Christian Macdonald, PhD
Postdoctoral Scholar
Bioengineering
School of Pharmacy

Publications (14)

Top publication keywords:
ProtonsOrganic Cation Transporter 1DepsipeptidesINDEL MutationBiologyMolecular StructureMutation, MissenseProteinsAntiportersGuanidineMolecular Dynamics SimulationIon ChannelsProto-Oncogene Proteins c-metFluoridesAntineoplastic Agents

• Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning.
  eLife 2025 Estevam GO, Linossi E, Rao J, Macdonald CB, Ravikumar A, Chrispens KM, Capra JA, Coyote-Maestas W, Pimentel H, Collisson EA, Jura N, Fraser JS
• Molecular basis of proton sensing by G protein-coupled receptors.
  Cell 2025 Howard MK, Hoppe N, Huang XP, Mitrovic D, Billesbølle CB, Macdonald CB, Mehrotra E, Rockefeller Grimes P, Trinidad DD, Delemotte L, English JG, Coyote-Maestas W, Manglik A
• Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning.
  bioRxiv : the preprint server for biology 2024 Estevam GO, Linossi EM, Rao J, Macdonald CB, Ravikumar A, Chrispens KM, Capra JA, Coyote-Maestas W, Pimentel H, Collisson EA, Jura N, Fraser JS
• Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.
  eLife 2024 Estevam GO, Linossi EM, Macdonald CB, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS
• Deep mutational scanning of EccD3 reveals the molecular basis of its essentiality in the mycobacterium ESX secretion system.
  bioRxiv : the preprint server for biology 2024 Trinidad DD, Macdonald CB, Rosenberg OS, Fraser JS, Coyote-Maestas W

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• Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.
  bioRxiv : the preprint server for biology 2024 Estevam GO, Linossi EM, Macdonald CB, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS
• The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics.
  Molecular cell 2024 Yee SW, Macdonald CB, Mitrovic D, Zhou X, Koleske ML, Yang J, Buitrago Silva D, Rockefeller Grimes P, Trinidad DD, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W
• Molecular basis of proton-sensing by G protein-coupled receptors.
  bioRxiv : the preprint server for biology 2024 Howard MK, Hoppe N, Huang XP, Macdonald CB, Mehrota E, Grimes PR, Zahm A, Trinidad DD, English J, Coyote-Maestas W, Manglik A
• DIMPLE: deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology.
  Genome biology 2023 Macdonald CB, Nedrud D, Grimes PR, Trinidad D, Fraser JS, Coyote-Maestas W
• The structural basis of promiscuity in small multidrug resistance transporters.
  Nature communications 2020 Kermani AA, Macdonald CB, Burata OE, Ben Koff B, Koide A, Denbaum E, Koide S, Stockbridge RB
• Guanidinium export is the primal function of SMR family transporters.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Kermani AA, Macdonald CB, Gundepudi R, Stockbridge RB
• A topologically diverse family of fluoride channels.
  Current opinion in structural biology 2017 Macdonald CB, Stockbridge RB
• Antineoplastic agents. 599. Total synthesis of dolastatin 16.
  Journal of natural products 2015 Pettit GR, Smith TH, Arce PM, Flahive EJ, Anderson CR, Chapuis JC, Xu JP, Groy TL, Belcher PE, Macdonald CB
• Antineoplastic agents. 600. From the South Pacific Ocean to the silstatins.
  Journal of natural products 2015 Pettit GR, Arce PM, Chapuis JC, Macdonald CB