MS, Slim R, Milgrom E, Bernheim A
• Human placental protein 14 gene: sequence and characterization of a short duplication.
  DNA and cell biology 1990 Vaisse C, Atger M, Potier B, Milgrom E
• cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Mellon SH, Vaisse C