Christian Macdonald, PhD
Postdoctoral Scholar
Bioengineering
School of Pharmacy

Publications (7)

Top publication keywords:
DepsipeptidesINDEL MutationDrug Resistance, Multiple, BacterialBiologyMolecular StructureMutation, MissenseProteinsAntiportersGuanidineIon ChannelsPorosityFluoridesAntineoplastic AgentsNitrobenzoatesAnhydrides

• Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.
  bioRxiv : the preprint server for biology 2023 Estevam GO, Linossi EM, Macdonald CB, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS
• DIMPLE: deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology.
  Genome biology 2023 Macdonald CB, Nedrud D, Grimes PR, Trinidad D, Fraser JS, Coyote-Maestas W
• The structural basis of promiscuity in small multidrug resistance transporters.
  Nature communications 2020 Kermani AA, Macdonald CB, Burata OE, Ben Koff B, Koide A, Denbaum E, Koide S, Stockbridge RB
• Guanidinium export is the primal function of SMR family transporters.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Kermani AA, Macdonald CB, Gundepudi R, Stockbridge RB
• A topologically diverse family of fluoride channels.
  Current opinion in structural biology 2017 Macdonald CB, Stockbridge RB
• Antineoplastic agents. 599. Total synthesis of dolastatin 16.
  Journal of natural products 2015 Pettit GR, Smith TH, Arce PM, Flahive EJ, Anderson CR, Chapuis JC, Xu JP, Groy TL, Belcher PE, Macdonald CB
• Antineoplastic agents. 600. From the South Pacific Ocean to the silstatins.
  Journal of natural products 2015 Pettit GR, Arce PM, Chapuis JC, Macdonald CB